PKC
Gli inibitori della proteina chinasi C (PKC) prendono di mira la famiglia delle chinasi PKC, coinvolte in una vasta gamma di processi cellulari, tra cui la regolazione del ciclo cellulare, l'apoptosi e la differenziazione. La PKC svolge un ruolo chiave nelle vie di trasduzione del segnale che influenzano la proliferazione e la sopravvivenza cellulare. L'inibizione della PKC può portare a cambiamenti nella progressione del ciclo cellulare, rendendo questi inibitori strumenti preziosi nella ricerca sul cancro, la neurobiologia e le malattie cardiovascolari. Presso CymitQuimica, offriamo una selezione diversificata di inibitori della PKC di alta qualità per supportare la tua ricerca sulla trasduzione del segnale, la regolazione del ciclo cellulare e lo sviluppo terapeutico.
Trovati 111 prodotti di "PKC"
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A-3 hydrochloride
CAS:<p>A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.</p>Formula:C12H14Cl2N2O2SPurezza:99.32%Colore e forma:SolidPeso molecolare:321.22Mitoxantrone dihydrochloride
CAS:<p>Mitoxantrone dihydrochloride (NSC-301739) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone is a type II topoisomerase inhibitor.</p>Formula:C22H30Cl2N4O6Purezza:97.05% - >99.99%Colore e forma:Blue-Black Solid From Water Ethanol SolidPeso molecolare:517.4Bisindolylmaleimide VIII acetate
CAS:Bisindolylmaleimide VIII acetate is a selective PKC inhibitor with an IC50 of 158 nM in rat brain and varying IC50s for different PKC isoforms.Formula:C26H26N4O4Purezza:99.27%Colore e forma:SolidPeso molecolare:458.51N-Desmethyltamoxifen hydrochloride
CAS:N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.Formula:C25H28ClNOPurezza:99.15%Colore e forma:SolidPeso molecolare:393.95PKC β pseudosubstrate acetate
PKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC.Purezza:95.42%Colore e forma:SoildDelcasertib
CAS:Delcasertib (KAI-9803) is a potent and selective inhibitor of δ-protein kinase C (δPKC).Formula:C120H199N45O34S2Purezza:99.96%Colore e forma:SolidPeso molecolare:2880.28CMPD101
CAS:<p>CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).</p>Formula:C24H21F3N6OPurezza:99.01% - 99.04%Colore e forma:SolidPeso molecolare:466.46LY 379196
LY 379196, a potent PKC-β inhibitor (IC 50: 50 nM for PKC βI and 30 nM for PKC βII), effectively suppresses the proliferation of bovine retinal microvascular endothelial cells (BREC) induced by VEGF, IGF-1, and bFGF. This compound serves as an antiproliferative agent for proliferative retinopathy.Formula:C30H34N4O5SColore e forma:SolidPeso molecolare:562.68Pep2m, myristoylated
CAS:Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.Formula:C63H118N18O14SPurezza:98%Colore e forma:SolidPeso molecolare:1383.8Delcasertib acetate
Delcasertib acetate is a selective δ protein kinase C (δPKC) inhibitor for the study of acute myocardial infarction and pain.Formula:C122H203N45O36S2Purezza:98.92%Colore e forma:SolidPeso molecolare:2940.33PKCiota-IN-2
CAS:PKCiota-IN-2 selectively inhibits PKC-ι (IC50=2.8nM) and also blocks PKC-α, ε (IC50s=71nM, 350nM).Formula:C24H21N5OPurezza:98.86%Colore e forma:SolidPeso molecolare:395.46Bisindolylmaleimide III
CAS:<p>Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC).Bisindolylmaleimide III selectively interacts with PKCα or ribosomal S6</p>Formula:C23H20N4O2Purezza:98.6%Colore e forma:SolidPeso molecolare:384.43(8R)-8-Hydroxyepoxyboetirane A
