Product Information
Name:AMG 458
Brand:Biosynth
Description:A potent and selective c-Met inhibitor. Anti-tumour activity demonstrated in xenograft models in vivo. Forms a thioether conjugate by reacting with thiol groups in proteins. Non-small-cell lung carcinoma (NSCLC) tumour cells that overexpress c-MET have increased sensitivity to AMG458.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:539.58 g/mol
Formula:C30H29N5O5
Purity:Min. 98 Area-%
Color/Form:Powder
InChI:InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)
InChI key:InChIKey=GLBZSOQDAOLMGC-UHFFFAOYSA-N
SMILES:COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Technical inquiry about: AMG 458
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