DS03090629
Ref. TM-T200155
Product Information
Name:DS03090629
Brand:Targetmol
Description:DS03090629, an orally active MEK inhibitor, functions by competitively inhibiting MEK activity in the presence of ATP. This compound demonstrates strong binding affinity to both MEK and phosphorylated MEK, with dissociation constants (Kd) of 0.11 and 0.15 nM, respectively. It has shown efficacy in suppressing the proliferation of melanoma cell lines that overexpress BRAF mutations, achieving IC50 values of 74.3 and 97.8 nM for BRAF V600E and MEK1 F53L transfected A375 cells, respectively. DS03090629 is thus considered promising for anti-melanoma therapies.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:463.96
Formula:C25H26ClN5O2
Color/Form:Solid
Technical inquiry about: DS03090629
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