(8R)-8-Hydroxyepoxyboetirane A is a neuroactivating compound that interacts with PKCδ-C1B. This compound binds into the PKC enzyme pocket through hydrogen bonds with glycine-253, leucine-251, and threonine-242. It induces the release of NRG1 and promotes the differentiation of neural stem cells into neurons. (8R)-8-Hydroxyepoxyboetirane A holds potential for research into nervous system disorders.Colore e forma:Odour SolidMyelin Basic Protein
CAS:Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.Formula:C60H103N21O17Purezza:98%Colore e forma:SolidPeso molecolare:1390.59Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS:Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.Formula:C56H110N22O14Purezza:98%Colore e forma:SolidPeso molecolare:1315.61Protein Kinase C (19-36)
CAS:Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.Formula:C93H159N35O24Purezza:98%Colore e forma:SolidPeso molecolare:2151.48PKC β pseudosubstrate
CAS:Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM).Formula:C177H294N62O38S3Purezza:98%Colore e forma:SolidPeso molecolare:3994.84Fasudil
CAS:<p>Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.</p>Formula:C14H17N3O2SPurezza:99.79% - 99.84%Colore e forma:SolidPeso molecolare:291.37ZIP
CAS:Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.Formula:C90H154N30O17Purezza:98%Colore e forma:SolidPeso molecolare:1928.4[Ala113]MBP(104-118)
CAS:Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 28 - 62 mM).Formula:C67H104N20O19Purezza:98%Colore e forma:SolidPeso molecolare:1493.68[Ala107]MBP(104-118)
CAS:Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 46 - 145 mM).Formula:C67H104N20O19Purezza:98%Colore e forma:SolidPeso molecolare:1493.68Neuropeptide DF2
CAS:Neuropeptide DF2 is an FMRFamide-related neuropeptide from crayfish.Formula:C44H67N15O10Purezza:98%Colore e forma:SolidPeso molecolare:966.1PKCδ Peptide Substrate
CAS:PKCδ Peptide Substrate is a highly specific substrate for the δ-type of Protein kinase C, composed of a sequence that mirrors murine eEF-1α (422-443) andFormula:C109H191N35O29SColore e forma:SolidPeso molecolare:2487.97Protein kinase C α peptide TFA
CAS:Protein Kinase C (alpha) Peptide (TFA) is a PKC-α-associated peptide functioning as a lipid-dependent serine/threonine protein kinase.Formula:C68H115F3N24O26SColore e forma:SolidPeso molecolare:1773.85NPC-15437 dihydrochloride
CAS:NPC-15437 dihydrochloride is a PKC inhibitor blocking enzyme activity and phorbol ester binding, selective over other kinases, in cellular signaling research.Formula:C25H52Cl2N4O2Colore e forma:SolidPeso molecolare:511.62K-252b
CAS:<p>K-252b, an indolocarbazole derived from the actinomycete Nocardiopsis, functions as a protein kinase C (PKC) inhibitor.</p>Formula:C26H19N3O5Purezza:98%Colore e forma:Ready-To-Use SolutionPeso molecolare:453.45Ac-MBP (1-11)
CAS:Ac-MBP 1-11, a primary encephalitogenic epitope in myelin basic protein (MBP), is a dominant short peptide sequence[1].Formula:C2H3K2OPS3Purezza:98%Colore e forma:SolidPeso molecolare:248.411-Oleoyl-2-acetyl-sn-glycerol
CAS:1-Oleoyl-2-acetyl-sn-glycerol (1-oleoyl-2-acetyl-glycerol) is a PKC activator that induces superoxide production.Formula:C23H42O5Colore e forma:SolidPeso molecolare:398.58[Ala9,10, Lys11,12] Glycogen Synthase (1-12)
