Proteasi/Proteasoma
Gli inibitori delle proteasi e del proteasoma sono composti che bloccano l'attività delle proteasi e del proteasoma, che sono coinvolti nella degradazione e nel turnover delle proteine. Questi inibitori sono fondamentali per studiare la regolazione dell'omeostasi proteica, il controllo del ciclo cellulare e l'apoptosi. Gli inibitori delle proteasi e del proteasoma vengono anche utilizzati nel trattamento di malattie come il cancro, dove la degradazione anomala delle proteine svolge un ruolo nella progressione della malattia. Inibendo le proteasi o il proteasoma, questi composti possono indurre la morte cellulare nelle cellule tumorali e sono strumenti critici sia per la ricerca di base che per lo sviluppo terapeutico. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle proteasi e del proteasoma di alta qualità per supportare la tua ricerca in biochimica, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Proteasi/Proteasoma"
- Acetil-CoA carbossilasi(38 prodotti)
- Cisteina proteasi(111 prodotti)
- DPP-4(27 prodotti)
- Glutaminasi(46 prodotti)
- Proteasi HIV(508 prodotti)
- PAI-1(26 prodotti)
- Inibitori della proteasi(50 prodotti)
- Ricettore attivato dalla proteasi(55 prodotti)
- Proteasoma(86 prodotti)
- Proteasi serina(54 prodotti)
- p97(15 prodotti)
Mostrare 3 più sottocategorie
Trovati 981 prodotti di "Proteasi/Proteasoma"
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LU-002i
CAS:LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].Formula:C35H52N4O7Purezza:98%Colore e forma:SolidPeso molecolare:640.81BMS-538305 HCl
CAS:BMS-538305 is a potent, selective inhibitor of dipeptidyl peptidase IV (DPP-IV).Formula:C17H27ClN2O2Colore e forma:SolidPeso molecolare:326.86Cardanol diene
CAS:Cardanol diene: phenol in cashew shells; anti-tyrosinase (IC50=52.5μM); used to make anti-E. coli biofilm complexes.Formula:C21H32OColore e forma:SolidPeso molecolare:300.48PTC725
CAS:PTC725 is a selective HCV 1b replicons inhibitor. It has been shown to target the nonstructural protein 4B.Formula:C23H18F4N6O2SPurezza:98%Colore e forma:SolidPeso molecolare:518.49Z-LVG
CAS:Z-LVG, an irreversible cysteine protease inhibitor and a tripeptide derivative of cystatin C, serves as an inhibitor of viral replication and is utilized inFormula:C21H31N3O6Colore e forma:SolidPeso molecolare:421.49LONP1-IN-2
CAS:LONP1-IN-2: Potent LONP1 inhibitor, IC50=0.187μM; weak on 20S proteasome (>10μM); for cancer research.Formula:C16H27BN4O4Colore e forma:SolidPeso molecolare:350.22MK-3281
CAS:MK-3281: Oral, potent HCV NS5B inhibitor with promising properties and efficacy in replication trials, suitable for clinical use.Formula:C29H37N3O3Colore e forma:SolidPeso molecolare:475.62ASP-8497
CAS:ASP8497 is a potent DPP-IV inhibitor enhancing GLP-1, used for type 2 diabetes and glucose intolerance.Formula:C18H27FN4O7SColore e forma:SolidPeso molecolare:462.49Cipemastat
CAS:Cipemastat is a competitive inhibitor of human collagenases 1, 2, and 3 (Kis: 3.0, 4.4, and 3.4 nM).Formula:C22H36N4O5Purezza:98%Colore e forma:SolidPeso molecolare:436.55Proteasome-IN-5
CAS:Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].Formula:C20H30BN5O7Purezza:98%Colore e forma:SolidPeso molecolare:463.29MMP3 inhibitor 1
CAS:MMP3 inhibitor 1 is a potent and highly selective inhibitor of MMP-3 (IC50 of 1 nM).Formula:C23H31N3O6SPurezza:98%Colore e forma:SolidPeso molecolare:477.57Collagen proline hydroxylase inhibitor
CAS:Collagen proline hydroxylase inhibitor is an inhibitor collagen proline hydroxylase and useful for antifibrotic proliferative agents.Formula:C18H18N4O4Purezza:98%Colore e forma:SolidPeso molecolare:354.36MMP-9-IN-8
CAS:MMP-9-IN-8 (Compound 3), an MMP-9 inhibitor, exhibits inhibitory activities of 42.16% at 10 μM and 58.28% at 50 μM.Formula:C20H21F4N7OColore e forma:SolidPeso molecolare:451.42LU-005i
CAS:LU-005i is a powerful inhibitor targeting the β5i subunit of immunoproteasomes, displaying a high potency with an IC 50 value of 6.6 nM, and exhibits selectivity by preferring β5i over the β5c subunit, which has an IC 50 value of 287 nM [1].Formula:C31H46N4O7Colore e forma:SolidPeso molecolare:586.72Proteasome β2c/i-IN-1
CAS:Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].Formula:C32H48N4O7Purezza:98%Colore e forma:SolidPeso molecolare:600.75LMP7-IN-2
CAS:LMP7-IN-2 is an inhibitor of LMP7 and may be utilized in the treatment of associated inflammatory diseases and disorders [1].Formula:C28H27N3O3SColore e forma:SolidPeso molecolare:485.6Z-PDLDA-NHOH
CAS:Z-PDLDA-NHOH is a potent, specific vertebrate collagenase inhibitor [1].Formula:C22H32N4O6Colore e forma:SolidPeso molecolare:448.51H-Gly-Pro-Hyp-OH acetate
