Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(6 prodotti)
- BCL(11 prodotti)
- Caspasi(125 prodotti)
- FOXO1(3 prodotti)
- IAP(66 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(125 prodotti)
- PDK(9 prodotti)
- PERK(25 prodotti)
- Chinasi di serina/treonina(15 prodotti)
- Survivin(13 prodotti)
- TNF(92 prodotti)
- c-RET(51 prodotti)
- p53(62 prodotti)
Mostrare 6 più sottocategorie
Trovati 5593 prodotti di "Apoptosi"
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Necroptosis-IN-4
<p>Necroptosis-IN-4 is an effective inhibitor of necroptosis, specifically targeting RIP kinase 1 (RIPK1) without inhibitory activity against RIPK3. It exhibits weak inhibitory effects on VEGFR1/2 and PDGFR-α.</p>Colore e forma:Odour Solid5-Fluorouracil-13C,15N2
CAS:<p>5-Fluorouracil-13C,15N2 is a standard for quantifying 5-fluorouracil via GC/LC-MS and blocks DNA synthesis, causing cell apoptosis.</p>Formula:C4H3FN2O2Colore e forma:SolidPeso molecolare:133.057Ganoderic acid Mk
CAS:<p>GA-Mk is a triterpenoid from Ganoderma lucidum mycelia, inhibits HeLa cell growth, and induces apoptosis via mitochondria; used in cervical cancer studies.</p>Formula:C34H50O7Colore e forma:SolidPeso molecolare:570.76Iparomlimab
CAS:<p>Iparomlimab: anti-PD-1 IgG4κ antibody, targets PSB103 γ4/κ-chains, forms dimers, used in cancer research.</p>Colore e forma:LiquidVEGFR-2-IN-61
<p>VEGFR-2-IN-61 (Compound 7b) is an inhibitor of VEGFR-2 with an IC50 of 2.83 µM. It effectively inhibits the proliferation of various cancer cells, including MCF-7 cells, with an IC50 of 2.12 µM. Additionally, VEGFR-2-IN-61 suppresses cell migration and induces oxidative stress and apoptosis in MCF-7 cells.</p>Formula:C27H25N5OColore e forma:SolidPeso molecolare:435.52Thalidomide-O-amido-C3-COOH
CAS:<p>Thalidomide-O-amido-C3-COOH is a cereblon ligand-linker for PROTACs, melding Thalidomide with a standard linker.</p>Formula:C19H19N3O8Purezza:98%Colore e forma:SolidPeso molecolare:417.37AFMK
CAS:<p>AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity.</p>Formula:C13H16N2O4Purezza:98.34% - 99.81%Colore e forma:SolidPeso molecolare:264.28Thalidomide-NH-PEG8-Ts
CAS:<p>Thalidomide-NH-PEG8-Ts: a synthesized Thalidomide-PEG8 E3 ligase linker for PROTAC-mediated IDO1 degradation.</p>Formula:C36H49N3O14SColore e forma:SolidPeso molecolare:779.86Ganoderic acid Mf
CAS:<p>Ganoderic acid Mf: antitumor triterpenoid, arrests G1 cell cycle, selective for cancer cells, triggers apoptosis via mitochondria.</p>Formula:C32H48O5Colore e forma:SolidPeso molecolare:512.72Malformin A
CAS:<p>Malformin A, from A. niger, is a plant growth regulator and has anti-TMV and cancer cell cytotoxic properties. Intraperitoneal LD50 in mice is 3.1 mg/kg.</p>Formula:C23H39N5O5S2Colore e forma:SolidPeso molecolare:529.72MDM2/4-p53-IN-2
<p>MDM2/4-p53-IN-2 (2q) is a dual MDM2/MDM4 inhibitor, p53 activator; IC50: 70.7 nM(MDM2), 81.4 nM(MDM4); tumor suppressor.</p>Formula:C25H17Cl3FN3O3Colore e forma:SolidPeso molecolare:532.78F1324 TFA
<p>F1324 TFA is a potent, high affinity peptidic inhibitor of B cell lymphoma 6 (BCL6), with an IC50 of 1 nM.</p>Formula:C85H122N21F3O22SPurezza:98%Colore e forma:SolidPeso molecolare:1879.06Finotonlimab
