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Segnalazione PI3K/Akt/mTOR

Segnalazione PI3K/Akt/mTOR

Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.

Sottocategorie di "Segnalazione PI3K/Akt/mTOR"

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Trovati 1025 prodotti di "Segnalazione PI3K/Akt/mTOR"

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  • Logo CymitQuimica
    Targetmol
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    GSK-3β inhibitor 7

    <p>GSK-3β inhibitor 7 is a GSK-3β inhibitor (IC50: 5.25 μM).</p>
    Formula:C27H23BrN4O2S
    Colore e forma:Solid
    Peso molecolare:547.47

    Ref: TM-T63866

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    Targetmol
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    EGFR-IN-24

    <p>EGFR-IN-24 is a potent inhibitor of EGFR and inhibits EGFR (del19/T790M/C797S) and EGFR (L858R/T790M/C797S).</p>
    Formula:C30H35FN6O3
    Colore e forma:Solid
    Peso molecolare:546.64

    Ref: TM-T63857

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    Targetmol
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    EGFR/HER2/DHFR-IN-1

    <p>Potent EGFR/HER2/DHFR inhibitor for MCF-7 breast cancer; IC50: 0.153/0.108/0.291 μM; arrests G1/S phase, triggers apoptosis.</p>
    Formula:C14H11BrN4O2S
    Colore e forma:Solid
    Peso molecolare:379.23

    Ref: TM-T61596

  • DNA-PK-IN-6
    Targetmol
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    DNA-PK-IN-6

    CAS:
    <p>DNA-PK-IN-6 inhibits DNA-PKcs, disrupting tumor DNA repair and triggering apoptosis; enhances radiotherapy and targets various tumors (WO2021197159A1).</p>
    Formula:C19H21N7O
    Colore e forma:Solid
    Peso molecolare:363.42

    Ref: TM-T61370

  • EGFR-IN-133
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    EGFR-IN-133

    CAS:
    <p>EGFR-IN-133 (Compound 24) serves as an inhibitor targeting various mutations of the EGFR, including the wild type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with respective IC50 values of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. The compound exhibits favorable pharmacokinetic properties and high oral bioavailability.</p>
    Formula:C27H29F2N7O3
    Colore e forma:Solid
    Peso molecolare:537.56

    Ref: TM-T201790

  • 4-FPBUA
    Targetmol
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    4-FPBUA

    CAS:
    <p>4-FPBUA, a semi-synthetic analog of lichen acid, enhances the functionality of cell-based blood-brain barriers (BBB) and increases the transport of β-amyloid (Aβ) in monolayer cells. Additionally, it acts as an inhibitor of mTOR, enhancing cellular autophagy (Autophagy) which can reverse BBB disruption in vivo, making it relevant for research in Alzheimer's disease.</p>
    Formula:C31H23FO7
    Colore e forma:Solid
    Peso molecolare:526.51

    Ref: TM-T89888

  • ES-072
    Targetmol
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    ES-072

    CAS:
    <p>ES-072, a selective inhibitor targeting the EGFR mutant (EGFR-T790M), is administered orally. By hindering EGFR-T790M activity, it activates GSK3α, which subsequently leads to the phosphorylation of PD-L1 at Ser279 and Ser283. This phosphorylation facilitates the recruitment of the E3 ubiquitin ligase ARIH1, resulting in the ubiquitination and proteasomal degradation of PD-L1. Such a process not only curtails the growth of cancer cells but also amplifies the anti-tumor immune response by diminishing PD-L1 levels. ES-072 has shown efficacy in impeding the proliferation of non-small cell lung cancer (NSCLC) cells.</p>
    Formula:C25H27F3N8O2
    Colore e forma:Solid
    Peso molecolare:528.53

    Ref: TM-T200087

  • Logo CymitQuimica
    Targetmol
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    EGFR/BRAF-IN-1

    <p>EGFR/BRAF-IN-1 inhibits EGFR/BRAF (BRAFV600E IC50: 45 nM, GI50: 35 nM) and has antioxidant properties.</p>
    Formula:C26H28ClN3O4
    Colore e forma:Solid
    Peso molecolare:481.97

    Ref: TM-T63189

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    EGFR-IN-17

    <p>EGFR-IN-17: potent, selective EGFR inhibitor, IC50 of 0.2 nM, overcomes C797S drug resistance.</p>
    Formula:C27H31ClN7O3P
    Colore e forma:Solid
    Peso molecolare:568.01

