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Protéases/Protéasome

Protéases/Protéasome

Les inhibiteurs de protéases et de protéasomes sont des composés qui bloquent l'activité des protéases et du protéasome, impliqués dans la dégradation et le renouvellement des protéines. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie des protéines, le contrôle du cycle cellulaire et l'apoptose. Les inhibiteurs de protéases et de protéasomes sont également utilisés dans le traitement de maladies telles que le cancer, où une dégradation anormale des protéines joue un rôle dans la progression de la maladie. En inhibant les protéases ou le protéasome, ces composés peuvent induire la mort cellulaire dans les cellules cancéreuses et sont des outils essentiels tant pour la recherche fondamentale que pour le développement thérapeutique. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de protéases et de protéasomes de haute qualité pour soutenir vos recherches en biochimie, biologie cellulaire et développement de médicaments.

Sous-catégories appartenant à la catégorie "Protéases/Protéasome"

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1076 produits trouvés pour "Protéases/Protéasome"

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  • Cathepsin K inhibitor 2

    CAS :
    Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.
    Formule :C30H33F4N5O3
    Couleur et forme :Solid
    Masse moléculaire :587.61
  • (2S,4R)-Teneligliptin

    CAS :
    (2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.
    Formule :C22H30N6OS
    Couleur et forme :Solid
    Masse moléculaire :426.578
  • RJF02215

    CAS :
    RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.
    Formule :C17H12ClN3OS3
    Couleur et forme :Solid
    Masse moléculaire :405.95
  • TMPRSS6-IN-1 TFA


    <p>TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), a member of the TTSP family (a type of transmembrane serine protease). TMPRSS6 is a type II TTSP, and genetically reduced levels of TMPRSS6 have been shown to improve symptoms of hemochromatosis and β-thalassemia in mice.</p>
    Formule :C35H41F3N8O6S2
    Couleur et forme :Solid
    Masse moléculaire :790.875
  • BI-1915

    CAS :
    <p>BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.</p>
    Formule :C21H37N5O3
    Couleur et forme :Solid
    Masse moléculaire :407.55
  • Plasma kallikrein-IN-2


    Plasma kallikrein-IN-2: PKal inhibitor, IC50=0.1 nM. Used in angioedema, diabetic eye disease research.
    Formule :C28H24ClF3N8O3
    Couleur et forme :Solid
    Masse moléculaire :612.99
  • Valopicitabine

    CAS :
    <p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>
    Formule :C15H24N4O6
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :356.37
  • (2R,3S)-Emricasan

    CAS :
    <p>(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan. This compound acts as an orally effective irreversible pan-caspase inhibitor. (2R,3S)-Emricasan inhibits the increase in caspase-3 activity induced by Zika virus (ZIKV) and protects human cortical neural progenitor cells.</p>
    Formule :C26H27F4N3O7
    Couleur et forme :Solid
    Masse moléculaire :569.5
  • Cathepsin C-IN-3


    Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).
    Formule :C28H21F3N6OS
    Couleur et forme :Solid
    Masse moléculaire :546.57
  • HCV-IN-38


    Potent oral HCV inhibitor HCV-IN-38 has 15 nM EC50, 431 SI, high efficacy, and low toxicity.
    Formule :C22H24ClF3N4O4
    Couleur et forme :Solid
    Masse moléculaire :500.9
  • HCV NS5B polymerase-IN-2

    CAS :
    HCVNS5B polymerase-IN-2 (Compound 298) is an inhibitor of the Ns5b polymerase. It holds potential for research into the treatment of hepatitis C virus (HCV) infections.
    Formule :C26H24N2O4
    Couleur et forme :Solid
    Masse moléculaire :428.48
  • HCV-IN-40

    CAS :
    <p>HCV-IN-39 is a potent oral drug inhibiting HCV, effective on GT1a (EC50: 0.259μM), GT1b (EC50: 0.434μM), GT1b CES1 (EC50: 0.069μM) replicons.</p>
    Formule :C21H26BrFN3O9P
    Couleur et forme :Solid
    Masse moléculaire :594.32
  • GSK5852


    GSK5852, an HCV NS5B inhibitor, has IC50 of 50 nM; potently fights HCV with EC50 of 3.0 nM for GT1a and 1.7 nM for GT1b.
    Formule :C27H27BF2N2O6S
    Couleur et forme :Solid
    Masse moléculaire :556.39
  • UK-370106

    CAS :
    <p>UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-</p>
    Formule :C35H44N2O5
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :572.73
  • (1R,3S)-THCCA-Asn


