AG 120

CAS: 1448347-49-6

Ref. 3D-FA145491

Product Information

• Name: AG 120
• Synonyms: Ivosidenib
• Brand: Biosynth
• Description: Inhibits isocitrate dehydrogenase 1 (IDH-1) harbouring a gain of function mutation at R132, which causes impaired cellular differentiation via epigenetic modulation. By inhibiting mutant IDH1, synthesis of oncometabolite 2-hydroxyglutarate is reduced. This compound therefore has therapeutic potential in solid and haematological malignancies, such as acute myeloid leukemia (AML).

Chemical properties

• Molecular weight: 582.96 g/mol
• Formula: C₂₈H₂₂ClF₃N₆O₃
• Purity: Min. 95%
• Color/Form: White To Off-White Solid