CymitQuimica logo
Segnalazione PI3K/Akt/mTOR

Segnalazione PI3K/Akt/mTOR

Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.

Sottocategorie di "Segnalazione PI3K/Akt/mTOR"

Mostrare 2 più sottocategorie

Trovati 1030 prodotti di "Segnalazione PI3K/Akt/mTOR"

Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
prodotti per pagina.
  • HER2-IN-8
    Targetmol
    + Info

    HER2-IN-8

    CAS:
    <p>HER2-IN-8 is an inhibitor of HER-2 that can be used in the study of cancer and inflammation-related diseases.</p>
    Formula:C26H25F2N9O3
    Colore e forma:Solid
    Peso molecolare:549.53

    Ref: TM-T63881

  • HER2-IN-7
    Targetmol
    + Info

    HER2-IN-7

    CAS:
    <p>HER2-IN-7 is a potent HER2 inhibitor with potential for researching ErbB-related diseases, especially cancer.</p>
    Formula:C28H26F3N7O3
    Colore e forma:Solid
    Peso molecolare:565.55

    Ref: TM-T64003

  • Sacibertinib
    Targetmol
    + Info

    Sacibertinib

    CAS:
    <p>Sacibertinib inhibits Trk, targeting EGFR-TK (EC50 110 nM) &amp; HER2 (EC50 244 nM), with anticancer properties.</p>
    Formula:C32H31ClN6O4
    Colore e forma:Solid
    Peso molecolare:599.08

    Ref: TM-T64225

  • ETP-47037
    Targetmol
    + Info

    ETP-47037

    CAS:
    <p>ETP-47037: strong PI3Kα inhibitor (IC50: 0.99 nM), also targets PI3Kβ, δ, γ; may protect telomeres.</p>
    Formula:C20H27N9O3S
    Colore e forma:Solid
    Peso molecolare:473.55

    Ref: TM-T63072

  • EGFR-IN-132
    Targetmol
    + Info

    EGFR-IN-132

    CAS:
    <p>EGFR-IN-132 (Compound 23) is an EGFR inhibitor effective against various EGFR mutations including the wild-type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with IC50 values of 1.6, 0.025, 0.019, 0.022, and 0.029 nM, respectively. This compound demonstrates favorable pharmacokinetics with high oral bioavailability.</p>
    Formula:C27H31N7O3
    Colore e forma:Solid
    Peso molecolare:501.58

    Ref: TM-T201638

  • NSC381467
    Targetmol
    + Info

    NSC381467

    CAS:
    <p>NSC381467: Potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>
    Formula:C20H16O7
    Colore e forma:Solid
    Peso molecolare:368.34

    Ref: TM-T61441

  • GSK-3β inhibitor 25
    Targetmol
    + Info

    GSK-3β inhibitor 25

    CAS:
    <p>GSK-3β inhibitor25 (Compound 6h) exhibits weak inhibitory activity against GSK-3β with an IC50 greater than 100 μM.</p>
    Formula:C16H15NOS
    Colore e forma:Solid
    Peso molecolare:269.361

    Ref: TM-T204501

  • Tesevatinib tosylate
    Targetmol
    + Info

    Tesevatinib tosylate

    CAS:
    <p>Tesevatinib tosylate (XL-647 tosylate) is an orally administered epidermal growth factor receptor (EGFR) inhibitor that can cross the blood-brain barrier. It significantly reduces cell viability with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM), demonstrating antitumor activity by inhibiting tumor proliferation.</p>
    Formula:C31H33Cl2FN4O5S
    Colore e forma:Solid
    Peso molecolare:663.59

    Ref: TM-T201865

  • Logo CymitQuimica
    Targetmol
    + Info

    EGFR/BRAF-IN-1

    <p>EGFR/BRAF-IN-1 inhibits EGFR/BRAF (BRAFV600E IC50: 45 nM, GI50: 35 nM) and has antioxidant properties.</p>
    Formula:C26H28ClN3O4
    Colore e forma:Solid
    Peso molecolare:481.97

    Ref: TM-T63189

  • PI3K-IN-37
    Targetmol
    + Info

    PI3K-IN-37

    CAS:
    <p>PI3K-IN-37 inhibits PI3K α/β/δ (IC50: 6/8/4 nM) and mTOR (IC50: 4 nM).</p>
    Formula:C25H26N6O2
    Colore e forma:Solid
    Peso molecolare:442.51

