Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(1 prodotti)
- Caspasi(154 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(134 prodotti)
- PDK(9 prodotti)
- PERK(23 prodotti)
- Chinasi di serina/treonina(17 prodotti)
- Survivin(14 prodotti)
- TNF(93 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6223 prodotti di "Apoptosi"
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(R,R)-S63845
(R,R)-S63845 is the isomer of S63845 and serves as a control compound in experiments. S63845 is a potent and selective inhibitor of myeloid cell leukemia 1 (MCL1), binding to human MCL1 with a dissociation constant (Kd) of 0.19 nM.Colore e forma:Odour SolidResveratrol-13C6
Resveratrol-13C6 is a carbon-13 labeled form of Resveratrol. Resveratrol (trans-Resveratrol; SRT501) is a natural polyphenol known for its antioxidant, anti-inflammatory, cardioprotective, and anticancer properties. It targets a variety of proteins, including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, and DNA polymerase, and acts as a specific activator of SIRT1. Additionally, Resveratrol is an effective Pregnane X Receptor (PXR) inhibitor and serves as an Nrf2 activator, capable of mitigating aging-related progressive renal injury in mouse models. It also enhances nitric oxide (NO) production in endothelial cells.Colore e forma:Odour SolidGarivulimab
CAS:Garivulimab (BGB-A333), a humanized IgG1 monoclonal antibody, binds to PD-L1, blocking PD-1 interaction and exhibiting antitumor activity.Colore e forma:Liquid2-Deoxy-D-glucose-d
CAS:2-Deoxy-D-glucose-d is the deuterated form of 2-Deoxy-D-glucose. This compound is a glucose analogue that acts as a glucose metabolism inhibitor by targeting hexokinase to hinder glycolysis.Formula:C6H12O5Colore e forma:SolidPeso molecolare:165.16Simvastatin-d3
CAS:Simvastatin-d3 is the deuterated form of Simvastatin. Simvastatin (MK 77333) acts as a competitive inhibitor of HMG-CoA reductase (HMGCR) with a Ki of 0.2 nM and is orally active. It reduces cholesterol synthesis and lowers blood cholesterol levels. Additionally, Simvastatin demonstrates antiproliferative effects on cancer cells and can induce apoptosis (apoptosis).Formula:C25H38O5Colore e forma:SolidPeso molecolare:421.59Tebentafusp
CAS:Tebentafusp (IMCgp100) is a protein that targets gp100 with potential anti-tumor activity.Purezza:97.2% (SDS-PAGE); 100% (SEC-HPLC) - 97.2% (SDS-PAGE); 100% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:76.14 kDaSpiroplatin
CAS:Spiroplatin (TNO-6) is a novel platinum-containing analogue with antitumor activity that is commonly used in the study of solid tumors.Formula:C8H18N2O4PtSPurezza:≥98%Colore e forma:SolidPeso molecolare:433.39TNF/IFNγ-IN-1
CAS:TNF/IFNγ-IN-1 (TGA) is a TNF and IFN-γ inhibitor with antioxidant and anti-inflammatory activities for neurodegenerative diseases such as Alzheimer.Formula:C20H23N3O6Purezza:99.39%Colore e forma:SoildPeso molecolare:401.41GB-223
GB-223 is a human monoclonal antibody (mAb) that targets TNFSF11/RANKL/CD254. It is applicable in the study of giant cell tumors of bone and postmenopausal osteoporosis.Colore e forma:Odour LiquidEnniatin A1
CAS:Enniatin A1, a cyclic hexadepsipeptide from Fusarium, induces apoptosis and disrupts ERK, inhibiting ACAT (IC50: 49 μM).Formula:C35H61N3O9Purezza:98%Colore e forma:SolidPeso molecolare:667.885G-Glu-Val
CAS:G-Glu-Val (γ-glutamyl-L-valine, H-Glu-Val -OH), a flavour-regulating dipeptide, is a major contributor to "mellow".
