Protéases/Protéasome
Les inhibiteurs de protéases et de protéasomes sont des composés qui bloquent l'activité des protéases et du protéasome, impliqués dans la dégradation et le renouvellement des protéines. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie des protéines, le contrôle du cycle cellulaire et l'apoptose. Les inhibiteurs de protéases et de protéasomes sont également utilisés dans le traitement de maladies telles que le cancer, où une dégradation anormale des protéines joue un rôle dans la progression de la maladie. En inhibant les protéases ou le protéasome, ces composés peuvent induire la mort cellulaire dans les cellules cancéreuses et sont des outils essentiels tant pour la recherche fondamentale que pour le développement thérapeutique. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de protéases et de protéasomes de haute qualité pour soutenir vos recherches en biochimie, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Protéases/Protéasome"
- Acétyl-CoA Carboxylase(38 produits)
- Cystéine protéase(111 produits)
- DPP-4(27 produits)
- Glutaminase(46 produits)
- Protéase du VIH(506 produits)
- PAI-1(26 produits)
- Inhibiteurs de protéase(50 produits)
- Récepteur activé par une protéase(55 produits)
- Protéasome(86 produits)
- Sérine protéase(54 produits)
- p97(15 produits)
Affichez 3 plus de sous-catégories
985 produits trouvés pour "Protéases/Protéasome"
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Feniralstat
CAS :Feniralstat (KVD-824) is a selective and potent kallikrein (kallikrein) inhibitor, useful in immune system diseases and cardiovascular disease research.Formule :C26H25F2N5O4Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :509.51ZINC09518833
CAS :ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).Formule :C24H25N3O5Couleur et forme :SolidMasse moléculaire :435.47CatD-IN-1
CAS :CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.Formule :C18H18Cl2N4O5Couleur et forme :SolidMasse moléculaire :441.265Tyrosinase-IN-37
CAS :Tyrosinase-IN-37 (Compound 3c) is a potent inhibitor of tyrosinase, with an IC50 value of 1.02 μM, which is 14 times more effective than kojic acid (IC50 of 14.74 μM). This compound effectively prevents the browning of Rosa roxburghii and can also inhibit browning not caused by tyrosinase.Formule :C12H12N6SCouleur et forme :SolidMasse moléculaire :272.33Matriptase-IN-2 free base
CAS :Matriptase-IN-2 free base, a matriptase inhibitor with a K i of 5 nM, has potential applications in musculoskeletal system disorder research (WO2011023958A1; compound 432) [1].Formule :C29H33Cl2N5O3SCouleur et forme :SolidMasse moléculaire :602.58GB111-NH2
CAS :GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].Formule :C33H39N3O6Couleur et forme :SolidMasse moléculaire :573.68Verducatib
CAS :Verducatib is an inhibitor of cathepsins (cathepsin).Formule :C31H35FN4O3Couleur et forme :SolidMasse moléculaire :530.633BMT-052
CAS :BMT-052 is a potent and selective Pan-genotypic HCV NS5B Polymerase Inhibitor (EC50 = 7 nM).Formule :C30H17D9F4N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :635.61SSR-182289A (Free)
CAS :SSR-182289A (Free) is a thrombin inhibitor.Formule :C30H33F2N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :597.68RJF02215
CAS :RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.Formule :C17H12ClN3OS3Couleur et forme :SolidMasse moléculaire :405.95CM-352
CAS :CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.Formule :C24H29N3O6SDegré de pureté :97.24%Couleur et forme :SolidMasse moléculaire :487.57NAPAP
CAS :NAPAP is a thrombin inhibitor with potent anticoagulant activity (Ki: 2.1 nM). It selectively inhibits thrombin through a rapid binding mechanism while exhibiting weaker inhibition of trypsin, Factor Xa, and plasmin. NAPAP can be utilized for research into thrombotic conditions, including venous thrombosis and myocardial infarction.Formule :C27H31N5O4SCouleur et forme :SolidMasse moléculaire :521.63Monosodium 2-sulfoterephthalate
CAS :Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.