CAS:[Ala9,10, Lys11,12] Glycogen Synthase (1-12): PKC's selective phosphorylation substrate, used to assess PKC activity. [1]Formula:C56H103N17O16Colore e forma:SolidPeso molecolare:1270.52FKKSFKL-NH2
CAS:FKKSFKL-NH2 is a selective peptide for protein kinase C, employed in biochemical research [1].Formula:C45H73N11O8Colore e forma:SolidPeso molecolare:896.13TAT-P4-(DATC5)2 TFA
TAT-P4-(DATC5)2 TFA, a high-affinity peptide inhibitor targeting the PDZ domain of protein interacting with C kinase-1 (PICK1), exhibits a K i of 1.7 nM andColore e forma:Odour SolidProtein Kinase C (19-35) Peptide
CAS:PKC (19-35) Peptide inhibits PKC by blocking its substrate-binding, rendering cytoplasmic PKC inactive.Formula:C89H153N33O22Colore e forma:SolidPeso molecolare:2037.4N-Myristoyl-Lys-Arg-Thr-Leu-Arg
CAS:N-Myristoyl-Lys-Arg-Thr-Leu-Arg: PKC inhibitor, IC50=75μM, blocks IL-2 in Jurkat cells.Formula:C42H82N12O8Colore e forma:SolidPeso molecolare:883.18PKC β pseudosubstrate TFA
PKC β pseudosubstrate TFA is a selective cell-permeable inhibitor of PKC [1] .Formula:C179H295F3N62O40S3Colore e forma:SolidPeso molecolare:4108.84pep2-EVKI
CAS:Peptide inhibits GluA2-PICK1 binding, sparing GluA2-GRIP/ABP interaction and LTD, without boosting AMPA current.Formula:C62H95N13O19Purezza:98%Colore e forma:SolidPeso molecolare:1326.51Bisindolylmaleimide XI hydrochloride
CAS:Bisindolylmaleimide XI hydrochloride is an orally active PKC inhibitor with inhibitory effects on PKCα, PKCβI, PKCβII, and PKCγ (IC50s of 9 nM, 28 nM, 31 nM, 37Formula:C28H29ClN4O2Purezza:99.45%Colore e forma:SolidPeso molecolare:489.01Protein Kinase C Peptide Substrate
CAS:PKC Peptide Substrate acts on cell spacers, driven by second messengers/adaptors due to external signals via g protein/tyrosine kinase receptors.Formula:C83H155N39O21SPurezza:98%Colore e forma:SolidPeso molecolare:2067.43Sangivamycin
CAS:<p>Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.</p>Formula:C12H15N5O5Purezza:99.85%Colore e forma:SolidPeso molecolare:309.28Protein kinase inhibitor H-7
CAS:H-7: potent PKC inhibitor with 6 μM Ki, also blocks cyclic nucleotide-dependent kinases.Formula:C14H17N3O2SPurezza:99.91%Colore e forma:SoildPeso molecolare:291.37Protein Kinase C (19-31)
CAS:Protein Kinase C (19-31), a PKC inhibitor derived from PKCa, has a serine at position 25 and tests PKC activity.Formula:C67H118N26O16Purezza:98%Colore e forma:Lyophilized PowderPeso molecolare:1543.82Protein Kinase C (19-31) (TFA)(121545-65-1,free)
Protein Kinase C (19-31) TFA is a serine-modified PKCa-derived inhibitor for testing PKC activity.Formula:C69H119F3N26O18Purezza:98%Colore e forma:SolidPeso molecolare:1657.84Aurothiomalate tetramer sodium
Aurothiomalate tetramer sodium, a tetrameric form of Aurothiomalate sodium, functions as an anti-arthritis gold agent. It also acts as a potent and selective inhibitor of the oncogenic PKCι signaling pathway.Colore e forma:Odour SolidSAMβA TFA
<p>SAMβA TFA, a selective antagonist of Mfn1-βIIPKC association conjugated to the cell permeable peptide TAT47-57, is a rationally designed inhibitor that improves</p>Formula:C50H73N17O16·xC2HF3O2Purezza:98%Colore e forma:SolidPeso molecolare:1168.22 (free acid)Psychosine
