Ferroptosi
La ferroptosi è una forma di morte cellulare regolata caratterizzata dall'accumulo di perossidi lipidici e dallo stress ossidativo dipendente dal ferro. A differenza dell'apoptosi, la ferroptosi non è guidata dalle caspasi, ma piuttosto dal fallimento delle difese antiossidanti cellulari, che porta alla morte cellulare. Gli inibitori e gli induttori della ferroptosi sono fondamentali per studiare questa particolare via di morte cellulare, implicata in varie malattie, tra cui il cancro, la neurodegenerazione e il danno da ischemia-riperfusione. Presso CymitQuimica, offriamo una vasta gamma di modulatori della ferroptosi di alta qualità per supportare la tua ricerca sui meccanismi di morte cellulare, stress ossidativo e patologia delle malattie.
Trovati 223 prodotti di "Ferroptosi"
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Simvastatin
CAS:Formula:C25H38O5Purezza:>97.0%(HPLC)Colore e forma:White to Almost white powder to crystalPeso molecolare:418.57Coenzyme Q9
CAS:Formula:C54H82O4Purezza:>98.0%(HPLC)Colore e forma:Light yellow to Yellow to Orange powder to crystalPeso molecolare:795.25Ferrostatin-1
CAS:Formula:C15H22N2O2Purezza:>98.0%(HPLC)Colore e forma:White to Amber to Dark purple powder to crystalPeso molecolare:262.35Sulfasalazine
CAS:Formula:C18H14N4O5SPurezza:>95.0%(T)(HPLC)Colore e forma:Light yellow to Amber to Dark green powder to crystalPeso molecolare:398.396-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid
CAS:Formula:C14H18O4Purezza:>98.0%(GC)(T)Colore e forma:White to Orange to Green powder to crystalinePeso molecolare:250.29Baicalein
CAS:Formula:C15H10O5Purezza:>98.0%(T)Colore e forma:Light yellow to Amber to Dark green powder to crystalPeso molecolare:270.24Ebselen
CAS:Formula:C13H9NOSePurezza:>98.0%(GC)Colore e forma:Light orange to Yellow to Green powder to crystalPeso molecolare:274.18Coenzyme Q10
CAS:Formula:C59H90O4Purezza:>98.0%(HPLC)Colore e forma:Light yellow to Yellow to Orange powder to crystalPeso molecolare:863.37L-Glutamic Acid
CAS:Formula:C5H9NO4Purezza:>99.0%(T)Colore e forma:White powder to crystalPeso molecolare:147.13Erastin
CAS:Formula:C30H31ClN4O4Purezza:>98.0%(HPLC)(qNMR)Colore e forma:White to Light yellow powder to crystalPeso molecolare:547.05Sulfasalazine
CAS:Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative. Sulfasalazine induces ferroptosis and inhibits NF-κB. Cost effective and quality assured.Formula:C18H14N4O5SPurezza:98.00% - 99.28%Colore e forma:Minute Brownish-Yellow CrystalsPeso molecolare:398.39Pioglitazone hydrochloride
CAS:Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplasticFormula:C19H20N2O3S·HClPurezza:99.64% - >99.99%Colore e forma:White Crystals Or Crystalline PowderPeso molecolare:392.90α-Vitamin E
CAS:α-Vitamin E (Dexrabeprazole Sodium) is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.Formula:C29H50O2Purezza:98% - 99.89%Colore e forma:Light Yellow LiquidPeso molecolare:430.71Fluvastatin sodium
CAS:Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterolFormula:C24H25FNNaO4Purezza:98.54% - 99.56%Colore e forma:Light Yellow Solid PowderPeso molecolare:433.45Sorafenib tosylate
CAS:<p>Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).</p>Formula:C21H16ClF3N4O3·C7H8O3SPurezza:99.24% - 99.94%Colore e forma:White To Off-White Crystalline PowderPeso molecolare:637.036-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
CAS:Formula:C14H18O4Purezza:98%Colore e forma:SolidPeso molecolare:250.2903Ref: IN-DA003N8E
