Protéases/Protéasome
Les inhibiteurs de protéases et de protéasomes sont des composés qui bloquent l'activité des protéases et du protéasome, impliqués dans la dégradation et le renouvellement des protéines. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie des protéines, le contrôle du cycle cellulaire et l'apoptose. Les inhibiteurs de protéases et de protéasomes sont également utilisés dans le traitement de maladies telles que le cancer, où une dégradation anormale des protéines joue un rôle dans la progression de la maladie. En inhibant les protéases ou le protéasome, ces composés peuvent induire la mort cellulaire dans les cellules cancéreuses et sont des outils essentiels tant pour la recherche fondamentale que pour le développement thérapeutique. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de protéases et de protéasomes de haute qualité pour soutenir vos recherches en biochimie, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Protéases/Protéasome"
- Acétyl-CoA Carboxylase(36 produits)
- Cystéine protéase(110 produits)
- DPP-4(20 produits)
- Glutaminase(44 produits)
- Protéase du VIH(506 produits)
- PAI-1(26 produits)
- Inhibiteurs de protéase(50 produits)
- Récepteur activé par une protéase(54 produits)
- Protéasome(95 produits)
- Sérine protéase(55 produits)
- p97(15 produits)
Affichez 3 plus de sous-catégories
1093 produits trouvés pour "Protéases/Protéasome"
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UK 356618
CAS :<p>UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).</p>Formule :C34H43N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.72Gemigliptin tartrate hydrate
CAS :Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 value of 10.3 nM for human recombinant DPP-4. It exhibits strong anti-glycation properties and is used in research on advanced glycation end product-related diabetic complications.Formule :C22H27F8N5O9Couleur et forme :SolidMasse moléculaire :657.47ABT-072
CAS :ABT-072 is a nonnucleoside NS5B polymerase inhibitor and a candidate drug evaluated for treatment of hepatitis C virus.Formule :C24H27N3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.55Antiplatelet agent 3
CAS :Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.Formule :C38H32N2O5Couleur et forme :SolidMasse moléculaire :596.671Matriptase-IN-2 free base
CAS :Matriptase-IN-2 free base, a matriptase inhibitor with a K i of 5 nM, has potential applications in musculoskeletal system disorder research (WO2011023958A1; compound 432) [1].Formule :C29H33Cl2N5O3SCouleur et forme :SolidMasse moléculaire :602.58Cathepsin C-IN-3
Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).Formule :C28H21F3N6OSCouleur et forme :SolidMasse moléculaire :546.57Cyclophilin inhibitor 1
CAS :Cyclophilin inhibitor 1: orally available, Kd 5 nM, potent against HCV, EC50 for HCV 2a is 98 nM.Formule :C31H39N5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.67CatD-IN-1
CAS :CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.Formule :C18H18Cl2N4O5Couleur et forme :SolidMasse moléculaire :441.265UK-370106
CAS :UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-Formule :C35H44N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :572.73Immunoproteasome activator 1
CAS :Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.Formule :C24H23N3O3Couleur et forme :SolidMasse moléculaire :401.46CE-2072
CAS :CE-2072 is a synthetic host serine proteases inhibitor.Formule :C33H41N5O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.71Marizomib
CAS :Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L, CT-T-laspase-like, and trypsin-like 20S proteasomes.Cost-effective and quality-assured.Formule :C15H20ClNO4Degré de pureté :98.03% - 99.41%Couleur et forme :SolidMasse moléculaire :313.78Narlaprevir
CAS :Narlaprevir (SCH 900518) is an HCV NS3 inhibitor with anti-HCV activity, inhibiting SARS-CoV-2, and useful in virus infection research.Formule :C36H61N5O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :707.96Napsagatran hydrate
CAS :Napsagatran hydrate is a novel and specific inhibitor of thrombin.Formule :C26H36N6O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :576.66BMT-052
CAS :BMT-052 is a potent and selective Pan-genotypic HCV NS5B Polymerase Inhibitor (EC50 = 7 nM).Formule :C30H17D9F4N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :635.61SSR-182289A (Free)
CAS :SSR-182289A (Free) is a thrombin inhibitor.Formule :C30H33F2N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :597.68Enantiomer of Sofosbuvir
Inactive enantiomer of Sofosbuvir, used for chronic hepatitis C; lacks reported biological activity.Formule :C22H29FN3O9PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.45JBJ-08-178-01
CAS :JBJ-08-178-01, a mutant-selective tyrosine kinase inhibitor, targets (HER2) human epidermal growth factor receptor 2 and exhibits antitumoral activity. This compound not only diminishes HER2's kinase activity and protein levels through the induction of proteasomal degradation of the receptor but also shows promise in non-small-cell lung cancer research.Formule :C31H30N8O3Couleur et forme :SolidMasse moléculaire :562.62RIPK1-IN-26
