Apoptosi

S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse sRANKL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse sRANKL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse sRANKL, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse sRANKL in the samples is then determined by comparing the OD of the samples to the standard curve.

MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis.

Benzbromarone (Desuric) is a CYP2C9 inhibitor with Ki value of 19.3 nM.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse Smad2/3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse Smad2/3. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse Smad2/3, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse Smad2/3 in the samples is then determined by comparing the OD of the samples to the standard curve.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat Bcl2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat Bcl2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat Bcl2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat Bcl2 in the samples is then determined by comparing the OD of the samples to the standard curve.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Sheep CASP8. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Sheep CASP8. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Sheep CASP8, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Sheep CASP8 in the samples is then determined by comparing the OD of the samples to the standard curve.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Cattle Bax. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Cattle Bax. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Cattle Bax, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Cattle Bax in the samples is then determined by comparing the OD of the samples to the standard curve.

Ramipril (Altace) is a long-acting angiotensin-converting enzyme inhibitor.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse SPTAN1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse SPTAN1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse SPTAN1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse SPTAN1 in the samples is then determined by comparing the OD of the samples to the standard curve.

Levonorgestrel (D-Norgestrel) is a Progestin and Progestin-containing Intrauterine Device.

<p>Sodium butanoate (Sodium Butyrate) is the sodium salt of butyrate with potential antineoplastic activity.</p>

GCN2iB is an ATP-competitive inhibitor of serine/threonine protein kinase, stress-responsive kinase (GCN2).Cost-effective and quality-assured.

Ibuprofen, an NSAID, reduces pain, inflammation, and fever by limiting prostaglandin production.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human RANKL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human RANKL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human RANKL, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human RANKL in the samples is then determined by comparing the OD of the samples to the standard curve.

Zinc pyrithione (OM-1563), an antibacterial and antifungal agent can disrupt membrane transport by blocking the proton pump.

<p>Ros-generating agent 1 has anticancer activity and generates ROS by covalently modifying Sec-498 residues of TrxR.</p>

Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).

Benralizumab (MEDI-563) is a monoclonal antibody targeting the interleukin-5 receptor alpha (IL-5Rα).

Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.

BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that induces pERK activation.BAY 2965501 can be used in the study of cancer.

Dabuzalgron (Ro 115-1240) is an orally active selective alpha-1A adrenergic receptor agonist used to treat urinary incontinence.

ACHP (IKK-2 Inhibitor VIII) is a novel selective and potent IKK inhibitor with inhibitory effects on IKK-α and IKK-β.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human sHLA-G. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human sHLA-G. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human sHLA-G, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human sHLA-G in the samples is then determined by comparing the OD of the samples to the standard curve.

<p>(R)-HTS-3 is a LPCAT3 inhibitor that remodels the polyunsaturated phospholipid content of human cells and prevents iron death.</p>

SLU-PP-1072: inverse agonist for ERRα/γ, disrupts PCa metabolism, induces apoptosis, studies prostate cancer.

Propafenone: a drug for ventricular arrhythmias with mild beta-blocker activity, prolongs refractory period, and reduces heart automaticity.

Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity.

<p>Tafasitamab (XmAb5574) is an FC-modified humanized monoclonal antibody targeting the human B-cell surface antigen CD19 for the study of diffuse large B-cell</p>

<p>Dequalinium chloride: topical bacteriostat, blocks apamin-sensitive K+ channels, used for wounds, oral infections, potential antifungal, risk of skin ulcers.</p>

Diethylstilbestrol (DES) is used in the treatment of menopausal and postmenopausal disorders.

<p>Serplulimab (HLX 10) is a humanized monoclonal anti-antibody to PD-1.</p>

<p>Catechin (Cianidanol) is a flavan-3-ol, a type of natural phenol and antioxidant.</p>

17-ODYA (Alkynyl Stearic Acid) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Isoliquiritigenin (ISL) is a natural flavonoid that inhibits influenza virus and aldose reductase. Isoliquiritigenin has antitumor effect. Cost-effective and quality-assured.

