STAT
Le proteine STAT sono componenti critici della via di segnalazione JAK/STAT, che trasmette segnali extracellulari da citochine e fattori di crescita al nucleo cellulare, influenzando l'espressione genica. Le proteine STAT sono coinvolte nella regolazione delle risposte immunitarie, della crescita cellulare, della differenziazione e della sopravvivenza. La disregolazione della segnalazione STAT è implicata in varie malattie, tra cui cancro, disturbi autoimmuni e infiammazione cronica. Presso CymitQuimica, offriamo una gamma completa di modulatori della via STAT per supportare la tua ricerca sulla trasduzione del segnale, immunologia e sviluppo terapeutico.
Trovati 98 prodotti di "STAT"
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L002
CAS:L002 is a potent inhibitor of acetyltransferase p300 with an IC50 of 1.98 μM, blocking histone and p53 acetylation, and may treat cardiac hypertrophy.Formula:C15H15NO5SPurezza:98.59%Colore e forma:SolidPeso molecolare:321.35Niclosamide
CAS:<p>Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.</p>Formula:C13H8Cl2N2O4Purezza:98.47% - 99.1%Colore e forma:Pale Yellow Crystals SolidPeso molecolare:327.12Fludarabine
CAS:<p>Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation.</p>Formula:C10H12FN5O4Purezza:99.65% - 99.89%Colore e forma:White SolidPeso molecolare:285.23Nifuroxazide
CAS:Nifuroxazide (Diarlidan), an oral nitrofuran antidiarrheal, blocks STAT1/3/5 activation.Formula:C12H9N3O5Purezza:99.79% - 99.95%Colore e forma:Yellow SolidPeso molecolare:275.22Garcinone C
CAS:Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Formula:C23H26O7Purezza:99.13% - 99.92%Colore e forma:SolidPeso molecolare:414.45UC-514321
CAS:UC-514321 directly targets STAT3/5 and represses TET1 expression.Formula:C26H35NO5Purezza:98.50%Colore e forma:SolidPeso molecolare:441.56STAT3-IN-1
CAS:<p>STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor</p>Formula:C28H29NO6Purezza:95.89% - 95.89%Colore e forma:SolidPeso molecolare:475.53Artesunate
CAS:Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria.Formula:C19H28O8Purezza:97.67% - 99.9%Colore e forma:White Crystalline PowderPeso molecolare:384.42Niclosamide olamine
CAS:<p>Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.</p>Formula:C15H15Cl2N3O5Purezza:99.89%Colore e forma:Bright Yellow Crystalline Physical Description Yellow Solid Insoluble In Water (Ntp 1992)Peso molecolare:388.20Diosgenin
CAS:Diosgenin (Nitogenin) is a spirostan found in DIOSCOREA and other plants.Formula:C27H42O3Purezza:99.87%Colore e forma:Flaky Or Needle CrystalPeso molecolare:414.62STAT3-IN-23
CAS:STAT3-IN-23 (PY*LKTK) acts as a potent inhibitor of STAT3 [1].Formula:C36H61N8O12PPeso molecolare:828.89Eflepedocokin alfa
CAS:<p>Eflepedocokin alfa is a recombinant IL-22/IgG2-Fc protein, potentially protecting cells and enhancing immune function and tissue repair.</p>Colore e forma:LiquidMNK8
CAS:MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.Formula:C15H12N2O2Purezza:99.74%Colore e forma:SolidPeso molecolare:252.27STAT3-IN-41
<p>STAT3-IN-41 (Compound 16) is a prodrug of compound 1. It gradually releases compound 1, which inhibits the STAT3 signaling pathway. STAT3-IN-41 exhibits antitumor activity against lung cancer, hepatocellular carcinoma, and pancreatic cancer.</p>Formula:C22H30F3NO7Colore e forma:SolidPeso molecolare:477.471STAT4-IN-1
<p>STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.</p>Colore e forma:Odour SolidCMD178
CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway.Formula:C46H59N9O7Purezza:98%Colore e forma:SolidPeso molecolare:850.03STAT5-IN-3
<p>STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.</p>Formula:C25H27N5OColore e forma:SolidPeso molecolare:413.51STAT3-IN-34
<p>STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.</p>Formula:C19H16N2O4SColore e forma:SolidPeso molecolare:368.41STAT3-IN-31
<p>STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).</p>Formula:C16H15NO3SColore e forma:SolidPeso molecolare:301.36JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Colore e forma:Odour Solid
