Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(1 prodotti)
- Caspasi(154 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(134 prodotti)
- PDK(9 prodotti)
- PERK(23 prodotti)
- Chinasi di serina/treonina(17 prodotti)
- Survivin(14 prodotti)
- TNF(93 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6222 prodotti di "Apoptosi"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
sEH-IN-21
CAS:sEH-IN-21 is an orally active inhibitor of sEH, exhibiting IC50 values of 0.1 nM for both hsEH and msEH. It significantly suppresses the NF-κB signaling pathway. sEH-IN-21 demonstrates potent anti-inflammatory activity by reducing IL-6 and TNF-α release and maintaining intestinal barrier integrity. It is applicable in research on inflammatory bowel disease (IBD).Formula:C30H40N4O5SColore e forma:SolidPeso molecolare:568.73ST-899
CAS:ST-899 is an innovative platelet-activating factor (PAF) receptor antagonist. It significantly reduces the mortality rate in mice experiencing shock induced by endotoxins (LPS). The compound markedly inhibits the LPS-induced increase in serum tumor necrosis factor (TNF) levels while leaving interleukin-6 (IL-6) unaffected. The mechanism by which ST-899 operates involves disrupting the positive feedback loop between PAF and TNF, thereby mitigating inflammatory responses. ST-899 is applicable for studies related to inflammatory diseases such as septic shock.Formula:C22H29BrClNO6Colore e forma:SolidPeso molecolare:518.83Elocalcitol
CAS:Elocalcitol is a calcitriol analog for inhibition of prostate cell growth.Formula:C29H43FO2Colore e forma:SolidPeso molecolare:442.65TH-6
TH-6, a potent HDAC inhibitor (IC50: HDAC1-0.115, 2-0.135, 3-0.242, 6-0.138, 8-2.120 μM), blocks cell migration, invasion, and has anti-tumor properties.Formula:C22H24FN3O5Colore e forma:SolidPeso molecolare:429.44FLT3-ITD-IN-3
CAS:FLT3-ITD-IN-3 (13v) is an orally active inhibitor of FLT3-ITD (internal tandem duplication of FLT3), which works by blocking FLT3 signaling. This inhibition leads to cell cycle arrest in the G0/G1 phase and induces apoptosis. The compound is currently employed in studies related to acute myeloid leukemia (AML).Formula:C27H21ClF2N6O5Colore e forma:SolidPeso molecolare:582.943AZD0424
CAS:AZD0424: oral Src/Abl kinase inhibitor; potential anticancer; induces apoptosis, cell cycle arrest in lymphoma.Formula:C25H29ClN6O5Purezza:98%Colore e forma:SolidPeso molecolare:528.99Hdm2 E3 ligase inhibitor 1
CAS:Hdm2 E3ligaseinhibitor 1 (Compound 1) is a reversible inhibitor of Hdm2-mediated p53 protein ubiquitination, with an IC50 of 12.7 μM. It binds to Hdm2, blocking the transfer of ubiquitin catalyzed by Hdm2 from pre-linked Ub-Ubc4 to p53, thereby inhibiting p53 ubiquitination, stabilizing p53 protein in tumor cells, and exerting antitumor activity.Formula:C10H8F6N2O3SPeso molecolare:350.24FKBP12 PROTAC dTAG-13
CAS:FKBP12 PROTAC dTAG-13 is a PROTAC and selective degrader for target validation by splicing FKBP12 F36V with CRBN and thereby degrading FKBP12 F36V.Formula:C57H68N4O15Purezza:97.31%Colore e forma:SolidPeso molecolare:1049.17MTDH-SND1 blocker 2
CAS:MTDH-SND1 blocker 2 (compound C19) is an effective MTDH-SND1 inhibitor with an IC50 value of 487 nM. It binds to the SND1 protein with a Kd of 279 nM and can degrade the SND1 protein. Additionally, MTDH-SND1 blocker 2 exhibits antiproliferative activity and induces apoptosis, showing potential for breast cancer research.Formula:C18H12FN3O2SColore e forma:SolidPeso molecolare:353.37WYJ-2
