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Apoptosi

Apoptosi

Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.

Sottocategorie di "Apoptosi"

Mostrare 6 più sottocategorie

Trovati 5622 prodotti di "Apoptosi"

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  • PD-L1/VISTA-IN-1
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    PD-L1/VISTA-IN-1

    CAS:
    <p>PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual inhibitor targeting PD-L1 and VISTA. It effectively hinders the PD-1/PD-L1 interaction (IC50: 0.1492 μM) and the VISTA pathway (KD: 0.2723 μM), leading to the reactivation of T cells. Additionally, PD-L1/VISTA-IN-1 exhibits antitumor activity.</p>
    Formula:C22H24N4O4
    Colore e forma:Solid
    Peso molecolare:408.45

    Ref: TM-T205067

  • Logo CymitQuimica
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    Topo I-IN-1

    <p>Topo I-IN-1 (14d) is a powerful Topo I inhibitor with antitumor effects and DNA intercalation, inducing apoptosis.</p>
    Formula:C20H14BrN3O2
    Colore e forma:Solid
    Peso molecolare:408.25

    Ref: TM-T62048

  • MI-888 TFA
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    MI-888 TFA

    CAS:
    <p>MI-888 (TFA) is an orally active inhibitor of the MDM2-p53 interaction with a Ki of 0.44 nM. It can induce rapid, complete, and durable tumor regression in xenograft mouse models.</p>
    Formula:C30H33Cl2F4N3O5
    Colore e forma:Solid
    Peso molecolare:662.5

    Ref: TM-T205437

  • GI-Y2
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    GI-Y2

    CAS:
    <p>GI-Y2 is a GSDMD inhibitor that suppresses macrophage pyroptosis induced by oxidized low-density lipoprotein (ox-LDL). In vivo, GI-Y2 dose-dependently reduces atherosclerotic plaques and decreases lesion size and fibrosis in the aortic root of ApoE-/- mice. GI-Y2 holds potential for research in pyroptosis and cardiovascular diseases, such as atherosclerosis.</p>
    Formula:C18H14N2O6S
    Colore e forma:Solid
    Peso molecolare:386.379

    Ref: TM-T206350

  • Logo CymitQuimica
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    FLT3/TrKA-IN-1

    <p>FLT3/TrKA-IN-1: Potent dual kinase inhibitor for FLT3 &amp; TrKA, promising for AML research.</p>
    Formula:C28H30N4O2
    Colore e forma:Solid
    Peso molecolare:454.56

    Ref: TM-T62801

  • Mcl-1 inhibitor 21
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    Mcl-1 inhibitor 21

    CAS:
    <p>Mcl-1 inhibitor21 (Example 1-36) is an Mcl-1 inhibitor with an IC50 of 328 nM. It exhibits pro-apoptotic and anti-proliferative activity against SUDHL5 and SUDHL10 cell lines, making it applicable for cancer research.</p>
    Formula:C32H33N3O4
    Colore e forma:Solid
    Peso molecolare:523.622

    Ref: TM-T204659

  • Logo CymitQuimica
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    Topoisomerase I/II inhibitor 4

    <p>Topoisomerase I/II inhibitor 4 halts cell growth and spread, induces apoptosis, and is used in liver cancer research.</p>
    Formula:C27H21N5O6
    Colore e forma:Solid
    Peso molecolare:511.49

    Ref: TM-T63526

  • APD-94
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    APD-94

    CAS:
    <p>APD-94 is a dual inhibitor targeting tubulin and Bmi-1. It disrupts the normal polymerization of tubulin and suppresses the expression of Bmi-1. This compound induces cell cycle arrest at the G2/M phase and triggers apoptosis, thereby inhibiting cancer cell proliferation. Additionally, APD-94 inhibits the growth of HT29 cell xenograft tumors in NOD/SCID mice and is applicable to colorectal cancer research.</p>
    Formula:C18H17N3O4
    Colore e forma:Solid
    Peso molecolare:339.345

    Ref: TM-T206828

  • IMB5046
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    IMB5046

    CAS:
    <p>IMB5046 is a microtubule inhibitor that induces apoptosis (cell death) by obstructing the G2/M phase of the cell cycle. It possesses antitumor properties.</p>
    Formula:C19H20N2O5S
    Colore e forma:Solid
    Peso molecolare:388.438

    Ref: TM-T204939

  • (S)-Purvalanol B
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    (S)-Purvalanol B

    CAS:
    <p>(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is an inhibitor of cyclin-dependent kinase(CDK) .</p>
    Formula:C20H25ClN6O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:432.9

