Tyrosine Kinase/Adaptateurs
Les inhibiteurs des tyrosines kinases et des adaptateurs sont des composés qui ciblent les tyrosines kinases et leurs protéines adaptatrices associées, jouant des rôles essentiels dans la signalisation cellulaire, la croissance et la différenciation. Ces inhibiteurs sont des outils essentiels dans la recherche sur le cancer, car de nombreuses tyrosines kinases sont impliquées dans les voies de signalisation qui favorisent la croissance tumorale et les métastases. En inhibant les tyrosines kinases, ces composés peuvent bloquer des cascades de signalisation cruciales, offrant ainsi des stratégies thérapeutiques potentielles pour divers cancers et autres maladies impliquant une signalisation cellulaire anormale. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de tyrosines kinases et d'adaptateurs de haute qualité pour soutenir vos recherches en oncologie, biologie moléculaire et développement de thérapies ciblées.
Sous-catégories appartenant à la catégorie "Tyrosine Kinase/Adaptateurs"
- ALK(129 produits)
- CSF-1R(42 produits)
- EGFR(591 produits)
- Récepteur Ephrin(25 produits)
- FLT(91 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(183 produits)
- SON(3 produits)
- Hck(3 produits)
- IGF-1R(104 produits)
- PDGFR(128 produits)
- PYK2(7 produits)
- Src(81 produits)
- Récepteur TAM(33 produits)
- Tie-2(20 produits)
- Récepteur Trk(57 produits)
- Tyrosine Kinases(25 produits)
- VEGFR(246 produits)
- c-Fms(112 produits)
- c-Kit(115 produits)
- c-Met/HGFR(139 produits)
- c-RET(62 produits)
Affichez 13 plus de sous-catégories
1167 produits trouvés pour "Tyrosine Kinase/Adaptateurs"
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Petosemtamab
CAS :<p>Petosemtamab (MCLA 158), a dual-action monoclonal antibody targets EGFR & LGR5, used in solid tumor research like HNSCC & CRC.</p>Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :145.97 kDaPyrotinib dimaleate
CAS :Pyrotinib dimaleate is a selective EGFR/HER2 dual inhibitor, respectively, for the treatment of HER2-positive breast cancer.Cost-effective and quality-assured.Formule :C40H39ClN6O11Degré de pureté :97.27% - 99.52%Couleur et forme :SolidMasse moléculaire :815.22Ref: TM-T12594
1mg155,00€5mg457,00€10mg610,00€25mg947,00€50mg1.301,00€100mg1.758,00€1mL*10mM (DMSO)620,00€Lacnotuzumab
CAS :Lacnotuzumab (MCS110) is a humanized monoclonal antibody targeting CSF-1, which can be used in research on retinal diseases.Degré de pureté :>95%Couleur et forme :LiquidCEP-28122 mesylate salt (1022958-60-6 free base)
CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).Formule :C29H39ClN6O6SDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :635.17Rilotumumab
CAS :<p>Rilotumumab (AMG 102) is an HGF-targeting antibody, inhibits HGF/MET signaling, and is used for CRPC and gastric cancer research.</p>Degré de pureté :SDS-PAGE:95% SEC-HPLC:97.51%Couleur et forme :LiquidMasse moléculaire :145.2 kDaIBT6A
CAS :<p>IBT6A is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.</p>Formule :C22H22N6ODegré de pureté :99.8% - 99.88%Couleur et forme :SolidMasse moléculaire :386.452-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-
CAS :Formule :C18H13BrN4ODegré de pureté :97%Couleur et forme :SolidMasse moléculaire :381.2260SKLB1002
CAS :Formule :C13H12N4O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :320.3900Tyrphostin RG 13022
CAS :Formule :C16H14N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :266.2946Allitinib
CAS :Allitinib (AST-1306) (AST-1306) has anti-cancer activity，and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]Formule :C24H18ClFN4O2Degré de pureté :99.89% - 99.91%Couleur et forme :SolidMasse moléculaire :448.88Ref: TM-T14336