CAS:WYJ-2, a selective agonist for toll-like receptor 2/1 (TLR2/1), demonstrates an EC50 of 18.57 nM in HEK 293T cells transiently co-transfected with human TLR2 and TLR1. It induces pyroptosis and has shown anticancer activity against non-small cell lung cancer (NSCLC) [1].Formula:C17H9F2N3O4Colore e forma:SolidPeso molecolare:357.27(2R,3S)-Emricasan
CAS:(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan. This compound acts as an orally effective irreversible pan-caspase inhibitor. (2R,3S)-Emricasan inhibits the increase in caspase-3 activity induced by Zika virus (ZIKV) and protects human cortical neural progenitor cells.Formula:C26H27F4N3O7Colore e forma:SolidPeso molecolare:569.5BRD-K56819078
CAS:BRD-K56819078, a Bcl-2 inhibitor, significantly reduces the burden of senescent cells and the mRNA expression of aging-related genes in the kidneys. It exerts its anti-aging effects by inhibiting cell apoptosis (apoptosis).Formula:C24H20FN3O4S2Colore e forma:SolidPeso molecolare:497.56Topo II/HDAC-IN-2
CAS:Topo II/HDAC-IN-2 (8d) demonstrates remarkable dual inhibitory effects on Topo II and HDAC, and also induces apoptosis [1].Formula:C17H20N4O3SColore e forma:SolidPeso molecolare:360.43BMS-751324
CAS:BMS-751324: p38α MAPK inhibitor with carbamyl-methyl, esters, phosphate from HPA. Reduces rat arthritis swelling and TNFα.Formula:C32H35N6O10PColore e forma:SolidPeso molecolare:694.63Neuroprotective agent 11
CAS:Neuroprotective agent 11 (Compound 1a) is an orally active polyphenolic compound that offers significant protection against cerebral ischemia. Its primary activities include inhibiting neuronal inflammation and apoptosis, reducing cerebral infarct size, and improving behavioral symptoms in mice with cerebral ischemia. The mechanism involves downregulating inflammatory factors (iNOS, COX-2) and apoptotic proteins (cleaved-Caspase3, p53). Neuroprotective agent 11 is applicable for research in ischemia-related brain diseases, such as ischemic stroke.Formula:C32H30O12Colore e forma:SolidPeso molecolare:606.57NCI-006
CAS:NCI-006, an LDH inhibitor, slows tumor growth and enhances pyruvate's role in mitochondrial metabolism.Formula:C31H24F2N4O4S3Colore e forma:SolidPeso molecolare:650.74Zharp1-211
CAS:Zharp1-211 is a RIPK3 inhibitor，reduces JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, (GVHD) for gastrointestinal inflammation.Formula:C24H25N5O4Purezza:99.71%Colore e forma:SolidPeso molecolare:447.49Ref: TM-T87664
1mg82,00€5mg173,00€1mL*10mM (DMSO)192,00€10mg268,00€25mg532,00€50mg827,00€100mg1.243,00€200mg1.674,00€Zotatifin
CAS:Zotatifin (eFT226) is a selective eIF4A inhibitor with antiviral and antitumor properties, inhibiting Sox4 translation and inducing apoptosis.Formula:C28H29N3O5Purezza:98.85%Colore e forma:SolidPeso molecolare:487.55Milademetan
CAS:Milademetan (DS-3032), an MDM2 inhibitor, exhibits antitumor activity, induces G1 cell cycle arrest and apoptosis, and can be used to study solid tumors.Formula:C30H34Cl2FN5O4Purezza:>99.99%Colore e forma:SolidPeso molecolare:618.53Ref: TM-T12040
1mg93,00€5mg167,00€1mL*10mM (DMSO)221,00€10mg260,00€25mg492,00€50mg802,00€100mg1.378,00€Enbezotinib
