Daunorubicinol-13C,d3 (mixture of diastereomers)

CAS: 28008-55-1

Ref. TR-D194512

Product Information

• Name: Daunorubicinol-13C,d3 (mixture of diastereomers)
• Synonyms: (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-[1-hydroxyethyl]-1-(methoxy-13C,d3)-5,12-naphthacenedione, 13-Dihydrodaunorubicin-13C,d3, Duborimycin-13C,d3, Leukaemomycin D-13C,d3
• Brand: TRC

Description

Applications A metabolite of Daunorubicin. Used as an antineoplastic. Complexes with DNA. Inhibits DNA and RNA synthesis.
References Mizuno, N.S., et al.: Cancer Res., 35, 1542 (1975), Munger, C., et al.: Cancer Res., 48, 2404 (1988), Kobayashi, Y., et al.: J. Biol. Chem., 275, 17639 ( 2000), Burke, B., et al.: Cardiovasc. Toxicol., 2, 41 (2002),

Chemical properties

• Molecular weight: 533.55
• Formula: CC₂₆D₃H₂₈NO₁₀
• Color/Form: Neat
• InChI: InChI=1S/C27H31NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10-11,14,16-17,22,29-30,32,34-35H,7-9,28H2,1-3H3/t10-,11?,14-,16-,17-,22+,27-/m0/s1/i3+1D3
• InChI key: InChIKey=HJEZFVLKJYFNQW-ZLLBQUENSA-N
• SMILES: [2H][13C]([2H])([2H])Oc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)([C@@H](C)O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1