Formula:C10H18N2O5Colore e forma:SolidPeso molecolare:246.26BC011
BC011 is a human monoclonal antibody (mAb) targeting TNFRSF1B. It enhances the proliferation of CD8+ T cells and depletes Treg cells, resulting in an increased proportion of effector T cells within the tumor microenvironment. BC011 is applicable in the study of tumor immunology.Colore e forma:Odour LiquidA011
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycleFormula:C27H28N6OPurezza:98%Colore e forma:SolidPeso molecolare:452.55Thymidine 3',5'-disphosphate
CAS:pdTp is a highly selective, small-molecule miRNA regulatory complex RISC subunit SND1 inhibitor.Formula:C10H16N2O11P2Colore e forma:SolidPeso molecolare:402.19RA-XII
CAS:RA-XII is a useful organic compound for research related to life sciences. The catalog number is T125868 and the CAS number is 143343-98-0.Formula:C46H58N6O14Colore e forma:SolidPeso molecolare:918.998Placulumab
CAS:Placulumab (ART621), an anti-TNF α monoclonal antibody, targets inflammation, potentially aiding arthritis treatment.Colore e forma:LiquidRasagiline
CAS:Rasagiline (AGN1135) is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of ParkinsonsFormula:C12H13NPurezza:98% - 99.87%Colore e forma:SolidPeso molecolare:171.24KRAS inhibitor-40
CAS:KRAS inhibitor-40 (Compound 41) is an inhibitor of KRAS, disrupting the KRAS G12C-BRAF complex and suppressing the phosphorylation of the downstream ERK signaling pathway. This compound also inhibits the proliferation of tumor cells with various KRAS mutations, exhibiting antitumor activity.Formula:C53H66ClF4N9O8SColore e forma:SolidPeso molecolare:1100.66PARP1-IN-17
PARP1-IN-17 is an inhibitor that targets PARP-1 (IC50=19.24 nM ) with a slightly reduced affinity for PARP-2 (IC50=32.58 nM ) and induces apoptosis.Purezza:98%Colore e forma:Odour SolidBaminercept
CAS:Baminercept (BG 9924) is a lymphotoxin-β receptor-immunoglobulin fusion protein that blocks the lymphotoxin-letter/LIGHT axis.Purezza:95% (SDS-PAGE); 98.3% (SEC-HPLC) - 95% (SDS-PAGE); 98.3% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:46.88 kDaLodapolimab
CAS:Lodapolimab (LY3300054) is an IgGλ anti- PD-1 monoclonal antibody [1] .Colore e forma:LiquidEGFR/HER2/DHFR-IN-3
EGFR/HER2/DHFR-IN-3 (compound 4c) serves as an efficacious dual inhibitor specifically targeting EGFR/HER2, exhibiting IC50 values of 0.138 μM for EGFR and 0.Purezza:98%Colore e forma:Odour SolidGSK2800528
GSK2800528 is a human monoclonal antibody (mAb) targeting TNFSF2/TNFa, utilized for research related to inflammation and psoriasis.Colore e forma:Odour LiquidDB2313
CAS:DB2313 is a potent PU.1 inhibitor (IC50=14 nM) that disrupts gene binding, induces AML cell apoptosis, and has anticancer properties.
Formula:C42H41FN8O2Purezza:98.63% - 99.29%Colore e forma:SolidPeso molecolare:708.83PROTAC PI3K/110β degrader-2
CAS:PROTACPI3K/110β degrader-2 is a selective PI3K/p110β PROTAC degrader. It effectively degrades the 110β protein and inhibits the expression of P-glycoprotein. Additionally, it increases reactive oxygen species (ROS) levels. PROTACPI3K/110β degrader-2 exerts antitumor effects by activating the endoplasmic reticulum stress (ERS) mediated mitochondrial apoptosis pathway and inhibiting the AKT/Bcl-2 signaling pathway. This compound is applicable in cancer research.Formula:C51H65N9O7SColore e forma:SolidPeso molecolare:948.18Lenalidomide-d5
