Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(1 prodotti)
- Caspasi(154 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(113 prodotti)
- PDK(9 prodotti)
- PERK(26 prodotti)
- Chinasi di serina/treonina(18 prodotti)
- Survivin(14 prodotti)
- TNF(65 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6107 prodotti di "Apoptosi"
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iNOS/TopoI-IN-1
Compound AuL9, also known as iNOS/TopoI-IN-1, is a multi-target hybrid molecule possessing anti-tumor, anti-inflammatory, and antioxidant properties. This compound effectively inhibits the growth of MCF-7 and MDA MB-231 breast cancer cells in vitro, exhibiting IC50 values of 3.5 μM and 6.3 μM respectively. It also prompts DNA damage and apoptosis in these cells by inhibiting human topoisomerase I (TopoI) with a K_i of 2.72 μM. Additionally, iNOS/TopoI-IN-1 reduces the expression of iNOS by suppressing the activation of NF-kB, with a K_i of 1.49 μM.Formula:C34H40AuBrCl2N3OSColore e forma:SolidPeso molecolare:886.54S-Adenosyl-L-methionine
CAS:S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.Formula:C15H22N6O5SPurezza:99.08%Colore e forma:SolidPeso molecolare:398.44PARP1-IN-17
PARP1-IN-17 is an inhibitor that targets PARP-1 (IC50=19.24 nM ) with a slightly reduced affinity for PARP-2 (IC50=32.58 nM ) and induces apoptosis.Purezza:98%Colore e forma:Odour SolidKRAS inhibitor-40
CAS:KRAS inhibitor-40 (Compound 41) is an inhibitor of KRAS, disrupting the KRAS G12C-BRAF complex and suppressing the phosphorylation of the downstream ERK signaling pathway. This compound also inhibits the proliferation of tumor cells with various KRAS mutations, exhibiting antitumor activity.Formula:C53H66ClF4N9O8SColore e forma:SolidPeso molecolare:1100.66PERK-IN-4
CAS:PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Formula:C24H19F4N5OPurezza:99.44% - 99.49%Colore e forma:SolidPeso molecolare:469.43PAA5
PAA5, a polynuclear Au(I) cluster, triggers ferroptosis and has anticancer effects by increasing pH2AX over time.Formula:C14H8Au5B2F8N2Colore e forma:SolidPeso molecolare:1348.66Antitumor photosensitizer-6
CAS:Compound Ru2 (Antitumor photosensitizer-6) exhibits synergistic type I/II photosensitization and photocatalytic activities under illumination at 595 nm. It causes oxidative redox imbalance within cells, affecting biosynthesis and metabolic processes, leading to cell apoptosis (Apoptosis). Compound Ru2 is applicable in studies of photodynamic therapy (PDT).Formula:C74H46F26N14P4Ru2S3Colore e forma:SolidPeso molecolare:2047.44EGFR kinase inhibitor 7
EGFRkinase inhibitor 7 (compound 18i) is an EGFR inhibitor with an IC50 of 42.3 nM, exhibiting anticancer properties. This compound demonstrates significant in vitro cytotoxicity and capacity to induce apoptosis. Furthermore, EGFRkinase inhibitor 7 displays anti-proliferative activity against human colon cancer cell line HCT116 and human non-small cell lung cancer cell line A549, with IC50 values of 4.82 µM and 1.43 µM, respectively.Formula:C28H26Cl2FN3O3SSeColore e forma:SolidPeso molecolare:653.45BTK-IN-37
BTK-IN-37 (compound 8d), a BTK inhibitor, demonstrates potent apoptotic effects on cancer cells by targeting BTK with K_i and IC_50 values of 5.07 nM and 3.6 nM, respectively. Additionally, this compound selectively promotes the enrichment of genes associated with necroptosis and pyroptosis.Formula:C29H29N9O4SColore e forma:SolidPeso molecolare:599.66Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl
CAS:Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl is an E3 ligase ligand-linker conjugate containing the E3 ubiquitin ligase cereblon (CRBN) and linker.Formula:C17H19ClN4O6Purezza:99.78%Colore e forma:SolidPeso molecolare:410.81Apoptosis inducer 33
Apoptosisinducer 33 (compound H2) is a hydrazone derivative. It exhibits antioxidant and antimicrobial properties, capable of inhibiting the growth of Staphylococcus aureus, Escherichia coli, and Candida albicans. Additionally, Apoptosisinducer 33 can suppress tumor cell proliferation and induce apoptosis (apoptosis), making it useful for tumor research.Formula:C16H13N3O2Colore e forma:SolidPeso molecolare:279.293JAK/HDAC-IN-2
JAK/HDAC-IN-2, a potent 2-amino-4-phenylaminopyrimidine dual-target inhibitor, effectively suppresses JAK1/2 and HDAC3/6 at nanomolar concentrations.Formula:C28H38N6O5SPurezza:98%Colore e forma:SolidPeso molecolare:570.7HNPMI
CAS:HNPMI is an epidermal growth factor receptor inhibitor that promotes apoptosis and is used in the study of colorectal cancer.Formula:C22H20N2O3Purezza:97.19%Colore e forma:SoildPeso molecolare:360.41PROTAC Bcl-xL degrader-2
PROTAC Bcl-xL degrader-2, based on von Hippel-Lindau ligand, is a potent degrader of Bcl-xL (a Bcl-2 family member), demonstrating an IC 50 of 0.6 nM.Formula:C68H80N8O14S3Colore e forma:SolidPeso molecolare:1329.6PRMT5-IN-31
PRMT5-IN-31 (Compound 3m), a selective PRMT5 inhibitor (IC50: 0.31 μM), increases hnRNP E1 protein levels by occupying the substrate site of PRMT5 andFormula:C21H24N2O2Purezza:98%Colore e forma:SolidPeso molecolare:336.43S65487 hydrochloride
CAS:S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y.Formula:C41H42Cl2N6O4Colore e forma:SolidPeso molecolare:753.73Enterodiol
Enterodiol is a natural product that can be used as a reference standard.Formula:C18H22O4Colore e forma:SolidPeso molecolare:302.37Thalidomide-NH-C6-NH2 TFA
CAS:Thalidomide-based cereblon ligand linked to PROTAC technology as E3 ligase ligand-linker.Formula:C21H25F3N4O6Purezza:98%Colore e forma:SolidPeso molecolare:486.44FC-116
CAS:FC-116 is a potent Tubulin inhibitor with antitumour activity and inhibits tumour growth in mice.FC-116 induces apoptosis and promotes protein degradation.Formula:C21H20FNO4Purezza:98.18%Colore e forma:SoildPeso molecolare:369.39Ref: TM-T77519
1mg52,00€5mg111,00€10mg177,00€25mg313,00€50mg447,00€100mg587,00€200mg800,00€1mL*10mM (DMSO)127,00€KT5823
CAS:KT5823 is a cGMP-dependent protein kinase (PKG) inhibitor that increases iodide ion uptake by regulating the expression of sodium iodide symporter protein.Formula:C29H25N3O5Purezza:95%Colore e forma:SolidPeso molecolare:495.53
