Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(1 prodotti)
- Caspasi(154 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(134 prodotti)
- PDK(9 prodotti)
- PERK(23 prodotti)
- Chinasi di serina/treonina(17 prodotti)
- Survivin(14 prodotti)
- TNF(93 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6222 prodotti di "Apoptosi"
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Z-LEHD-fmk
CAS:Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis.Z-LEHD-FMK exhibits antitumor andFormula:C32H43FN6O10Purezza:96.13%Colore e forma:SolidPeso molecolare:690.72IDH1/2-IN-1
IDH1/2-IN-1 (Compound 6b) is a dual inhibitor of IDH1(R132H)/IDH2(R140Q) with IC50 values of 0.22 μM and 1.6 μM, respectively. This compound effectively inhibits tumor growth by suppressing tumor cell proliferation and activating antioxidative enzymes to enhance host defense. Additionally, IDH1/2-IN-1 reduces inflammation and promotes apoptosis, demonstrating significant anti-tumor activity. It is also utilized in leukemia research.Colore e forma:Odour SoliddFKBP-1
CAS:dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].Formula:C53H64N6O14Purezza:98%Colore e forma:SolidPeso molecolare:1009.11PROTAC RIPK degrader-2
CAS:PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.Formula:C52H65N7O11S3Purezza:98%Colore e forma:SolidPeso molecolare:1060.31Thevetiaflavone
CAS:Thevetiaflavone, a natural flavonoid from W. indica, blocks LDH leakage, boosting cell survival.Formula:C16H12O5Purezza:98%Colore e forma:SolidPeso molecolare:284.26Aphidicolin
CAS:Aphidicolin blocks DNA synthesis, hinders herpes virus growth, and stimulates apoptosis in leukemia cells; it's a mold-derived DNA polymerase inhibitor.Formula:C20H34O4Purezza:>99.99%Colore e forma:SolidPeso molecolare:338.48Topoisomerase II inhibitor 14
CAS:Topoisomerase II inhibitor 14: powerful anticancer agent that induces apoptosis, halts S phase, and lowers GSH, MDA, and NO levels.Formula:C15H11Cl2N5Purezza:99.95%Colore e forma:SoildPeso molecolare:332.19CTP-347
CAS:CTP-347, a deuterated version of paroxetine, is potentially the best non-hormonal drug in its class for the treatment of hot flashes.Formula:C19H20FNO3Colore e forma:SolidPeso molecolare:331.38MS1943
CAS:MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).Formula:C42H54N8O3Purezza:95.41% - 95.82%Colore e forma:SolidPeso molecolare:718.93Ref: TM-T13780
1mg39,00€2mg52,00€5mg84,00€1mL*10mM (DMSO)120,00€10mg130,00€25mg250,00€50mg439,00€100mg802,00€200mg1.324,00€Ecdysone
CAS:Ecdysone is a major steroid hormone in insects and herbs.Formula:C27H44O6Purezza:99.22%Colore e forma:PowderPeso molecolare:464.63PAA5
PAA5, a polynuclear Au(I) cluster, triggers ferroptosis and has anticancer effects by increasing pH2AX over time.Formula:C14H8Au5B2F8N2Colore e forma:SolidPeso molecolare:1348.66TS-24
CAS:TS-24 is a cysteine protease histone S (CTSS) inhibitor that promotes BRCA1-mediated apoptosis.
