Protéases/Protéasome
Les inhibiteurs de protéases et de protéasomes sont des composés qui bloquent l'activité des protéases et du protéasome, impliqués dans la dégradation et le renouvellement des protéines. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie des protéines, le contrôle du cycle cellulaire et l'apoptose. Les inhibiteurs de protéases et de protéasomes sont également utilisés dans le traitement de maladies telles que le cancer, où une dégradation anormale des protéines joue un rôle dans la progression de la maladie. En inhibant les protéases ou le protéasome, ces composés peuvent induire la mort cellulaire dans les cellules cancéreuses et sont des outils essentiels tant pour la recherche fondamentale que pour le développement thérapeutique. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de protéases et de protéasomes de haute qualité pour soutenir vos recherches en biochimie, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Protéases/Protéasome"
- Acétyl-CoA Carboxylase(35 produits)
- Cystéine protéase(96 produits)
- DPP-4(20 produits)
- Glutaminase(40 produits)
- Protéase du VIH(451 produits)
- PAI-1(25 produits)
- Inhibiteurs de protéase(50 produits)
- Récepteur activé par une protéase(53 produits)
- Protéasome(94 produits)
- Sérine protéase(49 produits)
- p97(14 produits)
Affichez 3 plus de sous-catégories
1039 produits trouvés pour "Protéases/Protéasome"
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TG-2-IN-4
CAS :<p>TG-2-IN-4 (compound 8), an inhibitor of transglutaminase 2 (TG2) with an IC 50 value of less than 0.5 mM, is utilized in the study of inflammatory disorders [1].</p>Formule :C34H40N6O5Couleur et forme :SolidMasse moléculaire :612.72(2S,4R)-Teneligliptin
CAS :<p>(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.</p>Formule :C22H30N6OSCouleur et forme :SolidMasse moléculaire :426.578GB111-NH2
CAS :GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].Formule :C33H39N3O6Couleur et forme :SolidMasse moléculaire :573.68CM-352
CAS :<p>CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.</p>Formule :C24H29N3O6SDegré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :487.57Cathepsin K inhibitor 2
CAS :<p>Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.</p>Formule :C30H33F4N5O3Couleur et forme :SolidMasse moléculaire :587.61SAR107375
CAS :<p>SAR107375 is a potent, orally active dual inhibitor of thrombin and factor Xa, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively [1].</p>Formule :C24H30ClN5O5S2Couleur et forme :SolidMasse moléculaire :568.11MK-8876
CAS :<p>MK-8876 is an Inhibitor of HCV NS5B Site D.</p>Formule :C32H24F2N4O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :614.62Verducatib
CAS :<p>Verducatib is an inhibitor of cathepsins (cathepsin).</p>Formule :C31H35FN4O3Couleur et forme :SolidMasse moléculaire :530.633Kallikrein-IN-1
CAS :<p>Kallikrein-IN-1 (Formula A) is an inhibitor of the kinin-releasing enzyme Kallikrein.</p>Formule :C28H26FN5O4Couleur et forme :SolidMasse moléculaire :515.54GSK-2878175
CAS :<p>GSK-2878175, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>Formule :C27H23BClFN2O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :568.81Piceid 6″-O-azelaic acid ester
<p>Piceid 6″-O-azelaic acid ester exhibited strong intracellular tyrosinase inhibition and decolorization activity.</p>Formule :C24H36O10Couleur et forme :SolidMasse moléculaire :484.54SD-7300
CAS :<p>SD-7300 (SC-81490) functions as an orally active inhibitor targeting MMP-2, MMP-9, and MMP-13, exhibiting potent inhibition with K_i values of 0.03, 0.01, and 0.03 nM, respectively. By inhibiting these metalloproteinases, SD-7300 effectively reduces extracellular matrix degradation by tumor cells, thereby curbing their invasion and metastasis. Additionally, this compound acts as a dose-dependent inhibitor of mouse corneal angiogenesis and prevents interleukin-1-induced degradation of bovine cartilage. SD-7300 is applicable in the study of breast cancer.</p>Formule :C21H30F3N3O7SCouleur et forme :SolidMasse moléculaire :525.54RIPK1-IN-26
CAS :<p>RIPK1-IN-26 is a potent inhibitor of Receptor-Interacting Serine/Threonine Kinase 1 (RIPK1), exhibiting anti-necrotic properties in cells. This compound demonstrates good metabolic stability and binding specificity in mice. RIPK1-IN-26 holds potential for development as a PET imaging probe and in the research of neurodegenerative diseases.</p>Formule :C15H20FNO2Couleur et forme :SolidMasse moléculaire :265.32GW311616 hydrochloride
CAS :<p>GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).</p>Formule :C19H32ClN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :433.99Tyrosinase-IN-33
