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Segnalazione PI3K/Akt/mTOR

Segnalazione PI3K/Akt/mTOR

Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.

Sottocategorie di "Segnalazione PI3K/Akt/mTOR"

Mostrare 2 più sottocategorie

Trovati 1025 prodotti di "Segnalazione PI3K/Akt/mTOR"

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  • Alpelisib hydrochloride
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    Alpelisib hydrochloride

    CAS:
    <p>Alpelisib hydrochloride (BYL-719) is an oral, selective PI3Kα inhibitor with anticancer properties.</p>
    Formula:C19H23ClF3N5O2S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:477.93

    Ref: TM-T14191

  • Zandelisib
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    Zandelisib

    CAS:
    <p>Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.</p>
    Formula:C31H38F2N8O
    Purezza:99.88%
    Colore e forma:Solid
    Peso molecolare:576.68

    Ref: TM-T13386

  • DNA-PK-IN-10
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    DNA-PK-IN-10

    CAS:
    <p>DNA-PK-IN-10 is a DNA-PK inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1].</p>
    Formula:C25H28N6O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:444.53

    Ref: TM-T79165

  • PI3K/mTOR Inhibitor-1
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    PI3K/mTOR Inhibitor-1

    CAS:
    PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM)
    Formula:C18H22FN5O3S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:407.46

    Ref: TM-T12460

  • Sevabertinib
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    Sevabertinib

    CAS:
    <p>Sevabertinib (BAY 2927088) is an EGFR tyrosine kinase inhibitor, with anticancer activity, used in research on non-small cell lung cancer.</p>
    Formula:C24H25ClN4O5
    Purezza:99.81%
    Colore e forma:Solid
    Peso molecolare:484.93

    Ref: TM-T200964

  • Rheb inhibitor NR1
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    Rheb inhibitor NR1

    CAS:
    <p>Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor that promotes phosphorylation of S473pAKT.</p>
    Formula:C25H19BrCl2N2O3S
    Purezza:99.72%
    Colore e forma:Solid
    Peso molecolare:578.3

    Ref: TM-T16741

  • EGFR/ErbB-2 inhibitor-1
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    EGFR/ErbB-2 inhibitor-1

    CAS:
    <p>EGFR/ErbB-2 inhibitor-1 is a selective ErbB2/HER2 inhibitor that effectively blocks ErbB2 and HER2 signaling.</p>
    Formula:C23H15ClFN3OS2
    Purezza:98.93%
    Colore e forma:Solid
    Peso molecolare:467.97

    Ref: TM-T79861

  • EGFR-IN-87
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    EGFR-IN-87

    CAS:
    EGFR-IN-87 is an EGFR tyrosine kinase inhibitor with potent inhibitory activity, exhibiting IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM against EGFR_d746-750,
    Formula:C28H33N7O2
    Purezza:98.64%
    Colore e forma:Solid
    Peso molecolare:499.61

    Ref: TM-T79888

  • PI3K-IN-54
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    PI3K-IN-54

    CAS:
    <p>Compound 10w, a substituted pyrazolo[1,5-a]pyrimidinamide compound, is a ZSTK474 analog that shows anticancer activity against HeLa cells.</p>
    Formula:C20H24F2N8O3
    Purezza:98.15%
    Colore e forma:Solid
    Peso molecolare:462.45

    Ref: TM-T77771

  • BGB-8035
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    BGB-8035

    CAS:
    <p>BGB-8035 is a BTK inhibitor with antitumor activity that inhibits BTK, TEC, and EGFR.BGB-8035 is used in the study of tumors and autoimmune diseases.</p>
    Formula:C24H31N5O4
    Purezza:96.74%
    Colore e forma:Solid
    Peso molecolare:453.53

    Ref: TM-T73381

  • EGFR-IN-1 hydrochloride
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    EGFR-IN-1 hydrochloride

    CAS:
    <p>EGFR-IN-1 HCl targets L858R/T790M EGFR mutants over wild-type; IC50: 4 nM in H1975, 28 nM in mutant HCC827 cells.</p>
    Formula:C28H31ClN6O4
    Purezza:99.16%
    Colore e forma:Solid
    Peso molecolare:551.04

    Ref: TM-T11157L

  • EGFR-IN-8
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    EGFR-IN-8

    CAS:
    <p>EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLC</p>
    Formula:C32H23ClF3N7O4
    Purezza:99.51%
    Colore e forma:Solid
    Peso molecolare:662.02

    Ref: TM-T11162

  • PF-04979064
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    PF-04979064

    CAS:
    <p>PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).</p>
    Formula:C24H26N6O3
    Purezza:98.20% - ≥98%
    Colore e forma:Solid
    Peso molecolare:446.5

    Ref: TM-T7343

  • PKI-402
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    PKI-402

    CAS:
    <p>PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.</p>
    Formula:C29H34N10O3
    Purezza:99.94%
    Colore e forma:Solid
    Peso molecolare:570.65

    Ref: TM-T3656

  • GSK-F1
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    GSK-F1

    CAS:
    <p>GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.</p>
    Formula:C27H18F5N5O4S
    Purezza:97.03%
    Colore e forma:Solid
    Peso molecolare:603.52

    Ref: TM-T19840

  • GSK-3 inhibitor 1
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    GSK-3 inhibitor 1

    CAS:
    <p>GSK-3 inhibitor 1 is a GSK-3 inhibitor.</p>
    Formula:C22H17ClFN5O2
    Purezza:98.42%
    Colore e forma:Solid
    Peso molecolare:437.85

    Ref: TM-T11468

  • GDC-0349
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    GDC-0349

    CAS:
    <p>GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.</p>
    Formula:C24H32N6O3
    Purezza:96.00% - 98.17%
    Colore e forma:Solid
    Peso molecolare:452.55

    Ref: TM-T6510

  • Logo CymitQuimica
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    EGFR-IN-48

    <p>EGFR-IN-48: potent EGFR inhibitor, oral, IC50: 0.193-66.7 nM, blocks EGFR mutants &amp; BaF3/PC-9 cell proliferation.</p>
    Colore e forma:Solid

    Ref: TM-T64255

  • GLPG3312
    Targetmol
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    GLPG3312

    CAS:
    <p>GLPG3312 is a selective and potent pan-SIK inhibitor with the advantage of oral activity, for SIK1, SIK2 and SIK3, anti-inflammatory and immunomodulatory .</p>
    Formula:C23H21F2N5O3
    Purezza:98.53%
    Colore e forma:Solid
    Peso molecolare:453.44

    Ref: TM-T86509

  • EGFR-IN-132
    Targetmol
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    EGFR-IN-132

    CAS:
    <p>EGFR-IN-132 (Compound 23) is an EGFR inhibitor effective against various EGFR mutations including the wild-type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with IC50 values of 1.6, 0.025, 0.019, 0.022, and 0.029 nM, respectively. This compound demonstrates favorable pharmacokinetics with high oral bioavailability.</p>
    Formula:C27H31N7O3
    Colore e forma:Solid
    Peso molecolare:501.58

    Ref: TM-T201638