CAS:<p>Psychosine (Galactosylsphingosine) is a PKC inhibitor, and is highly cytotoxic, inducing cell death in a variety of cells.</p>Formula:C24H47NO7Purezza:98%Colore e forma:White PowderPeso molecolare:461.63PKC-θ inhibitor
CAS:PKC-theta inhibitor is PKC-θinhibitor, with an IC50 of 12 nM.Formula:C20H25F3N6O3Purezza:99.46%Colore e forma:SolidPeso molecolare:454.45Protein kinase inhibitor H-7 dihydrochloride
CAS:Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride) is a potent protein kinase C (PKC) inhibitor.Formula:C14H19Cl2N3O2SPurezza:99.81%Colore e forma:White Crystalline SolidPeso molecolare:364.29(±)-1,2-Diolein
CAS:(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein could increases myotubes Ca 2+ influx.Formula:C39H72O5Colore e forma:SolidPeso molecolare:620.99R59949
CAS:R59949 is used as a Diacylglycerol kinase (DGK) inhibitor.Formula:C28H25F2N3OSPurezza:97.04%Colore e forma:SolidPeso molecolare:489.58Taurolithocholic acid sodium salt
CAS:<p>Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but</p>Formula:C26H44NNaO5SPurezza:99.79% - 99.93%Colore e forma:SolidPeso molecolare:505.69Desmethylglycitein
CAS:Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which hasFormula:C15H10O5Purezza:97.93%Colore e forma:SolidPeso molecolare:270.24Afuresertib
CAS:<p>Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic</p>Formula:C18H17Cl2FN4OSPurezza:97.51% - 99.51%Colore e forma:SolidPeso molecolare:427.32Bisindolylmaleimide IV
CAS:<p>Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM)</p>Formula:C20H13N3O2Purezza:98.83%Colore e forma:Dark Red SolidPeso molecolare:327.34Hypocrellin A
CAS:Hypocrellin A is a natural PKC inhibitor with light-induced antitumor, antifungal and antiviral activities.Cost-effective and quality-assured.Formula:C30H26O10Purezza:98% - 99.95%Colore e forma:SolidPeso molecolare:546.52Daphnoretin
CAS:<p>1.</p>Formula:C19H12O7Purezza:98% - 99.85%Colore e forma:SolidPeso molecolare:352.29Bisindolylmaleimide V
CAS:Bisindolylmaleimide V, a bisindolylmaleimide derivative, is an inactive of a kinase inhibitor.Formula:C21H15N3O2Purezza:90%Colore e forma:Red SolidPeso molecolare:341.36TPPB
CAS:<p>TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).</p>Formula:C27H30F3N3O3Purezza:97.71% - 98.00%Colore e forma:SolidPeso molecolare:501.54Ro 31-8220 Mesylate
CAS:<p>Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.</p>Formula:C25H23N5O2S·CH4O3SPurezza:98.79% - 99.02%Colore e forma:SolidPeso molecolare:553.65Staurosporine
CAS:Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-FgrFormula:C28H26N4O3Purezza:99.24% - 99.82%Colore e forma:Off-White PowderPeso molecolare:466.53Procyanidin A1
CAS:Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+.Formula:C30H24O12Purezza:99.52%Colore e forma:SolidPeso molecolare:576.50Ingenol
CAS:<p>Ingenol mebutate treats actinic keratosis, has anticancer properties, and may reactivate latent HIV.</p>Formula:C20H28O5Purezza:99.78% - 99.87%Colore e forma:SolidPeso molecolare:348.43PKCβ inhibitor 1
CAS:<p>PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2,</p>Formula:C24H21N5O2Purezza:99.33%Colore e forma:SolidPeso molecolare:411.46Taurochenodeoxycholic Acid
CAS:Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.Formula:C26H45NO6SPurezza:99.53% - 99.86%Colore e forma:SolidPeso molecolare:499.7Ζ-Stat
