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Proteina G/GPCR

Proteina G/GPCR

Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.

Sottocategorie di "Proteina G/GPCR"

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Trovati 5373 prodotti di "Proteina G/GPCR"

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  • Logo CymitQuimica
    Targetmol
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    MrgprX2 antagonist-6

    <p>MrgprX2 antagonist-6 is a potent antiallergic agent with inhibitory effects on mast cell degranulation.</p>
    Formula:C24H23F3N6O3
    Colore e forma:Solid
    Peso molecolare:500.47

    Ref: TM-T63394

  • Ici D1542
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    Ici D1542

    CAS:
    Ici D1542: potent TXS inhibitor & TXA2 receptor antagonist, effective thromboxane blocker in vitro.
    Formula:C25H30N2O7
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:470.51

    Ref: TM-T24157

  • AH22921
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    AH22921

    CAS:
    <p>AH22921 is an EP4 prostaglandin receptor antagonist with the ability to antagonize the activation of adenylyl cyclase by prostaglandins in CHO cells. It induces a rightward shift in the PGE? concentration-response curve in these cells, functioning as a non-competitive antagonist. AH22921 is selective for the EP4 receptor, inhibiting its activity in CHO cells without affecting the PGE? concentration-response curve in NPE cells that contain the EP2 receptor.</p>
    Formula:C29H35NO5
    Colore e forma:Solid
    Peso molecolare:477.59

    Ref: TM-T200553

  • NBI 35965 hydrochloride
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    NBI 35965 hydrochloride

    CAS:
    <p>NBI 35965 hydrochloride is a selective CRF1 (corticotropin-releasing factor receptor 1) antagonist that is both orally active and capable of penetrating the brain. It possesses a K i value of 4 nM and a pK i of 8.5, and does not affect CRF2. This compound effectively diminishes CRF or stress-triggered ACTH (adrenocorticotropic hormone) production in vivo, demonstrating pIC 50 values of 7.1 and 6.9. Additionally, NBI 35965 hydrochloride exhibits anxiolytic properties [1] [2].</p>
    Formula:C21H23Cl3N4
    Colore e forma:Solid
    Peso molecolare:437.79

    Ref: TM-T86978

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    Dopamine D3 receptor ligand-1

    <p>Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki:</p>
    Formula:C27H29N5O
    Colore e forma:Solid
    Peso molecolare:439.55

    Ref: TM-T62528

  • DMPX
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    DMPX

    CAS:
    <p>DMPX (3,7-Dimethyl-1-propargylxanthine) is a caffeine-like compound capable of crossing the blood-brain barrier. It serves as an A2-selective adenosine receptor (AR) antagonist, effectively and selectively blocking the hypothermia and behavioral inhibition induced by A2 adenosine receptor agonists, such as NECA. DMPX is utilized in research on diseases like Parkinson's disease.</p>
    Formula:C10H10N4O2
    Colore e forma:Solid
    Peso molecolare:218.212

    Ref: TM-T204595

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    H3R antagonist 2

    <p>Compound 23: H3R antagonist with 170 nM Ki; inhibits AChE, BChE, hMAO B; IC50s: 180, 880, 775 nM; anti-pain, memory boost; crosses BBB. [1]</p>
    Formula:C24H29NO3
    Colore e forma:Solid
    Peso molecolare:379.49

    Ref: TM-T61603

  • Anthrotainin
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    Anthrotainin

    CAS:
    <p>Anthrotainin is a tetracyclic compound that acts as an inhibitor of the binding of P substance (substance P), with an IC50 of 3 μM.</p>
    Formula:C20H17NO9
    Colore e forma:Solid
    Peso molecolare:415.35

    Ref: TM-T205066

  • LY 215840
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    LY 215840

    CAS:
    <p>5-HT2/5-HT7 receptor antagonist</p>
    Formula:C24H33N3O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:395.54

    Ref: TM-T22940

  • OP-2507
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    OP-2507

    CAS:
    <p>OP-2507, a prostacyclin agonist, is used potentially for the treatment of hepatic insufficiency and hypertension.</p>
    Formula:C25H41NO4
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:419.6

    Ref: TM-T28254

  • SSR 146977
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    SSR 146977

    CAS:
    <p>NK3 receptor antagonist</p>
    Formula:C35H42Cl2N4O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:621.64

    Ref: TM-T23395

  • BIIE-0246 HCl
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    BIIE-0246 HCl

    CAS:
    <p>BIIE-0246: A potent, non-peptide Y2 receptor antagonist; &gt;650-fold more selective than Y1, Y4, Y5.</p>
    Formula:C49H59Cl2N11O6
    Colore e forma:Solid
    Peso molecolare:968.97

    Ref: TM-T69621

  • Merigolix
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    Merigolix

    CAS:
    <p>Merigolix is a potent gonadotrophin releasing hormone (GnRH) antagonist .</p>
    Formula:C36H35F7N4O6
    Colore e forma:Solid
    Peso molecolare:752.68

    Ref: TM-T73327

  • SCH-900822
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    SCH-900822

    CAS:
    <p>SCH-900822 is a potent and selective glucagon receptor antagonist.</p>
    Formula:C34H43Cl2N7O2
    Colore e forma:Solid
    Peso molecolare:652.66

    Ref: TM-T71201

  • Leukotriene F4
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    Leukotriene F4

    CAS:
    <p>LTF4, made in vitro from LTE4 with enzymes, contracts vascular muscle weakly; potency is LTD4 &gt; LTC4 &gt; LTE4 &gt;&gt; LTF4.</p>
    Formula:C28H44N2O8S
    Colore e forma:Solid
    Peso molecolare:568.72

    Ref: TM-T38129

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    hA3AR agonist 1

    <p>hA3AR agonist 1 is a potent human A 3 adenosine receptor (hA 3 AR) agonist (Ki = 2.40 nM) .</p>
    Formula:C10H14N6OS
    Colore e forma:Solid
    Peso molecolare:266.32

    Ref: TM-T60444

  • Logo CymitQuimica
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    MrgprX2 antagonist-7

    <p>MrgprX2 antagonist-7 is an anti-allergic agent with significant anti-allergic effects and inhibits mast cell degranulation.</p>
    Formula:C24H22ClF3N6O3
    Colore e forma:Solid
    Peso molecolare:534.92

    Ref: TM-T63766

  • Tofogliflozin
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    Tofogliflozin

    CAS:
    Tofogliflozin specifically inhibits SGLT2; IC50s are 2.9 nM (human), 14.9 nM (rat), 6.4 nM (mouse).
    Formula:C22H26O6
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:386.44

    Ref: TM-T13179

  • (S)-YNT-3708
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    (S)-YNT-3708

    CAS:
    <p>(S)-YNT-3708 is the S-isomer of YNT-3708, demonstrating relatively low activity against OX1R and OX2R receptors, with EC50 values of 3595 nM and 1661 nM, respectively.</p>
    Formula:C35H36N4O6S
    Colore e forma:Solid
    Peso molecolare:640.749

    Ref: TM-T206866

  • SSTR4 agonist 4
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    SSTR4 agonist 4

    CAS:
    <p>SSTR4 agonist 4, potent in pain research, shows promise in rodent pain models, with potential for Alzheimer's due to hippocampus activity.</p>
    Formula:C19H26N4O
    Colore e forma:Solid
    Peso molecolare:326.44

    Ref: TM-T60911