Apoptosi

<p>Traumatic Acid aids wound healing in plants by stimulating cell division to create a callus.</p>

AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.

Cerivastatin sodium (BAY W 6228 sodium) is an HMG-CoA reductase inhibitor with lipid-lowering activity that reduces LDL cholesterol levels.

SLF is a synthetic ligand for FKBP12 and increases Ca2+ efflux and protein synthesis.

<p>Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor with anticancer activity.</p>

<p>CCW16 is a covalent E3 ubiquitin ligase RNF4 ligand, cysteine reactivity, inducing ferroptosis in AML cells by activating ROS signalling.</p>

<p>Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2</p>

<p>Hematoporphyrin monomethyl ether is a porphyrin photosensitizer that can be used in studies of port wine stains.</p>

<p>IST5-002 (N6-Benzyladenosine-5'-phosphate) is a Stat5a/b inhibitor with anticancer activity and is used in cancer research.</p>

<p>Thalidomide-O-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1].</p>

<p>Galantamin-d6 is a deuterated compound of Galantamin.</p>

<p>Lestaurtinib (CEP 701) is a FLT3 inhibitor that inhibits the phosphorylation of RPTKs and can be used to study leukemia.</p>

<p>ODN 1826 is a TLR9 agonist and immunostimulant, which has antitumor effects and promotes cell apoptosis.</p>

Thalidomide-O-amido-C4-NH2 is a thalidomide cereblon ligand-linker used for PROTAC synthesis as an E3 ligase.

<p>1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil is a Nucleoside, fluoro-modified nucleoside; Arabino-nucleosidde.</p>

<p>AZD-5991, an antitumor compound, is a highly selective, potent and direct MCL-1 inhibitor, rapid apoptosis by Bak-dependent mitochondrial apoptotic pathway.</p>

<p>TMI-1 (WAY-171318), a novel orally active inhibitor of ADAM17 (TACE) and MMP, induces tumor apoptosis in a breast cancer.</p>

<p>4-Thiothymidine is a Nucleoside Derivative - Thio-nucleoside, 5-Modified pyrimidine nucleoside.</p>

BIX02188 is a selective and potent MEK5 inhibitor that inhibits MEK5-induced apoptosis in cells expressing the oncogenic mutant FLT3-ITD.

<p>(-)-Apomorphine hydrochloride hydrate is a broad-spectrum dopamine agonist and ferroptosis inhibitor.</p>

<p>6-Azauridine is a purine analog with antitumor effects, inhibiting DNA synthesis and inducing apoptosis in lymphatic cancers.</p>

<p>Cobimetinib hemifumarate is a potent and selective MEK1 inhibitor with an IC50 value of 4.2 nM for MEK1.</p>

Forodesine hydrochloride blocks lymphocyte growth and induces leukemia cell death by inhibiting PNP, effective across species.

<p>Bucladesine calcium: PDE inhibitor, boosts cAMP, activates PKA.</p>

Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM.

Phenoxyethanol (Standard) is the standard substance of Phenoxyethanol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Phenoxyethanol (NSC-1864) is germicidal. It often used together with quaternary ammonium compounds.

<p>Batabulin sodium, an antitumor compound, disrupts microtubules, alters cell shape, halts cell cycle, and induces apoptosis.</p>

Pitavastatin D4 is deuterium labeled Pitavastatin. Pitavastatin is a potent inhibitor of HMG-CoA reductase.

<p>Isoscabertopin has anticancer activity.</p>

<p>PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).</p>

Thalidomide-based E3 ligase linker for PROTACs with a PEG3 chain and hydrochloride salt.