CAS:<p>ζ-Stat (NSC37044), a specific and atypical inhibitor of PKC-ζ with an IC50 of 5 μM, demonstrates the ability to inhibit proliferation and induce apoptosis in</p>Formula:C10H8O10S3Purezza:99.85%Colore e forma:SolidPeso molecolare:384.36Chelerythrine chloride
CAS:<p>Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to</p>Formula:C21H18ClNO4Purezza:95% - 99.19%Colore e forma:Yellow To Orange SolidPeso molecolare:383.83Verbascoside
CAS:Verbascoside (Kusaginin) is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.Formula:C29H36O15Purezza:97.46% - 99.55%Colore e forma:SolidPeso molecolare:624.59Phorbol 12-myristate 13-acetate
CAS:<p>Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB.</p>Formula:C36H56O8Purezza:98.55% - >99.99%Colore e forma:White To Off-White SolidPeso molecolare:616.83Afuresertib hydrochloride
CAS:<p>Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)</p>Formula:C18H18Cl3FN4OSPurezza:99.96%Colore e forma:SolidPeso molecolare:463.8TAS-301
CAS:TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries.Formula:C23H19NO3Purezza:99.55%Colore e forma:SolidPeso molecolare:357.4Midostaurin
CAS:PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.Formula:C35H30N4O4Purezza:97.61% - >99.99%Colore e forma:SolidPeso molecolare:570.64PKC-θ inhibitor hcl
CAS:PKC-theta inhibitor hcl is a selective PKC-θinhibitor(IC50:12 nM).Formula:C20H26ClF3N6O3Purezza:98.93%Colore e forma:SolidPeso molecolare:490.91Darovasertib
CAS:Darovasertib (LXS196) is a potent PKC inhibitor, orally active, with IC50 of 1.9 nM (PKCα), 0.4 nM (PKCθ), 3.1 μM (GSK3β).Formula:C22H23F3N8OPurezza:98.72% - ≥95%Colore e forma:SolidPeso molecolare:472.47Aurothiomalate sodium
CAS:<p>Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.</p>Formula:C4H3AuNa2O4SPurezza:99.66%Colore e forma:SoildPeso molecolare:390.07Go 6983
CAS:<p>Go 6983 is a PKC inhibitor with IC50 values of 7, 7, 6, 10, and 60 nM for PKCα, PKCβ, PKCγ, PKCδ, and PKCζ, respectively. High-Quality, Low-Cost!</p>Formula:C26H26N4O3Purezza:98.41% - 99.85%Colore e forma:SolidPeso molecolare:442.51Enzastaurin
CAS:<p>Enzastaurin (LY317615) (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCα/γ/ε.</p>Formula:C32H29N5O2Purezza:98% - >99.99%Colore e forma:SolidPeso molecolare:515.6Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Formula:C9H6O4Purezza:97.47% - 99.8%Colore e forma:SolidPeso molecolare:178.14Decursinol angelate
CAS:Decursinol angelate is anti-tumor, anti-inflammatory, anti-oxidant, hepatoprotective, and inhibits VEGF and cancer cell invasion.Formula:C19H20O5Purezza:99.93%Colore e forma:SolidPeso molecolare:328.36Rottlerin
CAS:Rottlerin (NSC-56346), a Mallotus Philippinensis extract, inhibits PKC (3-100 μM IC50); triggers apoptosis by activating caspase 3.Formula:C30H28O8Purezza:97.41% - 99.44%Colore e forma:Orange To Brown PowderPeso molecolare:516.54Valrubicin
CAS:<p>Valrubicin (AD-32) (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.</p>Formula:C34H36F3NO13Purezza:98.63%Colore e forma:SolidPeso molecolare:723.64PKC-iota inhibitor 1
CAS:<p>PKC-iota inhibitor 1 is an inhibitor of protein kinase C-iota (PKC-ι ; IC50 : 0.34 μM)</p>Formula:C21H22N6OPurezza:98.82%Colore e forma:SolidPeso molecolare:374.44Sotrastaurin
