Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(1 prodotti)
- Caspasi(154 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(127 prodotti)
- PDK(9 prodotti)
- PERK(23 prodotti)
- Chinasi di serina/treonina(17 prodotti)
- Survivin(14 prodotti)
- TNF(90 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6170 prodotti di "Apoptosi"
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FW-1
FW-1 is a type I inhibitor of FLT3, with an IC50 of approximately 1 μM. It exhibits cytotoxic effects in FLT3-mutant AML cells, causes cell cycle arrest at the G0/G1 phase, and induces apoptosis in MV4-11 and MOLM-13 cells.
Formula:C24H27N7OColore e forma:SolidPeso molecolare:429.517Furazolidone
CAS:Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.Formula:C8H7N3O5Purezza:99.96%Colore e forma:Yellow Crystals From Dmf (N N-Dimethylformamide) SolidPeso molecolare:225.16DB2313
CAS:DB2313 is a potent PU.1 inhibitor (IC50=14 nM) that disrupts gene binding, induces AML cell apoptosis, and has anticancer properties.
Formula:C42H41FN8O2Purezza:98.63% - 99.29%Colore e forma:SolidPeso molecolare:708.83Lisaftoclax
CAS:Lisaftoclax, an oral Bcl-2/Bcl-xl inhibitor (IC50: 2 nM & 5.9 nM), treats CLL by promoting leukemia cell death.Formula:C45H48ClN7O8SPurezza:97.14% - 99.66%Colore e forma:SolidPeso molecolare:882.42Ref: TM-T10483
1mg177,00€5mg394,00€1mL*10mM (DMSO)558,00€10mg565,00€25mg837,00€50mg1.121,00€100mg1.520,00€Oligomycin B
CAS:Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis.Formula:C45H72O12Purezza:98%Colore e forma:SolidPeso molecolare:805.05Thymidine 3',5'-disphosphate
CAS:pdTp is a highly selective, small-molecule miRNA regulatory complex RISC subunit SND1 inhibitor.Formula:C10H16N2O11P2Colore e forma:SolidPeso molecolare:402.19MS1943
CAS:MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).Formula:C42H54N8O3Purezza:95.41% - 95.82%Colore e forma:SolidPeso molecolare:718.93Ref: TM-T13780
1mg39,00€2mg52,00€5mg84,00€1mL*10mM (DMSO)120,00€10mg130,00€25mg250,00€50mg439,00€100mg802,00€200mg1.324,00€VPC-70063
CAS:VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX.Formula:C16H12F6N2SPurezza:99.98%Colore e forma:SolidPeso molecolare:378.34Ref: TM-T60019
1mg49,00€5mg101,00€1mL*10mM (DMSO)130,00€10mg152,00€25mg268,00€50mg385,00€100mg560,00€200mg790,00€Tubulin polymerization-IN-43
CAS:Tubulin polymerization-IN-43 disrupts microtubules, arrests cell cycle, and induces apoptosis in leukemia by targeting colchicine sites.Formula:C17H13F4N3OPurezza:99.98%Colore e forma:SoildPeso molecolare:351.33-Methoxy-9H-Carbazole
CAS:3-methoxy-9H-carbazole: photosensitizer, anti-breast cancer, from Klauseneria spp., induces apoptosis.Formula:C13H11NOPurezza:99.24%Colore e forma:SolidPeso molecolare:197.23Mcl1-IN-12
CAS:Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.Formula:C45H46N4O6S2Purezza:98%Colore e forma:SolidPeso molecolare:803Endoplasmic Reticulum Stress Compound Library
A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);Colore e forma:Odour SolidRef: TM-L9700
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaVarlilumab
CAS:Varlilumab (CDX-1127) is a novel human IgG1 anti-CD27 monoclonal antibody. Varlilumab has antitumor activity and can be used to study advanced solid tumors.Purezza:SDS-PAGE:95% SEC-HPLC:98.65%Colore e forma:LiquidPeso molecolare:146 kDaFerroptosis-IN-16
Ferroptosis-IN-16 (Compound 13l) acts as a specific inhibitor of ferroptosis, demonstrating EC50 values of 0.7 nM in ES-2 cells and 0.9 nM in LX-2 cells. It effectively alleviates acute liver injury induced by Acetaminophen in mouse models and shows excellent metabolic stability in mouse liver microsomes.Formula:C26H23N5OColore e forma:SolidPeso molecolare:421.49PERK-IN-4
