Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(5 prodotti)
- Caspasi(151 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(105 prodotti)
- PDK(9 prodotti)
- PERK(26 prodotti)
- Chinasi di serina/treonina(18 prodotti)
- Survivin(14 prodotti)
- TNF(58 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6043 prodotti di "Apoptosi"
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ABBV-167
CAS:ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax.
Formula:C46H53ClN7O11PSColore e forma:SolidPeso molecolare:978.45Enniatin A1
CAS:Enniatin A1, a cyclic hexadepsipeptide from Fusarium, induces apoptosis and disrupts ERK, inhibiting ACAT (IC50: 49 μM).Formula:C35H61N3O9Purezza:98%Colore e forma:SolidPeso molecolare:667.885AKN-028
CAS:AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
Formula:C17H14N6Purezza:99.88%Colore e forma:SolidPeso molecolare:302.33TNF/IFNγ-IN-1
CAS:TNF/IFNγ-IN-1 (TGA) is a TNF and IFN-γ inhibitor with antioxidant and anti-inflammatory activities for neurodegenerative diseases such as Alzheimer.Formula:C20H23N3O6Purezza:99.39%Colore e forma:SoildPeso molecolare:401.41BIM-46174 HCl
BIM-46174 HCl is a G-protein inhibitor with anticancer activity that induces cysteine 3-dependent apoptosis.
Formula:C22H31ClN4OSPurezza:99.77% - 99.77%Colore e forma:SolidPeso molecolare:435.03Thalidomide-NH-PEG7
Thalidomide-NH-PEG7, a chemical for creating PROTAC iRucaparib-AP6, selectively degrades PARP1 and is used in ADCs.Formula:C27H39N3O11Purezza:98%Colore e forma:SolidPeso molecolare:581.61HDAC6-IN-16
HDAC6-IN-16 (compound 5c), a quinazolin-4(3H)-one-based inhibitor of histone deacetylase 6 (HDAC6), demonstrates an anticancer effect by inhibiting colonyFormula:C23H19N3O3SPurezza:98%Colore e forma:SolidPeso molecolare:417.48GPX4-IN-7
GPX4-IN-7 (Compound 31), an indirubin derivative, serves as a ferroptosis inducer in colon cancer treatment.Formula:C25H23ClN4O4Purezza:98%Colore e forma:SolidPeso molecolare:478.93TRAP-1
TRAP-1 (XJZ-06-462) is a p53 transcription activator that effectively activates mutant p53 and triggers the transcription of p53 target genes. In the p53Y220C pancreatic cell line, TRAP-1 rapidly upregulates p21 and other p53 target genes. TRAP-1 also inhibits cell proliferation, exhibiting IC50 values of 3.94 μM and 0.531 μM in BxPC-3 and A549 cell lines, respectively. Additionally, TRAP-1 modulates autophagy in lung cancer cells and provides protection against oxidative stress and apoptosis.Formula:C57H66ClF3N11O3PSColore e forma:SolidPeso molecolare:1108.69Apoptosis inducer 11
Apoptosis Inducer 11 (compound 3u) promotes apoptosis via the mitochondrial pathway and elicits a G2/M block alongside a marked reduction in the S phase withinFormula:C27H28N2O5Purezza:98%Colore e forma:SolidPeso molecolare:460.52SI-2
CAS:SI-2, a SRC-3 inhibitor, triggers breast cancer cell death (IC50: 3-20 nM), sparing normal cells.Formula:C15H15N5Purezza:98.4%Colore e forma:SolidPeso molecolare:265.31Ref: TM-T28773