<p>Finotonlimab (SCT-I10A), a humanized IgG PD-1 monoclonal antibody, shows potential in the research of solid tumors or lymphomas [1].</p>Colore e forma:Odour LiquidPROTAC 20S proteasome subunit β5 degrader 1
<p>PROTAC 20S proteasome subunit β5 degrader 1 (compound 12f) serves as a targeted degrader of the 20S proteasome subunit β5, exhibiting a DC50 value of 0.11 μM in FaDu cells. This compound disrupts the cell cycle and promotes apoptosis (apoptosis), while inhibiting cell proliferation and migration in both FaDu and KM3/BTZ cells. It is applicable for research into resistance to Bortezomib in pharyngeal carcinoma and multiple myeloma.</p>Colore e forma:Odour Solid1,2-Naphthoquinone
CAS:<p>1,2-Naphthoquinone inhibits urease, induces apoptosis in PBMC cells, inhibitory activity against hiCE, hCE1, hAChE, and hBChE.</p>Formula:C10H6O2Purezza:98.01%Colore e forma:Golden Yellow Needles Color On Standing (Ntp 1992)Peso molecolare:158.15PD0166285 dihydrochloride
CAS:<p>PD-166285 is an effective and broadly active inhibitor of protein tyrosine kinase.</p>Formula:C26H29Cl4N5O2Colore e forma:SolidPeso molecolare:585.35NQO2-IN-1
CAS:<p>NQO2-IN-1, a resveratrol analog, is a potent NQO2 inhibito,antitumor,generation of ROS and up-regulation of DR5 (death receptor 5) to promote apoptosis.</p>Formula:C18H18N2O3Purezza:99.83%Colore e forma:SoildPeso molecolare:310.35HJC0416 hydrochloride
CAS:<p>HJC0416 hydrochloride: potent oral STAT3 inhibitor, better anticancer effects than Stattic, promising for breast cancer research.</p>Formula:C18H18Cl2N2O4SColore e forma:SolidPeso molecolare:429.31hMAO-B-IN-11
<p>hMAO-B-IN-11 (Compound 12) is a selective and reversible inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 value of 0.11 µM. It operates by competitively binding to the active site of hMAO-B, thereby preventing the oxidative deamination of monoamines and reducing hydrogen peroxide production. Additionally, hMAO-B-IN-11 inhibits pro-inflammatory mediators (NO, TNF-α, IL-1β) in activated microglia. This compound holds potential for research in neurodegenerative diseases such as Parkinson's and Alzheimer's.</p>Colore e forma:Odour SolidiNOs-IN-5
<p>iNOs-IN-5 (Compound BN-4) is an inhibitor of iNOS with an IC50 value of 0.1707 μM, effectively reducing NO expression in RAW264.7 cells stimulated by LPS (HT-D1056). It further diminishes the expression of ROS and lactate dehydrogenase induced by hypoxic injury, displaying anti-necrotic and anti-apoptotic properties. In an SD rat model, iNOs-IN-5 exhibits neuroprotective effects against cerebral ischemia and is capable of crossing the blood-brain barrier.</p>Colore e forma:Odour SolidThalidomide-4-C3-NH2 hydrochloride
CAS:<p>Thalidomide-4-C3-NH2 HCl is a cereblon ligand for CRBN recruitment, used to make PROTACs with a linker.</p>Formula:C16H18ClN3O4Colore e forma:SolidPeso molecolare:351.785hCAIX-IN-23
<p>hCAIX-IN-23 (Compound 27) is a human carbonic anhydrase (hCA) inhibitor with Ki values of 10.4 nM for hCA IX and 8.5 nM for hCA XII. It not only inhibits hCA activity but also releases NO, exerting dual anti-tumor effects. By reducing the expression of hCA IX and iron regulatory proteins, hCAIX-IN-23 regulates mitochondrial caspase activity and the ferroptosis pathway, thereby inducing apoptosis. This compound is utilized in research focused on renal cancer.</p>Colore e forma:Odour SolidSBP-0636457
