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Segnalazione PI3K/Akt/mTOR

Segnalazione PI3K/Akt/mTOR

Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.

Sottocategorie di "Segnalazione PI3K/Akt/mTOR"

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Trovati 1030 prodotti di "Segnalazione PI3K/Akt/mTOR"

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  • Logo CymitQuimica
    Targetmol
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    GSK-3β inhibitor 6

    <p>GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM.</p>
    Formula:C20H17BrN4
    Colore e forma:Solid
    Peso molecolare:393.28

    Ref: TM-T61804

  • LSD1/EGFR-IN-1
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    LSD1/EGFR-IN-1

    CAS:
    <p>LSD1/EGFR-IN-1 (compound L-1) is an effective inhibitor of LSD1, EGFRT790M/L858R, and EGFRL858R/T790M/C797S, with IC50 values of 6.24, 2.06, and 5.01 μM, respectively. This compound plays a significant role in cancer research.</p>
    Formula:C21H20ClN3O4
    Colore e forma:Solid
    Peso molecolare:413.854

    Ref: TM-T204471

  • PF-5177624
    Targetmol
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    PF-5177624

    CAS:
    <p>PF-5177624 is a selective and potent PDK1 inhibitor inducing anti-tumor activity in breast cancer cells.</p>
    Formula:C25H25FN8O2
    Colore e forma:Solid
    Peso molecolare:488.52

    Ref: TM-T70911

  • Logo CymitQuimica
    Targetmol
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    Vps34-IN-3

    <p>Vps34-IN-3 is a potent, selective, and orally bioavailable inhibitor of VPS34 kinase .</p>
    Formula:C14H20N4O2
    Colore e forma:Solid
    Peso molecolare:276.33

    Ref: TM-T60506

  • PI4KIIIbeta-IN-11
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    PI4KIIIbeta-IN-11

    CAS:
    <p>PI4KIIIbeta-IN-11 is a PI4KIIIβ inhibitor (mean pIC50=9.1) that can be used to study diseases caused by RNA viruses and Plasmodium falciparum.</p>
    Formula:C33H39N7O3
    Colore e forma:Solid
    Peso molecolare:581.71

    Ref: TM-T64106

  • EGFR-IN-38
    Targetmol
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    EGFR-IN-38

    CAS:
    <p>EGFR-IN-38: low-toxic acrylamide-derived EGFR inhibitor, targets NSCLC, patented for research on EGFR mutation-related diseases.</p>
    Formula:C25H24ClN7O2
    Colore e forma:Solid
    Peso molecolare:489.96

    Ref: TM-T63283

  • PD-M6
    Targetmol
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    PD-M6

    CAS:
    <p>PD-M6 is an mTOR PROTAC degrader with a DC50 of 4.8 μM, which facilitates the ubiquitination and degradation of mTOR. It inhibits the proliferation of cancer cell lines HeLa, MCF-7, and HepG2 with IC50 values of 11.3, 2.58, and 3.23 μM, respectively, and induces autophagy. Additionally, PD-M6 specifically targets the degradation of the key protein LAMTOR1 in the mTOR signaling pathway.</p>
    Formula:C30H39N9O6
    Colore e forma:Solid
    Peso molecolare:621.69

    Ref: TM-T207406

  • SIK2-IN-3
    Targetmol
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    SIK2-IN-3

    CAS:
    <p>SIK2-IN-3 is an orally active selective inhibitor of SIK1/2 with IC50 values of 0.128/0.084 μM. It hinders the phosphorylation of CRTC3 and suppresses the production of pro-inflammatory factors in myeloid cells. Additionally, SIK2-IN-3 alleviates systemic and tissue inflammatory responses in a mouse anti-CD40 colitis model.</p>
    Formula:C23H24N6O2
    Colore e forma:Solid
    Peso molecolare:416.48

    Ref: TM-T207716

  • EGFR-IN-149
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    EGFR-IN-149

    CAS:
    <p>EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor with an IC50 value of 0.42 nM.</p>
    Formula:C16H15N3OS
    Colore e forma:Solid
    Peso molecolare:297.375

    Ref: TM-T205658

  • Logo CymitQuimica
    Targetmol
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    EGFR/HER2-IN-8

    <p>EGFR/HER2-IN-8 inhibits EGFR, HER2, DHFR (IC50: 0.45, 0.244, 5.669 μM); useful in cancer research, safe and selective.</p>
    Formula:C16H16N4O2S
    Colore e forma:Solid
    Peso molecolare:328.39

    Ref: TM-T60938

  • PI3kδ inhibitor 1
    Targetmol
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    PI3kδ inhibitor 1

    CAS:
    <p>PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).</p>
    Formula:C28H33FN6O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:504.60

