CymitQuimica logo
Segnalazione PI3K/Akt/mTOR

Segnalazione PI3K/Akt/mTOR

Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.

Sottocategorie di "Segnalazione PI3K/Akt/mTOR"

Mostrare 2 più sottocategorie

Trovati 1037 prodotti di "Segnalazione PI3K/Akt/mTOR"

Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
prodotti per pagina.
  • Logo CymitQuimica
    Targetmol
    + Info

    EGFR-IN-58

    <p>EGFR-IN-58 is a potent, selective, ATP-competitive inhibitor of EGFR. EGFR-IN-58 exhibits significant cytotoxicity against melanoma, colon and blood cancers.</p>
    Formula:C31H30FN7O
    Colore e forma:Solid
    Peso molecolare:535.61

    Ref: TM-T63774

  • Logo CymitQuimica
    Targetmol
    + Info

    DNA-PK-IN-9

    <p>DNA-PK-IN-9 (YK6) is a potent DNA-PK inhibitor with an IC50 of 10.47 nM, important in cancer research.</p>
    Formula:C21H21N5O2
    Colore e forma:Solid
    Peso molecolare:375.42

    Ref: TM-T61533

  • EG31
    Targetmol
    + Info

    EG31

    CAS:
    <p>EG31 is an EGFR inhibitor that effectively suppresses the proliferation of triple-negative breast cancer (TNBC) cells by inhibiting the EGFR signaling pathway. It demonstrates a GI50 value of 498.90 nM for MDA-MB-231 cells and 740.73 nM for Hs578T cells, while also inducing apoptosis. Additionally, EG31 retains its antiproliferative activity against 5-fluorouracil (5-FU) resistant TNBC cells, with a GI50 of 519.5 nM. EG31 is applicable in research on TNBC resistance.</p>
    Formula:C30H13Br2N3O6
    Colore e forma:Solid
    Peso molecolare:671.25

    Ref: TM-T207269

  • EGFR-IN-130
    Targetmol
    + Info

    EGFR-IN-130

    <p>EGFR-IN-130 (compound 14b) is an EGFR inhibitor and an inducer of apoptosis (apoptoosis). It effectively kills HeLa cancer cells by inducing apoptosis.</p>
    Formula:C27H25N3O6S
    Colore e forma:Solid
    Peso molecolare:519.57

    Ref: TM-T201686

  • Logo CymitQuimica
    Targetmol
    + Info

    EGFR/HER2-IN-5

    <p>EGFR/HER2-IN-5: Irreversible, oral dual EGFR inhibitor, IC50 0.6 nM, targets L858R/T790M mutations, anti-tumor in vivo for lung cancer study.</p>
    Colore e forma:Solid

    Ref: TM-T64254

  • NU5455
    Targetmol
    + Info

    NU5455

    CAS:
    <p>NU5455 is a potent DNA-PKcs inhibitor, oral, boosts doxorubicin in liver tumors, amplifies topoisomerase inhibitors, no adverse effects.</p>
    Formula:C34H33N3O5S
    Colore e forma:Solid
    Peso molecolare:595.71

    Ref: TM-T64204

  • Logo CymitQuimica
    Targetmol
    + Info

    EGFR/HER2-IN-8

    <p>EGFR/HER2-IN-8 inhibits EGFR, HER2, DHFR (IC50: 0.45, 0.244, 5.669 μM); useful in cancer research, safe and selective.</p>
    Formula:C16H16N4O2S
    Colore e forma:Solid
    Peso molecolare:328.39

    Ref: TM-T60938

  • GSK3β-IN-1
    Targetmol
    + Info

    GSK3β-IN-1

    CAS:
    <p>GSK3β-IN-1 (compound 1) is an inhibitor of glycogen synthase kinase-3β (GSK-3β) with an IC50 value of 65 nM, and it is utilized in Alzheimer's disease research.</p>
    Formula:C17H13FN2O4S
    Colore e forma:Solid
    Peso molecolare:360.36

    Ref: TM-T204474

  • GSK-3β inhibitor 26
    Targetmol
    + Info

    GSK-3β inhibitor 26

    CAS:
    <p>GSK-3β inhibitor26 (Compound D14) is a GSK-3β inhibitor with an IC50 of 18.23 μM. This compound is applicable in research related to cancer, inflammation, and neurodegenerative diseases.</p>
    Formula:C15H11N3O3
    Colore e forma:Solid
    Peso molecolare:281.266

    Ref: TM-T205441

  • HER2-IN-8
    Targetmol
    + Info

    HER2-IN-8

    CAS:
    <p>HER2-IN-8 is an inhibitor of HER-2 that can be used in the study of cancer and inflammation-related diseases.</p>
    Formula:C26H25F2N9O3
    Colore e forma:Solid
    Peso molecolare:549.53