1mg378,00€5mg922,00€10mg1.225,00€25mg1.853,00€50mg2.490,00€100mg3.353,00€1mL*10mM (DMSO)845,00€PROTAC HIF-1α degrader-1
PROTAC HIF-1α degrader-1 (compound V2) is an effective proteolysis-targeting chimeric (PROTAC) degrader of hypoxia-inducible factor-1α (HIF-1α), with an IC50 value of 7.54 µM. This compound exhibits anti-proliferative activity, reduces HIF-1α protein expression, and induces apoptosis.Formula:C51H72N6O7SColore e forma:SolidPeso molecolare:913.22NDI-Lyso
CAS:NDI-Lyso is an anticancer agent targeting lysosomes, functioning through an enzyme-induced self-assembly (EISA) mechanism catalyzed by Cathepsin B. In cancer cell lysosomes, it forms rigid long fibers, promoting lysosomal swelling, lysosomal membrane permeabilization (LMP), and membrane disruption. This leads to non-classical caspase-independent apoptosis (Apoptosis). NDI-Lyso demonstrates significant selective anticancer activity across various cancer cell lines and drug-resistant cancer cells (IC50 approximately 10 μM), while exhibiting low toxicity to normal cells (IC50 > 60 μM).Formula:C71H100N22O13Colore e forma:SolidPeso molecolare:1469.69Eldecalcitol
CAS:Eldecalcitol, orally active vitamin D analog, boosts bone density and treats osteoporosis.Formula:C30H50O5Purezza:98%Colore e forma:SolidPeso molecolare:490.72SCR7
CAS:SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).Formula:C18H14N4OSPurezza:98%Colore e forma:SolidPeso molecolare:334.4LIB3S0280
LIB3S0280 is a potent inhibitor of TBK1, with an IC50 of 493.9 nM. It suppresses TBK1 downstream signaling by reducing the phosphorylation of IκBα and AKT. LIB3S0280 causes G2/M phase arrest and induces apoptosis in pancreatic cancer cells. Notably, it exhibits significant inhibitory effects on pancreatic cancer cell lines with high TBK1 expression, with a 96-hour IC50 value ranging from 6.64-10.98 μM. LIB3S0280 shows potential for research in pancreatic ductal adenocarcinoma (PDAC).Colore e forma:Odour SolidDaporinad hydrochloride
CAS:Daporinad hydrochloride (FK 866 hydrochloride) is a NAMPT inhibitor with antitumor and antiangiogenic activity that induces apoptosis in tumor cells.Formula:C24H30ClN3O2Purezza:98.99%Colore e forma:SolidPeso molecolare:427.974-Epianhydrotetracycline hydrochloride
CAS:EATC, a tetracycline byproduct, combats Pseudomonas to E. coli with MIC50s of 0.75-16 mg/L.Formula:C22H23ClN2O7Colore e forma:SolidPeso molecolare:462.882'-epi-2'-O-Acetylthevetin B
CAS:2'-Epi-2'-O-Acetylthevetin B (GHSC-74), a cardiac glycoside extractable from Cerbera manghas L.Formula:C44H68O19Purezza:98%Colore e forma:SolidPeso molecolare:901Z-Asp-CH2-DCB
CAS:Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.Formula:C20H17Cl2NO7Purezza:99.08%Colore e forma:SolidPeso molecolare:454.264-N-Nonyloxyphenol
CAS:4-N-Nonyloxyphenol, kaolinite nanotube photosensitizer, degrades phenolic pesticides, and disrupts endocrine.
