Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(1 prodotti)
- Caspasi(154 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(109 prodotti)
- PDK(9 prodotti)
- PERK(26 prodotti)
- Chinasi di serina/treonina(18 prodotti)
- Survivin(14 prodotti)
- TNF(64 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6100 prodotti di "Apoptosi"
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Human PD-L1 inhibitor IV
CAS:PD-L1 inhibitor IV, a polypeptide, competitively blocks hPD-1 with a Kd of 1.38 μM, preventing hPD-1/hPD-L1 interaction.Formula:C80H113N25O27Colore e forma:SolidPeso molecolare:1856.932Anticancer agent 154
Anticancer agent 154 (Compound 8h) enhances reactive oxygen species production, causing mitochondrial damage, and promotes cell apoptosis and DNA damage.Formula:C22H23N5O2Purezza:98%Colore e forma:SolidPeso molecolare:389.45EPZ020411 hydrochloride
CAS:EPZ020411 hydrochloride is a selective and potent small molecule PRMT6 inhibitor with an IC50 value of 10 nM.Formula:C25H39ClN4O3Purezza:99.88%Colore e forma:SolidPeso molecolare:479.05Ref: TM-T22325
1mg60,00€5mg131,00€10mg215,00€25mg369,00€50mg563,00€100mg805,00€1mL*10mM (DMSO)145,00€PTD10
CAS:PTD10 is a BTK-targeting PROTAC degradator, induces apoptosis via caspase-dependent and mitochondrial pathways, B-cell dysregulation.Formula:C49H51N11O8Purezza:99.12%Colore e forma:SolidPeso molecolare:922.99NC-R17
NC-R17, an RSL3-based noncovalent GPX4 degrader implicated in ferroptosis, demonstrates anti-tumor activity and is utilized in the design of noncovalent GPX4-Formula:C53H67N7O7Purezza:98%Colore e forma:SolidPeso molecolare:914.14BCL-XL-IN-3
CAS:BCL-XL-IN-3 (Compound 11) is an inhibitor of BCL-XL, with a Ki of less than 0.01 nM. It suppresses cell viability in both normal Molt-4 cells and digitonin-permeabilized Molt-4 cells, with EC50 values of 77.8 nM and 0.07 nM, respectively. BCL-XL-IN-3 can be utilized as an ADC toxin for synthesizing Clezutoclax.Formula:C46H55N7O6SColore e forma:SolidPeso molecolare:834.04FR900359
CAS:FR900359 is a macrocyclic Gq protein inhibitor that inhibits melanoma cell proliferation and can be used to study asthma, inflammation and cancer.Formula:C49H75N7O15Purezza:98%Colore e forma:SolidPeso molecolare:1002.16Thalidomide-O-C5-acid
CAS:Thalidomide-O-C5-acid, a synthesized E3 ligase linker, merges cereblon and PROTAC tech.Formula:C19H20N2O7Colore e forma:SolidPeso molecolare:388.376N-Deshydroxyethyl Dasatinib
CAS:N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAPFormula:C20H22ClN7OSPurezza:95.96%Colore e forma:SolidPeso molecolare:443.95Ref: TM-T18750
1mg52,00€5mg111,00€10mg170,00€25mg294,00€50mg425,00€100mg583,00€200mg790,00€1mL*10mM (DMSO)127,00€EM 163
CAS:EM 163是一种 TIR-TIR 相互作用抑制剂，它是MyD88蛋白的TIR（Toll/白细胞介素-1受体）结构域拟态。EM 163针对IL-1受体中的TIR 结构域，阻断与MyD88的相互作用。EM 163抑制葡萄球菌肠毒素B（SEB）引起的体内炎症细胞因子的产生。EM 163能保护小鼠免受SEB 冲击引起的死亡。在体外的大鼠海马神经元中，EM 163阻断p38的激活和IL-1β对化学诱导的长期电位（LTP）引发的蛋白质合成的抑制作用。Formula:C44H60IN5O4Purezza:98.62%Colore e forma:SolidPeso molecolare:849.88Ref: TM-T41142