CAS:<p>SBP-0636457: SMAC mimetic, IAP inhibitor, binds BIR-domains (Ki=0.27μM), potential in tumor/cancer research.</p>Formula:C25H36N4O4Colore e forma:SolidPeso molecolare:456.587p53-HDM2-IN-1
<p>p53-HDM2-IN-1 is a potent inhibitor of the p53-HDM2 protein-protein interaction, demonstrating an inhibitory concentration (IC 50) of 0.103 μM.</p>Formula:C35H38F6N4O7SColore e forma:SolidPeso molecolare:772.75PPA-904 FA
<p>PPA-904 FA is a cationic photosensitizer with antimicrobial activity that can be used to study chronic leg ulcers and diabetic foot ulcers.</p>Formula:C29H43N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:497.74Chalcones A-N-5
CAS:<p>Chalcones A-N-5, a non-cytotoxic trihydroxy chalcone, aids cell growth & neuroprotection, inhibits ferroptosis, and targets AD research.</p>Formula:C21H20N4O4Colore e forma:SolidPeso molecolare:392.41ARV-393 HCl
<p>ARV-393 HCl is an orally active and potent PROTAC targeting BCL6 with antitumor activity for the study of non-Hodgkin's lymphoma.</p>Formula:C46H54Cl2FN9O7Purezza:99.79%Colore e forma:SolidPeso molecolare:934.88Sanggenon G
CAS:<p>Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.</p>Formula:C40H38O11Colore e forma:SolidPeso molecolare:694.72AMG-7209
CAS:<p>AMG-7209 is an effective and selective MDM2-p53 interaction inhibitor.</p>Formula:C37H41Cl2FN2O7SColore e forma:SolidPeso molecolare:747.7Onfekafusp alfa
CAS:<p>Onfekafusp alfa (L19TNF), a trimeric fusion of L19 scFv and human TNF, targets malignant glioma.</p>Colore e forma:LiquidIzuralimab
CAS:<p>Izuralimab is a bispecific IgG1 antibody that targets both the inducible T-cell costimulator (ICOS/CD278) and PD-1 [1].</p>Colore e forma:LiquidPexelizumab
CAS:<p>Pexelizumab is a humanized antibody targeting C5 to inhibit apoptosis and treat cerebral IR injury and myocardial infarction.</p>Colore e forma:LiquidEJMC-1
CAS:<p>EJMC-1 is an inhibitor of TNF-α with an IC50 value of 42 μM and can be used in studies about auto-inflammatory diseases.</p>Formula:C17H11ClN2O4SPurezza:98.38%Colore e forma:SolidPeso molecolare:374.8SPOP-IN-6lc
CAS:<p>SPOP-IN-6lc is a SPOP inhibitor with oncogenic effects in renal cancer cells.SPOP-IN-6lc can be used to study apoptosis.</p>Formula:C26H31N7O2SPurezza:99.19%Colore e forma:SolidPeso molecolare:505.64Z-Asp-CH2-DCB
CAS:<p>Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.</p>Formula:C20H17Cl2NO7Purezza:99.08%Colore e forma:SolidPeso molecolare:454.26Haemanthamine hydrochloride
<p>Haemanthamine hydrochloride, an alkaloid from Amaryllidaceae, has anticancer, antioxidant, antiviral, antimalarial, and anticonvulsant properties.</p>Formula:C17H20ClNO4Colore e forma:SolidPeso molecolare:337.8Thalidomide-PEG2-C2-NH2
CAS:<p>Thalidomide-O-amido-PEG3-C2-NH2 is a cereblon ligand-linked E3 ligase used in PROTAC with a 2-unit PEG.</p>Formula:C19H24N4O6Purezza:98%Colore e forma:SolidPeso molecolare:404.42TAT-NEP1-40 acetate
