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Proteina G/GPCR

Proteina G/GPCR

Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.

Sottocategorie di "Proteina G/GPCR"

Mostrare 18 più sottocategorie

Trovati 5378 prodotti di "Proteina G/GPCR"

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  • HU 433
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    HU 433

    CAS:
    <p>HU 433, a synthetic cannabinoid, acts as a CB2 receptor agonist and is an enantiomer of HU 308. It provides anti-inflammatory and neuroprotective effects by binding to the CB2 receptor, primarily found on immune cells, thereby modulating immune responses and inflammation. Additionally, HU 433 influences microglial signaling pathways, particularly LPS and IFNγ-mediated routes, affecting the phosphorylation of MAPKs, including ERK1/2, JNK, p38, and Akt. This compound is valuable in researching neuroinflammation and retinal diseases.</p>
    Formula:C27H42O3
    Colore e forma:Solid
    Peso molecolare:414.62

    Ref: TM-T88373

  • (2R,3S)-Azelaprag
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    (2R,3S)-Azelaprag

    CAS:
    <p>(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide is an Apelin receptor agonist</p>
    Formula:C25H29N7O4S
    Purezza:97.47% - >99.99%
    Colore e forma:Soild
    Peso molecolare:523.61

    Ref: TM-T14390L

  • Logo CymitQuimica
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    5-HT7R antagonist 1

    <p>5-HT7R antagonist 1 is a G protein-biased antagonist with Ki of 6.5 nM for 5-HT 7R.</p>
    Formula:C14H18Cl2N4
    Colore e forma:Solid
    Peso molecolare:313.23

    Ref: TM-T60790

  • (Rac)-Nebivolol
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    (Rac)-Nebivolol

    CAS:
    <p>(Rac)-Nebivolol, a racemic β1-adrenergic blocker (IC50=0.8 nM), has vasodilatory properties and mitigates ethanol-induced cardiac harm.</p>
    Formula:C22H25F2NO4
    Colore e forma:Solid
    Peso molecolare:405.43

    Ref: TM-T62004

  • Rodatristat
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    Rodatristat

    CAS:
    <p>Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).</p>
    Formula:C27H27ClF3N5O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:561.98

    Ref: TM-T16780

  • SSR 146977
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    SSR 146977

    CAS:
    <p>NK3 receptor antagonist</p>
    Formula:C35H42Cl2N4O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:621.64

    Ref: TM-T23395

  • GRK6-IN-4
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    GRK6-IN-4

    CAS:
    <p>GRK6-IN-4 is an inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 value of 1.56 μM. GRK6-IN-4 is applicable for research related to hematological malignancies, inflammatory diseases, and autoimmune disorders.</p>
    Formula:C15H15N5
    Colore e forma:Solid
    Peso molecolare:265.313

    Ref: TM-T204959

  • CVN766
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    CVN766

    CAS:
    <p>CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and &gt;10 μM for OX2R. CVN766 can be used to study schizophrenia [1].</p>
    Formula:C20H21F3N8O
    Colore e forma:Solid
    Peso molecolare:446.43

    Ref: TM-T86110

  • PSB 36
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    PSB 36

    CAS:
    <p>A1 adenosine receptor antagonist</p>
    Formula:C21H30N4O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:386.49

    Ref: TM-T23202

  • SJPYT-310
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    SJPYT-310

    CAS:
    <p>SJPYT-310 is a selective PXR antagonist, exhibiting no noticeable cytotoxicity.</p>
    Formula:C27H36N4O3
    Colore e forma:Solid
    Peso molecolare:464.6

    Ref: TM-T205404

  • (S)-Praziquantel
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    (S)-Praziquantel

    CAS:
    <p>(S)-Praziquantel is the inactive isomer of R-praziquantel.</p>
    Formula:C19H24N2O2
    Colore e forma:Solid
    Peso molecolare:312.406

    Ref: TM-T206068

  • Acyline
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    Acyline

    CAS:
    <p>Acyline, a GnRH antagonist, suppresses gonadotropins and testosterone in animals and maintains the effect for 2 weeks in men with one dose.</p>
    Formula:C80H102ClN15O14
    Colore e forma:Solid
    Peso molecolare:1533.21

    Ref: TM-T70266

  • CS-0777
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    CS-0777

    CAS:
    <p>CS-0777 is a potent, selective, and orally active S1P1 agonist (sphingosine 1-phosphate receptor modulator).</p>
    Formula:C21H31N2O5P
    Colore e forma:Solid
    Peso molecolare:422.45

    Ref: TM-T31107

  • Logo CymitQuimica
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    5-HT6R/MAO-B modulator 1

    <p>5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.</p>
    Formula:C33H38N4O3S
    Colore e forma:Solid
    Peso molecolare:570.74

    Ref: TM-T64036

  • GLP-1 receptor agonist 11
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    GLP-1 receptor agonist 11

    CAS:
    <p>GLP-1 Receptor Agonist 11 (compound 3) acts as an effective agonist for the GLP Receptor, finding use in research related to conditions like diabetes and non-alc. fatty liver disease [1].</p>
    Formula:C31H31ClFN3O4
    Colore e forma:Solid
    Peso molecolare:564.05

    Ref: TM-T86503

  • SSTR4 agonist 4
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    SSTR4 agonist 4

    CAS:
    <p>SSTR4 agonist 4, potent in pain research, shows promise in rodent pain models, with potential for Alzheimer's due to hippocampus activity.</p>
    Formula:C19H26N4O
    Colore e forma:Solid
    Peso molecolare:326.44

    Ref: TM-T60911

  • LY3154207
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    LY3154207

    CAS:
    <p>LY3154207: selective, potent oral human dopamine D1 receptor PAM, low agonist activity, EC50=3 nM.</p>
    Formula:C24H29Cl2NO3
    Colore e forma:Solid
    Peso molecolare:450.4

    Ref: TM-T11912

  • 25B-NBOH hydrochloride
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    25B-NBOH hydrochloride

    CAS:
    <p>25B-NBOH hydrochloride is a phenethylamine that exhibits high affinity for serotonin (5-HT) receptors 5-HT2A and 5-HT2C, with pKi values of 8.3 and 9.4, respectively.</p>
    Formula:C17H21BrClNO3
    Colore e forma:Solid
    Peso molecolare:402.711

    Ref: TM-T204858

  • D3/5-HT receptor modulator-1
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    D3/5-HT receptor modulator-1

    CAS:
    <p>D3/5-HT receptor modulator-1 (compound 5i) is a selective antagonist of the dopamine D3 and 5-HT2A receptors, and a partial agonist at the 5-HT1A receptor. It exhibits Ki values of 4.5 nM, 11.9 nM, and 15.3 nM for the dopamine D3, 5-HT2A, and 5-HT1A receptors respectively. The compound shows lower affinity for the dopamine D2 receptor, 5-HT2C receptor, and hERG channel. D3/5-HT receptor modulator-1 possesses atypical antipsychotic properties.</p>
    Formula:C24H29N3O2
    Colore e forma:Solid
    Peso molecolare:391.506

    Ref: TM-T205297

  • Zaladenant
    Targetmol
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    Zaladenant

    CAS:
    <p>Zaladenant is an adenosine receptor antagonist with antitumor properties.</p>
    Formula:C19H15F3N6O
    Colore e forma:Solid
    Peso molecolare:400.357

    Ref: TM-T205251