CAS:H-Gly-Pro-Hyp-OH, a peptide dipeptidyl peptidase 4 (DPP-4) inhibitor with an inhibition concentration (IC50) of 2.51 mM, effectively hinders the activity of the DPP-4 enzyme.Formula:C12H19N3O5C2H4O2Colore e forma:SolidPeso molecolare:345.35GSK-2485852
CAS:GSK-2485852, a NS5B inhibitor, is used potentially for treatment of HCV infection.Formula:C27H25BF2N2O6SColore e forma:SolidPeso molecolare:554.37XL-784 free base
CAS:XL-784 free base selectively inhibits MMPs with IC50: MMP-1 (1.9µM), MMP-2 (0.81nM), MMP-3 (120nM), MMP-8 (10.8nM), MMP-9 (18nM), MMP-13 (0.56nM).Formula:C21H22ClF2N3O8SPurezza:98%Colore e forma:SolidPeso molecolare:549.93MDL-101146, (R)-
CAS:MDL-101146, (R)- is an effective orally active inhibitor of human neutrophil elastase.Formula:C29H37F5N4O6Purezza:98%Colore e forma:SolidPeso molecolare:632.62SSR 69071
CAS:SSR69071: selective neutrophil elastase inhibitor, stronger for humans (Ki=0.0168 nM), may treat COPD, asthma, and reduce heart injury.Formula:C27H32N4O7SColore e forma:SolidPeso molecolare:556.63Phe-Pro-Ala-pNA
CAS:Phe-Pro-Ala-pNA is a chromogenic substrate utilized for assessing tripeptidyl peptidase activity.Formula:C23H27N5O5Colore e forma:SolidPeso molecolare:453.49MDL 27324
CAS:MDL 27324 is an inhibitor of human neutrophil elastase.Formula:C29H38F3N5O6SPurezza:98%Colore e forma:SolidPeso molecolare:641.7NS5A-IN-3
CAS:NS5A-IN-3 is a potent NS5A inhibitor with high efficacy against HCV 1b, good activity on 3a, and strong metabolic stability; superior to daclatasvir.Formula:C44H44N6O8Purezza:98%Colore e forma:SolidPeso molecolare:784.86TP0556351
CAS:TP0556351: potent MMP2 inhibitor with 0.2 nM IC50, reduces collagen in pulmonary fibrosis mice.Formula:C50H70N10O16Purezza:98%Colore e forma:SolidPeso molecolare:1067.15BAY-678
CAS:BAY-678: Oral selective human neutrophil elastase inhibitor; IC50: 20 nM; SGC-approved chemical probe.Formula:C20H15F3N4O2Purezza:99.36%Colore e forma:SolidPeso molecolare:400.35Ref: TM-T10473
5mg37,00€1mL*10mM (DMSO)42,00€10mg60,00€25mg119,00€50mg173,00€100mg264,00€200mg374,00€Z-FG-NHO-BzOME
CAS:Z-FG-NHO-BzOME is a chemical compound functioning as a cysteine protease inhibitor, selectively targeting and inhibiting cathepsin B, cathepsin L, cathepsin S,Formula:C27H27N3O7Colore e forma:SolidPeso molecolare:505.52ABP 25
CAS:ABP 25 is a highly potent and selective activity-based probe (ABP) for cathepsin K imaging.Formula:C55H66ClN5O3Colore e forma:SolidPeso molecolare:880.6KB-R7785
CAS:KB-R7785 is a novel ADAM12/MMP inhibitor improving heart function and insulin sensitivity by blocking HB-EGF and TNF-alpha.Formula:C18H27N3O4Colore e forma:SolidPeso molecolare:349.42MDL 101146
CAS:MDL 101146 is an orally active neutrophil elastase inhibitor.Formula:C29H37F5N4O6Purezza:98%Colore e forma:SolidPeso molecolare:632.62Cathepsin Inhibitor 2
CAS:Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).Formula:C19H21F6N3OPurezza:98%Colore e forma:SolidPeso molecolare:421.38NCI-B16
CAS:NCI-B16 is a small-molecule RNA binder that inhibits HCV (hepatitis C virus) replication [1].Formula:C27H26N8O4Colore e forma:SolidPeso molecolare:526.55O-Benzoylhydroxylamine
CAS:O-Benzoyl hydroxylamine exhibits properties as a dipeptidyl peptidase-IV (DPP-IV) inhibitor and demonstrates antidiabetic effects[1].Formula:C7H7NO2Colore e forma:SolidPeso molecolare:137.14Neurodegenerative Disorder-Targeting Compound 1
CAS:Neurodegenerative Disorder-Targeting Compound 1 is an inhibitor of calpain [1].Formula:C28H28N4O4Purezza:98%Colore e forma:SolidPeso molecolare:484.55MMP-7-IN-2
CAS:MMP-7-IN-2 acts as a selective and potent MMP7 inhibitor and can be used to study inflammatory responses and vascular-related diseases.Formula:C28H40ClF3N6O9SPurezza:97.82%Colore e forma:SolidPeso molecolare:729.17MMP13-IN-3
CAS:MMP13-IN-3 is an oral, selective MMP-13 inhibitor with IC50 of 1 nM, >1000x selective, for osteoarthritis treatment.Formula:C24H22N4O5Purezza:99.76%Colore e forma:SolidPeso molecolare:446.46Ref: TM-T16124
1mg93,00€5mg205,00€1mL*10mM (DMSO)227,00€10mg334,00€25mg587,00€50mg802,00€100mg1.108,00€MMP-145
CAS:MMP-145 is used as a protease inhibitor.Formula:C20H20N2O7SPurezza:98%Colore e forma:SolidPeso molecolare:432.45BMS-189664
CAS:BMS-189664 is an inhibitor of thrombin.Formula:C22H34N6O4SPurezza:98%Colore e forma:SolidPeso molecolare:478.61MMP-3 Inhibitor VIII
