CymitQuimica logo
Segnalazione PI3K/Akt/mTOR

Segnalazione PI3K/Akt/mTOR

Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.

Sottocategorie di "Segnalazione PI3K/Akt/mTOR"

Mostrare 2 più sottocategorie

Trovati 1037 prodotti di "Segnalazione PI3K/Akt/mTOR"

Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
prodotti per pagina.
  • Logo CymitQuimica
    Targetmol
    + Info

    EGFR-IN-17

    <p>EGFR-IN-17: potent, selective EGFR inhibitor, IC50 of 0.2 nM, overcomes C797S drug resistance.</p>
    Formula:C27H31ClN7O3P
    Colore e forma:Solid
    Peso molecolare:568.01

    Ref: TM-T64020

  • Lys(CO-C3-p-I-Ph)-O-tBu
    Targetmol
    + Info

    Lys(CO-C3-p-I-Ph)-O-tBu

    CAS:
    <p>Lys(CO-C3-p-I-Ph)-O-tBu, a pharmacokinetic modifier (PK modifier), enhances the pharmacokinetic properties of PSMA ligand molecules by increasing their residence time in plasma through improved binding to albumin and reducing absorption by the salivary glands, potentially extending the active compound's half-life. Moreover, Ac-PSMA-trillium is an effective PSMA-targeting compound for various biological applications when modified with different radioactive isotopes. When labeled with 111 In, it serves as a DOTA chelating agent and imaging agent. Alternatively, when labeled with 225 Ac, it acts as a Macropa chelator for targeted radionuclide therapy (TRT) in researching metastatic castration-resistant prostate cancer (mCRPC) [1] [2].</p>
    Formula:C20H31IN2O3
    Colore e forma:Solid
    Peso molecolare:474.38

    Ref: TM-T86837

  • GSK-3β inhibitor 20
    Targetmol
    + Info

    GSK-3β inhibitor 20

    CAS:
    <p>GSK-3β inhibitor20 (compound 3A) is an effective inhibitor of GSK-3β, exhibiting an IC50 value of 74.4 nM.</p>
    Formula:C22H21N5O2S
    Colore e forma:Solid
    Peso molecolare:419.50

    Ref: TM-T200457

  • Logo CymitQuimica
    Targetmol
    + Info

    EGFR-IN-48

    <p>EGFR-IN-48: potent EGFR inhibitor, oral, IC50: 0.193-66.7 nM, blocks EGFR mutants &amp; BaF3/PC-9 cell proliferation.</p>
    Colore e forma:Solid

    Ref: TM-T64255

  • Logo CymitQuimica
    Targetmol
    + Info

    EGFR-IN-18

    <p>EGFR-IN-18 strongly inhibits L858R/T790M/C797S mutant EGFR (4.9 nM) and also targets wild-type EGFR (47 nM).</p>
    Formula:C33H28N6O3S
    Colore e forma:Solid
    Peso molecolare:588.68

    Ref: TM-T64170

  • Logo CymitQuimica
    Targetmol
    + Info

    EGFR/HER2-IN-7

    <p>EGFR/HER2-IN-7: Potent, selective dual inhibitor for MCF-7 cancer; IC50: EGFR 0.18μM, HER2 0.146μM, DHFR 0.907μM.</p>
    Formula:C19H21N3O2S
    Colore e forma:Solid
    Peso molecolare:355.45

    Ref: TM-T61272

  • SIK2/3-IN-1
    Targetmol
    + Info

    SIK2/3-IN-1

    CAS:
    <p>SIK2/3-IN-1 (Compound 7S) is an orally active and selective inhibitor of SIK2/3. It significantly inhibits tumor growth without causing weight loss in the MV4-11 AML mouse CDX model. SIK2/3-IN-1 is applicable for research in MEF2C-dependent acute myeloid leukemia.</p>
    Formula:C20H19F3N6O2
    Colore e forma:Solid
    Peso molecolare:432.399

    Ref: TM-T206638

  • Logo CymitQuimica
    Targetmol
    + Info

    PIKfyve-IN-1

    <p>PIKfyve-IN-1: potent, cell-active inhibitor for PIKfyve research, IC50=6.9 nM.</p>
    Formula:C20H21N5
    Colore e forma:Solid
    Peso molecolare:331.41

    Ref: TM-T60980

  • EGFR-IN-159
    Targetmol
    + Info

    EGFR-IN-159

    CAS:
    <p>EGFR-IN-159 (compound 12) is a dihydropyrimidine and a potent EGFR inhibitor with an IC50 of 29.00 nM. It exhibits dose-dependent inhibition of EGFR and HER2. The compound shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 does not cross the blood-brain barrier (BBB) and demonstrates significant anticancer activity.</p>
    Formula:C21H23N3O5
    Colore e forma:Solid
    Peso molecolare:397.424