1g30,00€5g66,00€10g114,00€1kgPrezzo su richiesta25g159,00€50g284,00€100g526,00€500gPrezzo su richiesta100mg21,00€250mg25,00€L-Glutathione reduced
CAS:L-Glutathione reduced (Glutathione) is a naturally occurring tripeptide found in cells as an endogenous antioxidant that scavenges oxygen free radicals.Formula:C10H17N3O6SPurezza:97.37% - 99.99%Colore e forma:SolidPeso molecolare:307.32Pravastatin sodium
CAS:Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.Formula:C23H35NaO7Purezza:97.14% - 99.97%Colore e forma:White Crystalline PowderPeso molecolare:446.52Cisplatin
CAS:Cisplatin (CDDP) is a DNA cross-linking agent.Formula:Cl2H6N2PtPurezza:97.13% - 99.63%Colore e forma:Orange-Yellow To Deep Yellow Solid Or PowderPeso molecolare:300.04Lapatinib Ditosylate
CAS:Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).Formula:C29H26ClFN4O4S·2C7H8O3SPurezza:99.41%Colore e forma:Yellow SolidPeso molecolare:925.46(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
CAS:Formula:C25H38O5Purezza:98%Colore e forma:SolidPeso molecolare:418.5662Eugenol
CAS:Eugenol (Allylguaiacol) is a Standardized Chemical Allergen.Formula:C10H12O2Purezza:98.03%Colore e forma:Colorless Or Pale Yellow Liquid Pungent Taste (Ntp 1992)Peso molecolare:164.20Sorafenib
CAS:Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57Formula:C21H16ClF3N4O3Purezza:98% - 99.89%Colore e forma:SolidPeso molecolare:464.82Artemisinin
CAS:Artemisinin (Qinghaosu) is a natural sesquiterpene lactone. Artemisinin has anti-malarial, neuroprotective and anti-tumor effects. Cost-effective and quality-assured.Formula:C15H22O5Purezza:99.77% - 99.87%Colore e forma:Crystalline SolidPeso molecolare:282.33Artesunate
CAS:Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria.Formula:C19H28O8Purezza:97.67% - 99.9%Colore e forma:White Crystalline PowderPeso molecolare:384.42Deferiprone
CAS:Deferiprone (Deferidone) is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity.Formula:C7H9NO2Purezza:99.58% - ≥95%Colore e forma:White NeedlesPeso molecolare:139.15Baicalein
CAS:Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor.Formula:C15H10O5Purezza:97.06% - 98.48%Colore e forma:Yellow Crystalline SolidPeso molecolare:270.24Linagliptin
CAS:Linagliptin (BI 1356) is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.Formula:C25H28N8O2Purezza:99.15% - >99.99%Colore e forma:SolidPeso molecolare:472.542-(10-hydroxydecyl)-6-methoxy-3-methyl-5-(trideuteriomethoxy)cyclohexa-2,5-diene-1,4-dione
CAS:Formula:C19H30O5Purezza:98%Colore e forma:SolidPeso molecolare:338.4385NVS-ZP7-4
CAS:NVS-ZP7-4 is a inhibitor of Zinc transporter SLC39A7 (ZIP7).Formula:C28H28FN5OSPurezza:99.86%Colore e forma:SolidPeso molecolare:501.62Vildagliptin
CAS:Vildagliptin (LAF237), an oral DPP-4 inhibitor with hypoglycemic effects, is metabolized and excreted in urine.Formula:C17H25N3O2Purezza:97.81% - >99.99%Colore e forma:White Crystalline PowderPeso molecolare:303.40Ethylenediaminetetraacetic acid trisodium salt
CAS:Ethylenediaminetetraacetic acid trisodium salt (EDTA Trisodium) used to bind metal ions in the chelation therapy.Formula:C10H13N2Na3O8Purezza:99.92% - 99.96%Colore e forma:White CrystalsPeso molecolare:358.19Dopamine hydrochloride
CAS:Dopamine hydrochloride (ASL279) is a natural catecholamine neurotransmitter, dopamine receptors (D1-5 receptors) (EC50=2.7 nM). High-Quality, Low-Cost!Formula:C8H12ClNO2Purezza:99.47% - 99.72%Colore e forma:SolidPeso molecolare:189.64Simvastatin