1mg52,00€5mg111,00€10mg175,00€25mg329,00€50mg494,00€100mg700,00€1mL*10mM (DMSO)135,00€AZ-Dyrk1B-33
CAS :AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.Formule :C19H16N4Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :300.36Ref: TM-T14364
1mg47,00€5mg97,00€10mg156,00€25mg304,00€50mg442,00€100mg615,00€200mg832,00€1mL*10mM (DMSO)105,00€Emactuzumab
CAS :<p>Emactuzumab(RG 7155) is a monoclonal antibody against colony-stimulating factor-1 receptor targeting tumor-associated macrophages (TAMs) Emactuzumab has</p>Degré de pureté :SDS-PAGE:98.3%;SEC-HPLC:97.3%Couleur et forme :LiquidMasse moléculaire :144.4 kDaTirbanibulin Mesylate
CAS :Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).Formule :C27H33N3O6SDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :527.63Ref: TM-T15675
2mg38,00€5mg56,00€10mg70,00€25mg126,00€50mg243,00€100mg416,00€200mg562,00€1mL*10mM (DMSO)65,00€JNJ-38877618
CAS :JNJ-38877618 (OMO-1) is an effective and highly selective inhibitor of Met kinase (IC50s: 2 and 3 nM for wild type and mutant Met, respectively).Formule :C20H12F2N6Degré de pureté :98.84% - 99.74%Couleur et forme :SolidMasse moléculaire :374.35Ref: TM-T15617
1mg63,00€5mg137,00€10mg210,00€25mg424,00€50mg620,00€100mg817,00€200mg1.103,00€1mL*10mM (DMSO)153,00€Adrenalone hydrochloride
CAS :Adrenalone HCl: α1-adrenoceptor agonist, topical hemostatic, vasoconstrictor, prolongs local anesthesia.Formule :C9H11NO3·HClDegré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :217.65CSF1R-IN-1
CAS :CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM.Formule :C25H20F3N5O2Degré de pureté :97.02% - 98.56%Couleur et forme :SolidMasse moléculaire :479.45Ref: TM-T10894
1mg94,00€5mg210,00€10mg325,00€25mg550,00€50mg787,00€100mg1.093,00€200mg1.454,00€1mL*10mM (DMSO)230,00€Gefitinib
CAS :Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations.Formule :C22H24ClFN4O3Degré de pureté :99.92% - >99.99%Couleur et forme :Light-Yellow Crystalline PowderMasse moléculaire :446.9TYRPHOSTIN B48
CAS :Formule :C16H12N2O3Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :280.2781Mevastatin
CAS :Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Formule :C23H34O5Degré de pureté :99.12%Couleur et forme :White-Yellowish To Yellow Powder Solid PowderMasse moléculaire :390.51Losatuxizumab
CAS :Losatuxizumab (ABT-806) is an anti-EGFR monoclonal antibody with potential anti-tumor activity for the study of advanced malignant solid tumors.Degré de pureté :97.3% (SDS-PAGE); 95.1% (SEC-HPLC) - 97.3% (SDS-PAGE); 95.1% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :144.85 kDaEdicotinib
CAS :<p>Edicotinib (JNJ-527) is a blood-brain permeable, selective CSF-1R inhibitor, with lesser inhibitory effects on KIT and FLT3.Cost-effective and quality-assured.</p>Formule :C27H35N5O2Degré de pureté :98.58% - 99.72%Couleur et forme :SolidMasse moléculaire :461.6Axatilimab
CAS :Axatilimab (SNDX-6352) is a human IgG4 antibody that targets CSF-1R and can be used to study immune system diseases and respiratory diseases.Degré de pureté :97.9% (SDS-PAGE); 97% (SEC-HPLC) - 97.9% (SDS-PAGE); 97% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :147.17 kDaRobatumumab
CAS :Robatumumab (Sch 717454) is a fully humanized anti-IGF-1R monoclonal antibody with antitumor activity and antiproliferative activity.Degré de pureté :96.9% (SDS-PAGE); 98.1% (SEC-HPLC) - 96.9% (SDS-PAGE); 98.1% (SEC-HPLC)Couleur et forme :LiquidHyT36
CAS :HyT36: hydrophobic tag that destabilizes fusion proteins & Her3 pseudokinase; treats cells with acute erht.Formule :C25H44ClNO3Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :442.07Ref: TM-T72075