CAS:PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Formula:C24H19F4N5OPurezza:99.44% - 99.49%Colore e forma:SolidPeso molecolare:469.43Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine
CAS:Cereblon ligand for PROTAC R&D; has E3 ligase, alkylC1-PEG3-alkylC3 linker, terminal amine. Part of Arvinas-licensed tool molecules.Formula:C25H35ClN4O9Colore e forma:SolidPeso molecolare:571.02Glutathione arsenoxide hydrochloride
Glutathione arsenoxide hydrochloride: anti-cancer, inhibits tumour metabolism, targets ANT, promotes apoptosis, marks cell proteins.Formula:C18H26AsClN4O9SPurezza:99.74%Colore e forma:SoildPeso molecolare:584.86Enpp/Carbonic anhydrase-IN-2
CAS:Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.Formula:C23H24FNO4SPurezza:99.46%Colore e forma:SoildPeso molecolare:429.5Ref: TM-T77631
1mg44,00€5mg90,00€1mL*10mM (DMSO)96,00€10mg145,00€25mg236,00€50mg338,00€100mg460,00€200mg622,00€TNF-α-IN-9
CAS:TNF-α-IN-9 is an NDM-1 inhibitor-3 analog and is a TNF-α inhibitor.TNF-α-IN-9 shows low inhibitory activity.Formula:C17H14O4Purezza:99.21%Colore e forma:SoildPeso molecolare:282.29CLEFMA
CAS:CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.Formula:C23H17Cl2NO4Purezza:99.00%Colore e forma:SolidPeso molecolare:442.29Ref: TM-T9582
1mg64,00€5mg131,00€1mL*10mM (DMSO)149,00€10mg188,00€25mg299,00€50mg427,00€100mg575,00€200mg750,00€Cathepsin B
CAS:Cathepsin B, a cysteine protease located within the subcellular endosomes and lysosomal compartments, mediates apoptosis and can be used in cancer research.Colore e forma:SolidEGFR/VEGFR2-IN-1
EGFR/VEGFR2-IN-1 (Compound 10e) serves as an inhibitor for VEGFR-2 and EGFR, with respective IC50 values of 0.26 and 0.14 μM. It inhibits microtubule protein polymerization with an IC50 of 40.9 μM and induces cell apoptosis (Apoptosis). EGFR/VEGFR2-IN-1 is applicable in research related to anti-leukemia and anti-lymphoma treatments.Colore e forma:Odour SolidPQ401
CAS:PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).Formula:C18H16ClN3O2Purezza:99.77%Colore e forma:SolidPeso molecolare:341.79KSRP-IN-1
KSRP-IN-1 (compound 8) acts as an inhibitor of KSRP, inducing cell cycle arrest and apoptosis (Apoptosis). This compound demonstrates antitumor activity.Colore e forma:Odour SolidKT5823
CAS:KT5823 is a cGMP-dependent protein kinase (PKG) inhibitor that increases iodide ion uptake by regulating the expression of sodium iodide symporter protein.Formula:C29H25N3O5Purezza:95%Colore e forma:SolidPeso molecolare:495.53GDCNF-11
CAS:GDCNF-11, an HSP90-based HIM-PROTACGPX4 degrader, facilitates the ubiquitination and degradation of GPX4 through the HSP90 chaperone complex. This reduction in endogenous GPX4 induces ferroptosis in HT-1080 cells, with a DC50 value of 0.08 μM.Formula:C48H53Cl2N13O5SColore e forma:SolidPeso molecolare:994.99Uvarigrin
CAS:Uvarigrin induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation. Uvarigrin is isolated from the roots of Uvaria calamistrata.Formula:C37H68O6Purezza:98%Colore e forma:SolidPeso molecolare:608.93EGFR-IN-151
EGFR-IN-151 (Compound 10) inhibits EGFR and its downstream signaling pathways ERK/STAT3. It effectively suppresses the proliferation of various lung cancer cells, with IC50 values of 11.7, 5.19, 7.32, and 1.53 μM for NCI-H1781, HCC827, NCI-H3255, and NCI-H1975, respectively. Additionally, EGFR-IN-151 hinders colony formation and cell migration in H1975, induces G1 phase cell cycle arrest, and triggers apoptosis in H1975 cells.Colore e forma:Odour SolidUSP7-IN-9
USP7-IN-9 is a potent USP7 inhibitor (IC50 = 40.8 nM), induces apoptosis, arrests RS4;11 cells, and modulates key oncoproteins.Formula:C32H33ClF6N6O8Colore e forma:SolidPeso molecolare:779.08eIF4E-IN-3
CAS:eIF4E-IN-3: potent eIF4e inhibitor with promise for cancer study.