CAS:Lenalidomide-d5 is a deuterated form of Lenalidomide. Lenalidomide (CC-5013) is a derivative of Thalidomide and acts as an orally active immunomodulator in a molecular glue manner. It serves as a ligand for the ubiquitin E3 ligase cereblon (CRBN). Through the CRBN-CRL4 ubiquitin ligase complex, Lenalidomide selectively ubiquitinates and degrades the lymphocyte transcription factors IKZF1 and IKZF3. It effectively inhibits the growth of mature B-cell lymphomas, including multiple myeloma, and induces T cells to release interleukin-2 (IL-2).Formula:C13H13N3O3Colore e forma:SolidPeso molecolare:264.29PTD-p65-P1 Peptide
PTD-p65-P1: a NF-kappaB inhibitor blocking activation from multiple inflammatory stimuli.Formula:C168H275N57O44SPurezza:98%Colore e forma:SolidPeso molecolare:3829.5Furazolidone
CAS:Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.Formula:C8H7N3O5Purezza:99.96%Colore e forma:Yellow Crystals From Dmf (N N-Dimethylformamide) SolidPeso molecolare:225.16δ-secretase inhibitor 11
CAS:δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.Formula:C10H12N4O2Purezza:99.84%Colore e forma:SolidPeso molecolare:220.23Oxybenzone-d3
Oxybenzone-d3 (Benzophenone 3-d3) is a deuterium-labeled form of Oxybenzone. Commonly used as a UV filter in tanning and skin protection products, Oxybenzone (Benzophenone 3) acts as an endocrine-disrupting chemical (EDC) that can cross both the placental and blood-brain barriers. It impairs autophagy, alters epigenetic states, and disrupts retinoid X receptor signaling in apoptotic neuronal cells.Formula:C14H9D3O3Colore e forma:SolidPeso molecolare:231.26Lipustobart
CAS:Lipustobart is an IgG4-kappa humanized monoclonal antibody targeting PDCD1 (programmed cell death 1, PD1, PD-1, CD279), with immunostimulant and antineoplasticPurezza:98%Colore e forma:LiquidAnti-inflammatory agent 42
CAS:Anti-inflammatory agent 42 has anti-inflammatory activity and inhibits the expression of TNF-α and IL-6 in LPS-stimulated macrophages.Formula:C20H12N2OSPurezza:99.47%Colore e forma:SolidPeso molecolare:328.39Diethanolamine hydrochloride
CAS:Diethanolamine hydrochloride is HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4) and pregnane X receptor (PXR), p53 Estrogen receptor.Formula:C4H12ClNO2Purezza:99.69%Colore e forma:SolidPeso molecolare:141.6Isorhamnetin 3-glucuronide
Isorhamnetin 3-glucuronide is a useful organic compound for research related to life sciences and the catalog number is T124938.Formula:C22H20O13Colore e forma:SolidPeso molecolare:492.389Dazodalibep
CAS:Dazodalibep (MEDI 4920; VIB 4920) is a monoclonal antibody that specifically targets CD40LG/TNFSF5 and is fused to human serum albumin (ALB/HSA) [1].Colore e forma:LiquidThalidomide-NH-C8-NH2
CAS:Thalidomide-NH-C8-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand and a specific linker.Formula:C21H28N4O4Colore e forma:SolidPeso molecolare:400.479S-Adenosyl-L-methionine
CAS:S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.Formula:C15H22N6O5SPurezza:99.08%Colore e forma:SolidPeso molecolare:398.44Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
CAS:Thalidomide-based E3 ligase ligand with PEG2-C2 linker; used as an immunomodulatory cancer treatment.Formula:C21H27ClN4O8Purezza:98.09%Colore e forma:SolidPeso molecolare:498.914Oligomycin B
CAS:Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis.Formula:C45H72O12Purezza:98%Colore e forma:SolidPeso molecolare:805.05Antitumor agent-64
CAS:Antitumor Agent-64 (Compound 8d), a diosgenin derivative, exhibits potent cytotoxic activity against the A549 cell line and induces apoptosis in A549 cellsFormula:C35H47N3O3SColore e forma:SolidPeso molecolare:589.83Atibuclimab
CAS:Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region.Purezza:> 95% - > 95%Colore e forma:LiquidPeso molecolare:145.28 kDaABBV-167
CAS:ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax.Formula:C46H53ClN7O11PSColore e forma:SolidPeso molecolare:978.45Anti-ETBR Antibody (DEDN6526A Naked Antibody)