<p>TAT-NEP1-40 acetate, a potential therapeutic for axonal regeneration and functional recovery post-stroke, safeguards PC12 cells from oxygen and glucose</p>Formula:C268H438N88O77·xC2H4O2Purezza:98%Colore e forma:SolidPeso molecolare:6124.89 (free base)Sudubrilimab
<p>Sudubrilimab (HS636) is an IgG1-κ monoclonal antibody targeting PDL1, fused with TGFBR2-ECD to block PD-1/PDL1 and TGF-β in tumors.</p>Colore e forma:Odour LiquidRIPK1-IN-17
CAS:<p>RIPK1-IN-17 is a dual inhibitor of RIPK1 and RIPK3 inhibits necrosis by inhibiting phosphorylation of RIPK1, RIPK3 and MLKL,in a tnf-induced inflammation model.</p>Formula:C26H19F4N3O3SPurezza:95.22%Colore e forma:SolidPeso molecolare:529.51Tubulin/AKT1-IN-1
<p>Tubulin/AKT1-IN-1 (Compound D1-1) serves as an inhibitor of both tubulin polymerization and AKT pathway activation, effectively suppressing proliferation and</p>Formula:C38H34ClNO11Purezza:98%Colore e forma:SolidPeso molecolare:716.13FPR1 antagonist 1
<p>Compound 24a, an FPR1 antagonist, demonstrates potent inhibition of the formyl peptide receptor 1 (FPR1) with an IC50 value of 25 nM.</p>Formula:C25H28O5Colore e forma:SolidPeso molecolare:408.49Holothurin A
CAS:<p>Holothurin A is a triterpene glycoside.</p>Formula:C54H86NaO27SColore e forma:SolidPeso molecolare:1222.35-LOX-IN-8
<p>5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory properties. It suppresses IL-6, IL-1β, TNF-α, and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. Additionally, 5-LOX-IN-8 decreases the disease activity index in DSS colitis models. This compound is applicable for research in inflammatory bowel disease (IBD).</p>Colore e forma:Odour SolidRMC-6291
CAS:<p>RMC-6291: Oral, covalent KRAS G12C inhibitor, blocks signaling, forms tri-complex with CypA, suppresses RAS activity in tumors.</p>Formula:C55H78FN9O8Purezza:98.73%Colore e forma:SolidPeso molecolare:1012.26Anticancer agent 272
<p>Anticanceragent 272 (Compound 2) is an anticancer agent demonstrating significant activity against bladder cancer cells (T-24) with an IC50 of 2.81 μM. It depletes glutathione (GSH) through a Fenton-like reaction, generating reactive oxygen species (ROS) and hydroxyl radicals (•OH), thereby inducing apoptosis and ferroptosis. Anticanceragent 272 enhances chemodynamic therapy (CDT) and promotes tumor cell death through mitochondrial dysfunction and autophagy. It holds potential for further research in bladder cancer.</p>Formula:C26H34Br2Cl4Cu2N8Colore e forma:SolidPeso molecolare:881.86192MitoEbselen-2 chloride
CAS:<p>MitoEbselen-2 mitigates radiation, cuts lipid hydroperoxides, blocks cell death, and boosts survival in irradiated mice.</p>Formula:C35H30ClN2O2PSeColore e forma:SolidPeso molecolare:656.01DS-5272
CAS:<p>DS-5272 is a potent and orally active inhibitor of p53-MDM2 interaction.</p>Formula:C34H38Cl2F2N6O2SColore e forma:SolidPeso molecolare:703.67BM-1074
CAS:<p>BM-1074 is a potent and highly efficacious inhibitor of Bcl-2/Bcl-xL with Ki value of < 1nM [1].</p>Formula:C50H57ClN8O7S3Colore e forma:SolidPeso molecolare:1013.69Albanol B
CAS:<p>Albanol B, from mulberries, combats Alzheimer's, bacteria, and oxidation, hinders cancer growth, and triggers cell arrest and apoptosis.</p>Formula:C34H22O8Colore e forma:SolidPeso molecolare:558.53