Formula:C34H30ClF3N6O4SColore e forma:SolidPeso molecolare:711.16CDK-IN-14
CDK-IN-14 (B34) is a CDK2 inhibitor (IC50=0.097 μM) that exhibits anti-hepatocellular carcinoma activity. It inhibits the cell cycle in HepG-2 cancer cells and induces apoptosis (apoptosis) through a caspase-mediated mechanism.Colore e forma:Odour SolidCDK/HDAC-IN-4
CDK/HDAC-IN-4 is a highly selective dual inhibitor of cyclin-dependent kinase (CDK) and histone deacetylase (HDAC), with IC50 values of 88.4 nM and 168.9 nM, respectively. This compound exhibits antiproliferative effects in both hematologic and solid tumor cells. Additionally, CDK/HDAC-IN-4 induces apoptosis and S-phase cell cycle arrest in MV-4-11 cells. It has also demonstrated significant antitumor efficacy in an MV-4-11 xenograft model.Colore e forma:Odour SolidTNF-α (31-45), human
CAS:TNF-α (31-45), human is a peptide of tumor necrosis factor-α.Formula:C69H122N26O22Purezza:98%Colore e forma:SolidPeso molecolare:1667.895MitoTam bromide, hydrobromide
CAS:MitoTam bromide hydrobromide is an electron transport chain (ETC) inhibitor.Formula:C52H60Br2NOPPurezza:98%Colore e forma:SolidPeso molecolare:905.82Ferroptosis-IN-12
Ferroptosis-IN-12 (Cpd-A1) is an inhibitor of ferroptosis. It effectively suppresses ferroptosis in mouse renal tubular epithelial cells (mTECs) treated with Erastin and improves renal function in dose-dependent manners in mouse models of acute kidney injury (AKI) induced by ischemia/reperfusion (I/R) or cecal ligation and puncture (CLP). This compound also reduces renal tubular damage and eliminates inflammation. Exhibiting good plasma stability and high distribution in renal tissues during pharmacokinetic studies in mice, Ferroptosis-IN-12 shows promising potential for research in the field of AKI.Colore e forma:Odour SolidARD-61
CAS:ARD-61: potent PROTAC, degrades AR/PR in AR+ cancers, triggers apoptosis, inhibits tumor growth in mice.Formula:C61H71ClN8O7SColore e forma:SolidPeso molecolare:1095.8L-threo-PPMP
CAS:L-threo-PPMP blocks GlcT, curbs glycosphingolipid creation, and triggers cell death, showing anti-cancer effects.Formula:C29H50N2O3Colore e forma:SolidPeso molecolare:474.73NA-Ir
CAS:NA-Ir is a ferroptosis (Ferroptosis) inducer that targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to stimulate ferritin autophagy (). It also induces the production of reactive oxygen species (ROS) through photodynamic therapy (PDT), depletes glutathione (GSH), and downregulates glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and ferroptosis. NA-Ir exhibits enhanced anticancer activity under light exposure and selectively inhibits cancer cells with high H2S content.Formula:C49H36F6IrN8O4PColore e forma:SolidPeso molecolare:1138.04ZMF-24
ZMF-24 is an anti-triple-negative breast cancer (TNBC) agent that exhibits IC50 values of 0.22 μM and 0.44 μM against BT-549 and MDA-MB-231 TNBC cell proliferation, respectively. It targets the eukaryotic translation initiation factor 3 subunit D (EIF3D), disrupting TNBC's energy supply by inhibiting glycolysis. Additionally, ZMF-24 induces TNBC cell apoptosis (apoptosis) by stimulating sustained endoplasmic reticulum stress.Colore e forma:Odour SolidHDAC-IN-79
HDAC-IN-79 (compound 4) is an orally active dual inhibitor of xanthine oxidase and HDAC, exhibiting potent anti-hyperuricemia and antitumor activities in vivo (Xanthine oxidase: IC50=6.6 nM; HDAC1: IC50=134 nM; HDAC2: IC50=284 nM; HDAC3: IC50=173 nM; HDAC6: IC50=1.32 nM). Among leukemia cells, it is most effective in inhibiting the growth of HL60 cells (IC50=0.706 μM) and induces both apoptosis and autophagy. HDAC-IN-79 also modulates the expression levels of biomarkers associated with intracellular HDAC inhibition.Colore e forma:Odour SolidJC2-11
CAS:JC2-11 is an anti-inflammatory agent blocking NLRC 4, AIM 2, ROS production, caspase-1 activity, and reducing GSDMD, IL-1β, and LDH in vesicles.
