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Segnalazione PI3K/Akt/mTOR

Segnalazione PI3K/Akt/mTOR

Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.

Sottocategorie di "Segnalazione PI3K/Akt/mTOR"

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Trovati 1025 prodotti di "Segnalazione PI3K/Akt/mTOR"

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  • EGFR-IN-74
    Targetmol
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    EGFR-IN-74

    <p>EGFR-IN-74 is a potent inhibitor targeting EGFR, specifically effective against the L858R/T790M mutations, exhibiting an IC50 value of 138 nM.</p>
    Formula:C32H28BrF3N6O4S
    Colore e forma:Solid
    Peso molecolare:729.57

    Ref: TM-T73170

  • WYE-23
    Targetmol
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    WYE-23

    CAS:
    <p>WYE-23 is an inhibitor of mammalian target of rapamycin (mTOR).</p>
    Formula:C26H32N8O4
    Colore e forma:Solid
    Peso molecolare:520.58

    Ref: TM-T71514

  • EGFR-IN-29
    Targetmol
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    EGFR-IN-29

    CAS:
    <p>EGFR-IN-29 is a potent EGFR inhibitor.</p>
    Formula:C36H46BrN8O2P
    Colore e forma:Solid
    Peso molecolare:733.68

    Ref: TM-T73106

  • LDHA/PDKs-IN-1
    Targetmol
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    LDHA/PDKs-IN-1

    CAS:
    <p>Compound 20e inhibits PDKs (IC50: 0.8 μM) &amp; LDHA (IC50: 0.15 μM), halts A549 cell growth, lowers lactate, boosts oxygen use.</p>
    Formula:C19H21FN2O4
    Colore e forma:Solid
    Peso molecolare:360.38

    Ref: TM-T61339

  • Labuxtinib
    Targetmol
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    Labuxtinib

    CAS:
    <p>Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].</p>
    Formula:C20H16FN5O2
    Purezza:99.77%
    Colore e forma:Solid
    Peso molecolare:377.37

    Ref: TM-T79851

  • TCS 21311
    Targetmol
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    TCS 21311

    CAS:
    <p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ &amp; GSK3β; &gt;100x selective over JAK1, JAK2, TYK2.</p>
    Formula:C27H25F3N4O4
    Purezza:99.39% - ≥98%
    Colore e forma:Solid
    Peso molecolare:526.51

    Ref: TM-T17019

  • MIPS-21335
    Targetmol
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    MIPS-21335

    CAS:
    <p>MIPS-21335 is a potent PI3KC2α inhibitor with an IC50 value of 7 nM and additionally exhibits inhibitory activity against PI3KC2β, p110α, p110β, and p110δ with</p>
    Formula:C24H21N7O5
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:487.47

    Ref: TM-T81791

  • ZL-2201
    Targetmol
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    ZL-2201

    CAS:
    <p>ZL-2201 is a potent inhibitor of DNA-PK, demonstrating an IC50 value of 1 nM.</p>
    Formula:C20H25N9O5S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:503.54

    Ref: TM-T78645

  • Simotinib
    Targetmol
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    Simotinib

    CAS:
    Simotinib (AL-6802) is an EGFR tyrosine kinase inhibitor (IC50 : 19.9 nM) with antitumour activity for the study of non-small cell lung cancer.
    Formula:C25H26ClFN4O4
    Purezza:99.7%
    Colore e forma:Solid
    Peso molecolare:500.95

    Ref: TM-T35916

  • EGFR-IN-30
    Targetmol
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    EGFR-IN-30

    CAS:
    <p>EGFR-IN-30 is an EGFR inhibitor (IC50: 1-10 nM, &lt;1 nM WT/mutants) with potential in cancer research.</p>
    Formula:C28H33BrN7O2P
    Colore e forma:Solid
    Peso molecolare:610.49

    Ref: TM-T73108

  • PIK-inhibitors
    Targetmol
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    PIK-inhibitors

    CAS:
    <p>PIK-inhibitors (MDK34597) is a pan PI3K inhibitors, an analog of PI-103.</p>
    Formula:C19H17N5O2
    Purezza:96.98%
    Colore e forma:Solid
    Peso molecolare:347.37

    Ref: TM-T3190

  • EGFR-IN-33
    Targetmol
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    EGFR-IN-33

    CAS:
    <p>EGFR-IN-33, a low-toxicity acrylamide, inhibits EGFR, aiding against cancer, especially NSCLC (from WO2021185348A1, comp. 13).</p>
    Formula:C26H25ClN6O2
    Colore e forma:Solid
    Peso molecolare:488.97

    Ref: TM-T63264

  • SAR-260301
    Targetmol
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    SAR-260301

    CAS:
    <p>SAR-260301 is an orally available and selective inhibitor of PI3Kβ (IC50: 23 nM).</p>
    Formula:C19H22N4O3
    Purezza:99.74%
    Colore e forma:Solid
    Peso molecolare:354.4

    Ref: TM-T16841

  • Nazartinib S-enantiomer
    Targetmol
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    Nazartinib S-enantiomer

    CAS:
    <p>Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.</p>
    Formula:C26H31ClN6O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:495.02

    Ref: TM-T11156

  • PI5P4Kα-IN-1
    Targetmol
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    PI5P4Kα-IN-1

    CAS:
    <p>PI5P4Kα-IN-1 (Compound 13) is a phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) inhibitor, displaying IC50 values of 2 μM for PI5P4Kα and 9.4 μM for PI5P4Kβ</p>
    Formula:C20H17N3O2S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:363.43

    Ref: TM-T78178

  • MS 154
    Targetmol
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    MS 154

    CAS:
    MS 154 is a potent PROTAC® targeting mutant EGFR in lung cancer, sparing WT-EGFR; effective in mice, with DC50 of 11-25 nM.
    Formula:C46H54ClFN8O8
    Colore e forma:Solid
    Peso molecolare:901.42

    Ref: TM-T41155

  • PT-65
    Targetmol
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    PT-65

    CAS:
    <p>PT-65, a potent and selective GSK3 degrader, demonstrates the highest degradation capacity for GSK3α (DC50 = 28.3 nM) and GSK3β (DC50 = 34.2 nM) in SH-SY5Y cells, making it applicable for Alzheimer's disease research [1].</p>
    Formula:C51H63N13O12S
    Colore e forma:Solid
    Peso molecolare:1082.19

    Ref: TM-T84913

  • Antitrypanosomal agent 14
    Targetmol
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    Antitrypanosomal agent 14

    CAS:
    Antitrypanosomal agent 14 (Compound 1), a potent T.
    Formula:C14H23N3OS
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:281.42

    Ref: TM-T79254

  • BGB-102
    Targetmol
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    BGB-102

    CAS:
    <p>BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.</p>
    Formula:C22H25BrN4O2
    Purezza:99.02%
    Colore e forma:Solid
    Peso molecolare:457.36

    Ref: TM-T10531

  • (Z)-RG-13022
    Targetmol
    + Info

    (Z)-RG-13022

    CAS:
    <p>(Z)-RG-13022 is a tyrosine kinase (TK) inhibitor that preferentially inhibits the TK activity of the EGF receptor, restricting the EGF-stimulated growth of cultured cells. It demonstrates an IC50 of 11 μM for DNA synthesis in HN5 cells, showcasing thrice the potency of its isomer, (E)-RG-13022 (IC50 = 38 μM). This compound is applied in breast cancer cell research [1] [2].</p>
    Formula:C16H14N2O2
    Colore e forma:Solid
    Peso molecolare:266.29

    Ref: TM-T84525