CAS:Sotrastaurin (AEB071) is a potent pan-PKC inhibitor (Kis: 0.95/0.64/2.1/3.2/1.8/0.22 nM for PKCα/βI/δ/ε/η/θ).Formula:C25H22N6O2Purezza:98% - 99.70%Colore e forma:SolidPeso molecolare:438.48D-ERYTHRO-SPHINGOSINE
CAS:<p>D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator</p>Formula:C18H37NO2Purezza:98% - 99.85%Colore e forma:SolidPeso molecolare:299.49Decursin
CAS:Decursin: potential antiepileptic, hepatoprotective, anti-cancer, anti-amnesic; affects NOX activation, PKCα/MAPK/NF-κB pathways, AChE.Formula:C19H20O5Purezza:97.22% - 99.91%Colore e forma:SolidPeso molecolare:328.36Protein Kinase C 19-31 acetate
PKC 19-31 acetate, a serine-altered PKCa-derived PKC inhibitor, tests PKC activity.Formula:C69H122N26O18Purezza:>99.99%Colore e forma:SolidPeso molecolare:1603.9Hypericin
CAS:Hypericin (Cyclosan) is a natural anthraquinone compound. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant effects. Cost-effective and quality-assured.Formula:C30H16O8Purezza:98.90% - ≥98%Colore e forma:Red-Coloured Anthraquinone-DerivativePeso molecolare:504.441,2-Dimyristoyl-sn-glycerol
CAS:<p>1,2-Dimyristoyl-sn-glycerol (1,2-DMG) is able to increase AChE activity by 35-40% at concentrations of 25 micrograms/ml in the parasite S. mansoni..</p>Formula:C31H60O5Purezza:99.96%Colore e forma:White Powder With LumpsPeso molecolare:512.81Hispidin
CAS:<p>Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective properties</p>Formula:C13H10O5Purezza:98.27%Colore e forma:White Crystalline PowderPeso molecolare:246.22Taurochenodeoxycholic acid sodium
CAS:Sodium taurochenodeoxycholate: induces apoptosis, anti-inflammatory, boosts insulin, stimulates α2-cells, increases [Ca(2+)](c).Formula:C26H44NNaO6SPurezza:98.23% - 99.56%Colore e forma:White To Off-White PowderPeso molecolare:521.68Bisindolylmaleimide I
CAS:Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.Formula:C25H24N4O2Purezza:97.51% - 98.75%Colore e forma:Orange SolidPeso molecolare:412.48Fasudil hydrochloride
CAS:<p>Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.</p>Formula:C14H18ClN3O2SPurezza:99.54% - ≥95%Colore e forma:White SolidPeso molecolare:327.83Mitoxantrone
CAS:<p>Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.</p>Formula:C22H28N4O6Purezza:96.29% - 98.74%Colore e forma:Blue PowderPeso molecolare:444.48HA-100
CAS:<p>HA-100 is an inhibitor of protein kinase</p>Formula:C13H15N3O2SPurezza:99.44%Colore e forma:Pale Yellow Crystalline SolidPeso molecolare:277.34Ruboxistaurin hydrochloride
CAS:Ruboxistaurin HCl (LY 333531) selectively inhibits PKCβI/II with IC50 of 4.7/5.9 nM; much less effective on other PKC types and ATP-kinases.Formula:C28H28N4O3·HClPurezza:99.14% - 99.28%Colore e forma:SolidPeso molecolare:505.01Ionomycin calcium
CAS:<p>Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, exhibiting high specificity for calcium ions. Cost-effective and quality-assured.</p>Formula:C41H70CaO9Purezza:98% - 98.11%Colore e forma:SolidPeso molecolare:747.07Phorbol 12,13-dibutyrate
CAS:Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that induces contraction of isolated rabbit vascular smooth muscle.Formula:C28H40O8Purezza:99.32% - 99.37%Colore e forma:SolidPeso molecolare:504.61PS315
CAS:PS315, a PS48 derivative, allosterically inhibits PKCζ/η (IC50: 10/30 μM), targeting aPKC's PIF-pocket, with anti-cancer properties.Formula:C23H19ClO2Purezza:98%Colore e forma:SolidPeso molecolare:362.85AJH-836