1mg56,00€5mg119,00€10mg188,00€25mg393,00€50mg628,00€100mg908,00€1mL*10mM (DMSO)131,00€Dasatinib monohydrate
CAS :Dasatinib monohydrate, an oral SRC-kinase inhibitor, counters imatinib-resistant chronic myeloid leukemia.Formule :C22H28ClN7O3SDegré de pureté :99.68% - >99.99%Couleur et forme :SolidMasse moléculaire :506.03GW2580
CAS :Formule :C20H22N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.4137Dasatinib
CAS :<p>Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive.</p>Formule :C22H26ClN7O2SDegré de pureté :99.59% - 99.86%Couleur et forme :Pale-Yellow SolidMasse moléculaire :488.01Onartuzumab
CAS :Onartuzumab (MetMAb) is a humanized monoclonal antibody targeting c-MET, with antitumor effects by blocking HGF and signal transduction.Degré de pureté :97.3%Couleur et forme :LiquidMasse moléculaire :146.99 kDa2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
CAS :Formule :C21H15ClF4N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :482.8154Ref: IN-DA00ICN3
1g131,00€5g255,00€10g619,00€50g617,00€100gÀ demander10mg30,00€50mg46,00€100mg56,00€250mg69,00€500mg100,00€Margetuximab
CAS :Margetuximab (MGAH-22) is a second generation anti-HER2 monoclonal antibody with anti-tumor activity.Degré de pureté :95.3% (SDS-PAGE); 99.3% (SEC-HPLC) - 95.3% (SDS-PAGE); 99.3% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.86 kDaEGFR-IN-124
EGFR-IN-124 (compound 10A) is an EGFR inhibitor with an IC50 value of 0.54 μM, utilized in cancer research.Couleur et forme :Odour SolidHER2/neu (654-662) GP2 acetate
<p>GP2 acetate, from HER2 (654-662), triggers HLA-A2-restricted T cells to attack epithelial cancers.</p>Formule :C44H81N9O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :944.17Ref: TM-TP1583L
1mg185,00€5mg415,00€10mg622,00€25mg1.119,00€50mg1.679,00€100mg2.520,00€200mg3.780,00€EGFR-IN-127
EGFR-IN-127 is an ATP-competitive inhibitor targeting EGFR, with IC50 values of 136.3 nM for EGFRdel19 and 161.2 nM for EGFRdel19/T790M/C797S. This compound holds potential for the study of non-small cell lung cancer (NSCLC).Couleur et forme :Odour SolidAck1 inhibitor 2
CAS :Ack1 Inhibitor 2, also referred to as Example 259, effectively inhibits Ack1 with an IC50 value of 0.46 μM [1].Formule :C23H23N5O2Couleur et forme :SolidMasse moléculaire :401.46STAD 2
CAS :STAD-2 is a cell permeable akap disruptor, selectively binding to pka-rii and blocking the interaction of pka-ri with akapFormule :C102H182N24O22Couleur et forme :SolidMasse moléculaire :2096.724PRMT5/EGFR-IN-1
PRMT5/EGFR-IN-1 (Compound 10p) is an orally active dual inhibitor targeting PRMT5 and EGFR, with IC50 values of 15.47 μM and 19.31 μM, respectively. It demonstrates antiproliferative activity against the A549, MCF7, HeLa, and MDA-MB-231 cell lines. This compound also exhibits favorable pharmacokinetic (PK) and pharmacodynamic (PD) properties in vivo and significantly inhibits the growth of MCF7 orthotopic xenograft tumors.Formule :C27H22F6N2O2Masse moléculaire :520.15855pYEEI
<p>pYEEI, a tetrapeptide containing phosphotyrosine, binds to the SrcSH2 domain with a dissociation constant (Kd) of 100 nM and an inhibitory concentration (IC50) of 6.5 μM. This compound plays a crucial role in cancer research.</p>Formule :C25H36N3O14PCouleur et forme :SolidMasse moléculaire :633.54H1-7 (histone H1 phosphorylation site), PKA Substrate
CAS :H1-7 (histone H1 phosphorylation site), a synthetic polypeptide serving as a PKA substrate, demonstrates utility in PKA substrate applications [1] [2].Formule :C31H58N14O9Couleur et forme :SolidMasse moléculaire :770.88DS06652923