CAS:Matrix metalloproteinase-3 (MMP-3), also known as stromelysin-1, is a critical enzyme involved in tissue remodeling and repair through its role in degrading extracellular matrix proteins, facilitating cell migration. This enzyme has been implicated in various physiological processes including vascular remodeling associated with aneurysm formation, wound healing, the progression of atherosclerosis, and tumor initiation. MMP-3 inhibitor VIII, a cell-permeable sulfonamide-based hydroxamic acid, effectively inhibits MMP-3 by binding to its active site (Ki = 23 nM), thus blocking its enzymatic activity. Additionally, this inhibitor has been demonstrated to suppress the activity of mouse macrophage metalloelastase MME/MMP-12, with an IC50 value of 13 nM, highlighting its potential utility in research on tissue remodeling and disease processes involving MMPs.Formula:C20H26N2O5SColore e forma:SolidPeso molecolare:406.5GSK-625433
CAS:GSK-625433: Homochiral inhibitor blocks HCV genotypes 1a/1b polymerase.Formula:C26H32N4O5SColore e forma:SolidPeso molecolare:512.62NK3201
CAS:NK3201, a specific chymase inhibitor, suppresses bleomycin-induced pulmonary fibrosis in hamsters.Formula:C31H29N5O6Purezza:98%Colore e forma:SolidPeso molecolare:567.59Petesicatib
CAS:Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.Formula:C25H23F6N5O4SPurezza:99.76%Colore e forma:SolidPeso molecolare:603.54Ref: TM-T16474
1mg100,00€5mg236,00€1mL*10mM (DMSO)314,00€10mg371,00€25mg735,00€50mg1.134,00€100mg1.468,00€200mg1.972,00€FK706
CAS:FK706, a human neutrophil elastase inhibitor (IC50: 83 nM, Ki: 4.2 nM), also blocks mouse and porcine elastases. Anti-inflammatory.Formula:C26H33F3N4NaO7Colore e forma:SolidPeso molecolare:593.556XL-784
CAS:XL-784 is a selective MMP inhibitor with low IC50s for MMP-1,2,3,8,9,13, modulating extracellular matrix remodeling, tumor invasion, and metastasis in cancer.Formula:C42H42Cl2F4MgN6O16S2Purezza:98%Colore e forma:SolidPeso molecolare:1122.15ND-378
CAS:ND-378 is a potent and selective inhibitor of MMP-2 with no inhibition on MMP-9 and MMP-14.Formula:C18H19NO4S2Purezza:98%Colore e forma:SolidPeso molecolare:377.48AZD-7295
CAS:AZD-7295 (A-689) is an NS5A inhibitor that may be used to treat HCV infection.Formula:C32H35F3N4O5SColore e forma:SolidPeso molecolare:644.7ONO 4817
CAS:ONO-4817 suppresses MMPs, limiting plaque progression and aortic hyperplasia in hyperlipidemic rabbits.Formula:C22H28N2O6Colore e forma:SolidPeso molecolare:416.47DCLK1-IN-2
CAS:DCLK1-IN-2 (Compound I-5) is a potent inhibitor of DCLK1, exhibiting an IC50 of 171.3 nM, and demonstrates significant antiproliferative effects on SW1990 cellFormula:C26H32N8O3SColore e forma:SolidPeso molecolare:536.65Z-DEVD-CMK
CAS:Z-DEVD-CMK irreversibly inhibits various cathepsins in vitro [1].Formula:C27H35ClN4O12Colore e forma:SolidPeso molecolare:643.04Ecallantide
CAS:Ecallantide (DX-88) is a recombinant inhibitor specifically targeting plasma kallikrein, which serves to impede the synthesis of bradykinin.Formula:C305H448N88O91S8Colore e forma:SolidPeso molecolare:7059.88MeOSuc-AAPV-CMK
CAS:MeOSuc-AAPV-CMK (Elastase Inhibitor III) serves as an inhibitor of elastase, as well as cathepsin G and proteinase 3, and impedes leukocyte elastase-mediatedFormula:C22H35ClN4O7Colore e forma:SolidPeso molecolare:502.99(1R,4S)-Yimitasvir diphosphate
CAS:Yimitasvir diphosphate, also known as Emitasvir, is an orally-administered inhibitor of the hepatitis C virus (HCV) nonstructural protein 5A (NS5A).Formula:C49H64N8O14P2Colore e forma:SolidPeso molecolare:1051.03DS-1040 Tosylate
CAS:DS-1040 Tosylate is a thrombin-activated fibrinolysis inhibitor (TAFI) inhibitor and a fibrinolysis enhancer, used for researching thromboembolic diseases.Formula:C23H35N3O5SColore e forma:SolidPeso molecolare:465.61HCV-IN-44
CAS:HCV-IN-44 (compound 28) is an inhibitor of the HCV NS5B protein, efficacious in suppressing HCV virus replication and useful for researching HCV infection [1].Formula:C24H26FN3O5SColore e forma:SolidPeso molecolare:487.54GS-6620
CAS:GS-6620 is a HCV nonstructural protein 5B (NS5B) inhibitor.Formula:C29H37N6O9PColore e forma:SolidPeso molecolare:644.61Ro 32-7315
CAS:Ro 32-7315 is a selective inhibitor of ADAM17.Formula:C22H35N3O5SPurezza:98%Colore e forma:SolidPeso molecolare:453.6LM-030
CAS:LM-030, also known as BPR277, is a novel inhibitor of kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2).Formula:C46H72N8O12Colore e forma:SolidPeso molecolare:929.11Dim16
CAS:Dim16, a dual inhibitor of PCSK9/HMG-CoAR, demonstrates potent activity with an IC50 of 19 nM against PCSK9 and significantly impedes PCSK9-LDLR interactionFormula:C29H38IN5Colore e forma:SolidPeso molecolare:583.55Berotralstat HCl
CAS:Berotralstat HCl is a selective plasma kallikrein inhibitor, reducing pain and swelling in HAE by blocking bradykinin release.Formula:C30H28Cl2F4N6OColore e forma:SolidPeso molecolare:635.4886HCV-IN-43