Formula:C20H15NO2Purezza:99.41%Colore e forma:SoildPeso molecolare:301.34ReACp53
ReACp53 inhibits amyloid formation, restores p53 in cancer cells and HGSOC-derived organoids.Formula:C108H206N52O24Purezza:98%Colore e forma:SolidPeso molecolare:2617.13F1324
F1324: potent BCL6 inhibitor, IC50=1nM, binding t1/2=441s, strongly inhibits BCL6 PPI.Formula:C83H121N21O20SPurezza:98%Colore e forma:SolidPeso molecolare:1765.04TNF/IFNγ-IN-1
CAS:TNF/IFNγ-IN-1 (TGA) is a TNF and IFN-γ inhibitor with antioxidant and anti-inflammatory activities for neurodegenerative diseases such as Alzheimer.Formula:C20H23N3O6Purezza:99.39%Colore e forma:SoildPeso molecolare:401.41Spexin
CAS:Potent GAL2/GAL3 agonist (EC50 = 45.7, 112.2 nM), inactive at GAL1. Reduces appetite, fatty acid uptake in adipocytes, and LH in goldfish; anxiolytic in vivo.Formula:C74H114N20O19SPurezza:98%Colore e forma:SolidPeso molecolare:1619.9Chloranil
CAS:Chloranil (tetrachloro-p-benzoquinone) induces inflammation and neurological dysfunction and can be used to model inflammation in mice.Formula:C6Cl4O2Purezza:98.03%Colore e forma:SolidPeso molecolare:245.88Enniatin A1
CAS:Enniatin A1, a cyclic hexadepsipeptide from Fusarium, induces apoptosis and disrupts ERK, inhibiting ACAT (IC50: 49 μM).Formula:C35H61N3O9Purezza:98%Colore e forma:SolidPeso molecolare:667.885CYP51/PD-L1-IN-4
CYP51/PD-L1-IN-4 (compound 14a-2) is a potent dual-target inhibitor of CYP51/PD-L1, displaying IC50 values of 0.17 and 0.021 μM, respectively.Formula:C27H28N4O3Colore e forma:SolidPeso molecolare:456.54BOC-D-FMK
CAS:Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).Formula:C11H18FNO5Purezza:97.02%Colore e forma:SolidPeso molecolare:263.26Ref: TM-T10580
1mg50,00€5mg114,00€1mL*10mM (DMSO)132,00€10mg167,00€25mg326,00€50mg462,00€100mg640,00€200mg884,00€HPOB
CAS:HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.Formula:C17H18N2O4Purezza:99.91%Colore e forma:SolidPeso molecolare:314.34HKB99
CAS:HKB99 suppresses NSCLC growth, metastasis, and overcomes erlotinib resistance.Formula:C23H18N2O6SPurezza:97.35% - 97.35%Colore e forma:SolidPeso molecolare:450.46ABBV-167
CAS:ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax.Formula:C46H53ClN7O11PSColore e forma:SolidPeso molecolare:978.45Urelumab
CAS:"Urelumab (BMS-66513), a humanized IgG4 mAb CD137 agonist, boosts T-cell/NK cell-mediated cytotoxicity and anti-tumor activity."Purezza:97.70%Colore e forma:LiquidPeso molecolare:145.90 kDaAVJ16
CAS:AVJ16 as a member of the insulin growth factor 2 mRNA-binding protein family, binds to the mRNA of certain genes to regulate protein translation.Formula:C28H27N3O4Purezza:98.87% - 99.72%Colore e forma:SolidPeso molecolare:469.53Ref: TM-T9980
1mg130,00€5mg313,00€1mL*10mM (DMSO)323,00€10mg500,00€25mg807,00€50mg1.108,00€100mg1.485,00€200mg1.998,00€KRAS inhibitor-40
CAS:KRAS inhibitor-40 (Compound 41) is an inhibitor of KRAS, disrupting the KRAS G12C-BRAF complex and suppressing the phosphorylation of the downstream ERK signaling pathway. This compound also inhibits the proliferation of tumor cells with various KRAS mutations, exhibiting antitumor activity.Formula:C53H66ClF4N9O8SColore e forma:SolidPeso molecolare:1100.66PARP1-IN-17
PARP1-IN-17 is an inhibitor that targets PARP-1 (IC50=19.24 nM ) with a slightly reduced affinity for PARP-2 (IC50=32.58 nM ) and induces apoptosis.Purezza:98%Colore e forma:Odour SolidHumulone
Humulone is a natural product and has a wide range of applications in life science related research.Formula:C21H30O5Colore e forma:SolidPeso molecolare:362.47S-Adenosyl-L-methionine iodide
CAS:S-(5'-Adenosyl)-L-methionine iodide, also known as S-Adenosyl-L-methionine iodide, is a vital methyl donor present in all living organisms [1].Formula:C15H23IN6O5SColore e forma:SolidPeso molecolare:526.35Vorsetuzumab
CAS:Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a monoclonal antibody targeting the CD70 antibody.Purezza:SDS-PAGE:95% SEC-HPLC:99.29%Colore e forma:LiquidPeso molecolare:146.1 kDaAnticancer agent 267
Anticanceragent 267 (Compound 5q) serves as an activator of RIPK3 and MLKL. It effectively inhibits the proliferation of several cancer cell lines, with IC50 values of 9.79, 10.77, and 5.94 μM for MDA-MB-231, MDA-MB-486, and MCF-7, respectively. The compound induces cell cycle arrest at the subG1 phase and triggers necroptosis in MDA-MB-231 cells. Additionally, Anticanceragent 267 demonstrates antitumor activity in mouse xenograft models.Formula:C13H11N5O4SColore e forma:SolidPeso molecolare:333.32Syringolin A
CAS:Syringolin A is a useful organic compound for research related to life sciences. The catalog number is T125354 and the CAS number is 212115-96-3.