<p>Ubiquitin Isopeptidase Inhibitor I, G5 is a caspase-independent inducer of cell necrosis that induces cell death via the death receptor pathway .</p>

<p>Edaravone, a potent free radical scavenger, prevents MMP-9-induced brain bleeds in rats and has a deuterium variant, Edaravone D5.</p>

<p>Palmatine hydroxide: oral IDO-1 inhibitor (IC50: 3-157μM), targets WNV protease, has anti-cancer/viral and neuroprotective properties.</p>

<p>FMAU (2'-Deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine) is a thymine nucleoside analog with insertional activity on replicating DNA.FMAU can be used to label</p>

<p>Amoscanate is an antiparasitic agent. It is highly effective in animals against the four major species of schistosomes which infect humans.</p>

<p>KS100 inhibits ALDH1A1, ALDH2, ALDH3A1, boosts ROS, triggers apoptosis, and has anti-cancer properties.</p>

<p>2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert</p>

<p>Momelotinib sulfate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.</p>

<p>6-Formylpterin (Pterin-6-aldehyde) is an inhibitor of Xanthine Oxidase, which induces ROS generation and apoptosis in HL-60 cells.</p>

<p>Chlorhexidine digluconate is a disinfectant with antibacterial activity that induces apoptosis and can be used to study bacterial infections.</p>

<p>SU11652 is an effective and competitive receptor tyrosine kinase (RTK) inhibitor, including VEGFR, FGFR, PDGFR, and Kit.</p>

<p>BCL6-IN-5 is a highly effective inhibitor of BCL6. It exhibits a pIC50 value of 5.82.</p>

<p>Melflufen HCl: prodrug of Melphalan, has antitumor and antiangiogenic effects, causes DNA damage in MM cells.</p>

GLP-2, an intestinal growth factor, may treat various human intestinal diseases.

<p>Macitentan-d4 (ACT-064992 D4) is a C13-labeled inhibitor of the peptides ETA and ETB used to study diseases mediated by endothelin receptor mediation.</p>

<p>SC144 hydrochloride: oral gp130 inhibitor, blocks Stat3 and gene expression, triggers apoptosis in ovarian cancer cells.</p>

<p>PARG-IN-4 (compound A) is an orally active and cell-membrane permeable PARG inhibitor (EC50=1.9 nM) that inhibits tumour growth in mice with antitumour .</p>

<p>Acyclovir (Aciclovir) hydrochloride is an effective oral antiviral agent with potent anti-herpetic activity. It exhibits IC50 values of 0.85 μM for HSV-1 and 0.86 μM for HSV-2, indicating strong inhibitory effects against these strains. Additionally, Acyclovir hydrochloride induces cell cycle disturbances and apoptosis. This compound also prevents bacterial infections during induction therapy for acute leukemia.</p>

<p>Thalidomide-5,6-F, a cereblon ligand for CRBN protein recruitment, forms PROTACs for targeted protein degradation.</p>

GSK778 selectively inhibits BD1 bromodomains (BRD2, BRD3, BRD4, BRDT) and impedes cell growth, causing arrest and apoptosis.

<p>Nafamostat is a synthetic serine protease inhibitor and an anticoagulant used in haemodialysis. It induces apoptosis, inhibiting SARS-CoV-2 and COVID-19.</p>

4-Benzoyl-L-phenylalanine is an L-phenylalanine derivative and optically active amino acid.

<p>Z-Ile-Leu-aldehyde is an effective and competitive peptide aldehyde inhibitor of γ-secretase and notch.</p>

<p>DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.</p>

Fenvalerate (Evercide 2362) is a protein phosphatase 2B (calcineurin) inhibitor, a synthetic pyrethroid insecticide, that inhibits PP2B-Aα.

<p>Acyclovir sodium is an antimetabolite. Acyclovir sodium inhibits HSV-specified DNA polymerases and prevents further viral DNA synthesis.</p>

<p>Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with</p>

<p>(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor with neuroprotective activity that induces apoptosis.</p>

<p>TZ9 is a Rad6 inhibitor with anticancer activity.TZ9 inhibits Rad6B-induced ubiquitination of histone H2A.TZ9 induces cell cycle arrest and apoptosis.</p>

<p>L-Cystine, hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T124989 and the CAS number is 34760-60-6.</p>

EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).

