Estimated delivery in United States, on Thursday 16 Jan 2025
Product Information
Name:
APTO 253
Synonyms:
- LOR 2532-(5-Fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline
Description:
Induces Kruppel like factor 4 (KLF4) and reduces the expression of MYC. Anti-tumor activity of APTO 253 has been demonstrated in AML and haematological malignancies. Inducing KLP4 expression in ovarian cancer cells using APT0 253 sensitises cells to cisplatin and paclitaxel. BRCA1/2-deficient cancer cells are hypersensitive to APTO 253, which mediates its action by causing DNA damage.
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:
Chemical properties
Molecular weight:
367.38 g/mol
Formula:
C22H14FN5
Purity:
Min. 95%
Color/Form:
Solid
InChI:
InChI=1S/C22H14FN5/c1-11-17(15-10-12(23)6-7-16(15)26-11)22-27-20-13-4-2-8-24-18(13)19-14(21(20)28-22)5-3-9-25-19/h2-10,26H,1H3,(H,27,28)
InChI key:
InChIKey=NIRXBXIPHUTNNI-UHFFFAOYSA-N
SMILES:
Cc1[nH]c2ccc(F)cc2c1-c1nc2c3cccnc3c3ncccc3c2[nH]1
MDL:
Melting point:
Boiling point:
Flash point:
Density:
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EINECS:
Merck:
HS code:
Technical inquiry about: 3D-BA166663 APTO 253
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