CAS :<p>Tyrosinase-IN-33 (compound 5), a pyridine-based compound, acts as an effective inhibitor of diphenolase activity in mushroom tyrosinase. It significantly reduces enzyme activity with an IC50 of 9.0 μM.</p>Formule :C19H17NS2Couleur et forme :SolidMasse moléculaire :323.48AMG-222 tosylate
CAS :<p>AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.</p>Formule :C39H47N9O6SCouleur et forme :SolidMasse moléculaire :769.91BAY-7598
CAS :<p>BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).</p>Formule :C28H31N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.56Valopicitabine
CAS :<p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>Formule :C15H24N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.37Marizomib
CAS :Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L, CT-T-laspase-like, and trypsin-like 20S proteasomes.Cost-effective and quality-assured.Formule :C15H20ClNO4Degré de pureté :98.03% - 99.41%Couleur et forme :SolidMasse moléculaire :313.78UK 356618
CAS :<p>UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).</p>Formule :C34H43N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.72GLS-1-IN-1
<p>GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.</p>Formule :C26H25FN4OSCouleur et forme :SolidMasse moléculaire :460.57Tyrosinase-IN-35
CAS :<p>Tyrosinase-IN-35 (compound 6g), exhibiting a IC 50 value of 2.09 μM, serves as a more effective inhibitor of human tyrosinase compared to Kojic Acid (IC 50: 16.38 μM). At concentrations of 4 μM and 8 μM, this compound effectively lowers melanin levels in melanoma B16F10 cells in vitro.</p>Formule :C17H15N5OSCouleur et forme :SolidMasse moléculaire :337.40Tyrosinase-IN-39
<p>Tyrosinase-IN-39 (compound 5r) is a competitive inhibitor of tyrosinase, with an IC50 of 6.4 μM, and is used in the study of skin diseases.</p>Formule :C23H19N5O4S2Couleur et forme :SolidMasse moléculaire :493.56RJF02215
CAS :RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.Formule :C17H12ClN3OS3Couleur et forme :SolidMasse moléculaire :405.95MIV-247
CAS :<p>MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.</p>Formule :C17H24F3N3O4Degré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :391.39Vaniprevir
CAS :<p>Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.</p>Formule :C38H55N5O9SDegré de pureté :97.41%Couleur et forme :SolidMasse moléculaire :757.94JTK-109
CAS :<p>JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.</p>Formule :C37H33ClFN3O4Degré de pureté :98.48% - 99.68%Couleur et forme :SolidMasse moléculaire :638.13IDX184
CAS :<p>IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3</p>Formule :C25H35N6O9PSDegré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :626.62PD 151746
CAS :<p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>Formule :C11H8FNO2SDegré de pureté :98.63% - ≥95%Couleur et forme :SolidMasse moléculaire :237.25Sebetralstat
CAS :<p>Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.</p>Formule :C26H26FN5O4Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :491.512,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-
CAS :Formule :C37H48N6O5S2Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :720.9442MMP13-IN-2
CAS :<p>MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.</p>Formule :C24H19FN6O4SCouleur et forme :SolidMasse moléculaire :506.51IPN60090 dihydrochloride
CAS :<p>IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.</p>Formule :C24H29Cl2F3N8O3Couleur et forme :SolidMasse moléculaire :605.44ABT-072 potassium trihydrate
CAS :<p>ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).</p>Formule :C24H32KN3O8SCouleur et forme :SolidMasse moléculaire :561.69ALLM
CAS :<p>ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].</p>Formule :C19H35N3O4SDegré de pureté :98%Couleur et forme :White PowderMasse moléculaire :401.563-Deazaadenosine
CAS :<p>3-Deazaadenosine, an inhibitor of S-adenosylhomocysteine hydrolase with a Ki of 3.9 μM, exhibits anti-inflammatory, anti-proliferative, and anti-HIV activity.</p>Formule :C11H14N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :266.25Oxindole
CAS :<p>Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.</p>Formule :C8H7NODegré de pureté :99.34%Couleur et forme :Off-White Crystalline PowderMasse moléculaire :133.15Butabindide oxalate
CAS :<p>CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitor</p>Formule :C19H27N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :393.43Davelizomib
CAS :<p>Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].</p>Formule :C21H26BF2N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :481.25