CAS:HCV-IN-43 (compound 2), an HCV NS5B protein inhibitor, efficiently inhibits HCV virus replication and is utilized in the study of HCV infection [1].Formula:C26H26FN3O5SColore e forma:SolidPeso molecolare:511.57Kallikrein-IN-2
CAS:Kallikrein-IN-2 (compound 1) is an inhibitor of the kinin-releasing enzyme Kallikrein.Formula:C28H25F3N4O4Colore e forma:SolidPeso molecolare:538.52Proteasome-IN-4
Proteasome-IN-4, a potent non-covalent inhibitor (IC50=8.39nM), halts cancer cell growth, useful for oncology studies.Formula:C44H58N6O5Colore e forma:SolidPeso molecolare:750.97Collagen proline hydroxylase inhibitor-1
CAS:Collagen proline hydroxylase inhibitor-1 具有抗纤维增生活性。Formula:C24H21N5O4Purezza:99.57%Colore e forma:SolidPeso molecolare:443.45BMS-212122
CAS:BMS-212122 inhibits MTP, reduces lipids and plaque in animal tests.Formula:C43H36F6N4O2Purezza:99.85%Colore e forma:SolidPeso molecolare:754.76Ref: TM-T30506
1mg315,00€5mg745,00€10mg1.018,00€25mg1.431,00€50mg1.783,00€100mg2.250,00€500mg4.410,00€MK-0674
CAS:MK-0674 is a cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S for metabolism-related diseases.Formula:C26H27F6N3O2Purezza:97.3% - 99.91%Colore e forma:SolidPeso molecolare:527.5Nesbuvir
CAS:Nesbuvir: HCV NS5B polymerase inhibitor, IC50 9 nM against HCV 1b replicon in liver cancer cells.Formula:C22H23FN2O5SPurezza:99.99%Colore e forma:SolidPeso molecolare:446.49Ref: TM-TQ0090
1mg60,00€2mg88,00€5mg133,00€1mL*10mM (DMSO)147,00€10mg173,00€25mg301,00€50mg442,00€100mg577,00€200mg780,00€HIV-1 inhibitor-54
CAS:HIV-1 inhibitor-54: potent anti-HIV (EC50: 32 nM), targets WT HIV-1 IIIB in MT-4 cells for infection research.Formula:C27H30N6O4SPurezza:98.05% - 99.39%Colore e forma:SoildPeso molecolare:534.63ZED-1227
CAS:ZED-1227 (TAK-227) is a TG2 inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Diseas
Formula:C26H36N6O6Purezza:99.04%Colore e forma:SolidPeso molecolare:528.6Aderamastat
CAS:Aderamastat (FP-025) is an orally active matrix metalloproteinase 12 (MMP-12) inhibitor indicated for the study of allergic asthma, COPD and pulmonary fibrosis.Formula:C21H18N2O4SPurezza:99.35%Colore e forma:SolidPeso molecolare:394.44γ-Glu-Tyr
CAS:gamma-Glu-Tyr (gamma-Glutamyltyrosine) is a kokumi peptide against dipeptidyl peptidase-IV (DPP-IV) and is used in the study of diabetes mellitus.Formula:C14H18N2O6Purezza:98.92%Colore e forma:SolidPeso molecolare:310.3VBY-825
CAS:VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.Formula:C23H29F4N3O5SPurezza:99.91%Colore e forma:SolidPeso molecolare:535.55Belactin A
CAS:Belactin A acts as an inhibitor of vasohibin-1 [VASH-1] with an IC50 of 0.18 µg/ml.Formula:C17H21ClN2O4Colore e forma:SolidPeso molecolare:352.81Idraparinux Na
CAS:Idraparinux Na is an Antithrombotic, Indirect, Selective, Synthetic Factor Xa InhibitorFormula:C38H55Na9O49S7Colore e forma:SolidPeso molecolare:1727.14HCV-IN-7
CAS:HCV-IN-7: potent oral HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.Formula:C40H48N8O6SPurezza:98%Colore e forma:SolidPeso molecolare:768.92Tyrosinase-IN-20
CAS:Tyrosinase-IN-20 (compound 6a) acts as a potent Tyrosinase inhibitor, demonstrating an IC 50 value of 28.50 μM [1].Formula:C17H18N2O2SColore e forma:SolidPeso molecolare:314.4RDN2150
CAS:RDN2150 (Compound 25), a ZAP-70 inhibitor with an IC50 of 14.6 nM, covalently binds to the C346 residue of ZAP-70, suppressing the expression of CD25 and CD69Formula:C28H29ClN8O4Colore e forma:SolidPeso molecolare:577.03JBIR-22
CAS:JBIR-22 is a natural inhibitor for protein−protein interaction of the homodimer of proteasome assembly factor 3.Formula:C23H33NO6Colore e forma:SolidPeso molecolare:419.51TMPRSS6-IN-1 TFA
TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), a member of the TTSP family (a type of transmembrane serine protease). TMPRSS6 is a type II TTSP, and genetically reduced levels of TMPRSS6 have been shown to improve symptoms of hemochromatosis and β-thalassemia in mice.Formula:C35H41F3N8O6S2Colore e forma:SolidPeso molecolare:790.875BI-1915
CAS:BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.Formula:C21H37N5O3Colore e forma:SolidPeso molecolare:407.55Valopicitabine dihydrochloride
CAS:Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.Formula:C15H25ClN4O6Colore e forma:SolidPeso molecolare:392.84AEP-IN-1
APE-IN-1, a potent AEP inhibitor (IC50: 89 nM), aids Alzheimer's diagnosis and drug research.Formula:C18H27N3O3Colore e forma:SolidPeso molecolare:333.43CM-352
CAS:CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.Formula:C24H29N3O6SPurezza:97.24%Colore e forma:SolidPeso molecolare:487.57Monosodium 2-sulfoterephthalate
CAS:Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.