CAS:Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity.Formula:C25H38O5Purezza:98.54% - 99.13%Colore e forma:SolidPeso molecolare:418.57Deferasirox
CAS:<p>Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.</p>Formula:C21H15N3O4Purezza:98.79% - 99.4%Colore e forma:SolidPeso molecolare:373.36Lovastatin
CAS:Lovastatin (MK-803) is an HMG-CoA reductase inhibitor. Lovastatin lowers cholesterol and is used as a lipid-lowering agent. Cost-effective and quality-assured.Formula:C24H36O5Purezza:99.66% - 99.92%Colore e forma:The Substance Is A White-Yellowish To Yellow Powder Solid PowderPeso molecolare:404.54Ciclopirox
CAS:Ciclopirox is an antifungal that chelates Fe3+ and Al3+, inhibiting enzymes and has antibacterial and anti-inflammatory effects.Formula:C12H17NO2Purezza:97.72% - 99.78%Colore e forma:SolidPeso molecolare:207.27Roxadustat
CAS:Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.Formula:C19H16N2O5Purezza:99% - 99.88%Colore e forma:SolidPeso molecolare:352.34L-Glutamine
CAS:L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present in the human body and involved in many metabolic processes. High-Quality, Low-Cost!Formula:C5H10N2O3Purezza:99.66% - 99.98%Colore e forma:Solid CrystallinePeso molecolare:146.14Ref: IN-DA00396N
1g24,00€5g40,00€1kgPrezzo su richiesta25g99,00€2kgPrezzo su richiesta50g141,00€5kgPrezzo su richiesta100g196,00€Lapatinib ditosylate monohydrate
CAS:<p>Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.</p>Formula:C29H26ClFN4O4S·2(C7H8O3S)·H2OPurezza:98% - 99.41%Colore e forma:Colourless To Light-Yellow CrystalPeso molecolare:943.47Ciclopirox olamine
CAS:<p>Ciclopirox olamine is a broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities.</p>Formula:C14H24N2O3Purezza:99.16% - >99.99%Colore e forma:White To Yellow Solid Solid Particulate/PowderPeso molecolare:268.35DL-Glutamine
CAS:DL-Glutamine, a non-essential amino acid, is abundant in the body, aids metabolism, carries nitrogen, and fuels cells.Formula:C5H10N2O3Purezza:99.89%Colore e forma:White Crystalline Powder White Crystalline PowderPeso molecolare:146.14Pioglitazone
CAS:Pioglitazone (U 72107) is a selective and oral PPARγ agonist with EC50 of 0.93 and 0.99 μM on human and mouse PPARγ, respectively . High-Quality, Low-Cost!Formula:C19H20N2O3SPurezza:95% - 99.57%Colore e forma:White PowderPeso molecolare:356.44Matrine
CAS:<p>Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.</p>Formula:C15H24N2OPurezza:97.16% - >99.99%Colore e forma:SolidPeso molecolare:248.36Gallic acid
CAS:Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.Formula:C7H6O5Purezza:99.38% - 99.57%Colore e forma:White Solid Solid Particulate/PowderPeso molecolare:170.12Zileuton
CAS:Zileuton (A 64077) inhibits 5-lipoxygenase, reduces leukotrienes, aids bronchodilation, lessens mucus/edema, and helps manage asthma symptoms.Formula:C11H12N2O2SPurezza:98.72% - 99.43%Colore e forma:Crystalline SolidPeso molecolare:236.29Curcumin
CAS:Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity.Formula:C21H20O6Purezza:95% - 98.98%Colore e forma:Orange-Yellow Crystal Powder; Gives Brownish-Red Color With Alkali; Light-Yellow Color With Acids Physical Description Orange-Yellow Needles (Ntp 1992)Peso molecolare:368.38Imidazole ketone erastin
CAS:View and buy Imidazole ketone erastin from TargetMol.Imidazole ketone erastin (IKE) is an inducer of ferroptosis. It has inhibition of the system Xc- cystine/glutamate transporter.Cited in 22 publications.Formula:C35H35ClN6O5Purezza:98.48% - 99.87%Colore e forma:SolidPeso molecolare:655.14FSEN1
