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Sirtuin

Sirtuin

Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.

Found 95 products for "Sirtuin".

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  • Nicotinamide riboside
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    Nicotinamide riboside

    CAS:
    Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-
    Formula:C11H15N2O5
    Purity:99.58% - 99.89%
    Color and Shape:White Solid
    Molecular weight:255.25

    Ref: TM-T13795

  • Resveratrol
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    Resveratrol

    CAS:
    Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.
    Formula:C14H12O3
    Purity:99.82% - 99.96%
    Color and Shape:Solid
    Molecular weight:228.2433

    Ref: TM-T1558

  • MC3482
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    MC3482

    CAS:
    MC3482 is a specific inhibitor of sirtuin5 (SIRT5).
    Formula:C33H38N4O8
    Purity:98.56% - 99.90%
    Color and Shape:Yellow Solid
    Molecular weight:618.6768

    Ref: TM-T11962

  • SIRT-IN-2
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    SIRT-IN-2

    CAS:
    SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
    Formula:C15H21N5O3S2
    Purity:98.26%
    Color and Shape:Solid
    Molecular weight:383.489

    Ref: TM-T12919

  • SIRT3 activator 1
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    SIRT3 activator 1

    SIRT3 Activator 1 (Compound 5v) is a selective activator of SIRT3. It enhances the expression of SIRT3, leading to upregulation of SOD2 and OPA1. This activity effectively mitigates mitochondrial dysfunction, alleviates oxidative stress, and maintains the vitality of cardiac myocytes. SIRT3 Activator 1 is useful in the study of cardiovascular diseases.
    Formula:C32H41N2NaO5
    Color and Shape:Solid
    Molecular weight:556.67

    Ref: TM-T201386

  • WAY-323061
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    WAY-323061

    CAS:
    WAY-323061 is a SIRT2 inhibitor.
    Formula:C25H21N5O2S
    Purity:99.33%
    Color and Shape:Solid
    Molecular weight:455.532

    Ref: TM-T77605

  • MIND4-19
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    MIND4-19

    CAS:
    MIND4-19 is an inhibitor of SIRT2 with antitumor activity.
    Formula:C22H19N3OS
    Purity:99.99%
    Color and Shape:Solid
    Molecular weight:373.471

    Ref: TM-T9998

  • Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
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    Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)

    CAS:
    3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.
    Formula:C20H15N3O2S
    Purity:99.32%
    Color and Shape:Solid
    Molecular weight:361.417

    Ref: TM-T60001

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    Sirt1/2-IN-4

    Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (
    Formula:C21H20N4O3S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:440.54

    Ref: TM-T79565

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    SIRT2-IN-16

    SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).
    Formula:C55H91N9O15S
    Color and Shape:Solid
    Molecular weight:1150.43

    Ref: TM-T201246

  • SIRT1-IN-1
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    SIRT1-IN-1

    CAS:
    SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.
    Formula:C14H16N2O
    Purity:99.58%
    Color and Shape:Solid
    Molecular weight:228.2896

    Ref: TM-T9648

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    SIRT2-IN-12

    SIRT2-IN-12 (Compound 3) is a SIRT2 inhibitor with an IC50 value of 50 μM.
    Formula:C23H21Cl2NO3
    Color and Shape:Solid
    Molecular weight:429.08985

    Ref: TM-T209142

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    SIRT-IN-5

    SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.
    Color and Shape:Odour Solid

    Ref: TM-T200735

  • Et-29
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    Et-29

    CAS:
    Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.
    Formula:C34H46N6O6S
    Purity:99.52%
    Color and Shape:White Solid
    Molecular weight:666.831

    Ref: TM-T35347

  • Sirtuin modulator 2
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    Sirtuin modulator 2

    CAS:
    Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.
    Formula:C19H15N3O2S
    Purity:99.67%
    Color and Shape:Yellow Solid
    Molecular weight:349.406

    Ref: TM-T9999

  • SIRT5 inhibitor 8
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    SIRT5 inhibitor 8

    CAS:
    SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.
    Formula:C22H25ClN8O2S
    Purity:99.56%
    Color and Shape:Solid
    Molecular weight:501

    Ref: TM-T78856

  • Z26395438
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    Z26395438

    CAS:
    Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.
    Formula:C17H15FN2O
    Purity:99.54%
    Color and Shape:White Solid
    Molecular weight:282.3122

    Ref: TM-T77653

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    SIRT6 activator 3

    SIRT6 activator3 (Compound 24) is a SIRT6 activator with an EC50 of 5 μM. It demonstrates histone deacetylation activity and is applicable in cancer research.

    Ref: TM-T218458

  • SIRT5 inhibitor 9
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    SIRT5 inhibitor 9

    CAS:
    SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.
    Formula:C24H29ClN8O4S
    Purity:98.68%
    Color and Shape:Solid
    Molecular weight:561.06

    Ref: TM-T78857

  • HD-800
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    HD-800

    CAS:
    HD-800 is a highly selective SIRT2 inhibitor; IC50 37 nM; increases tubulin acetylation; regulates mitosis; cancer and neuroprotection research tool.
    Formula:C15H15N3O2
    Molecular weight:269.3

    Ref: TM-T212722