Protéases/Protéasome
Les inhibiteurs de protéases et de protéasomes sont des composés qui bloquent l'activité des protéases et du protéasome, impliqués dans la dégradation et le renouvellement des protéines. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie des protéines, le contrôle du cycle cellulaire et l'apoptose. Les inhibiteurs de protéases et de protéasomes sont également utilisés dans le traitement de maladies telles que le cancer, où une dégradation anormale des protéines joue un rôle dans la progression de la maladie. En inhibant les protéases ou le protéasome, ces composés peuvent induire la mort cellulaire dans les cellules cancéreuses et sont des outils essentiels tant pour la recherche fondamentale que pour le développement thérapeutique. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de protéases et de protéasomes de haute qualité pour soutenir vos recherches en biochimie, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Protéases/Protéasome"
- Acétyl-CoA Carboxylase(34 produits)
- Cystéine protéase(96 produits)
- DPP-4(20 produits)
- Glutaminase(40 produits)
- Protéase du VIH(449 produits)
- PAI-1(25 produits)
- Inhibiteurs de protéase(50 produits)
- Récepteur activé par une protéase(53 produits)
- Protéasome(94 produits)
- Sérine protéase(50 produits)
- p97(14 produits)
Affichez 3 plus de sous-catégories
1044 produits trouvés pour "Protéases/Protéasome"
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Cathepsin C-IN-5
CAS :<p>Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.</p>Formule :C21H17ClN6OSCouleur et forme :SolidMasse moléculaire :436.92BI 224436
CAS :<p>BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.</p>Formule :C27H26N2O4Couleur et forme :SolidMasse moléculaire :442.51SMCypI C31
<p>SMCypIC31, a non-peptide cyclophilin inhibitor, blocks PPIase at 0.1 μM IC50 and fights various HCV genotypes (EC50: 1.20-7.76 μM).</p>Formule :C27H30N4O2SCouleur et forme :SolidMasse moléculaire :474.62TCL1
CAS :<p>TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.</p>Formule :C19H14BrClN4O2SCouleur et forme :SolidMasse moléculaire :477.762HCV NS5B polymerase-IN-2
CAS :<p>HCVNS5B polymerase-IN-2 (Compound 298) is an inhibitor of the Ns5b polymerase. It holds potential for research into the treatment of hepatitis C virus (HCV) infections.</p>Formule :C26H24N2O4Couleur et forme :SolidMasse moléculaire :428.48Cathepsin K inhibitor 2
CAS :<p>Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.</p>Formule :C30H33F4N5O3Couleur et forme :SolidMasse moléculaire :587.61M826
<p>M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in</p>Formule :C28H45N7O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :575.7Dup-714
CAS :<p>Dup-714 is a thrombin inhibitor.</p>Formule :C21H33BN6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.33Feniralstat
CAS :<p>Feniralstat (KVD-824) is a selective and potent kallikrein (kallikrein) inhibitor, useful in immune system diseases and cardiovascular disease research.</p>Formule :C26H25F2N5O4Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :509.51Napsagatran hydrate
CAS :<p>Napsagatran hydrate is a novel and specific inhibitor of thrombin.</p>Formule :C26H36N6O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :576.66ZINC09518833
CAS :<p>ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).</p>Formule :C24H25N3O5Couleur et forme :SolidMasse moléculaire :435.47Tyrosinase-IN-37
CAS :<p>Tyrosinase-IN-37 (Compound 3c) is a potent inhibitor of tyrosinase, with an IC50 value of 1.02 μM, which is 14 times more effective than kojic acid (IC50 of 14.74 μM). This compound effectively prevents the browning of Rosa roxburghii and can also inhibit browning not caused by tyrosinase.</p>Formule :C12H12N6SCouleur et forme :SolidMasse moléculaire :272.33Tyrosinase-IN-29
CAS :<p>Tyrosinase-IN-29 (compound 5c) is an effective inhibitor of abTYR tyrosinase, demonstrating an IC50 value of 6.11 μM. It is suitable for further research into the inhibition of excessive skin pigmentation.</p>Formule :C10H9NO2Couleur et forme :SolidMasse moléculaire :175.18(2S,4R)-Teneligliptin
CAS :<p>(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.</p>Formule :C22H30N6OSCouleur et forme :SolidMasse moléculaire :426.578HCV-IN-7
CAS :<p>HCV-IN-7: potent oral HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.</p>Formule :C40H48N8O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :768.92Idraparinux Na
CAS :<p>Idraparinux Na is an Antithrombotic, Indirect, Selective, Synthetic Factor Xa Inhibitor</p>Formule :C38H55Na9O49S7Couleur et forme :SolidMasse moléculaire :1727.14Tyrosinase-IN-20
