Product Information
Name:N-desmethyl Regorafenib N-oxide
Brand:Targetmol
Description:N-Desmethyl Regorafenib N-oxide, an active metabolite of the multi-kinase inhibitor regorafenib, originates through the action of the cytochrome P450 (CYP) isoform CYP3A4. This compound demonstrates efficacy in vitro by inhibiting key enzymes such as VEGFR2, Tie2, c-Kit, and B-RAF, and it exhibits tumor growth inhibition in HT-29 and MDA-MB-231 mouse xenograft models at a dosage of 1 mg/kg.
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Chemical properties
Molecular weight:484.79
Formula:C20H13ClF4N4O4
Color/Form:Solid
Technical inquiry about: N-desmethyl Regorafenib N-oxide
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