Formula:C24H39N5O6Colore e forma:SolidPeso molecolare:493.605hMAO-B-IN-11
hMAO-B-IN-11 (Compound 12) is a selective and reversible inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 value of 0.11 µM. It operates by competitively binding to the active site of hMAO-B, thereby preventing the oxidative deamination of monoamines and reducing hydrogen peroxide production. Additionally, hMAO-B-IN-11 inhibits pro-inflammatory mediators (NO, TNF-α, IL-1β) in activated microglia. This compound holds potential for research in neurodegenerative diseases such as Parkinson's and Alzheimer's.Colore e forma:Odour SolidDTUN
DTUN: lipophilic radical initiator, starts STY-BODIPY liposome co-autoxidization at 0.2 mM, useful in FENIX assays.Colore e forma:SolidDC-Y13-27
Dc-y13-27, a derivative of DC-Y13, is a potent YTHDF2 inhibitor (KD: 37.9 μM).
Formula:C14H10N2O2SPurezza:99.75%Colore e forma:SoildPeso molecolare:270.31[1,1'-Biphenyl]-3-amine
CAS:[1,1'-Biphenyl]-3-amine is an inhibitor of MAO-A and MAO-B and can inhibit the cell viability of HT-29, HEK 293, and MCF-7 cells.Formula:C12H11NPurezza:99.78%Colore e forma:SolidPeso molecolare:169.22RAR/RXR agonist-1
Compound 7, also known as RAR/RXR agonist-1, is a chlorinated isomer of retinoic acid and acts as a selective RARα agonist and a partial RXRα agonist. It is capable of activating RXRα, thereby inducing G2/M arrest and apoptosis in cancer cells.Formula:C25H27ClO3Colore e forma:SolidPeso molecolare:410.932-Acetamidophenol
CAS:2-Acetamidophenol (Orthocetamol) has analgesic and antipyretic effects. 2-Acetamidophenol is an isomer of Paracetamol (4-acetamidophenol).
Formula:C8H9NO2Purezza:>99.99%Colore e forma:Light Brown PowderPeso molecolare:151.16Furazolidone
CAS:Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.Formula:C8H7N3O5Purezza:99.96%Colore e forma:Yellow Crystals From Dmf (N N-Dimethylformamide) SolidPeso molecolare:225.16KC01
CAS:KC01 selectively inhibits ABHD16A (IC50: 0.2-0.5 μM), much more potent than KC02 (>10 μM); human ABHD16A IC50: 90±20 nM.Formula:C22H39NO3Purezza:98%Colore e forma:SolidPeso molecolare:365.558DB2313
CAS:DB2313 is a potent PU.1 inhibitor (IC50=14 nM) that disrupts gene binding, induces AML cell apoptosis, and has anticancer properties.