DEDN6526A (RG-7636) is a humanized ADC compound targeting endothelin B receptor (ETBR), which can be used to study melanoma.Colore e forma:LiquidPeso molecolare:145.54 kDaXZ739
CAS:XZ739: Cereblon-based PROTAC, degrades BCL-XL (DC50 2.5 nM in MOLT-4, 16hr), induces caspase apoptosis.Formula:C65H76ClF3N8O12S3Colore e forma:SolidPeso molecolare:1349.99Linsidomine
CAS:Lincydomine relaxes smooth muscles, treats unstable angina, and opens human and guinea pig respiratory tracts.Formula:C6H10N4O2Colore e forma:Solid Off-WhitePeso molecolare:170.17Pamrevlumab
CAS:FG-3019 (Pamrevlumab), a human antibody, targets CTGF, potentially treating idiopathic pulmonary fibrosis.Purezza:100% (SEC-HPLC) - >95.0% (SDS-PAGE)Colore e forma:LiquidPeso molecolare:150 kDaIzuralimab
CAS:Izuralimab is a bispecific IgG1 antibody that targets both the inducible T-cell costimulator (ICOS/CD278) and PD-1 [1].Colore e forma:LiquidAY-4
AY-4 (Compound AY-4) is a potent PROTAC degrader targeting FTH1, with a dissociation constant (Kd) of 3.17 nM. It effectively increases intracellular ferrous (Fe2+) and ferric (Fe3+) ion levels. AY-4 is a potential anticancer candidate that regulates iron homeostasis through ferritin degradation, enhancing the efficacy of existing drugs. Additionally, AY-4 significantly reduces FTH1 levels in breast cancer cells.Colore e forma:Odour SolidAnti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2)
Anti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2) is an IgG2a, κ antibody inhibitor derived from mice, specifically targeting and inhibiting mouse PD-L1/B7-H1.Colore e forma:Odour LiquidSotigalimab
CAS:Sotigalimab (APX 005) is a monoclonal antibody targeting CD40 with anticancer activity for the study of metastatic pancreatic cancer.Purezza:98.50% - 98.50%Colore e forma:LiquidPeso molecolare:144.35 kDaTG101209 analog 1
TG101209 analog 1 (Compound 8h) serves as an inhibitor of BUB1B, exhibiting an IC50 of 10.36 μM. It also possesses cytotoxic properties, demonstrated by an IC50 of 1.347 μM against Caki-1 cells, and can induce necrosis and apoptosis.Formula:C24H31N5O5SColore e forma:SolidPeso molecolare:501.598PB28
CAS:PB28: A potent σ2 agonist (Ki 0.68 nM), σ1 antagonist (Ki 0.38 nM), with anti-tumor properties and inhibits SARS-CoV-2 interactions.Formula:C24H38N2OColore e forma:SolidPeso molecolare:370.581TS-24
CAS:TS-24 is a cysteine protease histone S (CTSS) inhibitor that promotes BRCA1-mediated apoptosis.
Formula:C20H15NO2Purezza:99.41%Colore e forma:SoildPeso molecolare:301.34PAA5
PAA5, a polynuclear Au(I) cluster, triggers ferroptosis and has anticancer effects by increasing pH2AX over time.Formula:C14H8Au5B2F8N2Colore e forma:SolidPeso molecolare:1348.66Antiproliferative agent-25
Antiproliferative Agent-25 (Compound 3s4) is a selective PRMT5 inhibitor displaying an IC50 of 0.11 μM.Formula:C20H21BrN2O2Purezza:98%Colore e forma:SolidPeso molecolare:401.3Thiamine-d4 hydrochloride
Thiamine-d4 (hydrochloride) is the deuterated form of Thiamine (hydrochloride). Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient, serving as a cofactor for numerous central metabolic enzymes.Colore e forma:Odour SolidMS1943
CAS:MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).Formula:C42H54N8O3Purezza:95.41% - 95.82%Colore e forma:SolidPeso molecolare:718.93Ref: TM-T13780
1mg39,00€2mg52,00€5mg84,00€1mL*10mM (DMSO)120,00€10mg130,00€25mg250,00€50mg439,00€100mg802,00€200mg1.324,00€Boc-AEVD-CHO
CAS:Boc-AEVD-CHO, a selective Caspase 8 inhibitor, facilitates apoptosis research and the investigation of immune and inflammatory diseases [1] [2].Formula:C22H36N4O10Purezza:98%Colore e forma:SolidPeso molecolare:516.54Rapamycin-13C,d3