CAS:AJH-836 is a compound that activates Munc13-1 and PKC ε/α, demonstrating a dissociation constant (Kd) of 4.5 nM for PKCα, and facilitates the translocation ofFormula:C22H38O5Purezza:98%Colore e forma:SolidPeso molecolare:382.53CGP60474
CAS:CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC.Formula:C18H18ClN5OPurezza:98.81%Colore e forma:SolidPeso molecolare:355.82SC-10
CAS:SC-10 is a direct activator of PKC with potential antiproliferative activity, useful in leukemia research.Formula:C17H22ClNO2SPurezza:99.24% - 99.58%Colore e forma:SolidPeso molecolare:339.88NSC668394
CAS:<p>NSC668394 is an ezrin phosphorylation inhibitor.NSC668394 has antitumor activity and increases ezrin cleavage.NSC668394 can be used to study tumor metastasis.</p>Formula:C17H12Br2N2O3Purezza:99.29% - 99.29%Colore e forma:SolidPeso molecolare:452.1DCPLA-ME
CAS:DCPLA-ME (2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) is the methyl ester form of DCPLA and can be used to treat neurodegenerativeFormula:C21H38O2Purezza:99.80%Colore e forma:SolidPeso molecolare:322.53PKC-θ inhibitor 1
CAS:<p>PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)</p>Formula:C17H15F3N4OPurezza:98%Colore e forma:SolidPeso molecolare:348.32VTX-27
CAS:VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM and 16 nM for PKC θ and PKC δ).Formula:C20H24ClFN6OPurezza:99.84%Colore e forma:SolidPeso molecolare:418.9(-)-Indolactam V
CAS:(-)-Indolactam V: PKC activator, antitumor, Ki 3.36 nM/1.03 μM for η/γ-CRD2, Kd 5.5-213 nM for C1 domains.Formula:C17H23N3O2Purezza:98%Colore e forma:SolidPeso molecolare:301.38TCS 21311
CAS:<p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.</p>Formula:C27H25F3N4O4Purezza:99.39% - ≥98%Colore e forma:SolidPeso molecolare:526.51PKC-IN-1
CAS:PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6,Formula:C25H37FN8O2Purezza:98% - 98.79%Colore e forma:SolidPeso molecolare:500.61YAP/TAZ-TEAD-IN-2
YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that disrupts the interaction between YAP/TAZ and TEAD. It inhibits the transcriptional activity of TEAD with an IC50 of 1.2 nM. Additionally, YAP/TAZ-TEAD-IN-2 suppresses the expression of target genes (Cyr61, CTGF, AXL, and Survivin) and the proliferation of breast cancer cells.Formula:C19H20N2O3SColore e forma:SolidPeso molecolare:356.44AS2521780
CAS:AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).Formula:C30H41N7OSPurezza:98%Colore e forma:SolidPeso molecolare:547.76PKCTheta-IN-2
CAS:PKCTheta-IN-2 (compound 14) is a potent and selective inhibitor of PKCθ, with an IC50 value of 0.25 nM. It demonstrates good selectivity across a broad range of kinases, including the PKC subfamily (30 kinases). Additionally, PKCTheta-IN-2 effectively inhibits the production of IL-2 in mice, where it exhibits an IC50 of 682 nM.Formula:C24H23N5O2Colore e forma:SolidPeso molecolare:413.47Cercosporin
CAS:<p>Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).</p>Formula:C29H26O10Purezza:98%Colore e forma:SolidPeso molecolare:534.5120-HETE
CAS:<p>20-HETE is a CYP450 product, vasoconstrictor, modulates K+ channels, affects NADPH, ROS, NF-κB, NO synthase, and cell apoptosis/proliferation.</p>Formula:C20H32O3Purezza:99.79%Colore e forma:SolidPeso molecolare:320.47
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