Protéases/Protéasome
Les inhibiteurs de protéases et de protéasomes sont des composés qui bloquent l'activité des protéases et du protéasome, impliqués dans la dégradation et le renouvellement des protéines. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie des protéines, le contrôle du cycle cellulaire et l'apoptose. Les inhibiteurs de protéases et de protéasomes sont également utilisés dans le traitement de maladies telles que le cancer, où une dégradation anormale des protéines joue un rôle dans la progression de la maladie. En inhibant les protéases ou le protéasome, ces composés peuvent induire la mort cellulaire dans les cellules cancéreuses et sont des outils essentiels tant pour la recherche fondamentale que pour le développement thérapeutique. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de protéases et de protéasomes de haute qualité pour soutenir vos recherches en biochimie, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Protéases/Protéasome"
- Acétyl-CoA Carboxylase(35 produits)
- Cystéine protéase(107 produits)
- DPP-4(20 produits)
- Glutaminase(42 produits)
- Protéase du VIH(489 produits)
- PAI-1(26 produits)
- Inhibiteurs de protéase(50 produits)
- Récepteur activé par une protéase(53 produits)
- Protéasome(95 produits)
- Sérine protéase(56 produits)
- p97(15 produits)
Affichez 3 plus de sous-catégories
1085 produits trouvés pour "Protéases/Protéasome"
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GSK5852
GSK5852, an HCV NS5B inhibitor, has IC50 of 50 nM; potently fights HCV with EC50 of 3.0 nM for GT1a and 1.7 nM for GT1b.Formule :C27H27BF2N2O6SCouleur et forme :SolidMasse moléculaire :556.39Zetomipzomib
CAS :KZR-616: Immunoproteasome inhibitor targeting LMP7 (IC50: 39/57 nM) & LMP2 (IC50: 131/179 nM), potential in autoimmune disease research.Formule :C30H42N4O8Couleur et forme :SolidMasse moléculaire :586.68Tilpisertib fosmecarbil
CAS :Tilpisertib fosmecarbil is a potent inhibitor of serine/threonine kinases with anti-inflammatory properties.Formule :C35H36ClN8O7PCouleur et forme :SolidMasse moléculaire :747.14Dup-714
CAS :Dup-714 is a thrombin inhibitor.Formule :C21H33BN6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.33Antiplatelet agent 3
CAS :<p>Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.</p>Formule :C38H32N2O5Couleur et forme :SolidMasse moléculaire :596.671M826
M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity inFormule :C28H45N7O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :575.7GW311616
CAS :GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).Formule :C19H31N3O4SCouleur et forme :SolidMasse moléculaire :397.53Feniralstat
CAS :Feniralstat (KVD-824) is a selective and potent kallikrein (kallikrein) inhibitor, useful in immune system diseases and cardiovascular disease research.Formule :C26H25F2N5O4Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :509.51GW311616 hydrochloride
CAS :GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).Formule :C19H32ClN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :433.99Monosodium 2-sulfoterephthalate
CAS :<p>Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.</p>Formule :C8H5NaO7SCouleur et forme :SolidMasse moléculaire :268.176NAPAP
CAS :NAPAP is a thrombin inhibitor with potent anticoagulant activity (Ki: 2.1 nM). It selectively inhibits thrombin through a rapid binding mechanism while exhibiting weaker inhibition of trypsin, Factor Xa, and plasmin. NAPAP can be utilized for research into thrombotic conditions, including venous thrombosis and myocardial infarction.Formule :C27H31N5O4SCouleur et forme :SolidMasse moléculaire :521.63DPP-4-IN-15
CAS :DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.Formule :C17H14F3N3O2SCouleur et forme :SolidMasse moléculaire :381.372Valopicitabine
CAS :<p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>Formule :C15H24N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.37TCL1
CAS :TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.Formule :C19H14BrClN4O2SCouleur et forme :SolidMasse moléculaire :477.762MeO-Suc-Ala-Ala-Pro-Ala-CMK
CAS :MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE) with an IC50 of 20.3 μM. It effectively inhibits the hydrolysis of substrates like lung tissue elastin by HNE and is applicable in studies related to conditions such as chronic obstructive pulmonary disease (COPD).Formule :C20H31ClN4O7Couleur et forme :SolidMasse moléculaire :474.936RBx-0597
CAS :<p>RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.</p>Formule :C19H20F2N4O2Couleur et forme :SolidMasse moléculaire :374.384Marizomib