DS06652923 is an orally active inhibitor targeting EGFR triple mutations. It exhibits growth-inhibitory effects on Ba/F3EGFRdel19/T90M/C795S cells, with a GI50 value of 9.4 nM. Additionally, DS06652923 induces tumor regression in the Ba/F3 syngeneic transplantation model.Couleur et forme :Odour SolidHerceptide
CAS :Herceptide (HER2-targeting peptide), a peptide that targets HER2, can be conjugated with the near-infrared fluorescent dye indocyanine green (ICG), facilitating the development of theranostic agents.Formule :C76H110N22O23Couleur et forme :SolidMasse moléculaire :1699.82PROTAC EGFR degrader 10
CAS :PROTAC EGF Rdegrader 10 (Compound B56) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR) with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 37 nM and degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibiting the proliferation of BaF3 wild-type and EGFR mutants with an IC50 of less than 150 nM.Formule :C49H65ClN10O7SCouleur et forme :SolidMasse moléculaire :973.62Etevritamab
CAS :Etevritamab is a monoclonal antibody that targets CD3E/EGFR.Couleur et forme :LiquidEGFR/HER2-IN-15
EGFR/HER2-IN-15 is a dihydropyrimidine and an effective inhibitor of EGFR/HER2. It significantly suppresses EGFRwt activity with an IC50 of 37.21 nM and exhibits anticancer properties.Formule :C28H29N3O6Masse moléculaire :503.20564Depatuxizumab MMAF
<p>Depatuxizumab-MMAF, an antibody-drug conjugate (ADC), comprises an EGFR-targeted antibody linked to McMMAF and is utilized in glioblastoma research.</p>Couleur et forme :LiquidMasse moléculaire :148.24 kDaPKI (5-24),amide
CAS :PKI (5-24),amide is a 20-residue peptide, a potent PKA inhibitor with a Ki of 2.3 nM, derived from a cAMP inhibitor protein.Formule :C94H149N33O30Couleur et forme :SolidMasse moléculaire :2221.4PROTAC EGFR degrader 11
CAS :<p>PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR), with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 36 nM. This compound effectively degrades EGFR, focal adhesion kinase (FAK), and RSK1, and inhibits the proliferation of BaF3 wild-type and EGFR mutant cells, exhibiting an IC50 of less than 100 nM.</p>Formule :C49H64ClFN10O7SCouleur et forme :SolidMasse moléculaire :991.61EGFR/PI3Kα-IN-1
EGFR/PI3Kα-IN-1 (compound 30k), a dual EGFR/PI3Kα inhibitor, exhibits potent activity with IC 50 values of 3.6 nM (EGFRL858R/T790M) and 30 nM (PI3Kα). It effectively inhibits tumor cell proliferation and demonstrates significant anticancer activity.Formule :C50H49N11O5SCouleur et forme :SolidMasse moléculaire :916.06[Pro3]-GIP (Mouse)
GIP receptor blocker, 2.6μM IC50, hinders insulin release, regulates glucose in ob/ob mice, and enhances glucose tolerance.Formule :C225H342N62O64SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :4971.62ErbB-2-binding peptide
CAS :ErbB-2-binding peptide (HER2-binding peptide), a tumor-targeting peptide, holds potential for cancer research applications [1].Formule :C43H60N8O11Couleur et forme :SolidMasse moléculaire :864.98DDR Inhibitor 2
DDR Inhibitor 2 (compound 5a) is a potent inhibitor of the discoidin domain receptor (DDR) with an IC50 value of 0.125 μM, and it is applicable in fibrotic disease research.Formule :C21H23N7OCouleur et forme :SolidMasse moléculaire :389.19641EGFR-IN-140
EGFR-IN-140 (Compound 31) is an inhibitor of EGFR, effectively targeting both wild-type EGFR and the EGFRL858R/T790M/C797S mutant, with Ki values of 0.95 nM and 2.1 nM, respectively. Additionally, it inhibits EGFRdel19/T790M/C797S in Ba/F3 cells with an IC50 of 56.9 nM and demonstrates antitumor activity in mouse models.Formule :C27H37FN8O2Couleur et forme :SolidMasse moléculaire :524.633Matuzumab
