Apoptosi

<p>Melflufen HCl: prodrug of Melphalan, has antitumor and antiangiogenic effects, causes DNA damage in MM cells.</p>

<p>Cobimetinib hemifumarate is a potent and selective MEK1 inhibitor with an IC50 value of 4.2 nM for MEK1.</p>

<p>Prinaberel (ERB-041) is an effective and selective ERβ agonist and &gt;200-fold selective for ERβ.</p>

<p>Sodium catechol sulfate is a bioactive chemical.</p>

<p>KS100 inhibits ALDH1A1, ALDH2, ALDH3A1, boosts ROS, triggers apoptosis, and has anti-cancer properties.</p>

<p>PGV-1, an oral Curcumin analog, induces apoptosis by inhibiting COX-2, VEGF, and NF-κB activation.</p>

PDK1-IN-RS2, a PIFtide mimic, selectively inhibits PDK1, blocking S6K1 activation (Kd: 9 μM).

<p>FPA-124 is a cell-permeable copper complex that acts as a selective Akt (protein kinase B) inhibitor to induce apoptosis in a variety of cancer cell lines.</p>

<p>Fenobucarb is a broad-spectrum carbamate insecticide and AChE inhibitor. It exhibits neurotoxicity to zebrafish foetal development and induces muscle spasms</p>

<p>Etoposide Phosphate is a selective and orally active topoisomerase II inhibitor and anticancer chemotherapy drug that apoptosise, the p53, and G2/M</p>

<p>PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).</p>

<p>(Rac)-Apremilast D5 is a deuterium-labeled version of the enantiomer (R)-Apremilast, also known as (R)-CC-10004, which itself is one specific form of Apremilast</p>

<p>(S)-Oxiracetam is a positive allosteric the AMPA receptorsmodulator.</p>

<p>Everolimus-d4 is a deuterated compound of Everolimus.</p>

<p>Thalidomide-5,6-F, a cereblon ligand for CRBN protein recruitment, forms PROTACs for targeted protein degradation.</p>

<p>GLP-2, an intestinal growth factor, may treat various human intestinal diseases.</p>

<p>Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM.</p>

<p>(-)-Apomorphine hydrochloride hydrate is a broad-spectrum dopamine agonist and ferroptosis inhibitor.</p>

<p>Thalidomide-5-CH2-NH2 (HCl) recruits CRBN protein, used to create PROTACs via a linker.</p>

<p>Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific inhibitor of mTOR(IC50 of 0.1 nM in HEK293 cells).</p>

<p>3,4,5-Trihydroxycinnamic acid decyl ester is an anti-obesity agent that inhibits lipid absorption and pancreatic lipase (EC50 ≈ 0.9μM).</p>

<p>MCL-1/BCL-2-IN-2 is a selective Mcl-1 and Bcl-2 inhibitor with potential antitumor activity for tumor research.</p>

<p>Curcumin D6 (difluoroformylmethane D6) is deuterium-labeled curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with various pharmacological effects, including anti-inflammatory, antioxidant, anti-proliferative and anti-a</p>

<p>Necrostatin 2 is a RIPK1 inhibitor that can be used to study inner ear disorders such as sudden deafness, dizziness and tinnitus.</p>

<p>Nafamostat is a synthetic serine protease inhibitor and an anticoagulant used in haemodialysis. It induces apoptosis, inhibiting SARS-CoV-2 and COVID-19.</p>

<p>LeDSF3 controls HSAF production in Lysobacter, has antifungal properties, and acts as an anti-tumor by inhibiting p-AKT and activating caspase-3.</p>

<p>5-Methoxyuridine (Mo5U) is an antitumor purine analog that inhibits DNA synthesis and induces apoptosis in lymphatic cancers.</p>

<p>SLF is a synthetic ligand for FKBP12 and increases Ca2+ efflux and protein synthesis.</p>

<p>Lestaurtinib (CEP 701) is a FLT3 inhibitor that inhibits the phosphorylation of RPTKs and can be used to study leukemia.</p>

<p>BIX02188 is a selective and potent MEK5 inhibitor that inhibits MEK5-induced apoptosis in cells expressing the oncogenic mutant FLT3-ITD.</p>

<p>Pancratistatin, an isoquinoline from Hymenocallis littoralis, triggers apoptosis in melanoma and is studied for neuroblastoma, leukemia, and breast cancer.</p>

<p>Macitentan-d4 (ACT-064992 D4) is a C13-labeled inhibitor of the peptides ETA and ETB used to study diseases mediated by endothelin receptor mediation.</p>

<p>MC1742 inhibits class I/IIb HDACs, blocks sarcoma CSC growth, and reactivates latent HIV. IC50: HDAC1-3/8 (0.02-0.61 μM), HDAC6/10 (7-40 nM).</p>

<p>(E/Z)-E64FC26 is a protein disulfide isomerase (PDI) family inhibitor with affinity for PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6.</p>

<p>Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c</p>

<p>Mepazine hydrochloride (Pecazine hydrochloride) is a MALT1 inhibitor with anticancer and antitumor activity, inhibiting RANK-induced osteoclastogenesis.</p>

<p>FKBP12 PROTAC RC32 is a PROTAC-like degrader targeting FKBP12. It can degrade FKBP12 in organs after intraperitoneal administration.</p>

<p>Palmatine hydroxide: oral IDO-1 inhibitor (IC50: 3-157μM), targets WNV protease, has anti-cancer/viral and neuroprotective properties.</p>

<p>Propylparaben sodium, a plant-based preservative used in cosmetics, pharma, and food, hinders follicle growth and sperm health.</p>

<p>Olanzapine D3 is the deuterium labeled Olanzapine.</p>

<p>PRDX1-IN-1 is a and PRDX1 inhibitor with potential anti-inflammatory and anti-cancer activity for the study of breast and esophageal cancer.</p>