<p>PRDX1-IN-1 is a and PRDX1 inhibitor with potential anti-inflammatory and anti-cancer activity for the study of breast and esophageal cancer.</p>

<p>PGV-1, an oral Curcumin analog, induces apoptosis by inhibiting COX-2, VEGF, and NF-κB activation.</p>

<p>Hydrolyzed Fumonisin B1 is the backbone and the main hydrolysis product of the mycotoxin fumonisin B1 (FB1), can weakly inhibit ceramide synthase.</p>

<p>PI-103 Hydrochloride is a dual PI3K/Akt and mTOR inhibitor exhibiting nM-level inhibition of p110α, p110β, p110δ, p110γ, DNA-PK, mTORC1, and mTORC2.</p>

<p>Capecitabine-d11 is a deuterated compound of Capecitabine. Capecitabine has a CAS number of 154361-50-9. Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.</p>

Devazepide is a competitive, selective, orally available non-peptide CCK1 receptor antagonist that inhibits proliferation, induce apoptosis.

<p>Fenobucarb is a broad-spectrum carbamate insecticide and AChE inhibitor. It exhibits neurotoxicity to zebrafish foetal development and induces muscle spasms</p>

4-PQBH is a potent Nur77-binding agent with antitumour activity.4-PQBH is used in the study of hepatocellular carcinoma.

<p>Melatonin D5, a deuterium-labeled version of melatonin, is a hormone produced by the pineal gland, known for its role as a selective ATF-6 inhibitor that promotes apoptosis in human hepatoma cells via COX-2 downregulation. Additionally, it activates melatonin receptors and exhibits antioxidative and anti-inflammatory properties.</p>

<p>5-Methoxyuridine (Mo5U) is an antitumor purine analog that inhibits DNA synthesis and induces apoptosis in lymphatic cancers.</p>

<p>C8 Ceramide, a cell-permeable analog, is analog to naturally occur ceramides.</p>

Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast.

<p>Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c</p>

Pevonedistat(MLN4924) hydrochloride is a NEDD8-activating enzyme inhibitor that induces apoptosis and can be used in the study of acute myeloid leukemias.

<p>N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL), a quorum-sensing signaling molecule synthesized by P. aeruginosa and specific B. cepacia complex strains [1][2], facilitates bacterial gene expression modulation in response to cell density escalation and triggers IL-8 production in 16HBE human bronchial epithelial cells [3].</p>

<p>ML291 triggers UPR, causing apoptosis in solid cancers by activating PERK/eIF2a/CHOP pathway and reducing leukemia cells.</p>

<p>Condurango glycoside A activates p53, induces ROS generation, up-regulates p53 expression, and triggers apoptosis as well as premature senescence associated</p>

<p>PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound with anticancer and antitumor activity that inhibits the growth of breast cancer cells.</p>

<p>Forodesine inhibits lymphocyte growth and induces apoptosis in leukemic cells; oral purine nucleoside phosphorylase blocker; IC50: 0.48-1.57 nM.</p>

<p>PND-1186 hydrochloride (VS-4718 hydrochloride) is a highly specific, reversible and potent inhibitor of FAK (IC50: 1.5 nM), which can selectively induce</p>

<p>Pancratistatin, an isoquinoline from Hymenocallis littoralis, triggers apoptosis in melanoma and is studied for neuroblastoma, leukemia, and breast cancer.</p>

<p>Prexasertib dimesylate is a selective CHK1 inhibitor with K i 0.9 nM, blocks CHK2 &amp; RSK1, induces DNA breakage, and has potent anti-tumor effects.</p>

PDK1-IN-RS2, a PIFtide mimic, selectively inhibits PDK1, blocking S6K1 activation (Kd: 9 μM).

<p>Ibuprofen D3 is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor (IC50s: 13 μM and 370 μM).</p>