CymitQuimica logo
Proteina G/GPCR

Proteina G/GPCR

Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.

Sottocategorie di "Proteina G/GPCR"

Mostrare 18 più sottocategorie

Trovati 5352 prodotti di "Proteina G/GPCR"

Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
prodotti per pagina.
  • Ro4368554
    Targetmol
    + Info

    Ro4368554

    CAS:
    <p>Ro4368554 is a selective 5-HT6 antagonist capable of crossing the blood-brain barrier. It can reverse memory deficits caused by scopolamine and tryptophan depletion. Ro4368554 is applicable for research related to memory impairments.</p>
    Formula:C19H21N3O2S
    Colore e forma:Solid
    Peso molecolare:355.454

    Ref: TM-T204915

  • AM9405
    Targetmol
    + Info

    AM9405

    <p>AM9405: peripheral CB1/5-HT3 agonist, suppresses gut motility, relieves GI disorder symptoms in mice.</p>
    Formula:C24H33BrN2O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:461.44

    Ref: TM-T10294

  • H1R ligand-1
    Targetmol
    + Info

    H1R ligand-1

    CAS:
    <p>H1R ligand-1 (Compound fragment 1) is a high-affinity ligand for the human histamine H1 receptor (H1R). It can serve as a scaffold for synthesizing a series of derivatives to investigate H1R binding kinetics.</p>
    Formula:C19H23NO
    Colore e forma:Solid
    Peso molecolare:281.392

    Ref: TM-T205504

  • 5-IAI hydrochloride
    Targetmol
    + Info

    5-IAI hydrochloride

    CAS:
    <p>5-IAI hydrochloride is a psychoactive analog of para-iodoamphetamine. 5-IAI hydrochloride significantly reduces serotonin uptake sites and hippocampal serotonin levels in rats.</p>
    Formula:C9H11ClIN
    Colore e forma:Solid
    Peso molecolare:295.548

    Ref: TM-T204949

  • Pexacerfont
    Targetmol
    + Info

    Pexacerfont

    CAS:
    <p>Pexacerfont (BMS-562086) is a selective antagonist of the corticotropin-releasing factor receptor (IC50: 6.1±0.6 nM for the human CRF1 receptor).</p>
    Formula:C18H24N6O
    Purezza:99.77%
    Colore e forma:Solid
    Peso molecolare:340.42

    Ref: TM-T16475

  • EP4 receptor antagonist 7
    Targetmol
    + Info

    EP4 receptor antagonist 7

    CAS:
    <p>EP4 receptor antagonist 7 (Compound 14) is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4, with an IC50 of 1.1 nM. This compound inhibits PGE2-induced β-arrestin recruitment in HEK293 cells with an IC50 of 0.9 nM. In RAW 264.7 macrophages, it reduces the expression of PGE2-induced IL-4, macrophage mannose receptor 1 (Mrc1), chitinase-like protein 3 (Chil3), chemokine (C-X-C motif) ligand 1 (Cxcl1), triggering receptor expressed on myeloid cells 2 (Trem2), and arginase 1 (Arg1) mRNA. In the CT26 mouse colon cancer model, EP4 receptor antagonist 7, combined with an anti-PD-1 antibody, inhibits tumor growth and enhances CD8+ T cell infiltration into the tumor.</p>
    Formula:C24H18F3N3O3
    Colore e forma:Solid
    Peso molecolare:453.413

    Ref: TM-T204782

  • Gemilukast
    Targetmol
    + Info

    Gemilukast

    CAS:
    <p>Gemilukast (ONO-6950) is a cysteinyl leukotriene 1 and 2 receptor inhibitor that inhibits bronchoconstriction and is used in the treatment of asthma.</p>
    Formula:C36H37F2NO5
    Purezza:98.27% - 99.5%
    Colore e forma:Solid
    Peso molecolare:601.68

    Ref: TM-T11388

  • BI-113823
    Targetmol
    + Info

    BI-113823

    CAS:
    <p>BI-113823 is an orally active and selective bradykinin B1 receptor antagonist. It alleviates mechanical hyperalgesia induced by complete Freund's adjuvant in rats. BI-113823 is applicable for research on chronic inflammatory pain.</p>
    Formula:C26H44N4O5S
    Colore e forma:Solid
    Peso molecolare:524.716