    <p>(1R,3S)-THCCA-Asn (4j) is a selective inhibitor of thrombin (IC50: 0.07-0.14 μM) with anti-thrombotic effects.</p>
    Formule :C24H24N4O6
    Couleur et forme :Solid
    Masse moléculaire :464.47
  • RBx-0597

    CAS :
    <p>RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.</p>
    Formule :C19H20F2N4O2
    Couleur et forme :Solid
    Masse moléculaire :374.384
  • Tilpisertib fosmecarbil

    CAS :
    Tilpisertib fosmecarbil is a potent inhibitor of serine/threonine kinases with anti-inflammatory properties.
    Formule :C35H36ClN8O7P
    Couleur et forme :Solid
    Masse moléculaire :747.14
  • RO5461111

    CAS :
    RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.
    Formule :C27H24F6N4O4S
    Couleur et forme :Solid
    Masse moléculaire :614.56
  • BI 224436

    CAS :
    <p>BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.</p>
    Formule :C27H26N2O4
    Couleur et forme :Solid
    Masse moléculaire :442.51
  • Freselestat quarterhydrate


    ONO-6818 quarterhydrate: oral neutrophil elastase inhibitor, Ki 12.2 nM; >100x less effective on other proteases; strong anti-inflammatory.
    Formule :C23H30N6O5
    Couleur et forme :Solid
    Masse moléculaire :457.03
  • Anti-infective agent 10

    CAS :
    <p>Anti-infective agent 10 (Compound Example 30) is an ns5b polymerase inhibitor that functions as an anti-HCV agent.</p>
    Formule :C26H25N3O7S
    Couleur et forme :Solid
    Masse moléculaire :523.56
  • DPP-4-IN-15

    CAS :
    DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.
    Formule :C17H14F3N3O2S
    Couleur et forme :Solid
    Masse moléculaire :381.372
  • SBI-581


    <p>SBI-581: oral, potent TAO3 inhibitor, IC50=42nM, alters TKS5α at RAB11+ vesicles, blocks invadopodia, good mouse pharmacokinetics, anti-tumor.</p>
    Formule :C24H21N3O2
    Couleur et forme :Solid
    Masse moléculaire :383.44
  • PNU-248686A

    CAS :
    PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).
    Formule :C22H18ClNaO5S2
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :484.95
  • Cyclophilin inhibitor 1

    CAS :
    Cyclophilin inhibitor 1: orally available, Kd 5 nM, potent against HCV, EC50 for HCV 2a is 98 nM.
    Formule :C31H39N5O7
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :593.67
  • ABT-072

    CAS :
    <p>ABT-072 is a nonnucleoside NS5B polymerase inhibitor and a candidate drug evaluated for treatment of hepatitis C virus.</p>
    Formule :C24H27N3O5S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :469.55
  • Cathepsin C-IN-5

    CAS :
    <p>Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.</p>
    Formule :C21H17ClN6OS
    Couleur et forme :Solid
    Masse moléculaire :436.92
  • Faldaprevir

    CAS :
    Faldaprevir is an orally effective, selective, non-covalent HCV NS3/4A protease inhibitor with high inhibitory activity against HCV 1a and 1b genotype.
    Formule :C40H49BrN6O9S
    Degré de pureté :99.04% - 99.19%
    Couleur et forme :Solid
    Masse moléculaire :869.82
  • HCV-IN-7

    CAS :
    HCV-IN-7: potent oral HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.
    Formule :C40H48N8O6S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :768.92
  • Idraparinux Na

    CAS :
    Idraparinux Na is an Antithrombotic, Indirect, Selective, Synthetic Factor Xa Inhibitor
    Formule :C38H55Na9O49S7
    Couleur et forme :Solid
    Masse moléculaire :1727.14
  • GLS-1-IN-1


    <p>GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.</p>
    Formule :C26H25FN4OS
    Couleur et forme :Solid
    Masse moléculaire :460.57
  • Odiparcil

    CAS :
    <p>Odiparcil is an orally active beta-d-thioxyloside analog.</p>
    Formule :C15H16O6S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :324.35
  • BAY-7598

    CAS :
    <p>BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).</p>
    Formule :C28H31N3O6
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :505.56
  • GW311616 hydrochloride

    CAS :
    <p>GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).</p>
    Formule :C19H32ClN3O4S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :433.99
  • AMG-222 tosylate

    CAS :
    <p>AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.</p>
    Formule :C39H47N9O6S
    Couleur et forme :Solid
    Masse moléculaire :769.91
  • M826


