3D-FS165340 - sodium-malonate

Applications SK-216 is a plasminogen activator inhibitor-1 (PAI-1) that limits tumor progression and angiogenesis, a therapeutic target in the management of malignancy.
References Masuda, T., et al.: Mol. Cancer Ther., 12, 2378 (2013)

Sodium barbiturate is a drug that binds to the malonic acid cycle and inhibits the production of energy. It also has antimicrobial properties, inhibiting the growth of bacteria and fungi. Sodium barbiturate has been shown to have cytotoxic effects on colorectal adenocarcinoma cells in vitro, although it does not have any significant cytotoxicity against bowel disease cells (Caco2). This drug has been shown to be effective in treating inflammatory bowel disease in human subjects. The mechanism behind this effect is not yet fully understood but may involve its ability to react with metal ions as well as its ability to inhibit tubule cells by binding to their plasma membrane.

1,3-Acetonedicarboxylic acid is a crystalline solid that belongs to the group of carboxylic acids. 1,3-Acetonedicarboxylic acid interacts with its receptor by binding to a hydroxyl group and two hydrogen atoms. It has been shown that 1,3-acetonedicarboxylic acid can inhibit HIV infection in vitro by preventing the virus from attaching to cells. It also inhibits malonic acid oxidation and citric acid cycle enzymes in rat liver mitochondria. The synthesis of 1,3-acetonedicarboxylic acid can be achieved through different methods:

1) By reacting sodium carbonate with malonic acid
2) By reacting hydrogen fluoride with malonic acid
3) By reacting sodium carbonate with citric acid (malonic ester) and then hydrolyzing it
4) By reacting sodium carbonate with malonitrile and then hydro

3-Aminophenylacetylene is a colorless liquid that is soluble in water. It has a molecular weight of 123.14 and a chemical formula of C6H5CHNH2. The transport rate of 3-aminophenylacetylene can be determined by FT-IR spectroscopy, and the epidermal growth factor can be used for the determination of 3-aminophenylacetylene. The anhydrous sodium copper complex is formed by the reaction of 3-aminophenylacetylene with hydrochloric acid. There are two possible mechanisms for this reaction: one involves the formation of a diazonium salt, while the other involves an analytical method that uses hydrogen bond or molecular docking analysis to determine the structure of 3-aminophenylacetylene. High values are obtained when 3-aminophenylacetylene reacts with malonic acid and protein synthesis.

Azidopalmitic acid is a synthetic fatty acid that is used in the detection of cellular DNA. It can be detected using methods such as tritiated, expressed, or myristic azide. Azidopalmitic acid has also been shown to be compatible with polymerase chain reaction (PCR) and immobilized metal ion affinity chromatography (IMAC). This molecule is useful for conjugates that are radiolabeled with [3H]azidoacetyl palmitate and [14C]azidoacetyl palmitate. Azidopalmitic acid has been synthetically produced by reacting malonic acid with sodium azide. This compound is also reusable, which makes it an ideal way to label nucleotides during PCR reactions.

2-Chloronaphthalene is a polychlorinated naphthalene that has been shown to be an effective inducer of p450 activity, which is a cytochrome P450 enzyme. 2-Chloronaphthalene is also a structural analog of the polychlorinated biphenyls (PCBs), and has been shown to have similar toxic effects on the liver. 2-Chloronaphthalene is used as an intermediate in organic synthesis and as a precursor for other compounds. It can be used to synthesize malonic acid, which can be reacted with sodium hydroxide or carbon disulfide to produce polymeric matrices such as polyvinyl chloride.