Product Information
Name:GNE 371
Brand:Biosynth
Description:A chemical probe for the dual bromodomains of human transcription-initiation-factor TFIID subunit 1 (TAF1). GNE 371 binds TAF1 with an IC50 of 10 nM and is selective over other bromodomain family members. Exerts anti-proliferative effects in synergy with BET inhibitor JQ1.
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Chemical properties
Molecular weight:431.49 g/mol
Formula:C24H25N5O3
Purity:(Hplc-Ms) Min. 98 Area-%
InChI:InChI=1S/C24H25N5O3/c1-3-4-7-29-14-19(17-5-6-25-22(17)24(29)31)18-12-16(13-20-21(18)26-15-27(20)2)23(30)28-8-10-32-11-9-28/h3,5-6,12-15,25H,1,4,7-11H2,2H3
InChI key:InChIKey=XJRUWGFZGQNPPD-UHFFFAOYSA-N
SMILES:C=CCCn1cc(-c2cc(C(=O)N3CCOCC3)cc3c2ncn3C)c2cc[nH]c2c1=O
Technical inquiry about: GNE 371
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