CAS :Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L, CT-T-laspase-like, and trypsin-like 20S proteasomes.Cost-effective and quality-assured.Formule :C15H20ClNO4Degré de pureté :98.03% - 99.41%Couleur et forme :SolidMasse moléculaire :313.78Ciluprevir
CAS :Ciluprevir is a selective HCV NS3 protease inhibitor, effective against non-genotype-1 HCV; less potent for genotypes 2/3.Formule :C40H50N6O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :774.93RJF02215
CAS :RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.Formule :C17H12ClN3OS3Couleur et forme :SolidMasse moléculaire :405.95SBI-581
SBI-581: oral, potent TAO3 inhibitor, IC50=42nM, alters TKS5α at RAB11+ vesicles, blocks invadopodia, good mouse pharmacokinetics, anti-tumor.Formule :C24H21N3O2Couleur et forme :SolidMasse moléculaire :383.44ABT-072
CAS :ABT-072 is a nonnucleoside NS5B polymerase inhibitor and a candidate drug evaluated for treatment of hepatitis C virus.Formule :C24H27N3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.55Piceid 6″-O-azelaic acid ester
Piceid 6″-O-azelaic acid ester exhibited strong intracellular tyrosinase inhibition and decolorization activity.Formule :C24H36O10Couleur et forme :SolidMasse moléculaire :484.54GSK-2878175
CAS :GSK-2878175, a NS5B inhibitor, is used potentially for the treatment of HCV infection.Formule :C27H23BClFN2O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :568.81BAY-7598
CAS :<p>BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).</p>Formule :C28H31N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.56(2R,3S)-Emricasan
CAS :<p>(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan. This compound acts as an orally effective irreversible pan-caspase inhibitor. (2R,3S)-Emricasan inhibits the increase in caspase-3 activity induced by Zika virus (ZIKV) and protects human cortical neural progenitor cells.</p>Formule :C26H27F4N3O7Couleur et forme :SolidMasse moléculaire :569.5Cyclophilin inhibitor 1
CAS :Cyclophilin inhibitor 1: orally available, Kd 5 nM, potent against HCV, EC50 for HCV 2a is 98 nM.Formule :C31H39N5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.67Kallikrein-IN-1
CAS :Kallikrein-IN-1 (Formula A) is an inhibitor of the kinin-releasing enzyme Kallikrein.Formule :C28H26FN5O4Couleur et forme :SolidMasse moléculaire :515.54HCV-IN-38
Potent oral HCV inhibitor HCV-IN-38 has 15 nM EC50, 431 SI, high efficacy, and low toxicity.Formule :C22H24ClF3N4O4Couleur et forme :SolidMasse moléculaire :500.9Anti-infective agent 10
CAS :<p>Anti-infective agent 10 (Compound Example 30) is an ns5b polymerase inhibitor that functions as an anti-HCV agent.</p>Formule :C26H25N3O7SCouleur et forme :SolidMasse moléculaire :523.56Enantiomer of Sofosbuvir
Inactive enantiomer of Sofosbuvir, used for chronic hepatitis C; lacks reported biological activity.Formule :C22H29FN3O9PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.45Isobutylamido thiazolyl resorcinol
CAS :Isobutylamido thiazolyl resorcinol is a tyrosinase (Tyrosinase) inhibitor that prevents pigment deposition induced by ultraviolet radiation.Formule :C13H14N2O3SCouleur et forme :SolidMasse moléculaire :278.33JBJ-08-178-01
CAS :JBJ-08-178-01, a mutant-selective tyrosine kinase inhibitor, targets (HER2) human epidermal growth factor receptor 2 and exhibits antitumoral activity. This compound not only diminishes HER2's kinase activity and protein levels through the induction of proteasomal degradation of the receptor but also shows promise in non-small-cell lung cancer research.Formule :C31H30N8O3Couleur et forme :SolidMasse moléculaire :562.62Idraparinux Na
CAS :Idraparinux Na is an Antithrombotic, Indirect, Selective, Synthetic Factor Xa InhibitorFormule :C38H55Na9O49S7Couleur et forme :SolidMasse moléculaire :1727.14Matriptase-IN-2 free base
CAS :Matriptase-IN-2 free base, a matriptase inhibitor with a K i of 5 nM, has potential applications in musculoskeletal system disorder research (WO2011023958A1; compound 432) [1].Formule :C29H33Cl2N5O3SCouleur et forme :SolidMasse moléculaire :602.58Tyrosinase-IN-20
CAS :<p>Tyrosinase-IN-20 (compound 6a) acts as a potent Tyrosinase inhibitor, demonstrating an IC 50 value of 28.50 μM [1].</p>Formule :C17H18N2O2SCouleur et forme :SolidMasse moléculaire :314.43-Aminobenzene-1,2-diol
CAS :<p>3-Aminobenzene-1,2-diol (compound C8) is an inhibitor of matrix metalloproteinases (MMP), with IC50 values of 20, 26, 16, and 16.3 μM against MMP-2, MMP-8, MMP-9, and MMP-14, respectively.</p>Formule :C6H7NO2Couleur et forme :SolidMasse moléculaire :125.13Tyrosinase-IN-39