Formula:C42H41FN8O2Purezza:98.63% - 99.29%Colore e forma:SolidPeso molecolare:708.83Ac-LEVD-CHO
CAS:Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].Formula:C22H36N4O9Colore e forma:SolidPeso molecolare:500.54EGFR/HER2/DHFR-IN-3
EGFR/HER2/DHFR-IN-3 (compound 4c) serves as an efficacious dual inhibitor specifically targeting EGFR/HER2, exhibiting IC50 values of 0.138 μM for EGFR and 0.Purezza:98%Colore e forma:Odour SolidOxybenzone-d3
Oxybenzone-d3 (Benzophenone 3-d3) is a deuterium-labeled form of Oxybenzone. Commonly used as a UV filter in tanning and skin protection products, Oxybenzone (Benzophenone 3) acts as an endocrine-disrupting chemical (EDC) that can cross both the placental and blood-brain barriers. It impairs autophagy, alters epigenetic states, and disrupts retinoid X receptor signaling in apoptotic neuronal cells.Formula:C14H9D3O3Colore e forma:SolidPeso molecolare:231.26(R)-MIK665
CAS:(R)-MIK665 is the less active enantiomer of MIK665. MIK665 is a special inhibitor of Mcl-1(IC50 of 1.81 nM).Formula:C47H44ClFN6O6SPurezza:98%Colore e forma:SolidPeso molecolare:875.41Spexin TFA
Spexin TFA: GAL2/GAL3 agonist (EC50: 45.7/112.2 nM), no activity at GAL1, reduces appetite, fatty acid uptake, and LH secretion; anxiolytic.Formula:C76H115F3N20O21SColore e forma:SolidPeso molecolare:1733.9Oxatomide
CAS:Oxatomide: Dual H1/P2X7 antagonist, antihistamine, anti-allergic, treats immune diseases, IC50: 0.95 μM (P2X7), 0.43 μM (5-HT).Formula:C27H30N4OPurezza:99.28% - 99.72%Colore e forma:White PowderPeso molecolare:426.55Ref: TM-T19839
1mg35,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg114,00€25mg222,00€50mg356,00€100mg557,00€500mg1.153,00€Z-Ala-Ala-Asp-CMK
CAS:Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor that blocks granzyme B protease activity, for inflammatory diseases and tumours.Formula:C19H24ClN3O7Purezza:99.967%Colore e forma:SolidPeso molecolare:441.86Oligomycin B
CAS:Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis.Formula:C45H72O12Purezza:98%Colore e forma:SolidPeso molecolare:805.05FLT3-IN-21
FLT3-IN-21 (compound LC-3), a potent FLT3 inhibitor with an IC50 value of 8.4 nM, induces apoptosis and arrests the cell cycle in the G1 phase.Formula:C20H22FN5O2Colore e forma:SolidPeso molecolare:383.42Anti-inflammatory agent 42
CAS:Anti-inflammatory agent 42 has anti-inflammatory activity and inhibits the expression of TNF-α and IL-6 in LPS-stimulated macrophages.Formula:C20H12N2OSPurezza:99.47%Colore e forma:SolidPeso molecolare:328.39BK50164
CAS:BK50164: CD73 inhibitor, IC50=13.089µM; binds CD99, KD=1.5µM; anticancer, induces apoptosis, arrests sub-G1.Formula:C13H13ClFN5O7Colore e forma:SolidPeso molecolare:405.72Thymidine 3',5'-disphosphate
CAS:pdTp is a highly selective, small-molecule miRNA regulatory complex RISC subunit SND1 inhibitor.Formula:C10H16N2O11P2Colore e forma:SolidPeso molecolare:402.19Tyroserleutide hydrochloride
CAS:Tyroserleutide HCl, a tripeptide from pig spleen, inhibits tumor growth in vivo/vitro.Formula:C18H28ClN3O6Purezza:98%Colore e forma:SolidPeso molecolare:417.88Curzerene
CAS:Curzerene, a sesquiterpene compound derived from the rhizome of Curculigo orchioides Gaertn, possesses potent anti-cancer properties.Formula:C15H20OPurezza:97.07%Colore e forma:SolidPeso molecolare:216.32Thalidomide-NH-C8-NH2
CAS:Thalidomide-NH-C8-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand and a specific linker.Formula:C21H28N4O4Colore e forma:SolidPeso molecolare:400.479S-Adenosyl-L-methionine
CAS:S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.Formula:C15H22N6O5SPurezza:99.08%Colore e forma:SolidPeso molecolare:398.44Hellebrin
CAS:Cytotoxic and antiproliferative effects of Hellebrin on breast and lung cancer cells.Formula:C36H52O15Colore e forma:SolidPeso molecolare:724.79A011
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycleFormula:C27H28N6OPurezza:98%Colore e forma:SolidPeso molecolare:452.55Z-DQMD-FMK
CAS:Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.