Formula:C8H5NaO7SColore e forma:SolidPeso molecolare:268.176SSR-182289A (Free)
CAS:SSR-182289A (Free) is a thrombin inhibitor.Formula:C30H33F2N5O4SPurezza:98%Colore e forma:SolidPeso molecolare:597.68Antiplatelet agent 3
CAS:Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.Formula:C38H32N2O5Colore e forma:SolidPeso molecolare:596.671Cathepsin C-IN-5
CAS:Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.Formula:C21H17ClN6OSColore e forma:SolidPeso molecolare:436.92Gemigliptin tartrate hydrate
CAS:Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 value of 10.3 nM for human recombinant DPP-4. It exhibits strong anti-glycation properties and is used in research on advanced glycation end product-related diabetic complications.Formula:C22H27F8N5O9Colore e forma:SolidPeso molecolare:657.47Plodicitinib
CAS:Plodicitinib is an inhibitor of Janus tyrosine kinase 3/TEC family kinase, exhibiting anti-inflammatory properties.Formula:C19H22FN7O2Colore e forma:SolidPeso molecolare:399.422RXP03
CAS:RXP03 is an MMPs inhibitor with K_i values of 20 nM for MMP-2, 2.5 nM for MMP-8, 10 nM for MMP-9, 5 nM for MMP-11, and 105 nM for MMP-14 [1].Formula:C39H43N4O6PColore e forma:SolidPeso molecolare:694.76ABT-072
CAS:ABT-072 is a nonnucleoside NS5B polymerase inhibitor and a candidate drug evaluated for treatment of hepatitis C virus.Formula:C24H27N3O5SPurezza:98%Colore e forma:SolidPeso molecolare:469.55Cyclophilin inhibitor 1
CAS:Cyclophilin inhibitor 1: orally available, Kd 5 nM, potent against HCV, EC50 for HCV 2a is 98 nM.Formula:C31H39N5O7Purezza:98%Colore e forma:SolidPeso molecolare:593.67Dup-714
CAS:Dup-714 is a thrombin inhibitor.Formula:C21H33BN6O5Purezza:98%Colore e forma:SolidPeso molecolare:460.33BMT-052
CAS:BMT-052 is a potent and selective Pan-genotypic HCV NS5B Polymerase Inhibitor (EC50 = 7 nM).Formula:C30H17D9F4N6O5Purezza:98%Colore e forma:SolidPeso molecolare:635.61Faldaprevir sodium
CAS:Faldaprevir sodium: HCV treatment, inhibits NS3/NS4A protease, P-glycoprotein, CYP3A4, UGT1A1.Formula:C40H48BrN6NaO9SColore e forma:SolidPeso molecolare:891.81Ciluprevir
CAS:Ciluprevir is a selective HCV NS3 protease inhibitor, effective against non-genotype-1 HCV; less potent for genotypes 2/3.Formula:C40H50N6O8SPurezza:98%Colore e forma:SolidPeso molecolare:774.93Pyridoxatin
CAS:Pyridoxatin: fungal metabolite; blocks TBARS production, prevents AAPH-induced hemolysis, and acts against C. albicans.Formula:C15H21NO3Colore e forma:SolidPeso molecolare:263.33PLGLAG
CAS:PLGLAG is a peptide chain that acts as a linker in activatable cell-penetrating peptides (ACPPs). ACPPs containing the PLGLAG linker are primarily sensitive to MMP-2 and MMP-9 in vivo. PLGLAG is applicable in cancer research.Formula:C24H42N6O7Colore e forma:SolidPeso molecolare:526.63Cathepsin C-IN-3
Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).Formula:C28H21F3N6OSColore e forma:SolidPeso molecolare:546.57Piceid 6″-O-azelaic acid ester
Piceid 6″-O-azelaic acid ester exhibited strong intracellular tyrosinase inhibition and decolorization activity.Formula:C24H36O10Colore e forma:SolidPeso molecolare:484.54GSK-2878175
CAS:GSK-2878175, a NS5B inhibitor, is used potentially for the treatment of HCV infection.Formula:C27H23BClFN2O6SPurezza:98%Colore e forma:SolidPeso molecolare:568.81MeO-Suc-Ala-Ala-Pro-Ala-CMK
CAS:MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE) with an IC50 of 20.3 μM. It effectively inhibits the hydrolysis of substrates like lung tissue elastin by HNE and is applicable in studies related to conditions such as chronic obstructive pulmonary disease (COPD).Formula:C20H31ClN4O7Colore e forma:SolidPeso molecolare:474.936MMP-13-IN-1
CAS:MMP-13-IN-1, with an IC50 value of 16 nM, is a potent and selective inhibitor of MMP-13, suitable for atherosclerosis research [1].Formula:C19H16F3N3O3Colore e forma:SolidPeso molecolare:391.34Freselestat
CAS:Freselestat (ONO-6818) inhibits neutrophil elastase, reduces interleukin 8, C5B-9, and inflammation in cardiopulmonary bypass.Formula:C23H28N6O4Colore e forma:SolidPeso molecolare:452.51Tyrosinase-IN-37
CAS:Tyrosinase-IN-37 (Compound 3c) is a potent inhibitor of tyrosinase, with an IC50 value of 1.02 μM, which is 14 times more effective than kojic acid (IC50 of 14.74 μM). This compound effectively prevents the browning of Rosa roxburghii and can also inhibit browning not caused by tyrosinase.Formula:C12H12N6SColore e forma:SolidPeso molecolare:272.33NAPAP
CAS:NAPAP is a thrombin inhibitor with potent anticoagulant activity (Ki: 2.1 nM). It selectively inhibits thrombin through a rapid binding mechanism while exhibiting weaker inhibition of trypsin, Factor Xa, and plasmin. NAPAP can be utilized for research into thrombotic conditions, including venous thrombosis and myocardial infarction.Formula:C27H31N5O4SColore e forma:SolidPeso molecolare:521.63Feniralstat