CAS :<p>Tyrosinase-IN-20 (compound 6a) acts as a potent Tyrosinase inhibitor, demonstrating an IC 50 value of 28.50 μM [1].</p>Formule :C17H18N2O2SCouleur et forme :SolidMasse moléculaire :314.4Monosodium 2-sulfoterephthalate
CAS :<p>Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.</p>Formule :C8H5NaO7SCouleur et forme :SolidMasse moléculaire :268.176BMT-052
CAS :<p>BMT-052 is a potent and selective Pan-genotypic HCV NS5B Polymerase Inhibitor (EC50 = 7 nM).</p>Formule :C30H17D9F4N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :635.61SSR-182289A (Free)
CAS :<p>SSR-182289A (Free) is a thrombin inhibitor.</p>Formule :C30H33F2N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :597.68GLS-1-IN-1
<p>GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.</p>Formule :C26H25FN4OSCouleur et forme :SolidMasse moléculaire :460.57Cathepsin C-IN-3
<p>Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).</p>Formule :C28H21F3N6OSCouleur et forme :SolidMasse moléculaire :546.57Antiplatelet agent 3
CAS :<p>Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.</p>Formule :C38H32N2O5Couleur et forme :SolidMasse moléculaire :596.671SCO-792
<p>SCO-792: potent, reversible oral enteropeptidase inhibitor, with slow in vitro dissociation and in vivo protein digestion blocking.</p>Formule :C22H22N4O8·xH2OCouleur et forme :SolidKallikrein-IN-1
CAS :<p>Kallikrein-IN-1 (Formula A) is an inhibitor of the kinin-releasing enzyme Kallikrein.</p>Formule :C28H26FN5O4Couleur et forme :SolidMasse moléculaire :515.54CM-352
CAS :<p>CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.</p>Formule :C24H29N3O6SDegré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :487.57Immunoproteasome activator 1
CAS :Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.Formule :C24H23N3O3Couleur et forme :SolidMasse moléculaire :401.46GSK-2878175
CAS :<p>GSK-2878175, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>Formule :C27H23BClFN2O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :568.81Piceid 6″-O-azelaic acid ester
<p>Piceid 6″-O-azelaic acid ester exhibited strong intracellular tyrosinase inhibition and decolorization activity.</p>Formule :C24H36O10Couleur et forme :SolidMasse moléculaire :484.54IDX184
CAS :<p>IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3</p>Formule :C25H35N6O9PSDegré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :626.62JTK-109
CAS :<p>JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.</p>Formule :C37H33ClFN3O4Degré de pureté :98.48% - 99.68%Couleur et forme :SolidMasse moléculaire :638.13Vaniprevir
CAS :<p>Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.</p>Formule :C38H55N5O9SDegré de pureté :97.41%Couleur et forme :SolidMasse moléculaire :757.94MIV-247
CAS :<p>MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.</p>Formule :C17H24F3N3O4Degré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :391.39PD 151746
CAS :<p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>Formule :C11H8FNO2SDegré de pureté :98.63% - ≥95%Couleur et forme :SolidMasse moléculaire :237.25Sebetralstat
CAS :<p>Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.</p>Formule :C26H26FN5O4Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :491.512,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-
CAS :Formule :C37H48N6O5S2Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :720.9442MMP13-IN-2
CAS :<p>MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.</p>Formule :C24H19FN6O4SCouleur et forme :SolidMasse moléculaire :506.51IPN60090 dihydrochloride
CAS :<p>IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.</p>Formule :C24H29Cl2F3N8O3Couleur et forme :SolidMasse moléculaire :605.44ALLM
CAS :<p>ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].</p>Formule :C19H35N3O4SDegré de pureté :98%Couleur et forme :White PowderMasse moléculaire :401.56ABT-072 potassium trihydrate
CAS :<p>ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).</p>Formule :C24H32KN3O8SCouleur et forme :SolidMasse moléculaire :561.693-Deazaadenosine
CAS :<p>3-Deazaadenosine, an inhibitor of S-adenosylhomocysteine hydrolase with a Ki of 3.9 μM, exhibits anti-inflammatory, anti-proliferative, and anti-HIV activity.</p>Formule :C11H14N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :266.25Oxindole
CAS :<p>Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.</p>Formule :C8H7NODegré de pureté :99.34%Couleur et forme :Off-White Crystalline PowderMasse moléculaire :133.15Butabindide oxalate
CAS :<p>CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitor</p>Formule :C19H27N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :393.43Davelizomib
CAS :<p>Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].</p>Formule :C21H26BF2N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :481.25
