APTO 253

CAS: 916151-99-0

Ref. 3D-BA166663

Product Information

• Name: APTO 253
• Synonyms: LOR 2532-(5-Fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline
• Brand: Biosynth
• Description: Induces Kruppel like factor 4 (KLF4) and reduces the expression of MYC. Anti-tumor activity of APTO 253 has been demonstrated in AML and haematological malignancies. Inducing KLP4 expression in ovarian cancer cells using APT0 253 sensitises cells to cisplatin and paclitaxel. BRCA1/2-deficient cancer cells are hypersensitive to APTO 253, which mediates its action by causing DNA damage.

Chemical properties

• Molecular weight: 367.38 g/mol
• Formula: C₂₂H₁₄FN₅
• Purity: Min. 95%
• Color/Form: Solid
• InChI: InChI=1S/C22H14FN5/c1-11-17(15-10-12(23)6-7-16(15)26-11)22-27-20-13-4-2-8-24-18(13)19-14(21(20)28-22)5-3-9-25-19/h2-10,26H,1H3,(H,27,28)
• InChI key: InChIKey=NIRXBXIPHUTNNI-UHFFFAOYSA-N
• SMILES: Cc1[nH]c2ccc(F)cc2c1-c1nc2c3cccnc3c3ncccc3c2[nH]1