Formule :C8H5NaO7SCouleur et forme :SolidMasse moléculaire :268.176Tyrosinase-IN-35
CAS :Tyrosinase-IN-35 (compound 6g), exhibiting a IC 50 value of 2.09 μM, serves as a more effective inhibitor of human tyrosinase compared to Kojic Acid (IC 50: 16.38 μM). At concentrations of 4 μM and 8 μM, this compound effectively lowers melanin levels in melanoma B16F10 cells in vitro.Formule :C17H15N5OSCouleur et forme :SolidMasse moléculaire :337.40Tyrosinase-IN-33
CAS :Tyrosinase-IN-33 (compound 5), a pyridine-based compound, acts as an effective inhibitor of diphenolase activity in mushroom tyrosinase. It significantly reduces enzyme activity with an IC50 of 9.0 μM.Formule :C19H17NS2Couleur et forme :SolidMasse moléculaire :323.48SD-7300
CAS :SD-7300 (SC-81490) functions as an orally active inhibitor targeting MMP-2, MMP-9, and MMP-13, exhibiting potent inhibition with K_i values of 0.03, 0.01, and 0.03 nM, respectively. By inhibiting these metalloproteinases, SD-7300 effectively reduces extracellular matrix degradation by tumor cells, thereby curbing their invasion and metastasis. Additionally, this compound acts as a dose-dependent inhibitor of mouse corneal angiogenesis and prevents interleukin-1-induced degradation of bovine cartilage. SD-7300 is applicable in the study of breast cancer.Formule :C21H30F3N3O7SCouleur et forme :SolidMasse moléculaire :525.54Beclabuvir
CAS :Beclabuvir blocks HCV NS5B polymerase at thumb site 1, effective on genotypes 1, 3, 4, 5 with IC50 <28 nM.Formule :C36H45N5O5SDegré de pureté :99.87% - 99.93%Couleur et forme :SolidMasse moléculaire :659.84Gemigliptin tartrate hydrate
CAS :Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 value of 10.3 nM for human recombinant DPP-4. It exhibits strong anti-glycation properties and is used in research on advanced glycation end product-related diabetic complications.Formule :C22H27F8N5O9Couleur et forme :SolidMasse moléculaire :657.47RXP03
CAS :RXP03 is an MMPs inhibitor with K_i values of 20 nM for MMP-2, 2.5 nM for MMP-8, 10 nM for MMP-9, 5 nM for MMP-11, and 105 nM for MMP-14 [1].Formule :C39H43N4O6PCouleur et forme :SolidMasse moléculaire :694.76HsClpP activator-1
CAS :HsClpP activator-1 (compound 24) is a potent activator of HsClpP, with an EC50 of 0.22 μM. It effectively inhibits cancer cell growth, exhibiting IC50 values ranging from 0.1 to 1 μM.Formule :C23H20F5N3O2Couleur et forme :SolidMasse moléculaire :465.42Duazomycin sodium
CAS :Duazomycin (Duazomycin A) sodium acts as a glutamine antagonist. It significantly enhances the efficacy of 6-Mercaptopurine (6-MP) in treating experimental autoimmune encephalomyelitis (EAE) without increasing toxicity.Formule :C8H10N3NaO4Couleur et forme :SolidMasse moléculaire :235.17MIV-247
CAS :MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.Formule :C17H24F3N3O4Degré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :391.39Vaniprevir
CAS :Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.Formule :C38H55N5O9SDegré de pureté :97.41%Couleur et forme :SolidMasse moléculaire :757.94IDX184
CAS :IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3Formule :C25H35N6O9PSDegré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :626.62JTK-109
CAS :JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.Formule :C37H33ClFN3O4Degré de pureté :98.48% - 99.68%Couleur et forme :SolidMasse moléculaire :638.13Ref: TM-T27696
1mg296,00€5mg718,00€10mg982,00€25mg1.485,00€50mg2.008,00€100mg2.637,00€1mL*10mM (DMSO)1.108,00€PD 151746
CAS :PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.Formule :C11H8FNO2SDegré de pureté :98.63% - ≥95%Couleur et forme :SolidMasse moléculaire :237.25Sebetralstat
CAS :Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.
Formule :C26H26FN5O4Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :491.512,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-
CAS :Formule :C37H48N6O5S2Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :720.9442MMP13-IN-2
CAS :MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.Formule :C24H19FN6O4SCouleur et forme :SolidMasse moléculaire :506.51ABT-072 potassium trihydrate
CAS :ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).Formule :C24H32KN3O8SCouleur et forme :SolidMasse moléculaire :561.69ALLM
CAS :ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].Formule :C19H35N3O4SDegré de pureté :98%Couleur et forme :White PowderMasse moléculaire :401.56IPN60090 dihydrochloride
CAS :IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.Formule :C24H29Cl2F3N8O3Couleur et forme :SolidMasse moléculaire :605.44Oxindole
CAS :Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.
Formule :C8H7NODegré de pureté :99.34%Couleur et forme :Off-White Crystalline PowderMasse moléculaire :133.15Butabindide oxalate
CAS :CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitorFormule :C19H27N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :393.43Davelizomib
CAS :Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].
Formule :C21H26BF2N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :481.25