CAS:Feniralstat (KVD-824) is a selective and potent kallikrein (kallikrein) inhibitor, useful in immune system diseases and cardiovascular disease research.Formula:C26H25F2N5O4Purezza:99.52%Colore e forma:SolidPeso molecolare:509.51SBI-581
SBI-581: oral, potent TAO3 inhibitor, IC50=42nM, alters TKS5α at RAB11+ vesicles, blocks invadopodia, good mouse pharmacokinetics, anti-tumor.Formula:C24H21N3O2Colore e forma:SolidPeso molecolare:383.44ZINC09518833
CAS:ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).Formula:C24H25N3O5Colore e forma:SolidPeso molecolare:435.47Kallikrein-IN-1
CAS:Kallikrein-IN-1 (Formula A) is an inhibitor of the kinin-releasing enzyme Kallikrein.Formula:C28H26FN5O4Colore e forma:SolidPeso molecolare:515.54BAY-7598
CAS:BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).Formula:C28H31N3O6Purezza:98%Colore e forma:SolidPeso molecolare:505.56Deleobuvir
CAS:Deleobuvir(BI207127) is an inhibitor of non-nucleoside hepatitis C virus NS5B polymerase for the treatment of hepatitis C.Formula:C34H33BrN6O3Colore e forma:SolidPeso molecolare:653.57HCV-IN-40
CAS:HCV-IN-39 is a potent oral drug inhibiting HCV, effective on GT1a (EC50: 0.259μM), GT1b (EC50: 0.434μM), GT1b CES1 (EC50: 0.069μM) replicons.Formula:C21H26BrFN3O9PColore e forma:SolidPeso molecolare:594.32HsClpP activator-1
CAS:HsClpP activator-1 (compound 24) is a potent activator of HsClpP, with an EC50 of 0.22 μM. It effectively inhibits cancer cell growth, exhibiting IC50 values ranging from 0.1 to 1 μM.Formula:C23H20F5N3O2Colore e forma:SolidPeso molecolare:465.42Duazomycin sodium
CAS:Duazomycin (Duazomycin A) sodium acts as a glutamine antagonist. It significantly enhances the efficacy of 6-Mercaptopurine (6-MP) in treating experimental autoimmune encephalomyelitis (EAE) without increasing toxicity.Formula:C8H10N3NaO4Colore e forma:SolidPeso molecolare:235.17GW311616
CAS:GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).Formula:C19H31N3O4SColore e forma:SolidPeso molecolare:397.53Tyrosinase-IN-29
CAS:Tyrosinase-IN-29 (compound 5c) is an effective inhibitor of abTYR tyrosinase, demonstrating an IC50 value of 6.11 μM. It is suitable for further research into the inhibition of excessive skin pigmentation.Formula:C10H9NO2Colore e forma:SolidPeso molecolare:175.18Immunoproteasome activator 1
CAS:Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.Formula:C24H23N3O3Colore e forma:SolidPeso molecolare:401.46GLS-1-IN-1
GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.Formula:C26H25FN4OSColore e forma:SolidPeso molecolare:460.57Tyrosinase-IN-35
CAS:Tyrosinase-IN-35 (compound 6g), exhibiting a IC 50 value of 2.09 μM, serves as a more effective inhibitor of human tyrosinase compared to Kojic Acid (IC 50: 16.38 μM). At concentrations of 4 μM and 8 μM, this compound effectively lowers melanin levels in melanoma B16F10 cells in vitro.Formula:C17H15N5OSColore e forma:SolidPeso molecolare:337.40Narlaprevir
CAS:Narlaprevir (SCH 900518) is an HCV NS3 inhibitor with anti-HCV activity, inhibiting SARS-CoV-2, and useful in virus infection research.Formula:C36H61N5O7SPurezza:98%Colore e forma:SolidPeso molecolare:707.96Marizomib
CAS:Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L, CT-T-laspase-like, and trypsin-like 20S proteasomes.Cost-effective and quality-assured.Formula:C15H20ClNO4Purezza:98.03% - 99.41%Colore e forma:SolidPeso molecolare:313.78Odiparcil
CAS:Odiparcil is an orally active beta-d-thioxyloside analog.Formula:C15H16O6SPurezza:98%Colore e forma:SolidPeso molecolare:324.35Tyrosinase-IN-33
CAS:Tyrosinase-IN-33 (compound 5), a pyridine-based compound, acts as an effective inhibitor of diphenolase activity in mushroom tyrosinase. It significantly reduces enzyme activity with an IC50 of 9.0 μM.Formula:C19H17NS2Colore e forma:SolidPeso molecolare:323.48SD-7300
CAS:SD-7300 (SC-81490) functions as an orally active inhibitor targeting MMP-2, MMP-9, and MMP-13, exhibiting potent inhibition with K_i values of 0.03, 0.01, and 0.03 nM, respectively. By inhibiting these metalloproteinases, SD-7300 effectively reduces extracellular matrix degradation by tumor cells, thereby curbing their invasion and metastasis. Additionally, this compound acts as a dose-dependent inhibitor of mouse corneal angiogenesis and prevents interleukin-1-induced degradation of bovine cartilage. SD-7300 is applicable in the study of breast cancer.Formula:C21H30F3N3O7SColore e forma:SolidPeso molecolare:525.54Beclabuvir
CAS:Beclabuvir blocks HCV NS5B polymerase at thumb site 1, effective on genotypes 1, 3, 4, 5 with IC50 <28 nM.Formula:C36H45N5O5SPurezza:99.87% - 99.93%Colore e forma:SolidPeso molecolare:659.84AMG-222 tosylate
CAS:AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.Formula:C39H47N9O6SColore e forma:SolidPeso molecolare:769.91Zetomipzomib