    Ref: TM-T63881

  • DNA-PK-IN-8
    Targetmol
    + Info

    DNA-PK-IN-8

    CAS:
    <p>DNA-PK-IN-8: Potent, selective oral DNA-PK inhibitor, IC50 = 0.8 nM, boosts anti-cancer effects with Doxorubicin.</p>
    Formula:C19H22N8O2
    Colore e forma:Solid
    Peso molecolare:394.43

    Ref: TM-T61828

  • D-69491 hydrochloride
    Targetmol
    + Info

    D-69491 hydrochloride

    CAS:
    <p>D-69491 hydrochloride is an inhibitor of HER-2 tyrosine kinase activity, blocking the phosphorylation of HER-2 and inhibiting the proliferation of SKOV-3 cells. It exhibits antitumor activity.</p>
    Formula:C25H26Cl2FN7O3
    Colore e forma:Solid
    Peso molecolare:562.42

    Ref: TM-T201568

  • PD-M6
    Targetmol
    + Info

    PD-M6

    CAS:
    <p>PD-M6 is an mTOR PROTAC degrader with a DC50 of 4.8 μM, which facilitates the ubiquitination and degradation of mTOR. It inhibits the proliferation of cancer cell lines HeLa, MCF-7, and HepG2 with IC50 values of 11.3, 2.58, and 3.23 μM, respectively, and induces autophagy. Additionally, PD-M6 specifically targets the degradation of the key protein LAMTOR1 in the mTOR signaling pathway.</p>
    Formula:C30H39N9O6
    Colore e forma:Solid
    Peso molecolare:621.69

    Ref: TM-T207406

  • PI4KIII β inhibitor 5
    Targetmol
    + Info

    PI4KIII β inhibitor 5

    CAS:
    <p>PI4KIII beta inhibitor 5 (Compound 43) is an inhibitor of PI4KIIIβ with an IC50 of 19 nM. By inhibiting the PI3K/AKT pathway, it induces apoptosis in cancer cells, causes cell cycle arrest at the G2/M phase, and promotes autophagy. Additionally, PI4KIII beta inhibitor 5 demonstrates significant anti-tumor activity in the H446 small cell lung cancer xenograft model. This compound is applicable in cancer research studies.</p>
    Formula:C24H27F2N3O4S2
    Colore e forma:Solid
    Peso molecolare:523.616

    Ref: TM-T206518

  • EGFR-IN-38
    Targetmol
    + Info

    EGFR-IN-38

    CAS:
    <p>EGFR-IN-38: low-toxic acrylamide-derived EGFR inhibitor, targets NSCLC, patented for research on EGFR mutation-related diseases.</p>
    Formula:C25H24ClN7O2
    Colore e forma:Solid
    Peso molecolare:489.96

    Ref: TM-T63283

  • EGFR-IN-35
    Targetmol
    + Info

    EGFR-IN-35

    CAS:
    <p>EGFR-IN-35, an acrylamide-based EGFR inhibitor, shows promise for EGFR mutation-related cancers like NSCLC.</p>
    Formula:C25H24ClN7O2
    Colore e forma:Solid
    Peso molecolare:489.96

    Ref: TM-T63282

  • Logo CymitQuimica
    Targetmol
    + Info

    GSK-3β inhibitor 6

    <p>GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM.</p>
    Formula:C20H17BrN4
    Colore e forma:Solid
    Peso molecolare:393.28

    Ref: TM-T61804

  • SIK2-IN-3
    Targetmol
    + Info

    SIK2-IN-3

    CAS:
    <p>SIK2-IN-3 is an orally active selective inhibitor of SIK1/2 with IC50 values of 0.128/0.084 μM. It hinders the phosphorylation of CRTC3 and suppresses the production of pro-inflammatory factors in myeloid cells. Additionally, SIK2-IN-3 alleviates systemic and tissue inflammatory responses in a mouse anti-CD40 colitis model.</p>
    Formula:C23H24N6O2
    Colore e forma:Solid
    Peso molecolare:416.48

    Ref: TM-T207716

  • Neptinib
    Targetmol
    + Info

    Neptinib

    CAS:
    <p>Neptinib (NEP010), a derivative of Afatinib, exhibits enhanced antitumor properties and improved pharmacokinetics when administered orally. It demonstrates a notable suppression of tumor expansion in mouse models of non-small cell lung cancer harboring various EGFR mutations. Furthermore, Neptinib effectively inhibits the EGFR kinase family, exhibiting IC 50 values of 0.24 nM for EGFR wt, 7.25 nM for EGFR L858R/T790M, 0.46 nM for EGFR L858R, and 1.79 nM for EGFR T790M.</p>
    Formula:C22H23ClFN5O2
    Colore e forma:Solid
    Peso molecolare:443.90

    Ref: TM-T89923

  • HER2-IN-21
    Targetmol
    + Info

    HER2-IN-21

    CAS:
    <p>HER2-IN-21 (compound 657994) is an inhibitor of the human epidermal growth factor receptor 2 (HER2) with an IC50 value of 3.85 μM.</p>
    Formula:C20H18N4O3S
    Colore e forma:Solid
    Peso molecolare:394.447

    Ref: TM-T205331