Formula:C15H24O2Purezza:99.94%Colore e forma:SoildPeso molecolare:236.35Ara-SH
Ara-SH, a derivative of Cytarabine with a mercaptopropionic acid substitution, serves as the initiator for the self-assembly of a smart, co-loaded CytarabineFormula:C12H17N3O6SPurezza:98%Colore e forma:SolidPeso molecolare:331.34Thalidomide-O-C6-NH2
CAS:Thalidomide-O-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1].Formula:C19H23N3O5Purezza:98%Colore e forma:SolidPeso molecolare:373.4HDAC6-IN-22
HDAC6-IN-22 (compound 30), an HDAC6 inhibitor, exhibits an IC50 of 4.63 nM and demonstrates antiproliferative effects against multiple myeloma both in vitro andFormula:C24H24N4O2Purezza:98%Colore e forma:SolidPeso molecolare:400.47BMH-7 HCl
BMH-7 HCl is a p53 activator, showing anti-cancer activity by activating the p53 pathway.Formula:C20H22ClN5OPurezza:99.62%Colore e forma:SolidPeso molecolare:383.88RMC-6291
CAS:RMC-6291: Oral, covalent KRAS G12C inhibitor, blocks signaling, forms tri-complex with CypA, suppresses RAS activity in tumors.Formula:C55H78FN9O8Purezza:98.73% - 99.92%Colore e forma:SolidPeso molecolare:1012.26Pimagedine
CAS:Pimagedine is a prototype therapeutic agent for the prevention of formation of advanced glycation endproducts.Formula:CH6N4Colore e forma:SolidPeso molecolare:74.09DAPK-IN-2
CAS:DAPK-IN-2: DAPK inhibitor with anticancer potential. Used in cerebral infarction and ischemia research.Formula:C17H14N2O4Purezza:97.36%Colore e forma:SolidPeso molecolare:310.3PROTAC KDM4 degrader-1
PROTACKDM4 degrader-1 (Compound 11) is a proteolysis-targeting chimera (PROTAC) degrader specifically designed for KDM4. It effectively degrades KDM4A-C while sparing KDM4D. In esophageal cancer cells, PROTACKDM4 degrader-1 demonstrates strong antiproliferative activity, inducing apoptosis and cell cycle arrest, and inhibits lysine demethylation of histone H3.Colore e forma:Odour SolidCS4
CS4 is a selective HDAC inhibitor, with IC50 values for HDAC1, HDAC6, HDAC8, HDAC4, and HDAC11 reported as 38 nM, 12 nM, 5.8 μM, 19 μM, and 61 μM, respectively. It enhances the acetylation of α-tubulin and histone 3 (histone 3). Additionally, CS4 activates PPARγ and blocks glycolysis (glycolysis). It induces cell cycle arrest at the G2 phase and triggers apoptosis (apoptosis), exhibiting anticancer effects both in vitro and in vivo.Colore e forma:Odour SolidAlbanol B
CAS:Albanol B, from mulberries, combats Alzheimer's, bacteria, and oxidation, hinders cancer growth, and triggers cell arrest and apoptosis.Formula:C34H22O8Colore e forma:SolidPeso molecolare:558.53dTAG-47
CAS:dTAG-47 targets FKBP12 F36V for protein degradation, useful in basal-like breast cancer research.Formula:C59H73N5O14Colore e forma:SolidPeso molecolare:1076.24BMf-BH3
BMf-BH3 is a Bcl-2 family peptide, key in HDAC inhibition affecting acetylation balance.Formula:C131H214N45O35SPurezza:98%Colore e forma:SolidPeso molecolare:3012.5Thalidomide-NH-C5-NH2 hydrochloride
CAS:Functionalized cereblon ligand with E3 ligase and alkylC5 linker for PROTAC R&D; ready for protein conjugation. Formerly Pomalidomide-linker 4.Formula:C18H23ClN4O4Colore e forma:SolidPeso molecolare:394.85FB49
FB49 is a selective Bcl-2-associated athanogene 3 (BAG3) inhibitor with a Ki of 45 μM.Formula:C17H18N2O6SPurezza:98%Colore e forma:SolidPeso molecolare:378.4Anticancer agent 154
Anticancer agent 154 (Compound 8h) enhances reactive oxygen species production, causing mitochondrial damage, and promotes cell apoptosis and DNA damage.Formula:C22H23N5O2Purezza:98%Colore e forma:SolidPeso molecolare:389.45icFSP1