CAS:FSEN1 is a novel and highly effective non-competitive FSP1 inhibitor with an IC50 value of 313 nM.Formula:C22H22BrN5OSPurezza:99.54% - 99.97%Colore e forma:SolidPeso molecolare:484.41Butylated hydroxytoluene
CAS:Butylated hydroxytoluene (BHT FCC/NF) is an organic chemical composed of 4-methylphenol modified with tert-butyl groups at positions 2 and 6.Formula:C15H24OPurezza:99.72%Colore e forma:Colourless Solid PowderPeso molecolare:220.35iFSP1
CAS:iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverseFormula:C20H13N5Purezza:98.74% - 99.74%Colore e forma:SolidPeso molecolare:323.35Lapatinib
CAS:Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity.Formula:C29H26ClFN4O4SPurezza:99.00% - 99.81%Colore e forma:PowderPeso molecolare:581.06Acetylcysteine
CAS:Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent.Formula:C5H9NO3SPurezza:98.01% - >99.99%Colore e forma:Crystals From Water SolidPeso molecolare:163.19Rosiglitazone maleate
CAS:Rosiglitazone maleate (BRL 49653) is an oral antidiabetic and potential anticancer agent.Formula:C22H23N3O7SPurezza:99.33% - 99.51%Colore e forma:Off-White SolidPeso molecolare:473.50Butylhydroxyanisole
CAS:BHA is an antioxidant with two isomers: 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole.Formula:C11H16O2Purezza:99.54% - 99.63%Colore e forma:White Solid WaxyPeso molecolare:180.25Ferroptosis inducer-6
CAS:Ferroptosisinducer 6 (6d) is an inducer of ferroptosis (ferroptosis) that exhibits potent potential for Type I/II photodynamic therapy by inducing ROS production, oxidative stress, and mitochondrial damage. Additionally, it demonstrates antitumor activity.Formula:C69H78F12N12P2RuColore e forma:SolidPeso molecolare:1466.44Ferumoxytol
CAS:Ferumoxytol is an iron oxide nanoparticle with anti-leukemia properties, specifically against acute myeloid leukemia (AML) cells with low ferroportin (FPN) expression. By increasing intracellular iron levels, Ferumoxytol induces the Fenton reaction to produce reactive oxygen species (ROS), resulting in oxidative stress and ferroptosis. It selectively kills leukemia cells with low FPN expression while sparing normal cells, making it useful for studying leukemia targeting iron metabolism abnormalities.Colore e forma:SolidGDCNF-11
CAS:<p>GDCNF-11, an HSP90-based HIM-PROTACGPX4 degrader, facilitates the ubiquitination and degradation of GPX4 through the HSP90 chaperone complex. This reduction in endogenous GPX4 induces ferroptosis in HT-1080 cells, with a DC50 value of 0.08 μM.</p>Formula:C48H53Cl2N13O5SColore e forma:SolidPeso molecolare:994.99Ferroptosis Compound Library
<p>A unique collection of 779 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study；</p>Colore e forma:Odour SolidPRLX-93936 HCL
CAS:PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.Formula:C21H26Cl2N4O2Purezza:98.4% - 99.94%Colore e forma:SolidPeso molecolare:437.37CQ-ER
<p>CQ-ER is a Coumarin-quinazolinone-based photosensitizer targeting the endoplasmic reticulum (ER). It induces ferroptosis, thereby enhancing photodynamic therapy (PDT).</p>Formula:C33H33N7O6SColore e forma:SolidPeso molecolare:655.72Chalcones A-N-5
CAS:Chalcones A-N-5, a non-cytotoxic trihydroxy chalcone, aids cell growth & neuroprotection, inhibits ferroptosis, and targets AD research.Formula:C21H20N4O4Colore e forma:SolidPeso molecolare:392.41W1131 TFA