1mg114,00€5mg264,00€10mg354,00€25mg592,00€50mg843,00€100mg1.144,00€500mg2.295,00€1mL*10mM (DMSO)414,00€Sandacanol
CAS:Sandacanol (Sandranol) is an olfactory receptor (OR10H1) agonist.Sandacanol induces cell cycle arrest and partial apoptosis in bladder cancer cells.Formula:C14H24OPurezza:99.59%Colore e forma:SolidPeso molecolare:208.34Antitumor agent-150
Antitumor agent-150 (V10) is a breast cancer treatment that functions as a PROTAC degrader of MDM2.Formula:C70H106N8O14SPeso molecolare:1314.75492Thrombospondin-1 (1016-1023) (human, bovine, mouse)
CAS:Thrombospondin-1 (1016-1023) (human, bovine, mouse) is part of Thrombospondin-1 (TSP-1), a peptide with CD47 agonism.Formula:C56H81N13O10SPurezza:99.23%Colore e forma:SolidPeso molecolare:1128.39Ref: TM-T75720
1mg52,00€5mg111,00€10mg175,00€25mg283,00€50mg439,00€100mg633,00€1mL*10mM (DMSO)212,00€PD-1/PD-L1-IN-39
PD-1/PD-L1-IN-39 (X 14) is an orally active PD-1/PD-L1 inhibitor with an IC50 value of 15.73 nM. It exhibits strong binding affinity to human and mouse PD-L1, with KD values of 14.62 and 392 nM, respectively. PD-1/PD-L1-IN-39 also demonstrates antitumor activity.Formula:C23H20ClFN2O3Peso molecolare:426.11465POV-PC
CAS:POV-PC is an oxidized phospholipid that inhibits VSMC growth under high serum conditions and induces cell apoptosis under low serum conditions.Formula:C29H56NO9PColore e forma:SolidPeso molecolare:593.73WK369
WK369 is an innovative small molecule inhibitor of BCL6, demonstrating remarkable bioactivity against ovarian cancer by inducing cell cycle arrest and triggering apoptosis. It binds directly to the BCL6-BTB domain, obstructing the interaction between BCL6 and SMRT, which results in the reactivation of p53, ATR, and CDKN1A.Formula:C19H20FN5O2Peso molecolare:369.1601Thiocolchicine
CAS:Thiocolchicine inhibits tubulin polymerization (IC50: 2.5 µM, Ki: 0.7 µM), induces apoptosis, and serves as an ADC cytotoxin.Formula:C22H25NO5SPurezza:98.19%Colore e forma:SolidPeso molecolare:415.5Antimycobacterial agent-5
Antimycobacterial agent-5 (compound 27) is an imidazopyridine amide compound that targets the Mycobacterium electron transport chain (ETC) respiratory CIII2CIV2 supercomplex. It acts on Mycobacterium smegmatis CIII2CIV2 with an IC50 of 441 nM.Formula:C25H34ClN3OPeso molecolare:427.23904Ru-Poma
Ru-Poma is an Ru(II)-based photosensitizer designed to enhance the efficacy of photodynamic therapy (PDT) against tumors resistant to Cisplatin. It targets Pomalidomide to partially degrade CRBN, inducing ferroptosis by increasing lipid peroxides and downregulating GPX4 and GAPDH expression. In A549 cells, Ru-Poma exhibits cytotoxicity with IC50 values of 18.46 μM in the dark and 0.37 μM under illumination.Formula:C89H75Cl2N11O11Ru·7H2OTopoisomerase II inhibitor 17
TopoisomeraseII inhibitor 17 (compound 4c) is a thiazolopyrimidine-based inhibitor of Topoisomerase II with an IC50 of 0.23 μM. This compound significantly disrupts the cell cycle and induces apoptosis.Formula:C25H22Cl3N3O5SPeso molecolare:581.03458