CAS:Enbezotinib is an inhibitor of RET autophosphorylation and can be used in cancer research.Formula:C21H21FN6O3Purezza:99.84%Colore e forma:SolidPeso molecolare:424.43Ref: TM-T62285
1mg77,00€5mg166,00€1mL*10mM (DMSO)182,00€10mg253,00€25mg414,00€50mg567,00€100mg745,00€Nalmefene
CAS:Nalmefene (ORF 11676) is a μ-opioid antagonist and partial κ agonist used in the study of opioid overdose and alcohol dependence.Formula:C21H25NO3Purezza:99.86%Colore e forma:SolidPeso molecolare:339.43Lometrexol
CAS:Lometrexol (LY 264618) is an antifolate that inhibits GARFT, blocks purine synthesis, induces apoptosis, and has anticancer properties.Formula:C21H25N5O6Purezza:97.76% - 99.56%Colore e forma:SolidPeso molecolare:443.45Ref: TM-T15826
1mg84,00€5mg178,00€1mL*10mM (DMSO)203,00€10mg295,00€25mg505,00€50mg747,00€100mg1.035,00€200mg1.378,00€HC-5404
CAS:HC-5404 is a potent and selective PERK inhibitor, blocking the activation of the PERK pathway, anti-tumor effects, advanced solid tumors and renal cell Cancer.Formula:C24H24F2N4O3Purezza:99.33%Colore e forma:SolidPeso molecolare:454.47Tuvusertib
CAS:Tuvusertib (M1774), an oral ATR inhibitor (Ki<1µM), selectively blocks CHK1 phosphorylation, disrupts DNA repair, and induces tumor cell apoptosis.Formula:C16H12F2N8OPurezza:98.44% - 99.66%Colore e forma:SolidPeso molecolare:370.32Ref: TM-T10406
1mg58,00€5mg124,00€1mL*10mM (DMSO)142,00€10mg187,00€25mg363,00€50mg505,00€100mg717,00€Darizmetinib
CAS:Darizmetinib (HRX215) is an MKK4 inhibitor.Formula:C21H17F2N5O3SPurezza:98.03% - 99.57%Colore e forma:SolidPeso molecolare:457.45Ref: TM-T72956
1mg69,00€2mg89,00€5mg147,00€1mL*10mM (DMSO)148,00€10mg224,00€25mg324,00€50mg400,00€100mg587,00€PF-07328948
CAS:PF-07328948 is a branched-chain keto-acid dehydrogenase kinase (BDK) inhibitor, useful for studying CVD metabolic disorders.Formula:C16H8F4O3SPurezza:98.42%Colore e forma:SolidPeso molecolare:356.29Vatalanib hydrochloride
CAS:Vatalanib hydrochloride (PTK787 hydrochloride) is an orally available and highly potent tyrosine kinase (VEGF) inhibitor that reduces the number and size of Aβ plaques in the cortex of 5xFAD mice, which may be useful in the study of Alzheimer's disease and cancer.Formula:C20H16Cl2N4Purezza:99.7%Colore e forma:SolidPeso molecolare:383.27BCL6-IN-3
CAS:BCL6-IN-3: potent BCL6 inhibitor, 70 nM GI50 in SU-DHL4, affects cell functions, antitumor.Formula:C24H31ClF2N6O2Purezza:98.17%Colore e forma:SolidPeso molecolare:508.99Ref: TM-T10487
500mgPrezzo su richiesta1mg109,00€5mg241,00€10mg355,00€1mL*10mM (DMSO)370,00€25mg532,00€50mg745,00€100mg1.018,00€SY-5609
CAS:SY-5609 (CDK7-IN-3) is a selective non-covalent CDK7 inhibitor, with weak inhibitory activity against CDK2, CDK9 and CDK12.Cost-effective and quality-assured.Formula:C23H26F3N6OPPurezza:99.34% - >99.99%Colore e forma:SolidPeso molecolare:490.46Ref: TM-T36038
25mgPrezzo su richiesta50mgPrezzo su richiesta1mg139,00€2mg200,00€5mg343,00€1mL*10mM (DMSO)373,00€10mg553,00€UH15-38
CAS:UH15-38 is a potent and selective RIPK3 inhibitor that blocks necroptosis in alveolar epithelial cells triggered by IAV, useful for studying lung inflammation.Formula:C26H27N5O2Purezza:99.85%Colore e forma:SolidPeso molecolare:441.53Gemcitabine elaidate hydrochloride
CAS:CP-4126, a lipophilic pro-drug of Gemcitabine, converts to active form by esterases, allowing oral administration with dose-dependent effects.
