ABT 737

CAS: 852808-04-9

Ref. 3D-FA16902

Product Information

• Name: ABT 737
• Synonyms: 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nit rophenyl]sulfonyl]benzamide
• Brand: Biosynth
• Description: Inhibits anti-apoptotic proteins Bcl-2, Bcl-xl and Bcl-w. Synergistic with chemotherapy and radiotherapy in several tumour cell lines. Potent activity as a single agent in lymphoid cancer and small cell lung cancer (SCLC) cell lines. Causes tumour regression in SCLC xenograft tumour in vivo.

Chemical properties

• Molecular weight: 813.43 g/mol
• Formula: C₄₂H₄₅ClN₆O₅S₂
• Purity: Min. 95%
• Color/Form: Yellow Solid