Product Information
Name:Neptinib
Synonyms:
- NEP010
Brand:Targetmol
Description:Neptinib (NEP010), a derivative of Afatinib, exhibits enhanced antitumor properties and improved pharmacokinetics when administered orally. It demonstrates a notable suppression of tumor expansion in mouse models of non-small cell lung cancer harboring various EGFR mutations. Furthermore, Neptinib effectively inhibits the EGFR kinase family, exhibiting IC 50 values of 0.24 nM for EGFR wt, 7.25 nM for EGFR L858R/T790M, 0.46 nM for EGFR L858R, and 1.79 nM for EGFR T790M.
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Chemical properties
Molecular weight:443.90
Formula:C22H23ClFN5O2
Color/Form:Solid
Technical inquiry about: Neptinib
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