CAS :Matuzumab (EMD 72000) is a humanized monoclonal antibody targeting EGFR that can be used to study non-small cell lung cancer.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :145.9 kDaTaletrectinib free base
CAS :Taletrectinib (AB-106) is a potent, selective oral ROS1/NTRK inhibitor with low IC50s against ROS1 and NTRK1-3, including Crizotinib-resistant mutations.Formule :C23H24FN5ODegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :405.47Ref: TM-T38995
1mg71,00€5mg157,00€10mg243,00€25mg487,00€50mg705,00€100mg998,00€1mL*10mM (DMSO)183,00€cis-NVP-ADW742
CAS :NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.Formule :C28H31N5OCouleur et forme :SolidMasse moléculaire :453.59WAY-270360
CAS :WAY-270360 (N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide) is a sirtuin modulator and an epidermal growth factor receptor (EGFR) inhibitor.Formule :C22H19N3O3Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :373.4[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153)
CAS :Insulin Receptor (1142-1153) binds insulin, is a substrate for its kinase, and has research/medical potential.Formule :C72H110N19O33P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1862.67EGFR T790M/L858R-IN-6
CAS :EGFR T790M/L858R-IN-6 (compound 53), classified as a pyrimidine compound, serves as an effective inhibitor of EGFR T790M/L858R, demonstrating 90.88% inhibition of enzyme activity at a concentration of 0.05 μM [1].Formule :C27H27N7O2Couleur et forme :SolidMasse moléculaire :481.55EGFR kinase inhibitor 2
EGFR kinase inhibitor 2 (compound A-7) is a potent EGFR inhibitor targeting the mutations EGFRL858R/T790M/C797S and EGFRDel19/T790M/C797S. This compound shows potential in addressing acquired resistance in the treatment of non-small cell lung cancer.Formule :C39H40N6O5Masse moléculaire :672.30602PF-04217903 phenolsulfonate
CAS :PF-04217903 phenolsulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).Formule :C25H22N8O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :546.56GW 583340
CAS :GW 583340 is a potent and selective dual inhibitor of EGFR/ErbB2 tyrosine kinase with the advantage of oral dosability and antitumor effects.Formule :C28H25ClFN5O3S2Degré de pureté :98.68%Couleur et forme :SoildMasse moléculaire :598.11Ref: TM-T22827L
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€200mg2.555,00€EGFR-IN-93
EGFR-IN-93 (compound 18) is an allosteric inhibitor of the T790M/L858R double mutant EGFR. It is applicable for research in non-small cell lung cancer (NSCLC).Formule :C22H18FN3O3Masse moléculaire :391.13322Insulin efsitora alfa
CAS :Insulin efsitora alfa(LY-3209590) is an IR agonist and a fusion protein that binds a novel single-chain insulin variant to the structural domain of human IgG FcDegré de pureté :98.3% (SDS-PAGE); 98.1% (SEC-HPLC) - 98.3% (SDS-PAGE); 98.1% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :32.04 kDaPertuzumab
CAS :Pertuzumab (anti-HER2) a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors impairs the ability of HER2Degré de pureté :98.00%Couleur et forme :LiquidMasse moléculaire :148 kDaEGFR WT/T790M/L858R-IN-1
EGFRWT/T790M/L858R-IN-1 (compound 10d) is a potent inhibitor of EGFR, demonstrating IC50 values of 0.097, 0.280, and 0.051 μM for EGFRWT, EGFRT790M, and EGFRL858R, respectively. This compound can be utilized in cancer research.Formule :C26H25Cl3N2O3Masse moléculaire :518.09308Timigutuzumab
CAS :Timigutuzumab (GEXMab73) is a humanized monoclonal antibody designed to target ErbB2, showing potential application in cancer research [1].Couleur et forme :LiquidZenocutuzumab
CAS :Zenocutuzumab (MCLA-128) is a humanized antibody targeting HER2, used for research on tumors driven by NRG1 gene rearrangement.Degré de pureté :97%Couleur et forme :LiquidMasse moléculaire :145.76 kDaPKA Inhibitor Fragment (6-22) amide TFA
