Apoptosi
Gli inibitori dell'apoptosi sono composti che prevengono o ritardano il processo di morte cellulare programmata, noto come apoptosi. Questi inibitori sono fondamentali per lo studio dei meccanismi di sopravvivenza cellulare e vengono utilizzati per indagare sulle malattie in cui l'apoptosi è disregolata, come il cancro, i disturbi neurodegenerativi e le malattie autoimmuni. Modulando l'apoptosi, questi inibitori possono aiutare nello sviluppo di terapie mirate a controllare la morte cellulare. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'apoptosi di alta qualità per supportare le tue ricerche in biologia cellulare, oncologia e campi correlati.
Sottocategorie di "Apoptosi"
- ASK(9 prodotti)
- BCL(1 prodotti)
- Caspasi(154 prodotti)
- FOXO1(2 prodotti)
- IAP(67 prodotti)
- Mdm2(12 prodotti)
- PD-1/PD-L1(127 prodotti)
- PDK(9 prodotti)
- PERK(23 prodotti)
- Chinasi di serina/treonina(17 prodotti)
- Survivin(14 prodotti)
- TNF(90 prodotti)
- c-RET(61 prodotti)
- p53(63 prodotti)
Mostrare 6 più sottocategorie
Trovati 6170 prodotti di "Apoptosi"
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YX-02-030
CAS:YX-02-030M is a PROTACMDM2 degrader. It inhibits the binding of MDM2 to p53 and VHL to HIF1α, with IC50 values of 63 nM and 1.35 μM, respectively. YX-02-030M binds to MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, effectively killing p53 mutant or deficient triple-negative breast cancer (TNBC) cells.
Formula:C66H85Cl2N9O10SPeso molecolare:1267.41AKN-028
CAS:AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
Formula:C17H14N6Purezza:99.88%Colore e forma:SolidPeso molecolare:302.33Mcl1-IN-12
CAS:Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.Formula:C45H46N4O6S2Purezza:98%Colore e forma:SolidPeso molecolare:803NAE-IN-1
NAE-IN-1 (compound X-10) is a potent inhibitor of NAE1. It induces apoptosis and causes cell cycle arrest in the G2/M phase. Furthermore, NAE-IN-1 increases ROS levels and inhibits cell migration, demonstrating antiproliferative activity.Formula:C29H30N4O2SPeso molecolare:498.20895HEMTAC CDK4/6 degrader 1
CAS:HEMTAC CDK4/6 degrader 1, a PROTAC targeting HSP90/CDK4/6, Kd of 35.7 μM, disrupts B16F10 melanoma cell cycle, and induces apoptosis.Formula:C48H53ClN16O4Colore e forma:SolidPeso molecolare:953.49BIM-46174 HCl
BIM-46174 HCl is a G-protein inhibitor with anticancer activity that induces cysteine 3-dependent apoptosis.
Formula:C22H31ClN4OSPurezza:99.77% - 99.77%Colore e forma:SolidPeso molecolare:435.03OPBP-1
OPBP-1 is a D-peptide developed through phage display screening, molecular docking, and molecular dynamics simulations. It exhibits high stability, strong antitumor activity, and oral bioavailability. OPBP-1 selectively binds to the PD-L1 protein, significantly blocking the interaction between PD-1 and PD-L1, which helps restore and enhance T lymphocyte function while reducing the proportion of myeloid-derived suppressor cells (MDSCs), counteracting tumor-induced immune evasion. OPBP-1 is applicable for research in cancer immunotherapy.Formula:C64H92N20O19SPeso molecolare:1476.65683PROTAC GPX4 degrader-2
PROTACGPX4 degrader-2 (compound 18a) is a proteolysis-targeting chimera (PROTAC) that targets the degradation of glutathione peroxidase 4 (GPX4), with a DC50, 48h value of 1.68 μM. It induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. Additionally, PROTACGPX4 degrader-2 exhibits antiproliferative activity.Formula:C50H61ClN8O9Peso molecolare:952.425MX106-4C
MX106-4C is a survivin inhibitor that selectively targets ABCB1-positive colorectal cancer cells. It can work synergistically with Doxorubicin for enhanced anticancer effects or restore Doxorubicin sensitivity in drug-resistant ABCB1 cells.Formula:C23H25BrN2O2Peso molecolare:440.10994Anticancer agent 204
Anticanceragent 204 (Compound 6) is a fluorinated derivative of cinnamamides with anticancer activity. It can arrest the cell cycle of HepG2 cells in the G1 phase and induces apoptosis by reducing mitochondrial membrane polarization (MMP) levels.Formula:C26H18FN5O3SPeso molecolare:499.11144Necrosis inhibitor 2 (hydrocholide)
Necrosis inhibitor 2 hydrochloride (Compound B19) is an agent that inhibits cellular necrosis. It is useful for researching diseases associated with necrotic pathways, including inflammation, cancer, metabolic disorders, and neurodegenerative diseases.Formula:C24H26ClN5O5Peso molecolare:499.16225Thalidomide-N-C3-O-C4-O-C3-OH
Thalidomide-N-C3-O-C4-O-C3-OH is a conjugate of an E3 ligase ligand and a linker, used in the synthesis of the Aster-APROTAC degrader.Formula:C23H31N3O7Peso molecolare:461.2162MALT1-IN-13
MALT1-IN-13 (compound 10m) is an inhibitor of the mucosa-associated lymphoid tissue lymphoma translocation protein (MALT1), forming a covalent and irreversible bond with the MALT1 protease, thereby inhibiting its activity with an IC50 of 1.7 μM. It suppresses the proliferation of ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1 cells. Additionally, MALT1-IN-13 regulates the mTOR and PI3K-Akt pathways.Formula:C20H15BrClN3O3S2Peso molecolare:522.94267EJMC-1
CAS:EJMC-1 is an inhibitor of TNF-α with an IC50 value of 42 μM and can be used in studies about auto-inflammatory diseases.Formula:C17H11ClN2O4SPurezza:98.38%Colore e forma:SolidPeso molecolare:374.8Delmitide
CAS:Delmitide, a TNF-alpha production inhibitor, is used potentially for the treatment of Crohn's disease and ulcerative colitis.Formula:C59H105N17O11Purezza:98%Colore e forma:SolidPeso molecolare:1228.57Cholesteryl Hemisuccinate Tris Salt
CAS:Cholesteryl Hemisuccinate Tris Salt is a cholesteryl ester with anticancer activity.Cholesteryl hemisuccinate has antitumor activity and inhibits tumor growth.Formula:C35H61NO7Purezza:≥98%Colore e forma:SolidPeso molecolare:607.86Z-DQMD-FMK
CAS:Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.
Formula:C29H40FN5O11SPurezza:98%Colore e forma:SolidPeso molecolare:685.72F1324 TFA
F1324 TFA is a potent, high affinity peptidic inhibitor of B cell lymphoma 6 (BCL6), with an IC50 of 1 nM.Formula:C85H122N21F3O22SPurezza:98%Colore e forma:SolidPeso molecolare:1879.06Ecdysone
CAS:Ecdysone is a major steroid hormone in insects and herbs.Formula:C27H44O6Purezza:99.22%Colore e forma:PowderPeso molecolare:464.63HPOB
CAS:HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.Formula:C17H18N2O4Purezza:99.91%Colore e forma:SolidPeso molecolare:314.34