    Ref: TM-T13454

  • Lysosomal P-gp targeted agent 1
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    Lysosomal P-gp targeted agent 1

    CAS:
    <p>Lysosomal P-gp targeted agent 1 (Compound 14) is an antitumor drug that targets lysosomal P-glycoprotein (Pgp). It is selectively transported to lysosomes via overexpressed Pgp, releasing nitric oxide that generates reactive oxygen species (ROS), causing lysosomal membrane permeabilization (LMP) and inducing apoptosis. This compound can overcome resistance mediated by P-glycoprotein, leading to cell cycle arrest while maintaining relatively low toxicity to normal cells. It exhibits antitumor activity by significantly inhibiting tumor growth.</p>
    Formula:C39H34N2O9S
    Colore e forma:Solid
    Peso molecolare:706.76

    Ref: TM-T206140

  • Casuarinin
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    Casuarinin

    CAS:
    <p>Casuarinin, an ellagitannin found in pomegranates and certain Casuarina/Stachyurus plants, is a carbonic anhydrase inhibitor and astringent.</p>
    Formula:C41H28O26
    Colore e forma:Solid
    Peso molecolare:936.65

    Ref: TM-T68681

  • (S)-JDQ-443
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    (S)-JDQ-443

    CAS:
    <p>(S)-JDQ-443, an isomer of JDQ-443, is a selective, potent oral KRAS G12C inhibitor with antitumor properties.</p>
    Formula:C29H28ClN7O
    Colore e forma:Solid
    Peso molecolare:526.03

    Ref: TM-T72971

  • Logo CymitQuimica
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    Tubulin inhibitor 14

    <p>Tubulin inhibitor 14 blocks NQO2 and microtubule formation, disrupts blood vessels, and may target tumors; IC50 of 1.0 μM.</p>
    Formula:C15H9F2NO
    Colore e forma:Solid
    Peso molecolare:257.23

    Ref: TM-T60402

  • BMS 310705
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    BMS 310705

    CAS:
    <p>BMS 310705, an Epothilone B analog, targets ovarian/renal/bladder/lung cancer, inducing apoptosis via mitochondria.</p>
    Formula:C27H42N2O6S
    Colore e forma:Solid
    Peso molecolare:522.70

    Ref: TM-T73084

  • Antitumor agent-202
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    Antitumor agent-202

    CAS:
    <p>Antitumor agent-202 is a stabilizer of the p53Y220C mutant, selectively inhibiting the proliferation of tumor cells carrying the p53Y220C mutation. It is applicable for research focused on cancers associated with the p53 Y220C mutation.</p>
    Formula:C17H13NO
    Colore e forma:Solid
    Peso molecolare:247.291

    Ref: TM-T206663

  • Bafilomycin C1
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    Bafilomycin C1

    CAS:
    <p>vacuolar H+-ATPases (V-ATPases) inhibitor</p>
    Formula:C39H60O12
    Purezza:98%
    Colore e forma:Light Tan Solid
    Peso molecolare:720.89

    Ref: TM-T22598

  • MRK003
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    MRK003

    CAS:
    <p>MRK003, a γ-secretase inhibitor, induces apoptosis, halts cell growth in myeloma/NHL, and affects notch signaling and PI3K/Akt pathway.</p>
    Formula:C25H31F6N3O2S
    Colore e forma:Solid
    Peso molecolare:551.59

    Ref: TM-T68980

  • TrxR/EGFR-IN-1
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    TrxR/EGFR-IN-1

    CAS:
    TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor with activity against both gefitinib-sensitive and -resistant lung cancer, effectively suppressing tumor proliferation and promoting apoptosis. It enhances GPX4 degradation through autophagosome-lysosome and proteasome pathways, leading to ferroptosis. Additionally, it induces endoplasmic reticulum stress and triggers immunogenic cell death, making it applicable for studies on gefitinib-resistant lung cancer.
    Formula:C24H24AuClFN6O2P
    Colore e forma:Solid
    Peso molecolare:710.878

    Ref: TM-T205519

  • TZEP7
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    TZEP7

    CAS:
    <p>TZEP7 functions as an EGFR kinase inhibitor in cancer cells. It exhibits cytotoxicity and induces apoptosis within these cells. TZEP7 downregulates the anti-apoptotic protein Bcl-2, upregulates the pro-apoptotic protein Bax, and increases caspase levels. This compound holds potential for research in anticancer drug development.</p>
    Formula:C27H19ClFNS
    Colore e forma:Solid
    Peso molecolare:443.963

    Ref: TM-T205353