CAS:KZR-616: Immunoproteasome inhibitor targeting LMP7 (IC50: 39/57 nM) & LMP2 (IC50: 131/179 nM), potential in autoimmune disease research.Formula:C30H42N4O8Colore e forma:SolidPeso molecolare:586.68(1R,3S)-THCCA-Asn
(1R,3S)-THCCA-Asn (4j) is a selective inhibitor of thrombin (IC50: 0.07-0.14 μM) with anti-thrombotic effects.Formula:C24H24N4O6Colore e forma:SolidPeso molecolare:464.47GSK5852
GSK5852, an HCV NS5B inhibitor, has IC50 of 50 nM; potently fights HCV with EC50 of 3.0 nM for GT1a and 1.7 nM for GT1b.Formula:C27H27BF2N2O6SColore e forma:SolidPeso molecolare:556.39SAR107375
CAS:SAR107375 is a potent, orally active dual inhibitor of thrombin and factor Xa, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively [1].Formula:C24H30ClN5O5S2Colore e forma:SolidPeso molecolare:568.11Valopicitabine
CAS:Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronicFormula:C15H24N4O6Purezza:98%Colore e forma:SolidPeso molecolare:356.37GW311616 hydrochloride
CAS:GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).Formula:C19H32ClN3O4SPurezza:98%Colore e forma:SolidPeso molecolare:433.99Napsagatran hydrate
CAS:Napsagatran hydrate is a novel and specific inhibitor of thrombin.Formula:C26H36N6O7SPurezza:98%Colore e forma:SolidPeso molecolare:576.66HCV NS5B polymerase-IN-2
CAS:HCVNS5B polymerase-IN-2 (Compound 298) is an inhibitor of the Ns5b polymerase. It holds potential for research into the treatment of hepatitis C virus (HCV) infections.Formula:C26H24N2O4Colore e forma:SolidPeso molecolare:428.48Cathepsin C-IN-4
Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).Formula:C21H14ClF3N4SColore e forma:SolidPeso molecolare:446.88Verducatib
CAS:Verducatib is an inhibitor of cathepsins (cathepsin).Formula:C31H35FN4O3Colore e forma:SolidPeso molecolare:530.633DPP-4-IN-15
CAS:DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.Formula:C17H14F3N3O2SColore e forma:SolidPeso molecolare:381.372Plasma kallikrein-IN-2
Plasma kallikrein-IN-2: PKal inhibitor, IC50=0.1 nM. Used in angioedema, diabetic eye disease research.Formula:C28H24ClF3N8O3Colore e forma:SolidPeso molecolare:612.99SMCypI C31
SMCypIC31, a non-peptide cyclophilin inhibitor, blocks PPIase at 0.1 μM IC50 and fights various HCV genotypes (EC50: 1.20-7.76 μM).Formula:C27H30N4O2SColore e forma:SolidPeso molecolare:474.62Anti-infective agent 10
CAS:Anti-infective agent 10 (Compound Example 30) is an ns5b polymerase inhibitor that functions as an anti-HCV agent.Formula:C26H25N3O7SColore e forma:SolidPeso molecolare:523.56Freselestat quarterhydrate
ONO-6818 quarterhydrate: oral neutrophil elastase inhibitor, Ki 12.2 nM; >100x less effective on other proteases; strong anti-inflammatory.Formula:C23H30N6O5Colore e forma:SolidPeso molecolare:457.03MK-8876
CAS:MK-8876 is an Inhibitor of HCV NS5B Site D.Formula:C32H24F2N4O5SPurezza:98%Colore e forma:SolidPeso molecolare:614.62RIPK1-IN-26
CAS:RIPK1-IN-26 is a potent inhibitor of Receptor-Interacting Serine/Threonine Kinase 1 (RIPK1), exhibiting anti-necrotic properties in cells. This compound demonstrates good metabolic stability and binding specificity in mice. RIPK1-IN-26 holds potential for development as a PET imaging probe and in the research of neurodegenerative diseases.Formula:C15H20FNO2Colore e forma:SolidPeso molecolare:265.32GB111-NH2
CAS:GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].Formula:C33H39N3O6Colore e forma:SolidPeso molecolare:573.68TCL1
CAS:TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.Formula:C19H14BrClN4O2SColore e forma:SolidPeso molecolare:477.762JBJ-08-178-01
CAS:JBJ-08-178-01, a mutant-selective tyrosine kinase inhibitor, targets (HER2) human epidermal growth factor receptor 2 and exhibits antitumoral activity. This compound not only diminishes HER2's kinase activity and protein levels through the induction of proteasomal degradation of the receptor but also shows promise in non-small-cell lung cancer research.Formula:C31H30N8O3Colore e forma:SolidPeso molecolare:562.62Faldaprevir
CAS:Faldaprevir is an orally effective, selective, non-covalent HCV NS3/4A protease inhibitor with high inhibitory activity against HCV 1a and 1b genotype.Formula:C40H49BrN6O9SPurezza:99.04% - 99.19%Colore e forma:SolidPeso molecolare:869.82Cathepsin K inhibitor 2
CAS:Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.Formula:C30H33F4N5O3Colore e forma:SolidPeso molecolare:587.61HCV-IN-38
Potent oral HCV inhibitor HCV-IN-38 has 15 nM EC50, 431 SI, high efficacy, and low toxicity.Formula:C22H24ClF3N4O4Colore e forma:SolidPeso molecolare:500.9Matriptase-IN-2 free base
CAS:Matriptase-IN-2 free base, a matriptase inhibitor with a K i of 5 nM, has potential applications in musculoskeletal system disorder research (WO2011023958A1; compound 432) [1].Formula:C29H33Cl2N5O3SColore e forma:SolidPeso molecolare:602.58Enantiomer of Sofosbuvir