<p>LNnT is a metabolite that reduces IL-8, has anti-inflammatory effects, and aids in wound healing.</p>

<p>Z-Ile-Leu-aldehyde is an effective and competitive peptide aldehyde inhibitor of γ-secretase and notch.</p>

<p>Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast.</p>

<p>PND-1186 hydrochloride (VS-4718 hydrochloride) is a highly specific, reversible and potent inhibitor of FAK (IC50: 1.5 nM), which can selectively induce</p>

<p>MRT00033659 inhibits CK1 (IC50=0.9 μM), CHK1 (IC50=0.23 μM), activates p53, and destabilizes E2F-1; it's a pyrazolo-pyridine.</p>

Tubulin inhibitor 1 blocks tubulin polymerization, with strong anti-tumor effects, induces apoptosis and G2/M mitotic arrest.

<p>EIF2α activator 2 is an activator of eIF2α phosphorylation, anti-proliferative in SRB, K562, and PBMC cells, suitable for cancer research.</p>

<p>C8 Ceramide, a cell-permeable analog, is analog to naturally occur ceramides.</p>

<p>DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.</p>

<p>BCL6-IN-5 is a highly effective inhibitor of BCL6. It exhibits a pIC50 value of 5.82.</p>

<p>Rutin trihydrate is a natural flavonoid with antioxidant, anti-inflammatory, anti-diabetic, and anti-cancer benefits, plus heart and brain protection.</p>

<p>Capecitabine-d11 is a deuterated compound of Capecitabine. Capecitabine has a CAS number of 154361-50-9. Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.</p>

<p>TZ9 is a Rad6 inhibitor with anticancer activity.TZ9 inhibits Rad6B-induced ubiquitination of histone H2A.TZ9 induces cell cycle arrest and apoptosis.</p>

<p>TMI-1 (WAY-171318), a novel orally active inhibitor of ADAM17 (TACE) and MMP, induces tumor apoptosis in a breast cancer.</p>

<p>Acyclovir-d4 is a deuterated compound of Acyclovir. Acyclovir has a CAS number of 59277-89-3. Acyclovir is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family.</p>

<p>Galantamin-d6 is a deuterated compound of Galantamin.</p>

<p>Fenvalerate (Evercide 2362) is a protein phosphatase 2B (calcineurin) inhibitor, a synthetic pyrethroid insecticide, that inhibits PP2B-Aα.</p>

<p>N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL), a quorum-sensing signaling molecule synthesized by P. aeruginosa and specific B. cepacia complex strains [1][2], facilitates bacterial gene expression modulation in response to cell density escalation and triggers IL-8 production in 16HBE human bronchial epithelial cells [3].</p>

<p>Diuron is an orally active benzoylurea herbicide. Diuron inhibits the production of ATP and NADH,, ROS and cancer.</p>

<p>Ibuprofen D3 is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor (IC50s: 13 μM and 370 μM).</p>

<p>Sodium cyclamate is a carbonic anhydrase inhibitor, artificial sweetener, with anticonvulsant properties, and used in cancer research.</p>

<p>Methopterin shows the activation and bone resorption function of murine osteoclasts.</p>

Venetoclax-d8 (ABT-199-d8) is a deuterated form of Venetoclax, a potent, selective, and orally active Bcl-2 inhibitor that induces autophagy and apoptosis.

<p>Degarelix is a peptide and selective GnRH (human gonadotropin-releasing hormone) receptor antagonist prostate cancer by lowering testosterone levels.</p>

<p>N-deacetylated BMS-202 is an inhibitor of PD-1/PD-L1 interaction with potential anticancer activity for cancer research.</p>

<p>PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound with anticancer and antitumor activity that inhibits the growth of breast cancer cells.</p>

<p>Pevonedistat(MLN4924) hydrochloride is a NEDD8-activating enzyme inhibitor that induces apoptosis and can be used in the study of acute myeloid leukemias.</p>

<p>Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor with anticancer activity.</p>

AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.

<p>AZD-5991, an antitumor compound, is a highly selective, potent and direct MCL-1 inhibitor, rapid apoptosis by Bak-dependent mitochondrial apoptotic pathway.</p>

<p>Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with</p>

<p>Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability.</p>

<p>Sonrotoclax is a potent, orally active inhibitor of Bcl2, demonstrating effective cell-killing activity against a range of lymphoma and leukemia cell lines [1].</p>

<p>Amifostine thiol (WR-1065), an active Amifostine metabolite, is a radioprotective cytoprotectant that activates p53 via JNK pathway.</p>

<p>Deferasirox (Fe3+ chelate) is an iron chelator with anticancer activity and can be used to study iron overload.</p>

<p>AMG-337 is an effective and highly specific ATP-competitive MET kinase inhibitor. In enzymatic assays, AMG-337 inhibits MET kinase activity (IC50: &lt; 5 nM).</p>

<p>Ac-DEVD-pNA is the preferred peptidic substrate for caspase-3.</p>

<p>Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.</p>

<p>Imipramine HCl: 1st-gen tricyclic antidepressant, inhibits serotonin and norepinephrine uptake, blocks aSMase, reduces MV/exosome secretion.</p>

<p>Thalidomide-O-C6-NH2 hydrochloride (4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride) is a synthesized E3 ligase ligand-</p>

<p>Pitavastatin sodium inhibits HMG-CoA reductase, enhances LDL-C receptors, and has various protective effects.</p>

<p>Oxychlororaphine (phenazine-1-carboxamide) inhibits strongly the growth of Streptomyces sp. 441.</p>

<p>GSK3326595 (EPZ015938) is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.).</p>

<p>Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives.</p>