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Segnalazione PI3K/Akt/mTOR

Segnalazione PI3K/Akt/mTOR

Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.

Sottocategorie di "Segnalazione PI3K/Akt/mTOR"

Mostrare 2 più sottocategorie

Trovati 1025 prodotti di "Segnalazione PI3K/Akt/mTOR"

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  • HER2-IN-5
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    HER2-IN-5

    CAS:
    <p>HER2-IN-5 is an effective inhibitor of orally active HER-2.</p>
    Formula:C27H33N7O3
    Colore e forma:Solid
    Peso molecolare:503.6

    Ref: TM-T63432

  • SAR502250
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    SAR502250

    CAS:
    <p>SAR502250: potent, selective GSK3 inhibitor, IC50=12nM, oral, brain-penetrant, potential for AD research, antidepressant-like properties.</p>
    Formula:C19H18FN5O2
    Colore e forma:Solid
    Peso molecolare:367.38

    Ref: TM-T35560

  • BPIQ-I
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    BPIQ-I

    CAS:
    <p>BPIQ-I (PD 159121), an ATP-competitive EGFR tyrosine kinase inhibitor, exhibits potent anti-proliferative activity.</p>
    Formula:C16H12BrN5
    Colore e forma:Solid
    Peso molecolare:354.2

    Ref: TM-T70227

  • PI3K/mTOR Inhibitor-6
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    PI3K/mTOR Inhibitor-6

    CAS:
    <p>Potent, stable PI3K/mTOR Inhibitor-6 surpasses gedatolisib in gastric fluid; 10 μM hinders PI3K/Akt/mTOR pathway, aids cancer research.</p>
    Formula:C30H34N10O4
    Colore e forma:Solid
    Peso molecolare:598.66

    Ref: TM-T64219

  • 17β-Hydroxywortmannin
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    17β-Hydroxywortmannin

    CAS:
    <p>17β-Hydroxywortmannin is an orally active phosphatidylinositol-3-kinase (PI-3-kinase) inhibitor, exhibiting an IC50 of 0.5 nM and notably suppresses osteoclast resorption at an IC50 of 10 nM. Additionally, it demonstrates antitumor activity.</p>
    Formula:C23H26O8
    Colore e forma:Solid
    Peso molecolare:430.45

    Ref: TM-T84510

  • JND3229
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    JND3229

    CAS:
    <p>JND3229 inhibits EGFRC797S; IC50: 5.8-30.5 nM; halts cell growth; effective in non-small cell lung cancer study.</p>
    Formula:C33H41ClN8O2
    Purezza:98.75%
    Colore e forma:Solid
    Peso molecolare:617.18

    Ref: TM-T15615

  • Tenalisib R Enantiomer
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    Tenalisib R Enantiomer

    CAS:
    <p>Tenalisib R Enantiomer is an R enantiomer of Tenalisib .</p>
    Formula:C23H18FN5O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:415.42

    Ref: TM-T13120

  • GSK-3β inhibitor 8
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    GSK-3β inhibitor 8

    CAS:
    <p>GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine</p>
    Formula:C20H20ClN5OS
    Purezza:98.46%
    Colore e forma:Solid
    Peso molecolare:413.92

    Ref: TM-T35556

  • PI3Kγ inhibitor 2
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    PI3Kγ inhibitor 2

    CAS:
    <p>PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).</p>
    Formula:C20H18F3N5O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:433.38

    Ref: TM-T12465

  • EGFR-IN-61
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    EGFR-IN-61

    CAS:
    <p>EGFR-IN-61 inhibits EGFR kinase (IC50: 42 nM L858R/T790M, 137 nM L858R/T790M/C797S, 743 nM WT) and slows A549 &amp; H1975 cell growth (IC50: 2.14 &amp; 1.82 μM).</p>
    Formula:C33H37ClN8O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:629.15

    Ref: TM-T73128

  • EGFR-IN-85
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    EGFR-IN-85

    CAS:
    <p>EGFR-IN-85 (Compound 1), an EGFR inhibitor, exhibits potent activity with an IC50 of 0.19 μM against EGFRvⅢ phosphorylation and can suppress intratumoral EGFR</p>
    Formula:C26H30N8O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:486.57

    Ref: TM-T78574

  • JGK-068S
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    JGK-068S

    CAS:
    <p>Compound I (JGK-068S) is a potent inhibitor of the epidermal growth factor receptor (EGFR) [1].</p>
    Formula:C22H23BrFN5O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:488.35

    Ref: TM-T79124

  • PI3K/mTOR Inhibitor-12
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    PI3K/mTOR Inhibitor-12

    CAS:
    <p>PI3K/mTOR Inhibitor-12: oral, potent, selective; IC50: PI3Kα 0.06 nM, mTOR 3.12 nM; strong antitumor; less liver toxicity.</p>
    Formula:C27H27F2N9O4S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:611.62

    Ref: TM-T72374

  • Logo CymitQuimica
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    EGFR/CSC-IN-1

    CAS:
    <p>EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potential</p>
    Formula:C54H54Cl2FN7O7S2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:1067.08

    Ref: TM-T73995

  • 2′-Thioadenosine
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    2′-Thioadenosine

    CAS:
    <p>2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM against</p>
    Formula:C10H13N5O3S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:283.31

    Ref: TM-T78634

  • BMS-599626 Hydrochloride
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    BMS-599626 Hydrochloride

    CAS:
    <p>BMS-599626 HCl (AC480 HCl) is an oral inhibitor of HER1, HER2, HER4 kinases, potentially blocking tumor growth. IC50: 22/32/190 nM.</p>
    Formula:C27H28ClFN8O3
    Purezza:99.98%
    Colore e forma:Solid
    Peso molecolare:567.01

    Ref: TM-T5390

  • DZD1516
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    DZD1516

    CAS:
    <p>DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in both</p>
    Formula:C28H27F2N7O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:547.56

    Ref: TM-T79297

  • Lifirafenib
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    Lifirafenib

    CAS:
    <p>Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant</p>
    Formula:C25H17F3N4O3
    Purezza:98% - 98.25%
    Colore e forma:Solid
    Peso molecolare:478.42

    Ref: TM-T22272

  • BEBT-109
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    BEBT-109

    CAS:
    <p>BEBT-109 is a selective epidermal growth factor receptor (EGFR) inhibitor that shows anti-tumor activity in EGFR-mutant non-small cell lung cancer.</p>
    Formula:C27H32N8O3
    Purezza:97.26%
    Colore e forma:Solid
    Peso molecolare:516.6

    Ref: TM-T80643

  • EGFR mutant-IN-1
    Targetmol
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    EGFR mutant-IN-1

    <p>EGFR mutant-in-1, a 5-methylpyrimidopyridone, selectively inhibits EGFRL858R/T790M/C797S mutants with an IC50 of 27.5 nM, lessening EGFRWT impact.</p>
    Formula:C34H39ClFN7O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:632.17

    Ref: TM-T11164