Inactive enantiomer of Sofosbuvir, used for chronic hepatitis C; lacks reported biological activity.Formula:C22H29FN3O9PPurezza:98%Colore e forma:SolidPeso molecolare:529.45SD-2590 HCl
CAS:SD-2590 HCl is an MMP-2,-3, -9, -8, 13, and -14 inhibitor.Formula:C22H26ClF3N2O7SPurezza:98%Colore e forma:SolidPeso molecolare:554.96(2S,4R)-Teneligliptin
CAS:(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.Formula:C22H30N6OSColore e forma:SolidPeso molecolare:426.578RO5461111
CAS:RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.Formula:C27H24F6N4O4SColore e forma:SolidPeso molecolare:614.56CatD-IN-1
CAS:CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.Formula:C18H18Cl2N4O5Colore e forma:SolidPeso molecolare:441.265Tilpisertib fosmecarbil
CAS:Tilpisertib fosmecarbil is a potent inhibitor of serine/threonine kinases with anti-inflammatory properties.Formula:C35H36ClN8O7PColore e forma:SolidPeso molecolare:747.14BI-1942
CAS:BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.Formula:C24H26N4O4Colore e forma:SolidPeso molecolare:434.488Isobutylamido thiazolyl resorcinol
CAS:Isobutylamido thiazolyl resorcinol is a tyrosinase (Tyrosinase) inhibitor that prevents pigment deposition induced by ultraviolet radiation.Formula:C13H14N2O3SColore e forma:SolidPeso molecolare:278.33TG-2-IN-4
CAS:TG-2-IN-4 (compound 8), an inhibitor of transglutaminase 2 (TG2) with an IC 50 value of less than 0.5 mM, is utilized in the study of inflammatory disorders [1].Formula:C34H40N6O5Colore e forma:SolidPeso molecolare:612.723-Aminobenzene-1,2-diol
CAS:3-Aminobenzene-1,2-diol (compound C8) is an inhibitor of matrix metalloproteinases (MMP), with IC50 values of 20, 26, 16, and 16.3 μM against MMP-2, MMP-8, MMP-9, and MMP-14, respectively.Formula:C6H7NO2Colore e forma:SolidPeso molecolare:125.13UK-370106
CAS:UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-Formula:C35H44N2O5Purezza:98%Colore e forma:SolidPeso molecolare:572.73RJF02215
CAS:RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.Formula:C17H12ClN3OS3Colore e forma:SolidPeso molecolare:405.95UK 356618
CAS:UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).Formula:C34H43N3O4Purezza:98%Colore e forma:SolidPeso molecolare:557.72PNU-248686A
CAS:PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).Formula:C22H18ClNaO5S2Purezza:98%Colore e forma:SolidPeso molecolare:484.95RBx-0597
CAS:RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.Formula:C19H20F2N4O2Colore e forma:SolidPeso molecolare:374.384CE-2072
CAS:CE-2072 is a synthetic host serine proteases inhibitor.Formula:C33H41N5O6Purezza:98%Colore e forma:SolidPeso molecolare:603.71MIV-247
CAS:MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.Formula:C17H24F3N3O4Purezza:99.27%Colore e forma:SolidPeso molecolare:391.39Vaniprevir
CAS:Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.Formula:C38H55N5O9SPurezza:97.41%Colore e forma:SolidPeso molecolare:757.94IDX184
CAS:IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3Formula:C25H35N6O9PSPurezza:97.15%Colore e forma:SolidPeso molecolare:626.62JTK-109
CAS:JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.Formula:C37H33ClFN3O4Purezza:98.48% - 99.68%Colore e forma:SolidPeso molecolare:638.13Ref: TM-T27696
1mg296,00€5mg718,00€10mg982,00€1mL*10mM (DMSO)1.108,00€25mg1.485,00€50mg2.008,00€100mg2.637,00€PD 151746
CAS:PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.Formula:C11H8FNO2SPurezza:98.63% - ≥95%Colore e forma:SolidPeso molecolare:237.25Sebetralstat
CAS:Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.
Formula:C26H26FN5O4Purezza:99.85%Colore e forma:SolidPeso molecolare:491.512,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-
CAS:Formula:C37H48N6O5S2Purezza:≥98%Colore e forma:SolidPeso molecolare:720.9442ABT-072 potassium trihydrate
CAS:ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).Formula:C24H32KN3O8SColore e forma:SolidPeso molecolare:561.69IPN60090 dihydrochloride
CAS:IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.Formula:C24H29Cl2F3N8O3Colore e forma:SolidPeso molecolare:605.44ALLM
CAS:ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].Formula:C19H35N3O4SPurezza:98%Colore e forma:White PowderPeso molecolare:401.56MMP13-IN-2
CAS:MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.Formula:C24H19FN6O4SColore e forma:SolidPeso molecolare:506.51Oxindole
CAS:Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.
Formula:C8H7NOPurezza:99.34%Colore e forma:Off-White Crystalline PowderPeso molecolare:133.15Butabindide oxalate
CAS:CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitorFormula:C19H27N3O6Purezza:98%Colore e forma:SolidPeso molecolare:393.43Davelizomib
CAS:Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].
Formula:C21H26BF2N3O7Purezza:98%Colore e forma:SolidPeso molecolare:481.25