CAS:icFSP1 is a mitochondria-associated apoptosis-inducing factor regulator with antitumor activity for the study and treatment of tumor diseases.Formula:C26H25N3O5Purezza:99.87% - 99.93%Colore e forma:SoildPeso molecolare:459.49PROTAC SMARCA2/4 degrader-38
PROTACSMARCA2/4 degrader-38 is a SMARCA2/4 PROTAC degrader with DC50 values of 3.0 nM and 4.0 nM, respectively. It facilitates the ubiquitination and degradation of SMARCA2/4 and can block the G0/G1 phase of the cell cycle, leading to the induction of apoptosis. PROTACSMARCA2/4 degrader-38 is applicable in acute myeloid leukemia (AML) research.Colore e forma:Odour SolidPyridinium bisretinoid A2E
CAS:Pyridinium bisretinoid A2E (A2E) is a fluorescent molecule isolated from the lipofuscin of retinal pigment epithelium, a weak photosensitizer.Formula:C42H58NOPurezza:83.65%Colore e forma:SolidPeso molecolare:592.92EPZ020411 hydrochloride
CAS:EPZ020411 hydrochloride is a selective and potent small molecule PRMT6 inhibitor with an IC50 value of 10 nM.Formula:C25H39ClN4O3Purezza:99.88%Colore e forma:SolidPeso molecolare:479.05Ref: TM-T22325
1mg60,00€5mg131,00€10mg215,00€25mg369,00€50mg563,00€100mg805,00€1mL*10mM (DMSO)145,00€PROTAC HDAC6 degrader 1
CAS:Compound A6, a potent PROTAC HDAC6 degrader, has a DC50 of 3.5 nM and induces apoptosis in myeloid leukemia cells.Formula:C37H46N6O10Colore e forma:SolidPeso molecolare:734.8Thalidomide-NH-C6-NH2
CAS:Thalidomide-NH-C6-NH2 is a synthetic conjugate compound designed as an E3 ligase ligand-linker.Formula:C19H24N4O4Purezza:98%Colore e forma:SolidPeso molecolare:372.42NC-R17
NC-R17, an RSL3-based noncovalent GPX4 degrader implicated in ferroptosis, demonstrates anti-tumor activity and is utilized in the design of noncovalent GPX4-Formula:C53H67N7O7Purezza:98%Colore e forma:SolidPeso molecolare:914.14Etoposide phosphate disodium
CAS:Etoposide phosphate disodium, a prodrug of etoposide, is a powerful anticancer drug inhibiting DNA topoisomerase II.
Formula:C29H31Na2O16PColore e forma:SolidPeso molecolare:712.5DPP-4-IN-8
DPP-4-IN-8 (compound 27) is a potent and selective inhibitor of dipeptidyl peptidase 4 (DPP4), with an inhibition constant (Ki) of 0.96 μM.Formula:C16H12ClNO6Colore e forma:SolidPeso molecolare:349.72Narasin
CAS:Narasin inhibits dengue virus, treats coccidiosis without harm to cells, and induces cancer cell apoptosis.Formula:C43H72O11Colore e forma:SolidPeso molecolare:765.03EGFR-IN-83
EGFR-IN-83 (Compound 9), an EGFR inhibitor with an IC50 of 2.53 nM, exhibits antiproliferative effects on MCF-7 and MDA-MB-231 cell lines, with respective IC50Formula:C22H17F3N4OPurezza:98%Colore e forma:SolidPeso molecolare:410.39MPP hydrochloride
MPP hydrochloride is a selective estrogen receptor (ERR) modulator.
Formula:C29H32ClN3O3Purezza:99.75% - 99.9%Colore e forma:SolidPeso molecolare:506.04Se-Aspirin
CAS:Se-Aspirin (Se-NSAID-8) has anticancer activity and gastroprotective effects, inhibits activation of proinflammatory and pro-survival NF-ĸB pathways, and inhibits the expression of anti-apoptotic targets downstream of NF-ĸB (e.g., Bcl-xL, Mcl-1, and survivin).Se-Aspirin induces Cell cycle arrest and activation of apoptosis accelerates ulcer healing and can be used to study pancreatic and colorectal cancer.Formula:C12H12N2O3SePurezza:98.07%Colore e forma:SolidPeso molecolare:311.2ZYH-23
ZYH-23 is a potent inhibitor of necroptosis. It targets HSP90 to inhibit the phosphorylation of RIPK1, RIPK3, and MLKL, effectively blocking programmed cell necrosis.
Formula:C41H50N4O3Colore e forma:SolidPeso molecolare:646.38829