Formula:C29H40FN5O11SPurezza:98%Colore e forma:SolidPeso molecolare:685.72Ianalumab
CAS:Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R.Purezza:100% (SEC-HPLC) - > 95%Colore e forma:LiquidPeso molecolare:146.44 kDaAc-IEPD-AFC
CAS:Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.Formula:C32H38F3N5O11Purezza:99.16%Colore e forma:SolidPeso molecolare:725.67Linsidomine
CAS:Lincydomine relaxes smooth muscles, treats unstable angina, and opens human and guinea pig respiratory tracts.Formula:C6H10N4O2Colore e forma:Solid Off-WhitePeso molecolare:170.17Thalidomide-Piperazine-PEG2-NH2
CAS:Thalidomide-Piperazine-PEG2-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand with a PEG2 linker.Formula:C23H31N5O6Colore e forma:SolidPeso molecolare:473.53Bcl-2-IN-2
CAS:Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL.Formula:C48H57N7O7SColore e forma:SolidPeso molecolare:876.09Tubulin inhibitor 34
Tubulin Inhibitor 34 (compound b5), a potent anticancer agent, inhibits tubulin polymerization and induces G2/M arrest and apoptosis.Formula:C21H22N4O3SColore e forma:SolidPeso molecolare:410.49PB28
CAS:PB28: A potent σ2 agonist (Ki 0.68 nM), σ1 antagonist (Ki 0.38 nM), with anti-tumor properties and inhibits SARS-CoV-2 interactions.Formula:C24H38N2OColore e forma:SolidPeso molecolare:370.581BM-1197
CAS:BM-1197, a highly potent and specific dual inhibitor of Bcl-2 and Bcl-xL, effectively targets these proteins with IC50 values of 3.5 nM and 5.2 nM for Bcl-2 andFormula:C53H59ClF4N6O7S4Colore e forma:SolidPeso molecolare:1131.77ATWLPPRAANLLMAAS
CAS:ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent antitumor capabilities. It effectively inhibits the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induces apoptosis (apoptosis).Formula:C76H123N21O20SPeso molecolare:1682.98Antiproliferative agent-25
Antiproliferative Agent-25 (Compound 3s4) is a selective PRMT5 inhibitor displaying an IC50 of 0.11 μM.Formula:C20H21BrN2O2Purezza:98%Colore e forma:SolidPeso molecolare:401.3Boc-AEVD-CHO
CAS:Boc-AEVD-CHO, a selective Caspase 8 inhibitor, facilitates apoptosis research and the investigation of immune and inflammatory diseases [1] [2].Formula:C22H36N4O10Purezza:98%Colore e forma:SolidPeso molecolare:516.54SRE-II
SRE-II, an amide derivative, serves as an activatable photosensitizer tailored for photodynamic cancer research, exhibiting diminished fluorescence andFormula:C15H9ClINO2Purezza:98%Colore e forma:SolidPeso molecolare:397.59Tubulin/HDAC-IN-2
Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor targeting Tubulin and HDAC, exhibiting IC50 values of 0.403 μM for HDAC1, 0.591 μM for HDAC2, 3.552 μMFormula:C21H19FN2O4Colore e forma:SolidPeso molecolare:382.38Ac-FEID-CMK
Ac-FEID-CMK: Potent inhibitor for zebrafish GSDMEb, reduces pyroptosis, and lessens septic AKI.Formula:C27H37ClN4O9Colore e forma:SolidPeso molecolare:597.06(D)-PPA 1 TFA
(D)-PPA 1 TFA is a hydrolysis-resistant D-peptide antagonist and a potent PD-1/PD-L1 inhibitor, exhibiting an affinity for PD-1 of 0.51 μM and demonstratingFormula:C72H99F3N20O23Purezza:98%Colore e forma:SolidPeso molecolare:1669.67Thalidomide-NH-PEG7
Thalidomide-NH-PEG7, a chemical for creating PROTAC iRucaparib-AP6, selectively degrades PARP1 and is used in ADCs.Formula:C27H39N3O11Purezza:98%Colore e forma:SolidPeso molecolare:581.61KB03-SLF
CAS:KB03-SLF is a protease with the capability to target specific proteins and regulate intracellular protein levels by inducing protein degradation. This mechanism renders KB03-SLF potentially valuable in the suppression of related diseases.Formula:C50H63ClF3N5O12Colore e forma:SolidPeso molecolare:1018.51AZD5582 TFA