W1131 TFA is a STAT3 inhibitor and ferroptosis inducer that regulates the IL6-JAK-STAT3 and ferroptosis pathways,gastric cancer.Formula:C25H20F3N5O6Purezza:98.1%Colore e forma:SolidPeso molecolare:543.45AY-4
AY-4 (Compound AY-4) is a potent PROTAC degrader targeting FTH1, with a dissociation constant (Kd) of 3.17 nM. It effectively increases intracellular ferrous (Fe2+) and ferric (Fe3+) ion levels. AY-4 is a potential anticancer candidate that regulates iron homeostasis through ferritin degradation, enhancing the efficacy of existing drugs. Additionally, AY-4 significantly reduces FTH1 levels in breast cancer cells.Colore e forma:Odour SolidMoracin N
CAS:Moracin N, a ferroptosis inhibitor derived from mulberry leaves, exhibits neuroprotective activity by mitigating oxidative stress [1].Formula:C19H18O4Purezza:98%Colore e forma:SolidPeso molecolare:310.342-Acetamidophenol
CAS:<p>2-Acetamidophenol (Orthocetamol) has analgesic and antipyretic effects. 2-Acetamidophenol is an isomer of Paracetamol (4-acetamidophenol).</p>Formula:C8H9NO2Purezza:>99.99%Colore e forma:Light Brown PowderPeso molecolare:151.16HDAC-IN-77
HDAC-IN-77 (HL-5s), an HDAC inhibitor, has the capability to induce ferroptosis and suppress the Nrf2/HO-1 signaling pathway. This compound is utilized in cancer research.Formula:C22H26N4O2SColore e forma:SolidPeso molecolare:410.531R,3R-RSL3
CAS:1R,3R-RSL3 is a negative control for1S, 3R-RSL3.Formula:C23H21ClN2O5Colore e forma:SolidPeso molecolare:440.88ZX703
ZX703 is a protein hydrolysis-targeting chimera (PROTAC) that mediates the degradation of GPX4 through the ubiquitin-proteasome and autophagy-lysosome pathways, with a DC50 of 0.315 µM. It induces the accumulation of lipid reactive oxygen species (ROS), thereby promoting ferroptosis in cancer cells.GPX4-IN-14
GPX4-IN-14 (compound 2c) acts as a GPX4 inhibitor, exhibiting both free radical scavenging activity (with a maximum scavenging rate of 72.52%) and anti-tumor proliferation activity in vitro. This compound targets GPX4 protein, elevating lipid peroxide and intracellular Reactive Oxygen Species (ROS) levels, which induces ferroptosis and contributes to its anti-tumor proliferation effects.Formula:C26H39NO8SeColore e forma:SolidPeso molecolare:572.55GPX4-IN-6
CAS:GPX4-IN-6 is a GPX4 inhibitor with antitumor activity.GPX4-IN-6 induces iron death and is used for the treatment and prevention of triple-negative breast cancerFormula:C18H17BrFNO5Purezza:99.54%Colore e forma:SoildPeso molecolare:426.231-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
CAS:<p>Phospholipid with stearic acid and 15(S)-HpETE boosts ferroptosis in MEFs upon GPX4 inhibition.</p>Formula:C43H78NO10PColore e forma:SolidPeso molecolare:800.068Ferroptosis-IN-13
Ferroptosis-IN-13 (compound NY-26) is an inhibitor of ferroptosis. It effectively suppresses RSL3-induced ferroptosis in 786-O cells, with an EC50 value of 62 nM.Formula:C32H30F2N4O3Colore e forma:SolidPeso molecolare:556.602TOFA-Plasmalogen
<p>TOFA-Plasmalogen (compound 1), a derivative of glyceraldehyde, exhibits ferroptosis-inducing properties. This compound promotes lipid peroxidation in cell membranes, leading to cytotoxic effects with an inhibition concentration (IC 50 = 32.87 μM).</p>Formula:C33H62NO7PColore e forma:SolidPeso molecolare:615.82Pro-GA
CAS:Pro-GA is a cell-permeable γ-glutamylcyclotransferase (γ-GGCT) inhibitor that inhibit proliferation in multiple bladder cancer cell lines. antitumour.Formula:C12H19NO7Colore e forma:SolidPeso molecolare:289.28Ferroptosis-IN-14