    Ref: TM-T62580

  • Andamertinib
    Targetmol
    + Info

    Andamertinib

    CAS:
    <p>Andamertinib is an EGFR inhibitor with antitumor activity.</p>
    Formula:C31H36N8O3
    Colore e forma:Solid
    Peso molecolare:568.669

    Ref: TM-T206579

  • EGFR-IN-135
    Targetmol
    + Info

    EGFR-IN-135

    <p>EGFR-IN-135 (compound 3d) is an EGFR inhibitor with an IC50 value of 0.086 µM. It inhibits cell growth and arrests the cell cycle in the S phase in breast cancer cell lines.</p>
    Formula:C12H14N4OS2
    Colore e forma:Solid
    Peso molecolare:294.4

    Ref: TM-T201484

  • NU5455
    Targetmol
    + Info

    NU5455

    CAS:
    <p>NU5455 is a potent DNA-PKcs inhibitor, oral, boosts doxorubicin in liver tumors, amplifies topoisomerase inhibitors, no adverse effects.</p>
    Formula:C34H33N3O5S
    Colore e forma:Solid
    Peso molecolare:595.71

    Ref: TM-T64204

  • Logo CymitQuimica
    Targetmol
    + Info

    EGFR-IN-17

    <p>EGFR-IN-17: potent, selective EGFR inhibitor, IC50 of 0.2 nM, overcomes C797S drug resistance.</p>
    Formula:C27H31ClN7O3P
    Colore e forma:Solid
    Peso molecolare:568.01

    Ref: TM-T64020

  • EGFR-IN-125
    Targetmol
    + Info

    EGFR-IN-125

    CAS:
    <p>EGFR-IN-125 (example 37) is a potent EGFR inhibitor with IC50 values of &lt;0.3 nM for EGFR(d746-750/T790M/C797S), 0.52 nM for EGFR(L858R/T790M/C797S), 0.5 nM for EGFR(d746-750/C797S), 0.69 nM for EGFR(L858R/C797S), and 0.92 nM for EGFR (wild type).</p>
    Formula:C30H26N8O
    Colore e forma:Solid
    Peso molecolare:514.58

    Ref: TM-T204450

  • Logo CymitQuimica
    Targetmol
    + Info

    EGFR-IN-18

    <p>EGFR-IN-18 strongly inhibits L858R/T790M/C797S mutant EGFR (4.9 nM) and also targets wild-type EGFR (47 nM).</p>
    Formula:C33H28N6O3S
    Colore e forma:Solid
    Peso molecolare:588.68

    Ref: TM-T64170

  • EGFR/VEGFR2-IN-2
    Targetmol
    + Info

    EGFR/VEGFR2-IN-2

    <p>EGFR/VEGFR2-IN-2 (compound 4b) serves as a dual inhibitor of VEGFR-2 and EGFR.</p>
    Formula:C24H15FO3
    Colore e forma:Solid
    Peso molecolare:370.37

    Ref: TM-T201505

  • EGFR-IN-147
    Targetmol
    + Info

    EGFR-IN-147

    CAS:
    <p>EGFR-IN-147 (compound ID-5841161) is a potent EGFR inhibitor, demonstrating a 14% inhibition rate at a concentration of 1μM. It holds promise for cancer research applications.</p>
    Formula:C13H13N5O
    Colore e forma:Solid
    Peso molecolare:255.275

    Ref: TM-T204935

  • Logo CymitQuimica
    Targetmol
    + Info

    GSK-3β inhibitor 7

    <p>GSK-3β inhibitor 7 is a GSK-3β inhibitor (IC50: 5.25 μM).</p>
    Formula:C27H23BrN4O2S
    Colore e forma:Solid
    Peso molecolare:547.47

    Ref: TM-T63866

  • EGFR-IN-159
    Targetmol
    + Info

    EGFR-IN-159

    CAS:
    <p>EGFR-IN-159 (compound 12) is a dihydropyrimidine and a potent EGFR inhibitor with an IC50 of 29.00 nM. It exhibits dose-dependent inhibition of EGFR and HER2. The compound shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 does not cross the blood-brain barrier (BBB) and demonstrates significant anticancer activity.</p>
    Formula:C21H23N3O5
    Colore e forma:Solid
    Peso molecolare:397.424

    Ref: TM-T206989