Rapamycin is a potent and specific mTOR inhibitor that suppresses mTOR in HEK293 cells with an IC50 of 0.1 nM. It binds to FKBP12, thereby inhibiting mTORC1. Additionally, Rapamycin serves as an autophagy (autophagy) activator and functions as an immunosuppressant.Colore e forma:Odour SolidMSU-42011
CAS:MSU-42011: oral RXR-like agonist, inhibits iNOS & p-ERK, antitumor in lung cancer model, effective preclinical treatment.Formula:C24H34N2O2Purezza:99.6%Colore e forma:SoildPeso molecolare:382.54Lenercept
CAS:Lenercept (Ro 45-2081) is a recombinant fusion protein combining the soluble TNF-receptor (p55) with the Fc portion of human IgG1 [1].Colore e forma:LiquidSRE-II
SRE-II, an amide derivative, serves as an activatable photosensitizer tailored for photodynamic cancer research, exhibiting diminished fluorescence andFormula:C15H9ClINO2Purezza:98%Colore e forma:SolidPeso molecolare:397.59Tubulin/HDAC-IN-2
Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor targeting Tubulin and HDAC, exhibiting IC50 values of 0.403 μM for HDAC1, 0.591 μM for HDAC2, 3.552 μMFormula:C21H19FN2O4Colore e forma:SolidPeso molecolare:382.38YTHu78
YTHu78 is a KDM5B PROTAC-based degrader. It induces the degradation of KDM5B through the ubiquitin-proteasome system and triggers apoptosis in MV-4-11 and MM.1S cell lines. YTHu78 demonstrates significant antiproliferative activity against various hematologic tumor cell lines and is useful for studying hematological malignancies.Colore e forma:Odour SolidLatikafusp
CAS:Latikafusp (AMG 256) is a fusion protein that is a PD-1 blocker and IL-21R agonist with antitumor activity.Purezza:97.1% (SDS-PAGE); 97.4% (SEC-HPLC) - 97.1% (SDS-PAGE); 97.4% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:159.55 kDaAZD5582 TFA
AZD5582 TFA is a potent IAP antagonist that binds to the BIR3 domain of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 nM, respectively.AZD5582 TFAFormula:C60H79F3N8O10Purezza:99.89%Colore e forma:SoildPeso molecolare:1129.31Ref: TM-T36201L
1mg55,00€5mg96,00€1mL*10mM (DMSO)144,00€10mg149,00€25mg259,00€50mg442,00€100mg647,00€8-Aminoadenosine
CAS:8-Aminoadenosine reduces ATP, blocks mRNA synthesis, and Akt/mTOR signaling, triggering autophagy and apoptosis independently of p53, with antitumor effects.
Formula:C10H14N6O4Colore e forma:SolidPeso molecolare:282.26MAO-B-IN-30
CAS:MAO-B-IN-30 is a selective and potent MAO-B inhibitor that crosses the blood-brain barrier with antiproliferative activity and inhibits both MAO-A and MAO-B.MAO-B-IN-30 reduces the levels of TNF-alpha, IL-6, and NF-kB in organisms, and can be used to study Parkinson's-type neurological disorders.Formula:C15H10BrN3O2Purezza:98.31%Colore e forma:SoildPeso molecolare:344.16dTAGV-1-NEG TFA
dTAGV-1-NEG TFA, a diastereomer, serves as the heterobifunctional negative control for dTAGV-1. It acts specifically as an FKBP12 F36V-selective degrader [1].Formula:C70H91F3N6O16SColore e forma:SolidPeso molecolare:1361.56Finotonlimab
Finotonlimab (SCT-I10A), a humanized IgG PD-1 monoclonal antibody, shows potential in the research of solid tumors or lymphomas [1].Colore e forma:Odour LiquidOnercept
CAS:Onercept, a recombinant soluble form of the human tumor necrosis factor-alpha (TNF-α) p55 receptor, is utilized in the study of Crohn's disease [1].Colore e forma:LiquidTRAP1-IN-1
CAS:TRAP1-IN-1 is a selective TRAP1 inhibitor, induces degradation of TRAP1 downstream proteins, inhibits OXPHOS, and disrupts mitochondrial membrane potential.Formula:C45H39F7N2O4P2Purezza:98%Colore e forma:SolidPeso molecolare:866.74Manelimab