Ferroptosis-IN-14 (compund 36) exhibits the most potent anti-ferroptotic activity with an EC50 value of 0.58 ± 0.02 μM, demonstrating excellent anti-ferroptotic efficacy, as well as stability in microsomes and plasma.Colore e forma:Odour SolidGPX4-IN-5
CAS:GPX4-IN-5 is a GPX4 inhibitor with antitumor activity.GPX4-IN-5 induces iron death and may be used for the treatment of triple negative breast cancer.Formula:C18H17ClFNO5Purezza:99.58%Colore e forma:SoildPeso molecolare:381.78NYY-6a
NYY-6a is a ferroptosis (Ferroptosis) inhibitor, demonstrating significant suppression of RSL3-induced ferroptosis in 786-O and HT-1080 cells, with EC50 values of 52 nM and 50 nM, respectively. As a radical-trapping antioxidant (RTA), NYY-6a effectively reduces lipid peroxidation, comparable to ferrostatin-1 and liproxstatin-1, making it useful for research into ferroptosis-related pathologies.Formula:C23H22N2O3Colore e forma:SolidPeso molecolare:374.43ZX782
ZX782 acts as a GPX4 protein degrader and an inducer of ferroptosis (Ferroptosis), targeting GPX4 for destruction via both the ubiquitin-proteasome system and the autophagy-lysosome pathway. Following the degradation of GPX4 induced by ZX782, there is a significant increase in the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells.Formula:C39H48ClN5O8Colore e forma:SolidPeso molecolare:750.28UAMC-4821
UAMC-4821 is a ferroptosis inhibitor with an IC50 of 5.2 nM. It effectively scavenges free radicals, inhibits lipid peroxidation, and prevents ML162-induced ferroptosis, providing protective effects on HT-1080 cells. With favorable pharmacokinetic properties in mice, UAMC-4821 presents an oral bioavailability of 63% and demonstrates blood-brain barrier permeability.Formula:C15H19N3OColore e forma:SolidPeso molecolare:257.33Fluorescein-diisobutyrate-6-amide
CAS:Fluorescein-diisobutyrate-6-amide, a powerful inducer of ferroptosis, shows promise for cancer research applications [1].Formula:C62H61ClN6O16Colore e forma:SolidPeso molecolare:1181.63VK-28
CAS:VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.Formula:C16H21N3O2Purezza:99.87%Colore e forma:SolidPeso molecolare:287.36PROTAC GPX4 degrader-1
CAS:PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation concentration (DC 50) of 0.03 μM in HT1080Formula:C50H57ClN10O10Colore e forma:SolidPeso molecolare:993.5DTUN
<p>DTUN: lipophilic radical initiator, starts STY-BODIPY liposome co-autoxidization at 0.2 mM, useful in FENIX assays.</p>Colore e forma:SolidRu-Poma
<p>Ru-Poma is an Ru(II)-based photosensitizer designed to enhance the efficacy of photodynamic therapy (PDT) against tumors resistant to Cisplatin. It targets Pomalidomide to partially degrade CRBN, inducing ferroptosis by increasing lipid peroxides and downregulating GPX4 and GAPDH expression. In A549 cells, Ru-Poma exhibits cytotoxicity with IC50 values of 18.46 μM in the dark and 0.37 μM under illumination.</p>Formula:C89H75Cl2N11O11Ru·7H2OPROTAC GPX4 degrader-2
PROTACGPX4 degrader-2 (compound 18a) is a proteolysis-targeting chimera (PROTAC) that targets the degradation of glutathione peroxidase 4 (GPX4), with a DC50, 48h value of 1.68 μM. It induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. Additionally, PROTACGPX4 degrader-2 exhibits antiproliferative activity.Formula:C50H61ClN8O9Peso molecolare:952.425Photosensitizer-5
