Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(2 prodotti)
- Caspasi(153 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(94 prodotti)
- PDK(9 prodotti)
- PERK(26 prodotti)
- Chinasi di serina/treonina(18 prodotti)
- Survivin(14 prodotti)
- TNF(49 prodotti)
- c-RET(60 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6037 prodotti di "Apoptosi"
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MC-25B
MC-25B is a selective FKBP12 PROTAC degrader. It effectively degrades FKBP12 with a DC50 of 0.35 μM and a Dmax of 89%. MC-25B facilitates the degradation of nuclear-localized FKBP12 through a mechanism dependent on DCAF16.Formula:C65H92ClN7O14Colore e forma:SolidPeso molecolare:1230.92GL392
GL392 is a senolytic agent that delivers the potent senescence-clearing compound Dasatinib specifically to senescent cells. By targeting the LBD domain, it binds lipofuscin in these cells and releases Dasatinib via an ester linkage, inducing apoptosis (Apoptosis) in senescent cells. Additionally, GL392 is encapsulated in PEO-b-PCL microcapsules to ensure efficient intracellular delivery while minimizing systemic toxicity. GL392 is applicable in cancer research.Formula:C55H52ClN13O5SColore e forma:SolidPeso molecolare:1042.610-SLF
CAS:10-SLF is a PROTAC FKBP12 degrader. It facilitates the formation of a ternary complex between FKBP12 and FBXW7-R465C, leading to the proteasomal degradation of FKBP12 in a FBXW7-R465C-dependent manner. 10-SLF selectively reduces FKBP12 levels in cells that express FBXW7-R465C.Formula:C59H76Cl2N4O13Colore e forma:SolidPeso molecolare:1120.16C-Met/Axl-IN-1
C-Met/Axl-IN-1 (Compound 22a) is an oral, selective type II c-Met/Axl inhibitor with IC50 values of 1 nM and 10 nM, respectively. It effectively suppresses tumor cell proliferation, induces cell cycle arrest, and apoptosis (apoptosis), showcasing potent anti-tumor activity.Formula:C25H18F2N6O2Colore e forma:SolidPeso molecolare:472.45SPOP-IN-6lc
CAS:SPOP-IN-6lc is a SPOP inhibitor with oncogenic effects in renal cancer cells.SPOP-IN-6lc can be used to study apoptosis.
Formula:C26H31N7O2SPurezza:99.19%Colore e forma:SolidPeso molecolare:505.64Cuprichydroxide
CAS:Cuprichydroxide exhibits inhibitory activity against Ralstonia solanacearum and A549 cells and has acute pulmonary toxicity.Formula:CuH2O2Colore e forma:SolidPeso molecolare:97.56Moracin N
CAS:Moracin N, a ferroptosis inhibitor derived from mulberry leaves, exhibits neuroprotective activity by mitigating oxidative stress [1].Formula:C19H18O4Purezza:98%Colore e forma:SolidPeso molecolare:310.34Thalidomide-O-PEG2-propargyl
CAS:Thalidomide-O-PEG2-propargyl is a cereblon-based E3 ligase ligand with a PEG linker for PROTAC-induced protein degradation.Formula:C20H20N2O7Purezza:98%Colore e forma:SolidPeso molecolare:400.38TNF-α-IN-6
CAS:TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM).
Formula:C26H25N9O2Colore e forma:SolidPeso molecolare:495.547Monactin
CAS:Monactin is a Marcrotetrolide antibiotic produced by cycloheximide producing species of Streptomyces. It is a homolog of nonactin from the same species.Formula:C41H66O12Purezza:98%Colore e forma:SolidPeso molecolare:750.96Cefatrizine
CAS:Cefatrizine inhibits eEF-2 kinase, affecting apoptosis, autophagy, and ER stress in cancers.Formula:C18H18N6O5S2Purezza:98%Colore e forma:SolidPeso molecolare:462.5PROTAC FLT-3 degrader 1
CAS:PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity.Formula:C52H61N9O9S2Purezza:98%Colore e forma:SolidPeso molecolare:1020.23Methyl-4-oxoretinoate
CAS:Methyl-4-oxoretinoate is a synthetic retinoid with anticancer properties, used for skin conditions and potential ocular treatments.Formula:C21H28O3Purezza:99.95%Colore e forma:SolidPeso molecolare:328.45KB02-SLF
KB02-SLF, a molecular glue, degrades nuclear FKBP12 by modifying E3 ligase DCAF16 and extends protein degradation.Formula:C50H65ClN4O12Purezza:98%Colore e forma:SolidPeso molecolare:949.52Fosbretabulin [free base]
CAS:Fosbretabulin is a natural cis-stilbene that interferes with cellular tubulin dynamics and selectively destroys tumor blood vessels.
Formula:C18H21O8PColore e forma:SolidPeso molecolare:396.33Thalidomide-O-amido-PEG3-C2-NH2
CAS:Thalidomide-O-amido-PEG3-C2-NH2 is a cereblon ligand-linker for PROTACs with a 3-unit PEG.Formula:C23H30N4O9Purezza:98%Colore e forma:SolidPeso molecolare:506.51KWCN-41
CAS:KWCN-41, Selective RIPK1 inhibitor (IC50=88 nM), inhibits necrosis specifically, anti-inflammatory effects.Formula:C18H17N3O2Colore e forma:SolidPeso molecolare:307.35BIO8898
BIO8898: potent CD40-CD154 inhibitor, IC50 of 25 µM, prevents CD40L-induced apoptosis.Formula:C53H64N8O6Colore e forma:SolidPeso molecolare:909.13GSK-3β inhibitor 15
GSK-3β inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Aβ 1-42-induced phosphorylation of GSK-3β and tau protein, as well as LPS-Formula:C17H16N6OSColore e forma:SolidPeso molecolare:352.41HDAC-IN-57
CAS:HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4Formula:C21H19N3O4Purezza:98.62%Colore e forma:SoildPeso molecolare:377.39
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