CAS:Manelimab is a monoclonal antibody that inhibits programmed death-ligand 1 ( PD-L1 ) [1] .Colore e forma:LiquidCarbonic anhydrase inhibitor 33
Carbonic anhydrase inhibitor33 (11D) is a dual inhibitor that targets both CA (carbonic anhydrase) IX/XII and CDK6. It exhibits Ki values of 19.7 nM for hCA IX and 26.1 nM for hCA XII. Additionally, Carbonic anhydrase inhibitor33 (11D) can induce G1 phase cell cycle arrest and apoptosis, making it relevant for research in non-small cell lung cancer (NSCLC).Formula:C19H15FN6O2SColore e forma:SolidPeso molecolare:410.09612KH16
KH16 is an HDAC inhibitor.KH16 stimulates apoptosis and is able to inhibit gene expression patterns in a variety of tumor cells.Formula:C18H20N6O2Purezza:98.15%Colore e forma:SolidPeso molecolare:352.39Ankaflavin
CAS:Ankaflavin, from red rice fermentation, is a PPARγ agonist with anti-inflammatory properties and selectively kills cancer cells.Formula:C23H30O5Purezza:98%Colore e forma:SolidPeso molecolare:386.48Anticancer agent 273
Anticanceragent 273 (Compound 9q) is an effective anticancer compound identified from matrine. It inhibits cancer cell proliferation, with an IC50 of 4.48 μM against HeLa cells. Anticanceragent 273 exerts its anticancer effects by modulating PI3K/AKT expression and activating activating transcription factor 4 (ATF4), which induces endoplasmic reticulum stress and triggers apoptosis. It holds potential for cancer research, including cervical cancer.Colore e forma:Odour SolidBak BH3
Flu-BakBH3 peptide, derived from Bak's BH3 domain, binds tightly to a crucial pocket of Bcl-XL, essential for its anti-death role.Formula:C72H125N25O24Purezza:98%Colore e forma:SolidPeso molecolare:1724.9Balstilimab
CAS:Balstilimab (AGEN2034) is a fully human monoclonal IgG4 antibody against PD-1 [1] .Colore e forma:LiquidPROTAC Bcl2 degrader-1
CAS:PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).Formula:C45H45BrN6O10SPurezza:98%Colore e forma:SolidPeso molecolare:941.84Ref: TM-T10485
10mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiesta1mg1.080,00€5mg2.340,00€Zeluvalimab
CAS:Zeluvalimab (AMG-404) is a monoclonal antibody designed to target the PD-1 receptor, and is utilized in cancer research [1].Colore e forma:LiquidPROTAC EGFR degrader 7
Compound 13b, a potent EGFR degrader, inhibits and induces apoptosis in NSCLC cells with a DC50 of 13.2 nM.Formula:C46H48N10O6Colore e forma:SolidPeso molecolare:836.94Atacicept
CAS:Atacicept (TACI-Ig) is a homodimeric fusion protein that inhibits B cell stimulation.Purezza:97.9% (SDS-PAGE); 98.7% (SEC-HPLC) - 97.9% (SDS-PAGE); 98.7% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:35.36 kDaSM-164 Hydrochloride (957135-43-2 free base)
SM-164 Hydrochloride: cell-permeable, binds to XIAP (BIR2/3 domains), IC50 of 1.39 nM, potent XIAP antagonist.Formula:C62H85ClN14O6Purezza:98%Colore e forma:SolidPeso molecolare:1157.88Efaprinermin alfa
CAS:Efaprimermin alfa (OMP-336B11) is a human monoclonal antibody that targets TNFRSF18, and functions as a GITR ligand-Fc fusion protein [1].Colore e forma:LiquidAc-AAVALLPAVLLALLAP-YVAD-CHO
CAS:Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1 exhibiting antitumor activity [1].Formula:C97H160N20O24Purezza:98%Colore e forma:SolidPeso molecolare:1990.43Thalidomide-NH-C4-NH2 TFA
CAS:Compound 29c, a Thalidomide-linker conjugate for potent PROTAC BRD2/BRD4 degrader-1, targets BET proteins.Formula:C19H21F3N4O6Purezza:98%Colore e forma:SolidPeso molecolare:458.39UBX1325
CAS:UBX1325, a potent Bcl-xL inhibitor, induces cell death in aging cells, useful for age-related eye disease research.