Photosensitizer-5, a photodynamic agent, exhibits cytotoxicity towards HeLa and HepG2 cells, with IC50 values of 10.4 nM and 6.9 nM, respectively. It induces cell death through lipid peroxidation via an iron-independent ferroptosis pathway. Additionally, Photosensitizer-5 displays antitumor activity in HeLa-tumor-bearing mice.Formula:C35H26BF2IN4O2Colore e forma:SolidPeso molecolare:710.32Ferroptosis-IN-20
Ferroptosis-IN-20 (Compound 34a) is an inhibitor of ferroptosis targeting voltage-dependent anion channels (VDAC) with an EC50 of 24.2 nM. It prevents VDAC oligomerization and lipid peroxidation. Additionally, Ferroptosis-IN-20 reduces ROS levels, diminishes TFR1-mediated iron uptake, inhibits Fe2+ levels, and restores glutathione (GSH) levels. It also alleviates acute kidney injury (AKI) caused by folic acid.Colore e forma:Odour SolidFerroptosis-IN-17
Ferroptosis-IN-17 (Compound 18) is an inhibitor of ferroptosis with an EC50 value of 0.57 μM. It effectively reduces the accumulation of intracellular ferrous ions and lipid peroxidation while restoring levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4). In rat plasma, Ferroptosis-IN-17 demonstrates good solubility and notable metabolic stability. This compound holds potential for research in tumor suppression, neurodegenerative diseases, and cardiovascular disorders.Formula:C21H26N4O5SColore e forma:SolidPeso molecolare:446.52PROTAC NCOA4 degrader-1
PROTACNCOA4 degrader-1 (Compound V3) is a PROTAC-based degrader of NCOA4, exhibiting a DC50 of 3 nM in HeLa cells. Besides acting as a ferroptosis inhibitor, this compound effectively reduces the levels of NCOA4 and decreases intracellular ferrous (Fe2+) levels. Moreover, PROTACNCOA4 degrader-1 ameliorates liver damage in a CCl4-induced acute liver injury model.Colore e forma:Odour SolidVEGFR-2-IN-68
<p>VEGFR-2-IN-68 (13b) is an inhibitor of VEGFR-2 with an IC50 value of 41.51 nM. It can induce apoptosis and cause G2/M cell cycle arrest, as well as exhibit anti-cancer metastasis properties.</p>Formula:C27H25N5O2SColore e forma:SolidPeso molecolare:483.1729Ferroptosis inducer-4
Ferroptosisinducer-4 (Compound 5) is a phospholipid-based ferroptosis inducer featuring a terminal double bond at the sn-2 position. It exhibits significant cytotoxicity towards HT-1080 cells with an IC50 value of 18 μM. The toxicity mechanism involves the generation of lipid peroxides and oxidative damage to the cell membrane induced by the terminal double bond. Ferroptosisinducer-4 can be utilized in studies pertaining to the regulation of ferroptosis.Formula:C33H64NO7PColore e forma:SolidPeso molecolare:617.84Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
CAS:Iron(III) compound induces ferroptosis in NB1 cells at 3μM, not apoptosis/necroptosis; inhibits various cancers, effective against drug-resistant NALM-6.Formula:C20H14ClFeN2O2Colore e forma:SolidPeso molecolare:405.64PROTAC GPX4 degrader-4
CAS:PROTACGPX4 degrader-4 is a GPX4 PROTAC degrader with a DC50 of 5.32 nM. It inhibits the activity of cancer cell lines RT4, T24, and J82 with IC50 values of 0.09, 2.97, and 7.58 μM, respectively. This compound elevates lipid ROS levels and induces ferroptosis in T24 and RT4 cells. In T24 tumor-bearing BALB/c nude mouse models, PROTACGPX4 degrader-4 demonstrates antitumor activity. It is applicable to bladder cancer research.Formula:C43H58N2O13Colore e forma:SolidPeso molecolare:810.93
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