AZD5582 TFA is a potent IAP antagonist that binds to the BIR3 domain of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 nM, respectively.AZD5582 TFAFormula:C60H79F3N8O10Purezza:99.89%Colore e forma:SoildPeso molecolare:1129.31Ref: TM-T36201L
1mg55,00€5mg96,00€1mL*10mM (DMSO)144,00€10mg149,00€25mg259,00€50mg442,00€100mg647,00€8-Aminoadenosine
CAS:8-Aminoadenosine reduces ATP, blocks mRNA synthesis, and Akt/mTOR signaling, triggering autophagy and apoptosis independently of p53, with antitumor effects.
Formula:C10H14N6O4Colore e forma:SolidPeso molecolare:282.26Ascochlorin
CAS:Ascochlorin, an isoprenoid antibiotic, inhibits STAT3 to combat tumors, induces apoptosis, and reduces inflammation.Formula:C23H29ClO4Purezza:98%Colore e forma:SolidPeso molecolare:404.93Tasisulam sodium
CAS:Tasisulam triggers apoptosis, halts mitosis, and normalizes blood vessels to combat cancer.Formula:C11H5BrCl2NNaO3S2Colore e forma:SolidPeso molecolare:437.09VB-85247
VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.Colore e forma:Odour SolidPROTAC EGFR degrader 5
CAS:PROTAC EGFR degrader 5 effectively breaks down EGFR Del19 in HCC827 cells at 34.8 nM, inducing apoptosis and G1 arrest.Formula:C57H72FN13O5SColore e forma:SolidPeso molecolare:1070.33PROTAC Bcl-xL degrader-1
PROTAC Bcl-xL degrader-1 targets Bcl-xL & IAP E3 ligases, degrades Bcl-xL, toxic to human platelets & MyLa 1929 (IC50: 62 nM, 8.5 μM).Formula:C76H96ClF3N10O11S3Colore e forma:SolidPeso molecolare:1514.28ChoKα inhibitor-3
ChoKα Inhibitor-3, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoK α1 with an IC50 value of 0.66 μM and possesses the capability toFormula:C50H54Br2Cl2N4S2Colore e forma:SolidPeso molecolare:1005.83Didocosahexaenoin
CAS:Didocosahexaenoin, omega-3 diglyceride, disrupts mitochondria, induces ROS, apoptosis, and is cytotoxic to prostate cancer cells.Formula:C25H40O5Colore e forma:SolidPeso molecolare:420.58Bak BH3
Flu-BakBH3 peptide, derived from Bak's BH3 domain, binds tightly to a crucial pocket of Bcl-XL, essential for its anti-death role.Formula:C72H125N25O24Purezza:98%Colore e forma:SolidPeso molecolare:1724.9PROTAC EGFR degrader 7
Compound 13b, a potent EGFR degrader, inhibits and induces apoptosis in NSCLC cells with a DC50 of 13.2 nM.Formula:C46H48N10O6Colore e forma:SolidPeso molecolare:836.94Vallesiachotamine
CAS:Vallesiachotamine, a recognized monoterpene indole alkaloid, exhibits anti-tumor activity [1].Formula:C21H22N2O3Colore e forma:SolidPeso molecolare:350.41Tubulin polymerization-IN-67
Tubulin polymerization-IN-67 (Compound 5h) serves as an inhibitor of microtubule protein polymerization at the colchicine binding site, exhibiting an IC50 value of 2.92 μM. It effectively inhibits the proliferation of various cancer cell lines including HT29, A549, U2OS, MG-63, and HeLa, with IC50 values ranging from 0.12 to 4.13 μM. Additionally, Tubulin polymerization-IN-67 induces cell cycle arrest at the G2/M phase and triggers apoptosis in U2OS cells. It also inhibits cell migration in A549 and reduces mitochondrial membrane potential (MMP) while increasing intracellular ROS levels, thereby suppressing angiogenesis in HUVEC cells. Furthermore, this compound demonstrates antitumor activity in mice.Colore e forma:Odour SolidRozanolixizumab
CAS:Rozanolixizumab (RYSTIGGO) is a humanized IgG4 monoclonal antibody that targets FcRn in newborns for autoimmune research.