Formula:C27H44ClF2N3O5Purezza:98.50% - 99.6%Colore e forma:SolidPeso molecolare:564.11JAK2-IN-7
CAS:JAK2-IN-7 selectively inhibits JAK2 (IC50: 3 nM), shows 14-fold selectivity over JAK1/3, FLT3, induces G0/G1 arrest, apoptosis, and has antitumor effects.Formula:C26H33N7OPurezza:99.54%Colore e forma:SolidPeso molecolare:459.59Ref: TM-T35900
1mg138,00€5mg334,00€1mL*10mM (DMSO)339,00€10mg597,00€25mg1.234,00€50mg1.648,00€100mg2.232,00€FX-11
CAS:FX-11: potent LDHA inhibitor (Ki 8 μM), activates PKM2, reduces ATP, induces oxidative stress/ROS, cell death, shows antitumor effects.Formula:C22H22O4Purezza:98.95% - 98.95%Colore e forma:SolidPeso molecolare:350.41β-Zearalanol
CAS:Beta-Zearalenol, a derivative of zearalenone (ZEA) capable of conjugating with glucuronic acid[2], is a mycotoxin produced by Fusarium spp. It induces apoptosis and oxidative stress in mammalian reproductive cells[1].Formula:C18H26O5Colore e forma:SolidPeso molecolare:322.4OBAA
CAS:OBAA is a potent inhibitor of phospholipase A2 (PLA2) with an IC 50 of 70 nM. OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei with an IC 50 of 0.4 μM [1] [2] [3].Formula:C28H44O3Purezza:98%Colore e forma:SolidPeso molecolare:428.65PIM-447 dihydrochloride
CAS:PIM-447 dihydrochloride is an orally available and selective inhibitor of pan-PIM kinase(Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively).Formula:C24H25Cl2F3N4OPurezza:98%Colore e forma:SolidPeso molecolare:513.38AP1867-3-(aminoethoxy)
CAS:AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.Formula:C38H50N2O9Colore e forma:SolidPeso molecolare:678.81WEHI-539 hydrochloride
CAS:WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.Formula:C31H30ClN5O3S2Purezza:98%Colore e forma:SolidPeso molecolare:620.18(R)-Verapamil hydrochloride
CAS:(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is an inhibitor of P-Glycoprotein.Formula:C27H39ClN2O4Colore e forma:SolidPeso molecolare:491.06Platinum, diammine[1,1-cyclobutanedi(carboxylato-kO)(2-)]-, (SP-4-2)-
CAS:Formula:C6H10N2O4PtPurezza:98%Colore e forma:SolidPeso molecolare:369.2326Ref: IN-DA00I84B
Prodotto fuori produzionePRGL493
CAS:PRGL493 blocks ACSL4, halts PC3/MDA-MB-231 cancer cell spread, and inhibits MA-10 tumor progesterone. Effective in mouse PC3 tumor model at 0.25 mg/kg.Formula:C25H21N7O2Purezza:98.80% - 99.11%Colore e forma:SolidPeso molecolare:451.485-Amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide
CAS:Formula:C9H14N4O5Purezza:95%Colore e forma:SolidPeso molecolare:258.2313ENMD-2076 tartrate
CAS:ENMD-2076 is an orally active kinase inhibitor. It also has antiangiogenic and antiproliferative mechanisms of action.Formula:C25H31N7O6Colore e forma:SolidPeso molecolare:525.56Mcl-1 inhibitor 6
CAS:Mcl-1 inhibitor 6 binds Mcl-1 with KD 0.23 nM and Ki 0.02 μM, shows strong selectivity over Bcl-2 family, and demonstrates antitumor efficacy.Formula:C26H28ClNO6SColore e forma:SolidPeso molecolare:518.02Prostaglandin A2
CAS:PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity.[1] At a 25 uM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase .[2] It has also been shown to act as a vasodilator with natriuretic properties.[3]Formula:C20H30O4Colore e forma:SolidPeso molecolare:334.45Ciprofloxacin lactate
CAS:Ciprofloxacin lactate is a useful organic compound for research related to life sciences. The catalog number is T66299 and the CAS number is 97867-33-9.Formula:C20H24FN3O6Colore e forma:SolidPeso molecolare:421.43A-192621
CAS:A-192621 is a potent, nonpeptide, orally active, and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. A-192621 promotes apoptosis in PASMCs and elevates both arterial blood pressure and plasma ET-1 levels[1][2][3]. Its selectivity is 636-fold higher for ETB than ETA (IC50 of 4280 nM and Ki of 5600 nM).Formula:C33H38N2O6Purezza:98%Colore e forma:SolidPeso molecolare:558.66XMU-MP-3
CAS:XMU-MP-3 is a robust, non-covalent inhibitor of BTK, exhibiting exceptional potency with IC50 values of 10.7 nM and 17.0 nM for BTK WT and BTK C481S mutation, respectively, in the presence of 10 μM ATP. Moreover, XMU-MP-3 elicits apoptosis.Formula:C27H27F3N8OColore e forma:SolidPeso molecolare:536.563Thalidomide-O-amido-C4-NH2 hydrochloride
CAS:Thalidomide-O-amido-C4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate, combines the cereblon ligand derived from Thalidomide with a linker and is commonly used in the synthesis of PROTACs[1].Formula:C19H23ClN4O6Purezza:98%Colore e forma:SolidPeso molecolare:438.86Carubicin hydrochloride
CAS:Carubicin HCl is an anthracycline antineoplastic antibiotic. Through intercalates into DNA and interacts with topoisomerase II, Carubicin inhibits DNA replication and repair and RNA and protein synthesis.Formula:C26H28ClNO10Colore e forma:SolidPeso molecolare:549.95
![Platinum, diammine[1,1-cyclobutanedi(carboxylato-kO)(2-)]-, (SP-4-2)-](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb-webp%2FDA00I84B.webp&w=3840&q=75)