CAS :<p>RIPK1-IN-26 is a potent inhibitor of Receptor-Interacting Serine/Threonine Kinase 1 (RIPK1), exhibiting anti-necrotic properties in cells. This compound demonstrates good metabolic stability and binding specificity in mice. RIPK1-IN-26 holds potential for development as a PET imaging probe and in the research of neurodegenerative diseases.</p>Formule :C15H20FNO2Couleur et forme :SolidMasse moléculaire :265.32Faldaprevir sodium
CAS :Faldaprevir sodium: HCV treatment, inhibits NS3/NS4A protease, P-glycoprotein, CYP3A4, UGT1A1.Formule :C40H48BrN6NaO9SCouleur et forme :SolidMasse moléculaire :891.81Zetomipzomib
CAS :KZR-616: Immunoproteasome inhibitor targeting LMP7 (IC50: 39/57 nM) & LMP2 (IC50: 131/179 nM), potential in autoimmune disease research.Formule :C30H42N4O8Couleur et forme :SolidMasse moléculaire :586.68HCV-IN-7
CAS :HCV-IN-7: potent oral HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.Formule :C40H48N8O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :768.92Plodicitinib
CAS :Plodicitinib is an inhibitor of Janus tyrosine kinase 3/TEC family kinase, exhibiting anti-inflammatory properties.Formule :C19H22FN7O2Couleur et forme :SolidMasse moléculaire :399.422AEP-IN-1
APE-IN-1, a potent AEP inhibitor (IC50: 89 nM), aids Alzheimer's diagnosis and drug research.Formule :C18H27N3O3Couleur et forme :SolidMasse moléculaire :333.43Tyrosinase-IN-20
CAS :<p>Tyrosinase-IN-20 (compound 6a) acts as a potent Tyrosinase inhibitor, demonstrating an IC 50 value of 28.50 μM [1].</p>Formule :C17H18N2O2SCouleur et forme :SolidMasse moléculaire :314.4Tyrosinase-IN-29
CAS :Tyrosinase-IN-29 (compound 5c) is an effective inhibitor of abTYR tyrosinase, demonstrating an IC50 value of 6.11 μM. It is suitable for further research into the inhibition of excessive skin pigmentation.Formule :C10H9NO2Couleur et forme :SolidMasse moléculaire :175.18Valopicitabine
CAS :<p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>Formule :C15H24N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.37SBI-581
SBI-581: oral, potent TAO3 inhibitor, IC50=42nM, alters TKS5α at RAB11+ vesicles, blocks invadopodia, good mouse pharmacokinetics, anti-tumor.Formule :C24H21N3O2Couleur et forme :SolidMasse moléculaire :383.44Vaniprevir
CAS :Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.Formule :C38H55N5O9SDegré de pureté :97.41%Couleur et forme :SolidMasse moléculaire :757.94JTK-109
CAS :JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.Formule :C37H33ClFN3O4Degré de pureté :98.48% - 99.68%Couleur et forme :SolidMasse moléculaire :638.13Ref: TM-T27696
1mg313,00€5mg758,00€10mg1.035,00€25mg1.568,00€50mg2.118,00€100mg2.783,00€1mL*10mM (DMSO)À demanderIDX184
CAS :IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3Formule :C25H35N6O9PSDegré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :626.62MIV-247
CAS :MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.Formule :C17H24F3N3O4Degré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :391.39PD 151746
CAS :PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.Formule :C11H8FNO2SDegré de pureté :98.63% - ≥95%Couleur et forme :SolidMasse moléculaire :237.25Sebetralstat
CAS :<p>Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.</p>Formule :C26H26FN5O4Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :491.512,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-
CAS :Formule :C37H48N6O5S2Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :720.9442ABT-072 potassium trihydrate
CAS :ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).Formule :C24H32KN3O8SCouleur et forme :SolidMasse moléculaire :561.69MMP13-IN-2
CAS :MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.Formule :C24H19FN6O4SCouleur et forme :SolidMasse moléculaire :506.51IPN60090 dihydrochloride
CAS :IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.Formule :C24H29Cl2F3N8O3Couleur et forme :SolidMasse moléculaire :605.44ALLM
CAS :ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].Formule :C19H35N3O4SDegré de pureté :98%Couleur et forme :White PowderMasse moléculaire :401.563-Deazaadenosine
CAS :3-Deazaadenosine, an inhibitor of S-adenosylhomocysteine hydrolase with a Ki of 3.9 μM, exhibits anti-inflammatory, anti-proliferative, and anti-HIV activity.Formule :C11H14N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :266.25Oxindole
CAS :<p>Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.</p>Formule :C8H7NODegré de pureté :99.34%Couleur et forme :Off-White Crystalline PowderMasse moléculaire :133.15Butabindide oxalate
CAS :<p>CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitor</p>Formule :C19H27N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :393.43Davelizomib
CAS :<p>Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].</p>Formule :C21H26BF2N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :481.25