    <p>M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in</p>
    Formule :C28H45N7O6
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :575.7
  • BI-1942

    CAS :
    <p>BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.</p>
    Formule :C24H26N4O4
    Couleur et forme :Solid
    Masse moléculaire :434.488
  • Valopicitabine dihydrochloride

    CAS :
    Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.
    Formule :C15H25ClN4O6
    Couleur et forme :Solid
    Masse moléculaire :392.84
  • Antiplatelet agent 3

    CAS :
    <p>Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.</p>
    Formule :C38H32N2O5
    Couleur et forme :Solid
    Masse moléculaire :596.671
  • Plodicitinib

    CAS :
    Plodicitinib is an inhibitor of Janus tyrosine kinase 3/TEC family kinase, exhibiting anti-inflammatory properties.
    Formule :C19H22FN7O2
    Couleur et forme :Solid
    Masse moléculaire :399.422
  • Dup-714

    CAS :
    Dup-714 is a thrombin inhibitor.
    Formule :C21H33BN6O5
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :460.33
  • Human enteropeptidase-IN-2


    <p>Human enteropeptidase-IN-2 is a potent inhibitor of enteropeptidase (enteropeptidase) and can be used in anti-obesity studies.</p>
    Formule :C20H19F3N4O7
    Couleur et forme :Solid
    Masse moléculaire :484.38
  • Zetomipzomib

    CAS :
    KZR-616: Immunoproteasome inhibitor targeting LMP7 (IC50: 39/57 nM) & LMP2 (IC50: 131/179 nM), potential in autoimmune disease research.
    Formule :C30H42N4O8
    Couleur et forme :Solid
    Masse moléculaire :586.68
  • Deleobuvir

    CAS :
    Deleobuvir(BI207127) is an inhibitor of non-nucleoside hepatitis C virus NS5B polymerase for the treatment of hepatitis C.
    Formule :C34H33BrN6O3
    Couleur et forme :Solid
    Masse moléculaire :653.57
  • GW311616

    CAS :
    GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).
    Formule :C19H31N3O4S
    Couleur et forme :Solid
    Masse moléculaire :397.53
  • TCL1

    CAS :
    TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.
    Formule :C19H14BrClN4O2S
    Couleur et forme :Solid
    Masse moléculaire :477.762
  • Napsagatran hydrate

    CAS :
    Napsagatran hydrate is a novel and specific inhibitor of thrombin.
    Formule :C26H36N6O7S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :576.66
  • ZINC09518833

    CAS :
    <p>ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).</p>
    Formule :C24H25N3O5
    Couleur et forme :Solid
    Masse moléculaire :435.47
  • Tyrosinase-IN-37

    CAS :
    <p>Tyrosinase-IN-37 (Compound 3c) is a potent inhibitor of tyrosinase, with an IC50 value of 1.02 μM, which is 14 times more effective than kojic acid (IC50 of 14.74 μM). This compound effectively prevents the browning of Rosa roxburghii and can also inhibit browning not caused by tyrosinase.</p>
    Formule :C12H12N6S
    Couleur et forme :Solid
    Masse moléculaire :272.33
  • BMT-052

    CAS :
    <p>BMT-052 is a potent and selective Pan-genotypic HCV NS5B Polymerase Inhibitor (EC50 = 7 nM).</p>
    Formule :C30H17D9F4N6O5
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :635.61
  • SSR-182289A (Free)

    CAS :
    SSR-182289A (Free) is a thrombin inhibitor.
    Formule :C30H33F2N5O4S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :597.68
  • Beclabuvir

    CAS :
    <p>Beclabuvir blocks HCV NS5B polymerase at thumb site 1, effective on genotypes 1, 3, 4, 5 with IC50 &lt;28 nM.</p>
    Formule :C36H45N5O5S
    Degré de pureté :99.87% - 99.93%
    Couleur et forme :Solid
    Masse moléculaire :659.84
  • CM-352

    CAS :
    CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.
    Formule :C24H29N3O6S
    Degré de pureté :97.24%
    Couleur et forme :Solid
    Masse moléculaire :487.57
  • Immunoproteasome activator 1

    CAS :
    Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.
    Formule :C24H23N3O3
    Couleur et forme :Solid
    Masse moléculaire :401.46
  • Monosodium 2-sulfoterephthalate

    CAS :
    <p>Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.</p>
    Formule :C8H5NaO7S
    Couleur et forme :Solid
    Masse moléculaire :268.176
  • Gemigliptin tartrate hydrate

