Merbarone

CAS: 97534-21-9

Ref. TM-T28017

Product Information

• Name: Merbarone
• Synonyms: RLBN-1001, RLBN1001, NSC-336628, NSC336628
• Brand: Targetmol
• Description: Merbarone is a Type II DNA topoisomerase inhibitor that suppresses the catalytic activity of human topoisomerase IIα by blocking DNA cleavage, subsequently inducing activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix, Merbarone triggers apoptosis in CEM cells through activation of ICE/CED-3-like proteases, making it a mechanistically informative compound for studying DNA damage responses and apoptosis pathways.

Chemical properties

• Molecular weight: 263.27
• Formula: C₁₁H₉N₃O₃S
• Purity: 99.51%
• Color/Form: Solid