<p>Tyrosinase-IN-39 (compound 5r) is a competitive inhibitor of tyrosinase, with an IC50 of 6.4 μM, and is used in the study of skin diseases.</p>Formule :C23H19N5O4S2Couleur et forme :SolidMasse moléculaire :493.56HCV-IN-7
CAS :HCV-IN-7: potent oral HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.Formule :C40H48N8O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :768.92Tyrosinase-IN-29
CAS :Tyrosinase-IN-29 (compound 5c) is an effective inhibitor of abTYR tyrosinase, demonstrating an IC50 value of 6.11 μM. It is suitable for further research into the inhibition of excessive skin pigmentation.Formule :C10H9NO2Couleur et forme :SolidMasse moléculaire :175.18RIPK1-IN-26
CAS :<p>RIPK1-IN-26 is a potent inhibitor of Receptor-Interacting Serine/Threonine Kinase 1 (RIPK1), exhibiting anti-necrotic properties in cells. This compound demonstrates good metabolic stability and binding specificity in mice. RIPK1-IN-26 holds potential for development as a PET imaging probe and in the research of neurodegenerative diseases.</p>Formule :C15H20FNO2Couleur et forme :SolidMasse moléculaire :265.32GB111-NH2
CAS :GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].Formule :C33H39N3O6Couleur et forme :SolidMasse moléculaire :573.68UK-370106
CAS :<p>UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-</p>Formule :C35H44N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :572.73SAR107375
CAS :SAR107375 is a potent, orally active dual inhibitor of thrombin and factor Xa, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively [1].Formule :C24H30ClN5O5S2Couleur et forme :SolidMasse moléculaire :568.11TG-2-IN-4
CAS :TG-2-IN-4 (compound 8), an inhibitor of transglutaminase 2 (TG2) with an IC 50 value of less than 0.5 mM, is utilized in the study of inflammatory disorders [1].Formule :C34H40N6O5Couleur et forme :SolidMasse moléculaire :612.72(1R,3S)-THCCA-Asn
<p>(1R,3S)-THCCA-Asn (4j) is a selective inhibitor of thrombin (IC50: 0.07-0.14 μM) with anti-thrombotic effects.</p>Formule :C24H24N4O6Couleur et forme :SolidMasse moléculaire :464.47GLS-1-IN-1
<p>GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.</p>Formule :C26H25FN4OSCouleur et forme :SolidMasse moléculaire :460.57Tyrosinase-IN-37
CAS :<p>Tyrosinase-IN-37 (Compound 3c) is a potent inhibitor of tyrosinase, with an IC50 value of 1.02 μM, which is 14 times more effective than kojic acid (IC50 of 14.74 μM). This compound effectively prevents the browning of Rosa roxburghii and can also inhibit browning not caused by tyrosinase.</p>Formule :C12H12N6SCouleur et forme :SolidMasse moléculaire :272.33ZINC09518833
CAS :<p>ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).</p>Formule :C24H25N3O5Couleur et forme :SolidMasse moléculaire :435.47BMT-052
CAS :<p>BMT-052 is a potent and selective Pan-genotypic HCV NS5B Polymerase Inhibitor (EC50 = 7 nM).</p>Formule :C30H17D9F4N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :635.61UK 356618
CAS :<p>UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).</p>Formule :C34H43N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.72BI-1942
CAS :<p>BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.</p>Formule :C24H26N4O4Couleur et forme :SolidMasse moléculaire :434.488MK-8876
CAS :MK-8876 is an Inhibitor of HCV NS5B Site D.Formule :C32H24F2N4O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :614.62SSR-182289A (Free)
CAS :SSR-182289A (Free) is a thrombin inhibitor.Formule :C30H33F2N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :597.68Napsagatran hydrate
CAS :Napsagatran hydrate is a novel and specific inhibitor of thrombin.Formule :C26H36N6O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :576.66RXP03
CAS :RXP03 is an MMPs inhibitor with K_i values of 20 nM for MMP-2, 2.5 nM for MMP-8, 10 nM for MMP-9, 5 nM for MMP-11, and 105 nM for MMP-14 [1].Formule :C39H43N4O6PCouleur et forme :SolidMasse moléculaire :694.76CatD-IN-1
CAS :CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.Formule :C18H18Cl2N4O5Couleur et forme :SolidMasse moléculaire :441.265Cathepsin C-IN-5
CAS :<p>Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.</p>Formule :C21H17ClN6OSCouleur et forme :SolidMasse moléculaire :436.92Cathepsin C-IN-3
Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).Formule :C28H21F3N6OSCouleur et forme :SolidMasse moléculaire :546.57Gemigliptin tartrate hydrate
CAS :Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 value of 10.3 nM for human recombinant DPP-4. It exhibits strong anti-glycation properties and is used in research on advanced glycation end product-related diabetic complications.Formule :C22H27F8N5O9Couleur et forme :SolidMasse moléculaire :657.47Plodicitinib