Purezza:SDS-PAGE:97.2%;SEC-HPLC:95.9%Colore e forma:LiquidPeso molecolare:145.19 kDaSI-2
CAS:SI-2, a SRC-3 inhibitor, triggers breast cancer cell death (IC50: 3-20 nM), sparing normal cells.Formula:C15H15N5Purezza:98.4%Colore e forma:SolidPeso molecolare:265.31Ref: TM-T28773
1mg358,00€1mL*10mM (DMSO)800,00€5mg873,00€10mg1.161,00€25mg1.755,00€50mg2.358,00€100mg3.177,00€CRM1-IN-2
CRM1-IN-2 (Compound KL2) is a noncovalent inhibitor that targets CRM1, localizing it to the nuclear periphery, depleting its nuclear presence, and inhibitingFormula:C29H48N2O5Purezza:98%Colore e forma:SolidPeso molecolare:504.7TNF-α (46-65), human
CAS:Human TNF alpha (46-65) peptide.Formula:C110H172N24O30Purezza:98%Colore e forma:SolidPeso molecolare:2310.69Thalidomide-NH-C4-NH2 TFA
CAS:Compound 29c, a Thalidomide-linker conjugate for potent PROTAC BRD2/BRD4 degrader-1, targets BET proteins.Formula:C19H21F3N4O6Purezza:98%Colore e forma:SolidPeso molecolare:458.39UBX1325
CAS:UBX1325, a potent Bcl-xL inhibitor, induces cell death in aging cells, useful for age-related eye disease research.
Formula:C53H59ClF3N6O10PS3Colore e forma:SolidPeso molecolare:1159.69Antitumor agent-61
CAS:Antitumor agent-61, a potent Irinotecan derivative, exhibits IC50s of 0.92-3.23 μM in 6 cancer cells, inducing apoptosis via mitochondrial pathways.Formula:C54H63FN5O10PColore e forma:SolidPeso molecolare:992.08LIB3S0280
LIB3S0280 is a potent inhibitor of TBK1, with an IC50 of 493.9 nM. It suppresses TBK1 downstream signaling by reducing the phosphorylation of IκBα and AKT. LIB3S0280 causes G2/M phase arrest and induces apoptosis in pancreatic cancer cells. Notably, it exhibits significant inhibitory effects on pancreatic cancer cell lines with high TBK1 expression, with a 96-hour IC50 value ranging from 6.64-10.98 μM. LIB3S0280 shows potential for research in pancreatic ductal adenocarcinoma (PDAC).Colore e forma:Odour SolidPD0166285 dihydrochloride
CAS:PD-166285 is an effective and broadly active inhibitor of protein tyrosine kinase.Formula:C26H29Cl4N5O2Colore e forma:SolidPeso molecolare:585.35Methyl-4-oxoretinoate
CAS:Methyl-4-oxoretinoate is a synthetic retinoid with anticancer properties, used for skin conditions and potential ocular treatments.Formula:C21H28O3Purezza:99.95%Colore e forma:SolidPeso molecolare:328.45
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