Estimated delivery in United States, on Wednesday 22 May 2024
Product Information
Name:
AMG 458
CAS:
Description:
A potent and selective c-Met inhibitor. Anti-tumour activity demonstrated in xenograft models in vivo. Forms a thioether conjugate by reacting with thiol groups in proteins. Non-small-cell lung carcinoma (NSCLC) tumour cells that overexpress c-MET have increased sensitivity to AMG458.
Brand:
Biosynth
Long term storage:
Notes:
Chemical properties
Molecular weight:
539.58 g/mol
Formula:
C30H29N5O5
Purity:
Min. 98 Area-%
Color/Form:
Powder
InChI:
InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)
InChI key:
InChIKey=GLBZSOQDAOLMGC-UHFFFAOYSA-N
SMILES:
COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:
Technical inquiry about: 3D-FA64937 AMG 458
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