Tolperisone hydrochloride (Muscalm) is a muscle relaxant for treating muscle tone disorders from neurological diseases.

Umbelliferone, aka 7-Hydroxycoumarin, in anise and many plants, is a phytoalexin with antioxidant effects.

Penfluridol (TLP-607) is a highly potent antipsychotic.

<p>Trimebutine maleate (Polibutin) is a weak mu-opioid agonist and has antimuscarinic effects.</p>

Isatuximab targets CD38 in blood cancers, with high expression in multiple myeloma, inducing apoptosis and impairing cellular functions.

<p>Lercanidipine (Masnidipine) is a calcium channel blocker of the dihydropyridine class.</p>

<p>Emeramide (BDTH2) is a thiol-redox antioxidant. It is also a heavy metal chelator.</p>

MYCMI-6 inhibits MYC:MAX, reduces tumor growth, triggers apoptosis, minimal side effects.

Adarotene (ST1926) induces apoptosis, causes DNA damage, and has strong antiproliferative effects on human tumors.

Ecabet Sodium (TA-2711) is a potential new agent in the management of distal colitis.

Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.

Metamizole sodium hydrate (Analgin) is a potent analgesic drug that has been demonstrated to inhibit cyclooxygenase (COX).

Nitroxoline (5-nitroquinolin-8-ol) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in

<p>S-allyl-L-cysteine (S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals.</p>

Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.

Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a mitogen-activated protein kinase blocker and pro-inflammatory cytokine production inhibitor.

Lirentelimab (AK002) is a humanized anti-Siglec-8 antibody that induces IL-5-activated apoptosis in eosinophils and inhibits IL-5-mediated mast cell activation.

Nebivolol hydrochloride is a beta-1 blocker and vasodilator treating hypertension and heart failure in the elderly.

Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.

Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.

<p>GPI-1046: immunophilin ligand, no antibiotic effect, reduces ethanol intake by boosting GLT1 in PFC and NAc-core.</p>

Vildagliptin (LAF237), an oral DPP-4 inhibitor with hypoglycemic effects, is metabolized and excreted in urine.

Ifabotuzumab (KB-004) is an antibody targeting EphA3+ cells, significantly reducing CCR10+ cells and improving pulmonary fibrosis in humanized NSG mice.

Conatumumab (AMG 655) targets DR5 to induce apoptosis in tumors, with Kd of 1 nM (long DR5) and 0.8 nM (short DR5).

ABT-510 acetate: a TSP peptide mimicking anti-angiogenic, anti-inflammatory, and anti-cancer agent, inhibits tumor growth and angiogenesis in cancer and IBD.

STIMA-1 (2-Vinylquinazolin-4-ol), an active compound, can restore the activity of p63.

Sodium etidronate (Didronel), a bisphosphonate, resists degradation, inhibits osteoclasts, and may boost bone formation.

Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.

Q-VD-OPh is an irreversible caspase inhibitor with an IC50 value of 48 nM against caspase-7 and between 25 and 400 nM against caspase-1, 3, 8, 9, 10, 12.

Cinchonine (LA40221), a potent amide local anesthetic for surface use, is toxic and limited to spinal anesthesia.

(E)-Cardamonin (Alpinetin chalcone) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera.

PF-03732010 is a humanized antibody targeting P-calmodulin with antitumor and antimetastatic activity.

Geniposidic acid, an iridoid glucoside, used in therapy of jaundice, inflammation and hepatic disorders.

MV1 is an IAP antagonist. When combined with HaloTag ligand, MV1 causes protein knockdown of HaloTag-fused proteins.

Farudodstat (ASLAN003) is an orally active and potent inhibitor of DHODH with antitumor activity. It has the potential to be a first-in-class candidate in AML.

Emamectin Benzoate (MK-244), by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods

Acyclovir (Aciclovir) is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2,

Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II HDACs resulting in a global increase in gene expression.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human soluble DPP4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human soluble DPP4. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human soluble DPP4, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human soluble DPP4 in the samples is then determined by comparing the OD of the samples to the standard curve.