    Ref: TM-T64020

  • BPI-15086
    Targetmol
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    BPI-15086

    CAS:
    <p>BPI-15086 is an orally active, effective, irreversible inhibitor selective for mutations, targeting both EGFR and the T790M resistance mutation tyrosine kinase. It can be utilized in the study of non-small cell lung cancer.</p>
    Formula:C29H33ClN8O4
    Colore e forma:Solid
    Peso molecolare:593.08

    Ref: TM-T200004

  • PI4KIIIbeta-IN-11
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    PI4KIIIbeta-IN-11

    CAS:
    <p>PI4KIIIbeta-IN-11 is a PI4KIIIβ inhibitor (mean pIC50=9.1) that can be used to study diseases caused by RNA viruses and Plasmodium falciparum.</p>
    Formula:C33H39N7O3
    Colore e forma:Solid
    Peso molecolare:581.71

    Ref: TM-T64106

  • EGFR-IN-149
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    EGFR-IN-149

    CAS:
    <p>EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor with an IC50 value of 0.42 nM.</p>
    Formula:C16H15N3OS
    Colore e forma:Solid
    Peso molecolare:297.375

    Ref: TM-T205658

  • PI3Kδ-IN-23
    Targetmol
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    PI3Kδ-IN-23

    CAS:
    <p>PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with an IC50 of 0.27 nM. It binds to PI3Kδ through covalent interaction with Lys779 and plays a significant role in cancer research.</p>
    Formula:C30H30N6O5
    Colore e forma:Solid
    Peso molecolare:554.596

    Ref: TM-T204114

  • Logo CymitQuimica
    Targetmol
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    PI3K-IN-23

    <p>PI3K-IN-23 is a (E)-9-oxooctadec-10-en-12-ynoic acid analogue that promotes glucose uptake (EC50: 7.00 μM).</p>
    Formula:C24H33NO4S
    Colore e forma:Solid
    Peso molecolare:431.59

    Ref: TM-T62409

  • GSK3-IN-9
    Targetmol
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    GSK3-IN-9

    CAS:
    GSK3-IN-9 (0713) is a selective inhibitor of glycogen synthase kinase 3 (GSK3). It holds potential for research into fragile X syndrome, attention deficit hyperactivity disorder (ADHD), childhood epilepsy, intellectual disabilities, diabetes, acute myeloid leukemia (AML), autism, and mental disorders.
    Formula:C18H20N4O
    Colore e forma:Solid
    Peso molecolare:308.378

    Ref: TM-T205647

  • Andamertinib
    Targetmol
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    Andamertinib

    CAS:
    <p>Andamertinib is an EGFR inhibitor with antitumor activity.</p>
    Formula:C31H36N8O3
    Colore e forma:Solid
    Peso molecolare:568.669

    Ref: TM-T206579

  • Logo CymitQuimica
    Targetmol
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    EGFR-IN-58

    <p>EGFR-IN-58 is a potent, selective, ATP-competitive inhibitor of EGFR. EGFR-IN-58 exhibits significant cytotoxicity against melanoma, colon and blood cancers.</p>
    Formula:C31H30FN7O
    Colore e forma:Solid
    Peso molecolare:535.61

    Ref: TM-T63774

  • Logo CymitQuimica
    Targetmol
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    PIKfyve-IN-1

    <p>PIKfyve-IN-1: potent, cell-active inhibitor for PIKfyve research, IC50=6.9 nM.</p>
    Formula:C20H21N5
    Colore e forma:Solid
    Peso molecolare:331.41

    Ref: TM-T60980

  • GSK-3β inhibitor 25
    Targetmol
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    GSK-3β inhibitor 25

    CAS:
    <p>GSK-3β inhibitor25 (Compound 6h) exhibits weak inhibitory activity against GSK-3β with an IC50 greater than 100 μM.</p>
    Formula:C16H15NOS
    Colore e forma:Solid
    Peso molecolare:269.361

    Ref: TM-T204501

  • EGFR-IN-135
    Targetmol
    + Info

    EGFR-IN-135

    <p>EGFR-IN-135 (compound 3d) is an EGFR inhibitor with an IC50 value of 0.086 µM. It inhibits cell growth and arrests the cell cycle in the S phase in breast cancer cell lines.</p>
    Formula:C12H14N4OS2
    Colore e forma:Solid
    Peso molecolare:294.4

    Ref: TM-T201484