Formula:C17H15FO4Purezza:98.6%Colore e forma:SoildPeso molecolare:302.3CDK9-IN-24
CDK9-IN-24 (compound 21a) is a potent and selective inhibitor of CDK9 that exhibits a pronounced inhibitory impact on tumor proliferation.Formula:C27H31N3O4Purezza:98%Colore e forma:SolidPeso molecolare:461.55Met-12
CAS:Met-12 is a peptide inhibitor of the Fas receptor. It suppresses Fas receptor-mediated apoptosis in photoreceptor cells and reduces Caspase activation, making it a potential candidate for research on photoreceptor protectants.Formula:C71H99N17O17Colore e forma:SolidPeso molecolare:1462.65GPX4-IN-6
CAS:GPX4-IN-6 is a GPX4 inhibitor with antitumor activity.GPX4-IN-6 induces iron death and is used for the treatment and prevention of triple-negative breast cancerFormula:C18H17BrFNO5Purezza:99.54%Colore e forma:SoildPeso molecolare:426.23MDMX/MDM2-IN-2
MDMX/MDM2-IN-2 is a potent dual inhibitor of p53-MDM2/MDMX, demonstrating dissociation constants (Kis) of 0.23 μM for MDM2 and 2.45 μM for MDMX.Formula:C28H25Cl3FN3O3Colore e forma:SolidPeso molecolare:576.87HNPMI
CAS:HNPMI is an epidermal growth factor receptor inhibitor that promotes apoptosis and is used in the study of colorectal cancer.Formula:C22H20N2O3Purezza:97.19%Colore e forma:SoildPeso molecolare:360.41Apoptosis inducer 32
Apoptosisinducer 32 (Compound 7g) is an apoptosis inducer with a KD of 42 μM, demonstrating antitumor activity by causing significant morphological changes, such as membrane blebbing, nuclear fragmentation, and apoptotic body formation, in MDA-MB-231 cells. The IC50 values for Apoptosisinducer 32 are 4.77 μM in MCF-7 cells, 6.56 μM in MDA-MB-231 cells, and 337.8 μM in HEK cells.Formula:C29H27Cl2N3O8Colore e forma:SolidPeso molecolare:616.45CAY10726
CAS:CAY10726, an arylurea fatty acid, cuts ATP by 28% and promotes apoptosis in breast cancer cells by depleting mitochondrial lipids.Formula:C24H36ClF3N2O3Colore e forma:SolidPeso molecolare:493Pipernonaline
CAS:Pipernonaline is a useful organic compound for research related to life sciences. The catalog number is T124000 and the CAS number is 88660-10-0.Formula:C21H27NO3Colore e forma:SolidPeso molecolare:341.451eIF4E-IN-2
CAS:eIF4E-IN-2 effectively inhibits eIF4e, crucial for research on diseases like cancer.Formula:C37H33ClF2N8O4S2Colore e forma:SolidPeso molecolare:791.29