PKA Inhibitor Fragment (6-22) amide TFA (PKA Inhibitor Fragment (6-22) amide TFA) is an inhibitor of cAMP-dependent protein kinase A (PKA).Formule :C82H131F3N28O26Degré de pureté :99.61% - 99.87%Couleur et forme :SolidMasse moléculaire :1982.08EGFR-IN-95
EGFR-IN-95 is a derivative of 2,4-diaminonicotinamide. It effectively inhibits the activity of EGFRdel19/T790M/C797S and L858R/T790M/C797S.Formule :C23H28F2N8O3SMasse moléculaire :534.19731MS39N
CAS :<p>MS39N (compound 27) serves as the negative control for MS39, capable of binding to EGFR without causing its degradation.</p>Formule :C55H71ClFN9O7SMasse moléculaire :1056.73MS9449
CAS :MS9449 is a powerful EGFR PROTAC; Kd: 17 nM (WT), 10 nM (L858R); targets mutant EGFRs via UPS and autophagy; hinders NSCLC cell growth.Formule :C60H76ClFN10O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1151.82Kemptide Phospho-Ser5
Kemptide (Phospho-Ser5) is a phosphoreceptor peptide that is a specific substrate for camp-dependent protein kinase (PKA).Formule :C32H62N13O12PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :851.89MS9427 TFA
MS9427 TFA: PROTAC EGFR degrader, Kd 7.1 nM (WT), 4.3 nM (L858R), targets mutant EGFR, inhibits NSCLC cell growth, for cancer research.Formule :C50H59ClF4N8O14Couleur et forme :SolidMasse moléculaire :1107.5Eflapegrastim
CAS :Eflapegrastim: humanized IgG4 antibody and G-CSF that boosts neutrophils and shortens neutropenia.Couleur et forme :LiquidVarlitinib
CAS :Varlitinib (ASLAN001) is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively.Formule :C22H19ClN6O2SDegré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :466.94HER2-IN-13
CAS :HER2-IN-13 (Compound 33) serves as an effective HER2 inhibitor, exhibiting an IC50 value of 8 nM, and additionally demonstrates inhibition of wt-EGFR with anFormule :C26H23ClF2N8O3Couleur et forme :SolidMasse moléculaire :568.96JBJ-09-063 TFA
JBJ-09-063 TFA, an EGFR inhibitor selective for EGFR mutations, IC50s: 0.147-0.396 nM, blocks EGFR/Akt/ERK signaling, for EGFR-mutant lung cancer research.Formule :C33H30F4N4O5SCouleur et forme :SolidMasse moléculaire :670.67Gefitinib N-oxide hydrochloride
Gefitinib N-oxide hydrochloride is an N-oxide of EGFR inhibitor Gefitinib with IC50 of 2-37 nM.Formule :C22H24ClFN4O41·5HClCouleur et forme :SolidMasse moléculaire :517.59DSPE-PEG5000-GE11
DSPE-PEG5000-GE11 is a PEG compound composed of DSPE and the EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells with EGFR overexpression. DSPE-PEG5000-GE11 is utilized in drug delivery.Couleur et forme :Odour SolidCompound TPX-0046
CAS :Compound TPX-0046 is an inhibitor of RET. Compound TPX-0046 can inhibit the RET autophosphorylation. Compound TPX-0046 can be used for the research of cancer.Formule :C21H21FN6O3Degré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :424.43Sotuletinib hydrochloride
CAS :Sotuletinib hydrochloride (BLZ945 HCl) is a selective, brain-penetrant CSF-1R (c-Fms) inhibitor (IC50=1 nM),for ALS and TNBC.Formule :C20H23ClN4O3SDegré de pureté :98.812%Couleur et forme :SolidMasse moléculaire :434.94SJF 1528
CAS :Potent EGFR & HER2 degrader; DC50 of 39.2 nM in OVCAR8, 736 nM in HeLa; has lapatinib, VHL ligand; inhibits HER2+ breast cancer (IC50=102 nM for SKBr3).Formule :C55H57ClFN7O8SCouleur et forme :SolidMasse moléculaire :1030.61HER2-IN-20
HER2-IN-20 (compound 32) is a potent and selective inhibitor of HER2WT and HER2YVMA, with IC50 values of 49 and 42 nM, respectively. It holds potential for research in non-small cell lung cancer (NSCLC).Formule :C30H27ClFN7O2Masse moléculaire :571.18988TrkA-IN-6