Formula:C53H59ClF3N6O10PS3Colore e forma:SolidPeso molecolare:1159.69BRD-810
CAS:BRD-810 is a highly selective MCL1 inhibitor (Kd=0.3 nM) capable of inducing tumour cell apoptosis, for haematological malignancies and solid tumours.Formula:C39H44ClFN4O5Purezza:97.88%Colore e forma:SolidPeso molecolare:703.24Ref: TM-T89869
1mL*10mM (DMSO)Prezzo su richiesta1mg665,00€5mg1.935,00€10mg3.087,00€25mg4.609,00€50mg6.201,00€Anti-Mouse CD44 Antibody (IM7)
Anti-Mouse CD44 Antibody (IM7) is a monoclonal antibody targeting CD44 in mice.Purezza:99%Colore e forma:Odour LiquidPeso molecolare:150 kDaObexelimab
CAS:ACBI3 is a pan-KRAS degrader with anticancer activity, degrading oncogenic KRAS.Purezza:98% (SDS-PAGE); 100% (SEC-HPLC) - 98% (SDS-PAGE); 100% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:147.44 kDaIRF1-IN-2
CAS:IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.Formula:C18H20N2O4SPurezza:99.85%Colore e forma:SolidPeso molecolare:360.43FF2039
FF2039 (compound 1j) is a PROTAC degrader specifically targeting HDAC1, HDAC6, and various subtypes of class I, IIa, and IIb HDACs. It induces cell cycle arrest and apoptosis, showing significant antiproliferative activity against both hematological and solid tumor cell lines. The IC50 values for FF2039 against HDAC1, HDAC2, HDAC4, and HDAC6 are 1.03, 2.15, 12.4, and 0.053 μM, respectively. FF2039 exhibits antiproliferative effects on solid tumors such as MM.1S, MDA-MB-231, and U-87MG, with EC50 values of 2.8, 28, and 30 μM, respectively.Formula:C43H56Cl3N5O6Colore e forma:SolidPeso molecolare:845.29LH1307
CAS:LH1307 blocks PD-1/PD-L1 interaction, IC50 = 3 nM (HTRF assay), activates Jurkat cells, EC50s: 79 nM (U2OS), 763 nM (CHO).
Formula:C54H58N8O6Colore e forma:SolidPeso molecolare:915.108Reproxalap
CAS:Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.
Formula:C12H13ClN2OPurezza:99.4% - 99.97%Colore e forma:SolidPeso molecolare:236.7RIPK1-IN-25
RIPK1-IN-25 (WL8) is a RIPK1 inhibitor with blood-brain barrier permeability, displaying an EC50 of 19.9 nM and a Kd of 25 nM. It is utilized in the research of neurodegenerative diseases.Colore e forma:Odour Solid1,2-Naphthoquinone
CAS:1,2-Naphthoquinone inhibits urease, induces apoptosis in PBMC cells, inhibitory activity against hiCE, hCE1, hAChE, and hBChE.Formula:C10H6O2Purezza:98.01%Colore e forma:Golden Yellow Needles Color On Standing (Ntp 1992)Peso molecolare:158.15EMB-02
EMB-02 is a bispecific antibody targeting both PD-1 and LAG-3. It inhibits the downregulation of T cell activation and proliferation mediated by PD-1 and LAG-3, showing potent anti-cancer properties.Colore e forma:Odour LiquidThalidomide 4'-oxyacetamide-alkyl-C2-amine HCl
CAS:Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl is an E3 ligase ligand-linker conjugate containing the E3 ubiquitin ligase cereblon (CRBN) and linker.Formula:C17H19ClN4O6Purezza:99.78%Colore e forma:SolidPeso molecolare:410.81Apoptosis inducer 33
Apoptosisinducer 33 (compound H2) is a hydrazone derivative. It exhibits antioxidant and antimicrobial properties, capable of inhibiting the growth of Staphylococcus aureus, Escherichia coli, and Candida albicans. Additionally, Apoptosisinducer 33 can suppress tumor cell proliferation and induce apoptosis (apoptosis), making it useful for tumor research.Formula:C16H13N3O2Colore e forma:SolidPeso molecolare:279.293