    Ref: TM-T205108

  • Zaladenant
    Targetmol
    + Info

    Zaladenant

    CAS:
    <p>Zaladenant is an adenosine receptor antagonist with antitumor properties.</p>
    Formula:C19H15F3N6O
    Colore e forma:Solid
    Peso molecolare:400.357

    Ref: TM-T205251

  • D3/5-HT receptor modulator-1
    Targetmol
    + Info

    D3/5-HT receptor modulator-1

    CAS:
    <p>D3/5-HT receptor modulator-1 (compound 5i) is a selective antagonist of the dopamine D3 and 5-HT2A receptors, and a partial agonist at the 5-HT1A receptor. It exhibits Ki values of 4.5 nM, 11.9 nM, and 15.3 nM for the dopamine D3, 5-HT2A, and 5-HT1A receptors respectively. The compound shows lower affinity for the dopamine D2 receptor, 5-HT2C receptor, and hERG channel. D3/5-HT receptor modulator-1 possesses atypical antipsychotic properties.</p>
    Formula:C24H29N3O2
    Colore e forma:Solid
    Peso molecolare:391.506

    Ref: TM-T205297

  • 25B-NBOH hydrochloride
    Targetmol
    + Info

    25B-NBOH hydrochloride

    CAS:
    <p>25B-NBOH hydrochloride is a phenethylamine that exhibits high affinity for serotonin (5-HT) receptors 5-HT2A and 5-HT2C, with pKi values of 8.3 and 9.4, respectively.</p>
    Formula:C17H21BrClNO3
    Colore e forma:Solid
    Peso molecolare:402.711

    Ref: TM-T204858

  • LY3154207
    Targetmol
    + Info

    LY3154207

    CAS:
    <p>LY3154207: selective, potent oral human dopamine D1 receptor PAM, low agonist activity, EC50=3 nM.</p>
    Formula:C24H29Cl2NO3
    Colore e forma:Solid
    Peso molecolare:450.4

    Ref: TM-T11912

  • Logo CymitQuimica
    Targetmol
    + Info

    5-HT6R/MAO-B modulator 1

    <p>5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.</p>
    Formula:C33H38N4O3S
    Colore e forma:Solid
    Peso molecolare:570.74

    Ref: TM-T64036

  • PSB 36
    Targetmol
    + Info

    PSB 36

    CAS:
    <p>A1 adenosine receptor antagonist</p>
    Formula:C21H30N4O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:386.49

    Ref: TM-T23202

  • SSR 146977
    Targetmol
    + Info

    SSR 146977

    CAS:
    <p>NK3 receptor antagonist</p>
    Formula:C35H42Cl2N4O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:621.64

    Ref: TM-T23395

  • (Rac)-Nebivolol
    Targetmol
    + Info

    (Rac)-Nebivolol

    CAS:
    <p>(Rac)-Nebivolol, a racemic β1-adrenergic blocker (IC50=0.8 nM), has vasodilatory properties and mitigates ethanol-induced cardiac harm.</p>
    Formula:C22H25F2NO4
    Colore e forma:Solid
    Peso molecolare:405.43

    Ref: TM-T62004

  • Logo CymitQuimica
    Targetmol
    + Info

    5-HT7R antagonist 1

    <p>5-HT7R antagonist 1 is a G protein-biased antagonist with Ki of 6.5 nM for 5-HT 7R.</p>
    Formula:C14H18Cl2N4
    Colore e forma:Solid
    Peso molecolare:313.23

    Ref: TM-T60790

  • Macitentan (n-butyl analogue)
    Targetmol
    + Info

    Macitentan (n-butyl analogue)

    CAS:
    <p>Macitentan n-butyl analogue, an oral ETA/ETB receptor blocker, may treat IPF and PAH.</p>
    Formula:C20H21Br2N5O4S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:587.29

    Ref: TM-T11935

  • S1P1 agonist 4
    Targetmol
    + Info

    S1P1 agonist 4

    CAS:
    <p>S1P1 agonist 4 exhibits enhanced potency with an EC 50 value of less than 0.05 mg/kg and a predicted human half-life (t1/2) of approximately 5 days, indicating</p>
    Formula:C24H31NO3
    Colore e forma:Solid
    Peso molecolare:381.51

    Ref: TM-T61639

  • IRL 2500
    Targetmol
    + Info

    IRL 2500

    CAS:
    <p>IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.</p>
    Formula:C36H35N3O4
    Purezza:99.36%
    Colore e forma:White Crystalline Solid
    Peso molecolare:573.68

    Ref: TM-T15596