AMG 458

CAS: 913376-83-7

Ref. 3D-FA64937

Product Information

• Name: AMG 458
• Brand: Biosynth
• Description: A potent and selective c-Met inhibitor. Anti-tumour activity demonstrated in xenograft models in vivo. Forms a thioether conjugate by reacting with thiol groups in proteins. Non-small-cell lung carcinoma (NSCLC) tumour cells that overexpress c-MET have increased sensitivity to AMG458.

Chemical properties

• Molecular weight: 539.58 g/mol
• Formula: C₃₀H₂₉N₅O₅
• Purity: Min. 98 Area-%
• Color/Form: Powder
• InChI: InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)
• InChI key: InChIKey=GLBZSOQDAOLMGC-UHFFFAOYSA-N
• SMILES: COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1