CAS :Plodicitinib is an inhibitor of Janus tyrosine kinase 3/TEC family kinase, exhibiting anti-inflammatory properties.Formule :C19H22FN7O2Couleur et forme :SolidMasse moléculaire :399.422BI 224436
CAS :BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.Formule :C27H26N2O4Couleur et forme :SolidMasse moléculaire :442.51SD-2590 HCl
CAS :SD-2590 HCl is an MMP-2,-3, -9, -8, 13, and -14 inhibitor.Formule :C22H26ClF3N2O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :554.96Odiparcil
CAS :Odiparcil is an orally active beta-d-thioxyloside analog.Formule :C15H16O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.35SMCypI C31
SMCypIC31, a non-peptide cyclophilin inhibitor, blocks PPIase at 0.1 μM IC50 and fights various HCV genotypes (EC50: 1.20-7.76 μM).Formule :C27H30N4O2SCouleur et forme :SolidMasse moléculaire :474.62CE-2072
CAS :CE-2072 is a synthetic host serine proteases inhibitor.Formule :C33H41N5O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.71Cathepsin C-IN-4
Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).Formule :C21H14ClF3N4SCouleur et forme :SolidMasse moléculaire :446.88Narlaprevir
CAS :Narlaprevir (SCH 900518) is an HCV NS3 inhibitor with anti-HCV activity, inhibiting SARS-CoV-2, and useful in virus infection research.Formule :C36H61N5O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :707.96CM-352
CAS :CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.Formule :C24H29N3O6SDegré de pureté :97.24%Couleur et forme :SolidMasse moléculaire :487.57Freselestat
CAS :Freselestat (ONO-6818) inhibits neutrophil elastase, reduces interleukin 8, C5B-9, and inflammation in cardiopulmonary bypass.Formule :C23H28N6O4Couleur et forme :SolidMasse moléculaire :452.51Tyrosinase-IN-35
CAS :<p>Tyrosinase-IN-35 (compound 6g), exhibiting a IC 50 value of 2.09 μM, serves as a more effective inhibitor of human tyrosinase compared to Kojic Acid (IC 50: 16.38 μM). At concentrations of 4 μM and 8 μM, this compound effectively lowers melanin levels in melanoma B16F10 cells in vitro.</p>Formule :C17H15N5OSCouleur et forme :SolidMasse moléculaire :337.40MIV-247
CAS :MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.Formule :C17H24F3N3O4Degré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :391.39Vaniprevir
CAS :Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.Formule :C38H55N5O9SDegré de pureté :97.41%Couleur et forme :SolidMasse moléculaire :757.94JTK-109
CAS :JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.Formule :C37H33ClFN3O4Degré de pureté :98.48% - 99.68%Couleur et forme :SolidMasse moléculaire :638.13IDX184
CAS :IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3Formule :C25H35N6O9PSDegré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :626.62PD 151746
CAS :<p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>Formule :C11H8FNO2SDegré de pureté :98.63% - ≥95%Couleur et forme :SolidMasse moléculaire :237.25Sebetralstat
CAS :<p>Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.</p>Formule :C26H26FN5O4Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :491.512,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-
CAS :Formule :C37H48N6O5S2Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :720.9442ALLM
CAS :ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].Formule :C19H35N3O4SDegré de pureté :98%Couleur et forme :White PowderMasse moléculaire :401.56MMP13-IN-2
CAS :<p>MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.</p>Formule :C24H19FN6O4SCouleur et forme :SolidMasse moléculaire :506.513-Deazaadenosine
CAS :3-Deazaadenosine, an inhibitor of S-adenosylhomocysteine hydrolase with a Ki of 3.9 μM, exhibits anti-inflammatory, anti-proliferative, and anti-HIV activity.Formule :C11H14N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :266.25ABT-072 potassium trihydrate
CAS :ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).Formule :C24H32KN3O8SCouleur et forme :SolidMasse moléculaire :561.69IPN60090 dihydrochloride
CAS :IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.Formule :C24H29Cl2F3N8O3Couleur et forme :SolidMasse moléculaire :605.44Oxindole
CAS :<p>Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.</p>Formule :C8H7NODegré de pureté :99.34%Couleur et forme :Off-White Crystalline PowderMasse moléculaire :133.15Butabindide oxalate
CAS :<p>CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitor</p>Formule :C19H27N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :393.43Davelizomib
CAS :<p>Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].</p>Formule :C21H26BF2N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :481.25