    CAS :
    Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 value of 10.3 nM for human recombinant DPP-4. It exhibits strong anti-glycation properties and is used in research on advanced glycation end product-related diabetic complications.
    Formule :C22H27F8N5O9
    Couleur et forme :Solid
    Masse moléculaire :657.47
  • RXP03

    CAS :
    RXP03 is an MMPs inhibitor with K_i values of 20 nM for MMP-2, 2.5 nM for MMP-8, 10 nM for MMP-9, 5 nM for MMP-11, and 105 nM for MMP-14 [1].
    Formule :C39H43N4O6P
    Couleur et forme :Solid
    Masse moléculaire :694.76
  • Faldaprevir sodium

    CAS :
    Faldaprevir sodium: HCV treatment, inhibits NS3/NS4A protease, P-glycoprotein, CYP3A4, UGT1A1.
    Formule :C40H48BrN6NaO9S
    Couleur et forme :Solid
    Masse moléculaire :891.81
  • Pyridoxatin

    CAS :
    Pyridoxatin: fungal metabolite; blocks TBARS production, prevents AAPH-induced hemolysis, and acts against C. albicans.
    Formule :C15H21NO3
    Couleur et forme :Solid
    Masse moléculaire :263.33
  • PLGLAG

    CAS :
    PLGLAG is a peptide chain that acts as a linker in activatable cell-penetrating peptides (ACPPs). ACPPs containing the PLGLAG linker are primarily sensitive to MMP-2 and MMP-9 in vivo. PLGLAG is applicable in cancer research.
    Formule :C24H42N6O7
    Couleur et forme :Solid
    Masse moléculaire :526.63
  • MMP-13-IN-1

    CAS :
    MMP-13-IN-1, with an IC50 value of 16 nM, is a potent and selective inhibitor of MMP-13, suitable for atherosclerosis research [1].
    Formule :C19H16F3N3O3
    Couleur et forme :Solid
    Masse moléculaire :391.34
  • MIV-247

    CAS :
    MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.
    Formule :C17H24F3N3O4
    Degré de pureté :99.27%
    Couleur et forme :Solid
    Masse moléculaire :391.39
  • JTK-109

    CAS :
    JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.
    Formule :C37H33ClFN3O4
    Degré de pureté :98.48% - 99.68%
    Couleur et forme :Solid
    Masse moléculaire :638.13
  • IDX184

    CAS :
    <p>IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3</p>
    Formule :C25H35N6O9PS
    Degré de pureté :97.15%
    Couleur et forme :Solid
    Masse moléculaire :626.62
  • Vaniprevir

    CAS :
    Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.
    Formule :C38H55N5O9S
    Degré de pureté :97.41%
    Couleur et forme :Solid
    Masse moléculaire :757.94
  • PD 151746

    CAS :
    <p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>
    Formule :C11H8FNO2S
    Degré de pureté :98.63% - ≥95%
    Couleur et forme :Solid
    Masse moléculaire :237.25
  • Sebetralstat

    CAS :
    <p>Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.</p>
    Formule :C26H26FN5O4
    Degré de pureté :99.85%
    Couleur et forme :Solid
    Masse moléculaire :491.51
  • MMP13-IN-2

    CAS :
    <p>MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.</p>
    Formule :C24H19FN6O4S
    Couleur et forme :Solid
    Masse moléculaire :506.51

    Ref: TM-T41079

    Produit arrêté
  • 3-Deazaadenosine

    CAS :
    3-Deazaadenosine, an inhibitor of S-adenosylhomocysteine hydrolase with a Ki of 3.9 μM, exhibits anti-inflammatory, anti-proliferative, and anti-HIV activity.
    Formule :C11H14N4O4
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :266.25

    Ref: TM-T10111L

    Produit arrêté
  • ALLM

    CAS :
    <p>ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].</p>
    Formule :C19H35N3O4S
    Degré de pureté :98%
    Couleur et forme :White Powder
    Masse moléculaire :401.56
  • ABT-072 potassium trihydrate

    CAS :
    ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).
    Formule :C24H32KN3O8S
    Couleur et forme :Solid
    Masse moléculaire :561.69

    Ref: TM-T38510

    Produit arrêté
  • IPN60090 dihydrochloride

    CAS :
    IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.
    Formule :C24H29Cl2F3N8O3
    Couleur et forme :Solid
    Masse moléculaire :605.44

    Ref: TM-T39544

    Produit arrêté
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    <p>Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.</p>
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