IDO
L'indoleamina 2,3-diossigenasi (IDO) è un enzima coinvolto nel catabolismo del triptofano, che porta alla produzione di chinurenina e altri metaboliti. L'IDO svolge un ruolo nella tolleranza immunitaria ed è spesso sovraregolato nel cancro e nelle condizioni infiammatorie croniche. Gli inibitori dell'IDO vengono esplorati come potenziali agenti immunoterapici nel cancro e nelle malattie autoimmuni. Presso CymitQuimica, forniamo inibitori dell'IDO per supportare la tua ricerca in immunologia, oncologia e regolazione metabolica.
Trovati 84 prodotti di "IDO"
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GNF-PF-3777
CAS:<p>GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).</p>Formula:C15H7N3O4Purezza:97.88%Colore e forma:SolidPeso molecolare:293.23IDO-IN-13
CAS:<p>IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).</p>Formula:C26H17F3N4OPurezza:99.29%Colore e forma:SolidPeso molecolare:458.43LY3381916
CAS:<p>IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.</p>Formula:C23H25FN2O3Purezza:99.3%Colore e forma:SolidPeso molecolare:396.45CAY10581
CAS:CAY10581, a derivative of pyranonaphthoquinone, serves as a highly specific and reversible uncompetitive inhibitor of IDO, demonstrating potency with an IC50Formula:C22H21NO4Colore e forma:SolidPeso molecolare:363.41human TDO2-IN-1
<p>Human TDO2-IN-1 (Cpd-2) is a potent inhibitor of human TDO2, with an IC50 of 14.8 nM. It plays a significant role in studies related to metabolism, inflammation, and tumor immune surveillance.</p>Formula:C30H36N4O5Colore e forma:SolidPeso molecolare:532.631XW-032
<p>XW-032 is an apo-IDO1 inhibitor with an IC50 of 21 nM. In the CT26 syngeneic mouse model, XW-032 demonstrates significant in vivo antitumor efficacy with a TGI of 63%, showing potential for cancer research applications.</p>Colore e forma:Odour SolidIDO1-IN-24
IDO1-IN-24 (compound 2c) inhibits the production of IDO1 during cell assays, with an IC50 value of 17 μM.Formula:C18H22N2O4Peso molecolare:330.15796NLG802
CAS:<p>NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.</p>Formula:C20H30ClN3O3Purezza:99.61%Colore e forma:SolidPeso molecolare:395.92TDO-IN-2
TDO-IN-2 is an orally active TDO inhibitor with an IC50 of 1.25 μM. It exhibits antitumor activity in a Hepa1-6 liver cancer allograft mouse model. Additionally, TDO-IN-2 works synergistically with PD-1/PD-L1 inhibitor BMS-202, making it useful for studying tumor immune tolerance.Formula:C20H15N3O3Colore e forma:SolidPeso molecolare:345.11134BMT-297376
CAS:<p>BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.</p>Formula:C23H29F2N3O3Colore e forma:SolidPeso molecolare:433.5NU227326
CAS:<p>NU227326 is a PROTAC degrader of indoleamine 2,3-dioxygenase 1 (IDO1) with a DC50 value of 4.5 nM. It effectively degrades IDO1 in U87 and GBM43 cells, with DC50 values of 7.1 nM and 11.8 nM, respectively. NU227326 exhibits favorable pharmacokinetic properties, with a plasma half-life of 5.7 hours and a brain tissue half-life of 11.8 hours. (Pink: ligand for target protein IDO1 ligand-1; Black: linker; Blue: ligand for E3 ligase Cereblon).</p>Formula:C53H61FN8O7Colore e forma:SolidPeso molecolare:941.099IDO1-IN-7
CAS:IDO1-IN-7 is a potent IDO1 inhibitor with a 6.1 nM IC50 and immunomodulatory effects for cancer research.Formula:C22H19ClFN3O3Colore e forma:SolidPeso molecolare:427.86PROTAC IDO1 Degrader-1
CAS:First potent PROTAC IDO1 degrader; links IDO1 to CRBN E3 ligase for UPS-induced degradation (DC50=2.84 μM), boosts H ER2 CAR-T cell efficacy.Formula:C40H53BrFN9O13Colore e forma:SolidPeso molecolare:966.816IDO1-IN-23
<p>IDO1-IN-23 (compound 41) is a potent inhibitor of human indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 of 13 μM [1].</p>Purezza:98%Colore e forma:Odour SolidIDO-IN-15
CAS:IDO-IN-15 is an IDO1 inhibitor ( IC 50 < 0.51 nM).Formula:C29H39N5O4Colore e forma:SolidPeso molecolare:521.662IDO1/TDO-IN-8
<p>IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor capable of crossing the blood-brain barrier, with EC50 values of 0.33 μM and 1.78 μM, respectively. It modulates the kynurenine pathway of tryptophan metabolism, reducing the kynurenine/tryptophan ratio. IDO1/TDO-IN-8 has neuroprotective effects, alleviating motor dysfunction and improving depressive behavior, making it relevant for research into Parkinson's disease with comorbid depression.</p>Formula:C17H14N2SColore e forma:SolidPeso molecolare:278.37IDO1-IN-11
CAS:<p>IDO1-IN-11 is an IDO1 inhibitor with an IC 50 value of 0.6 nM.</p>Formula:C22H17ClFN3O3Colore e forma:SolidPeso molecolare:425.84NU223612
CAS:<p>"NU223612 is a potent IDO1-degrading PROTAC with Kd 640 nM, binds CRBN at 290 nM, and crosses the BBB."</p>Formula:C49H55FN6O9Colore e forma:SolidPeso molecolare:890.99IDO1-IN-12
CAS:IDO1-IN-12 is a potent and orally available IDO1 inhibitor.Formula:C21H19F3N2O2Colore e forma:SolidPeso molecolare:388.39IDO1/TDO-IN-7
<p>IDO1/TDO-IN-7 (Compound 43b), an isochinoline derivative, functions as a potent dual inhibitor of IDO1/TDO with IC50 values of 0.31 μM and 0.08 μM, respectively. Demonstrating favorable pharmacokinetics and strong antitumor efficacy in the B16-F10 tumor model, this compound also exhibits low toxicity.</p>Colore e forma:Odour Solid
