Apoptosi

Applications Aurintricarboxylic Acid is a cell-permeable apoptosis inhibitor.

Applications Monosialoganglioside GM3 can have anti-tumor effects by regulating cell apoptosis, angiogenesis. Monosialoganglioside GM3 can also regulate peripheral insulin receptor signaling and increases in GM3 in adipose tissue of obese humans may contribute to insulin resistance.
References Zhu, Y., et al.: Zhongliu Fangzhi Yanjiu, 42, 450 (2015); Herzer, S., et al.: Diabetes, 64, 3363 (2015); Wentworth, J., et al.: ?Int. J. Obes., 40, 706 (2016)

Applications Intermediate in the production of cell death regulators and apoptosis promoters.
References Park, C., et al.: J. Med. Chem., 51, 6902 (2008),

Stability Hygroscopic
Applications A potent and selective ATP-competitive dual inhibitor cdc7/cdk9. It blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2).
References Anderson, D.R. et al.: J. Med. Chem., 50, 2647 (2007); Montagnoli, A. et al.: Nature Chem. Biol., 4, 357 (2008); Charych, D.H. et al.: J Cell. Biochem., 104, 1075 (2008); Jackson, P.K. et al.: Nature Chem. Biol., 4, 331 (2008);

Applications Semi-synrhetic antitumor agent derived from Illudin S. Inhibits DNA synthesis and induces apoptosis in tumor cells. Antineoplastic.
References Woynarowski, J.M., et al.: Biochem. Pharmacol., 54, 1181 (1997), Alexandre, J., et al.: Clin. Cancer Res., 10, 3377 (2004), Senzer, N., et al.: Am. J. Clin. Oncol., 28, 36 (2005),

Applications N-(Ethoxycarbonylmethyl)piperazine is used in the preparation of aralkylpiperazine- and aryl-substituted hydrazines, particularly benzylpiperazineacetyl hydrazones of hydroxyaryl aldehydes, as selective inducers of apoptosis and activators of procaspases for use as anticancer agents.
References Nakagawara, A., et al.: Cancer Res., 57, 4578 (1997), Denault, J., et al.: J. Biol. Chem., 278, 34042 (2003), Traven, A., et al.: Cancer Cell, 5, 107 (2004), Becattini, B., et al.: Chem. Biol., 11, 389 (2004),

L-Cystathionine: nonprotein amino acid; important for sulfur amino acid metabolism; used in cardiovascular research.

Dibenz[a,h]anthracene (CCRIS 208) has induced DNA damage and gene mutations in bacteria and gene mutations and transformation in several types of mammalian cell

Simmiparib (SMOCL-9112) is a PARP1 and PARP2 inhibitor that promotes apoptosis.Simmiparib is used to study Parkinson's disease and melanoma.

Prinomastat HCl, an oral MMP (1, 3, 9) inhibitor, IC50s: 79, 6.3, 5.0 nM, shows antitumor activity.

RDR03871 is an MDM2 inhibitor.