<p>TrkA-IN-6 (compound R48) is a hydrazone-based, selective inhibitor of the tropomyosin receptor kinase A (TrkA). It exhibits greater cytotoxicity towards U87 GBM cells compared to Temozolomide, with an IC50 of 68.99 μM.</p>Formule :C16H13N3O5Masse moléculaire :327.08552EGFR-IN-15
CAS :EGFR-IN-15 (compound I-005) is a potent EGFR inhibitor, exhibiting an IC50 value of 4 nM. This compound holds potential for oncological research applications.Formule :C24H25BrN6O2Couleur et forme :SolidMasse moléculaire :509.408PKG Substrate
CAS :PKG Substrate is selective for PKG, favors PKG Iα (Km=59µM) over PKG II (Km=305µM).Formule :C35H67N17O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :902.01GIP, human
CAS :<p>Insulinotropic hormone from K-cells, binds GIP receptors, boosts insulin, affects lipids, and has antiapoptotic properties.</p>Formule :C226H338N60O66SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :4983.6Anti-ERBB3/HER3 (29Z6)
Anti-ERBB3/HER3 (29Z6) is an antibody inhibitor targeting human ERBB3/HER3.Couleur et forme :Odour LiquidMC-Val-Cit-PAB-Amide-TLR7 agonist 4 Conjugate
CAS :MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Conjugate is a conjugate formed by linking MC-Val-Cit-PAB-Amide and TLR7 agonist 4, useful for cancer research.Formule :C52H72N12O11Degré de pureté :97.70%Couleur et forme :SolidMasse moléculaire :1041.2Istiratumab
CAS :Istiratumab (M-6495) is a bispecific antibody against IGF-1R/ErbB3 for cancer research, promoting receptor degradation.Couleur et forme :LiquidCetuximab (PBS)
Cetuximab (PBS) is a human IgG1 monoclonal antibody that inhibits the epidermal growth factor receptor (EGFR), with a dissociation constant (Kd) of 0.201 nM for EGFR as measured by the SPR method. It exhibits potent antitumor activity.Couleur et forme :Odour LiquidEGFR-IN-43
EGFR-IN-43 (17c) is a potent EGFR inhibitor with ER antagonist action, tamoxifen/endoxifen+gefitinib linkage, and strong anticancer activity.Formule :C50H55ClFN5O5Couleur et forme :SolidMasse moléculaire :860.45JAK1/2/3 Inhibitor 1
CAS :JAK1/2/3 Inhibitor 1 is a potent protein kinase inhibitor.JAK1/2/3 Inhibitor 1 has antitumor activity that inhibits the growth of a variety of cancer cell linesFormule :C6H2Cl2N2SDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :205.06EGFR-IN-76
CAS :EGFR-IN-76 is a potent EGFR inhibitor.Formule :C30H30ClFN6O2Degré de pureté :97.02% - 97.72%Couleur et forme :SolidMasse moléculaire :561.05BMS-777607
CAS :BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3.Formule :C25H19ClF2N4O4Degré de pureté :98.16% - 98.56%Couleur et forme :SolidMasse moléculaire :512.89Ref: TM-T2658
2mg63,00€5mg90,00€10mg142,00€25mg265,00€50mg409,00€100mg727,00€200mg1.091,00€500mg1.636,00€PD-360324
PD-360324 is a human monoclonal antibody (mAb) that targets CSF1/M-CSF. It can be utilized in research related to skin lupus, pulmonary sarcoidosis, and rheumatoid arthritis.Couleur et forme :Odour LiquidDuligotuzumab
CAS :Duligotuzumab is a dual-targeting anti-EGFR/HER3 mAb that blocks signaling and induces ADCC for tumors with poor prognosis.Degré de pureté :97.7% (SDS-PAGE); 96.3% (SEC-HPLC) - ≥95% (SDS-PAGE); 95.19% (SEC-HPLC)Couleur et forme :LiquidHER2-IN-14
CAS :HER2-IN-14 (Compound 34) is a potent inhibitor of HER2, achieving an inhibitory concentration (IC50) of 18 nM.Formule :C26H23ClF2N8O3Couleur et forme :SolidMasse moléculaire :568.96ALW-II-49-7
CAS :<p>ALW-II-49-7 is a selective and potent inhibitor of EphB2 kinase with an EC50 value of 40 nM in cell.</p>Formule :C21H17F3N4O2Degré de pureté :99.72%Couleur et forme :SoildMasse moléculaire :414.38
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