    Ref: TM-T206989

  • GSK3-IN-9
    Targetmol
    + Info

    GSK3-IN-9

    CAS:
    <p>GSK3-IN-9 (0713) is a selective inhibitor of glycogen synthase kinase 3 (GSK3). It holds potential for research into fragile X syndrome, attention deficit hyperactivity disorder (ADHD), childhood epilepsy, intellectual disabilities, diabetes, acute myeloid leukemia (AML), autism, and mental disorders.</p>
    Formula:C18H20N4O
    Colore e forma:Solid
    Peso molecolare:308.378

    Ref: TM-T205647

  • JBJ-09-063
    Targetmol
    + Info

    JBJ-09-063

    CAS:
    <p>JBJ-09-063: EGFR inhibitor, IC50s 0.147-0.396 nM for various mutants; hinders EGFR/Akt/ERK1/2 phosphorylation; targets TKI-sensitive/resistant lung cancer.</p>
    Formula:C31H29FN4O3S
    Colore e forma:Solid
    Peso molecolare:556.65

    Ref: TM-T63939

  • LSD1/EGFR-IN-1
    Targetmol
    + Info

    LSD1/EGFR-IN-1

    CAS:
    <p>LSD1/EGFR-IN-1 (compound L-1) is an effective inhibitor of LSD1, EGFRT790M/L858R, and EGFRL858R/T790M/C797S, with IC50 values of 6.24, 2.06, and 5.01 μM, respectively. This compound plays a significant role in cancer research.</p>
    Formula:C21H20ClN3O4
    Colore e forma:Solid
    Peso molecolare:413.854

    Ref: TM-T204471

  • PI3Kδ-IN-23
    Targetmol
    + Info

    PI3Kδ-IN-23

    CAS:
    <p>PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with an IC50 of 0.27 nM. It binds to PI3Kδ through covalent interaction with Lys779 and plays a significant role in cancer research.</p>
    Formula:C30H30N6O5
    Colore e forma:Solid
    Peso molecolare:554.596

    Ref: TM-T204114

  • Sacibertinib
    Targetmol
    + Info

    Sacibertinib

    CAS:
    <p>Sacibertinib inhibits Trk, targeting EGFR-TK (EC50 110 nM) &amp; HER2 (EC50 244 nM), with anticancer properties.</p>
    Formula:C32H31ClN6O4
    Colore e forma:Solid
    Peso molecolare:599.08

    Ref: TM-T64225

  • SST0116CL1
    Targetmol
    + Info

    SST0116CL1

    CAS:
    <p>SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 μM) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT). It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 μM) and exhibits antiproliferative activity, inhibiting tumor growth.</p>
    Formula:C22H31ClN4O6
    Colore e forma:Solid
    Peso molecolare:482.96

    Ref: TM-T200022

  • PI3kδ inhibitor 1
    Targetmol
    + Info

    PI3kδ inhibitor 1

    CAS:
    <p>PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).</p>
    Formula:C28H33FN6O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:504.60

    Ref: TM-T12463

  • ETP-47037
    Targetmol
    + Info

    ETP-47037

    CAS:
    <p>ETP-47037: strong PI3Kα inhibitor (IC50: 0.99 nM), also targets PI3Kβ, δ, γ; may protect telomeres.</p>
    Formula:C20H27N9O3S
    Colore e forma:Solid
    Peso molecolare:473.55

    Ref: TM-T63072

  • AZD 3147
    Targetmol
    + Info

    AZD 3147

    CAS:
    <p>AZD 3147 inhibits mTORC1 (40.7 nM), mTORC2 (5.75 nM), and PI3Kα/β/δ/γ (912/5495/9333/6310 nM IC50s).</p>
    Formula:C24H31N5O4S2
    Purezza:99.99%
    Colore e forma:Solid
    Peso molecolare:517.66

    Ref: TM-T36200

  • Aldometanib
    Targetmol
    + Info

    Aldometanib

    CAS:
    <p>Aldometanib (LXY-05-029) is an oral aldolase inhibitor that maintains metabolic balance by blocking FBP and activating lysosomal AMPK.</p>
    Formula:C27H43Cl2IN2
    Purezza:99.32% - 99.55%
    Colore e forma:Solid
    Peso molecolare:593.46

    Ref: TM-T60122

  • BAY-8400
    Targetmol
    + Info

    BAY-8400

    <p>BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy in</p>
    Formula:C21H17F2N5O
    Purezza:99.53%
    Colore e forma:Solid
    Peso molecolare:393.39

    Ref: TM-T9498