Lp-PLA2 -IN-1

CAS: 1420367-28-7

Ref. 3D-VGC36728

Product Information

• Name: Lp-PLA2 -IN-1
• Brand: Biosynth
• Description: Lp-PLA2-IN-1 is a small molecule inhibitor, which is derived from chemical synthesis, designed to specifically inhibit the activity of lipoprotein-associated phospholipase A2 (Lp-PLA2). This enzyme is involved in the hydrolysis of oxidized phospholipids on low-density lipoproteins (LDL), leading to the production of pro-inflammatory mediators. The mode of action involves the selective binding to the active site of Lp-PLA2, thus preventing the enzyme from catalyzing its reaction and subsequently reducing the formation of pro-inflammatory lysophosphatidylcholine and oxidized free fatty acids.The primary application of Lp-PLA2-IN-1 is in the study of cardiovascular diseases, where Lp-PLA2 has been identified as a biomarker and therapeutic target due to its role in the pathogenesis of atherosclerosis. By inhibiting Lp-PLA2, this compound aids in reducing vascular inflammation, thereby potentially decreasing the risk of atherosclerotic plaque development and rupture. Researchers utilize this inhibitor to validate the involvement of Lp-PLA2 in disease states and to explore therapeutic strategies aimed at mitigating cardiovascular risk factors.

Chemical properties

• Molecular weight: 468.38 g/mol
• Formula: C₂₁H₁₇F₅N₄O₃
• Purity: Min. 95%