    Ref: TM-T12463

  • GSK3-IN-9
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    GSK3-IN-9

    CAS:
    <p>GSK3-IN-9 (0713) is a selective inhibitor of glycogen synthase kinase 3 (GSK3). It holds potential for research into fragile X syndrome, attention deficit hyperactivity disorder (ADHD), childhood epilepsy, intellectual disabilities, diabetes, acute myeloid leukemia (AML), autism, and mental disorders.</p>
    Formula:C18H20N4O
    Colore e forma:Solid
    Peso molecolare:308.378

    Ref: TM-T205647

  • Lys(CO-C3-p-I-Ph)-O-tBu
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    Lys(CO-C3-p-I-Ph)-O-tBu

    CAS:
    <p>Lys(CO-C3-p-I-Ph)-O-tBu, a pharmacokinetic modifier (PK modifier), enhances the pharmacokinetic properties of PSMA ligand molecules by increasing their residence time in plasma through improved binding to albumin and reducing absorption by the salivary glands, potentially extending the active compound's half-life. Moreover, Ac-PSMA-trillium is an effective PSMA-targeting compound for various biological applications when modified with different radioactive isotopes. When labeled with 111 In, it serves as a DOTA chelating agent and imaging agent. Alternatively, when labeled with 225 Ac, it acts as a Macropa chelator for targeted radionuclide therapy (TRT) in researching metastatic castration-resistant prostate cancer (mCRPC) [1] [2].</p>
    Formula:C20H31IN2O3
    Colore e forma:Solid
    Peso molecolare:474.38

    Ref: TM-T86837

  • GSK3β-IN-1
    Targetmol
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    GSK3β-IN-1

    CAS:
    <p>GSK3β-IN-1 (compound 1) is an inhibitor of glycogen synthase kinase-3β (GSK-3β) with an IC50 value of 65 nM, and it is utilized in Alzheimer's disease research.</p>
    Formula:C17H13FN2O4S
    Colore e forma:Solid
    Peso molecolare:360.36

    Ref: TM-T204474

  • SIK2/3-IN-1
    Targetmol
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    SIK2/3-IN-1

    CAS:
    <p>SIK2/3-IN-1 (Compound 7S) is an orally active and selective inhibitor of SIK2/3. It significantly inhibits tumor growth without causing weight loss in the MV4-11 AML mouse CDX model. SIK2/3-IN-1 is applicable for research in MEF2C-dependent acute myeloid leukemia.</p>
    Formula:C20H19F3N6O2
    Colore e forma:Solid
    Peso molecolare:432.399

    Ref: TM-T206638

  • Logo CymitQuimica
    Targetmol
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    EGFR/HER2-IN-5

    <p>EGFR/HER2-IN-5: Irreversible, oral dual EGFR inhibitor, IC50 0.6 nM, targets L858R/T790M mutations, anti-tumor in vivo for lung cancer study.</p>
    Colore e forma:Solid

    Ref: TM-T64254

  • Logo CymitQuimica
    Targetmol
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    DNA-PK-IN-9

    <p>DNA-PK-IN-9 (YK6) is a potent DNA-PK inhibitor with an IC50 of 10.47 nM, important in cancer research.</p>
    Formula:C21H21N5O2
    Colore e forma:Solid
    Peso molecolare:375.42

    Ref: TM-T61533

  • Vulolisib
    Targetmol
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    Vulolisib

    CAS:
    <p>Vulolisib inhibits PI3K (α: IC50 0.2nM, β: 168nM, γ: 90nM, δ: 49nM), taken orally with anti-cancer properties.</p>
    Formula:C18H19F2N5O3S
    Colore e forma:Solid
    Peso molecolare:423.44

    Ref: TM-T62273

  • PI4KIII β inhibitor 5
    Targetmol
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    PI4KIII β inhibitor 5

    CAS:
    <p>PI4KIII beta inhibitor 5 (Compound 43) is an inhibitor of PI4KIIIβ with an IC50 of 19 nM. By inhibiting the PI3K/AKT pathway, it induces apoptosis in cancer cells, causes cell cycle arrest at the G2/M phase, and promotes autophagy. Additionally, PI4KIII beta inhibitor 5 demonstrates significant anti-tumor activity in the H446 small cell lung cancer xenograft model. This compound is applicable in cancer research studies.</p>
    Formula:C24H27F2N3O4S2
    Colore e forma:Solid
    Peso molecolare:523.616

    Ref: TM-T206518

  • HER2-IN-21
    Targetmol
    + Info

    HER2-IN-21

    CAS:
    <p>HER2-IN-21 (compound 657994) is an inhibitor of the human epidermal growth factor receptor 2 (HER2) with an IC50 value of 3.85 μM.</p>
    Formula:C20H18N4O3S
    Colore e forma:Solid
    Peso molecolare:394.447

    Ref: TM-T205331